Association between interleukin-1A polymorphism and cerebral amyloid angiopathy-related hemorrhage.

Abstract:

BACKGROUND AND PURPOSE:It has been suggested that the interleukin-1A (IL-1A) allele 2 is a risk factor for Alzheimer's disease (AD). Because cerebral amyloid angiopathy-related hemorrhage (CAAH) often coexists with AD, we examined the IL-1A polymorphism in CAAH. METHODS:In a case-control study, patients with pathologically verified CAAH, AD patients without intracerebral hemorrhage, and neuropathologically normal control subjects were studied. DNA was extracted from brain tissue, and IL-1A was genotyped. Logistic regression was used to examine the IL-1A polymorphism in CAAH patients with and without AD compared with AD and non-AD control subjects. RESULTS:There were 42 patients with CAAH, 232 AD patients, and 167 non-AD control subjects. In age-adjusted analyses, there was no association between possession of IL-1A allele 2 and risk of CAAH compared with AD control subjects (odds ratio [OR], 0.94; 95% confidence interval [CI], 0.45 to 1.97; P=0.87) or non-AD control subjects (OR, 0.94; 95% CI, 0.47 to 1.87; P=0.86). Stratifying for the presence of apolipoprotein E epsilon2 or epsilon4 demonstrated the known increased risk of CAAH from these lipoprotein E alleles. Subgroup analyses demonstrated a nonsignificant excess of the IL-1A 2,2 genotype in patients with CAAH and AD compared with those CAAH patients who did not have histological evidence indicating AD (OR, 2.17; 95% CI, 0.15 to 122.3; P=0.64). Comparisons between CAAH patients with AD and AD control subjects and between CAAH patients without AD and non-AD control subjects did not demonstrate an association between CAAH and possession of either the IL-1A allele 2 or the 2,2 genotype. CONCLUSIONS:The IL-1A allele 2 or 2,2 genotype does not appear to be a major risk factor for CAAH.

journal_name

Stroke

journal_title

Stroke

authors

McCarron MO,Stewart J,McCarron P,Love S,Vinters HV,Ironside JW,Mann DM,Graham DI,Nicoll JA

doi

10.1161/01.STR.0000089294.85447.1E

subject

Has Abstract

pub_date

2003-10-01 00:00:00

pages

e193-5

issue

10

eissn

0039-2499

issn

1524-4628

pii

01.STR.0000089294.85447.1E

journal_volume

34

pub_type

杂志文章

相关文献

STROKE文献大全
  • The effect of a stroke unit: reductions in mortality, discharge rate to nursing home, length of hospital stay, and cost. A community-based study.

    abstract:BACKGROUND AND PURPOSE:Treatment of stroke patients in specialized stroke units has become more frequent, yet the effect of this treatment has not been determined. METHODS:In a community-based, prospective, and consecutive study of 1241 unselected acute stroke patients, we compared outcome of stroke treatment between ...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.26.7.1178

    authors: Jørgensen HS,Nakayama H,Raaschou HO,Larsen K,Hübbe P,Olsen TS

    更新日期:1995-07-01 00:00:00

  • Safety and Outcome of Endovascular Treatment in Prestroke-Dependent Patients.

    abstract::Background and Purpose- Prestroke dependence is an exclusion criterion in most trials of endovascular treatment (EVT) for acute ischemic stroke. Little is known about outcomes after EVT in these patients. We compared outcome and safety of EVT between prestroke-dependent and prestroke-independent patients. Methods- We ...

    journal_title:Stroke

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1161/STROKEAHA.118.022352

    authors: Goldhoorn RB,Verhagen M,Dippel DWJ,van der Lugt A,Lingsma HF,Roos YBWEM,Majoie CBLM,Vos JA,Boiten J,van Zwam WH,van Oostenbrugge RJ,van den Wijngaard I,MR CLEAN Registry Investigators.

    更新日期:2018-10-01 00:00:00

  • Blinded-reader comparison of magnetic resonance angiography and duplex ultrasonography for carotid artery bifurcation stenosis.

    abstract:BACKGROUND AND PURPOSE:We compared two-dimensional time-of-flight magnetic resonance angiography (MRA) and duplex ultrasonography with arteriography for the detection of 70% to 99% stenoses at the carotid artery bifurcation (ie, surgical disease according to findings of the North American Carotid Endarterectomy Trial)....

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.25.1.4

    authors: Mittl RL Jr,Broderick M,Carpenter JP,Goldberg HI,Listerud J,Mishkin MM,Berkowitz HD,Atlas SW

    更新日期:1994-01-01 00:00:00

  • Delay of stroke onset by milk proteins in stroke-prone spontaneously hypertensive rats.

    abstract:BACKGROUND AND PURPOSE:There is an inverse association between dairy food consumption and the incidence of stroke in observational studies. However, it is unknown whether the relationship is causal or, if so, what components in milk are responsible for reducing the incidence of stroke. METHODS:Stroke-prone spontaneous...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/STROKEAHA.111.618496

    authors: Chiba T,Itoh T,Tabuchi M,Ooshima K,Satou T,Ezaki O

    更新日期:2012-02-01 00:00:00

  • The effect of graduated compression stockings on long-term outcomes after stroke: the CLOTS trials 1 and 2.

    abstract:BACKGROUND AND PURPOSE:Most randomized controlled trials of venous thromboembolism prophylaxis have focused on reduction of deep vein thrombosis, predominantly asymptomatic deep vein thrombosis, detected on imaging. We aimed to estimate the effects of graduated compression stockings on venous thromboembolism events, su...

    journal_title:Stroke

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1161/STROKEAHA.111.680298

    authors: CLOTS Trials Collaboration.,Dennis M,Sandercock P,Reid J,Graham C,Murray G,Venables G,Rudd A,Bowler G

    更新日期:2013-04-01 00:00:00

  • Strictly Lobar Microbleeds Reflect Amyloid Angiopathy Regardless of Cerebral and Cerebellar Compartments.

    abstract:BACKGROUND AND PURPOSE:We aimed to determine whether lobar cerebellar microbleeds or concomitant lobar cerebellar and deep microbleeds, in the presence of lobar cerebral microbleeds, attribute to underlying advanced cerebral amyloid angiopathy pathology or hypertensive arteriopathy. METHODS:We categorized 71 patients ...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/STROKEAHA.119.028487

    authors: Jung YH,Jang H,Park SB,Choe YS,Park Y,Kang SH,Lee JM,Kim JS,Kim J,Kim JP,Kim HJ,Na DL,Seo SW

    更新日期:2020-12-01 00:00:00

  • Is occult atrial disorder a frequent cause of non-hemorrhagic stroke? Long-term ECG in 86 patients.

    abstract::To assess the importance of occult atrial disorder with possible embolization as a cause of non-hemorrhagic stroke, 68 patients with neurologic symptoms lasting 24 hours or more and 18 patients with transient ischemic attacks were examined by long-term electrocardiographic recording (LTER). Lacking matched controls we...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.13.6.832

    authors: Abdon NJ,Zettervall O,Carlson J,Berglund S,Sterner G,Tejler L,Turesson I

    更新日期:1982-11-01 00:00:00

  • Complex plaques in the proximal descending aorta: an underestimated embolic source of stroke.

    abstract:BACKGROUND AND PURPOSE:To investigate the incidence of retrograde flow from complex plaques (> or =4-mm-thick, ulcerated, or superimposed thrombi) of the descending aorta (DAo) and its potential role in embolic stroke. METHODS:Ninety-four consecutive acute stroke patients with aortic plaques > or =3-mm-thick in transe...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/STROKEAHA.109.577775

    authors: Harloff A,Simon J,Brendecke S,Assefa D,Helbing T,Frydrychowicz A,Weber J,Olschewski M,Strecker C,Hennig J,Weiller C,Markl M

    更新日期:2010-06-01 00:00:00

  • Assessing the laryngeal cough reflex and the risk of developing pneumonia after stroke: an interhospital comparison.

    abstract:BACKGROUND AND PURPOSE:We sought to evaluate the efficacy of testing the laryngeal cough reflex in identifying pneumonia risk in acute stroke patients. METHODS:We performed a prospective study of 400 consecutive acute stroke patients examined using the reflex cough test (RCT) compared with 204 consecutive acute stroke...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.30.6.1203

    authors: Addington WR,Stephens RE,Gilliland KA

    更新日期:1999-06-01 00:00:00

  • Rivaroxaban for stroke prevention in East Asian patients from the ROCKET AF trial.

    abstract:BACKGROUND AND PURPOSE:In Rivaroxaban Once Daily Oral Direct Factor Xa Inhibitor Compared With Vitamin K Antagonism for Prevention of Stroke and Embolism Trial in Atrial Fibrillation (ROCKET AF) trial, rivaroxaban was noninferior to dose-adjusted warfarin in preventing stroke or systemic embolism among patients with no...

    journal_title:Stroke

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1161/STROKEAHA.113.002968

    authors: Wong KS,Hu DY,Oomman A,Tan RS,Patel MR,Singer DE,Breithardt G,Mahaffey KW,Becker RC,Califf R,Fox KA,Berkowitz SD,Hacke W,Hankey GJ,Executive Steering Committee and the ROCKET AF Study Investigators.

    更新日期:2014-06-01 00:00:00

  • Cardiac arrhythmias and stroke: increased risk in men with high frequency of atrial ectopic beats.

    abstract:BACKGROUND AND PURPOSE:With the exception of atrial fibrillation (AF), little scientific attention has been given the associations between cardiac arrhythmias and incidence of stroke. We sought to study whether atrial and ventricular arrhythmias assessed during a 24-hour ambulatory ECG registration are associated with ...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.31.12.2925

    authors: Engström G,Hedblad B,Juul-Möller S,Tydén P,Janzon L

    更新日期:2000-12-01 00:00:00

  • Electrical forepaw stimulation during reversible forebrain ischemia decreases infarct volume.

    abstract:BACKGROUND AND PURPOSE:Functional stimulation is accompanied by increases in regional cerebral blood flow which exceed metabolic demands under normal circumstances, but it is unknown whether functional stimulation is beneficial or detrimental in the setting of acute ischemia. The aim of this study was to determine the ...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.STR.0000217305.82123.d8

    authors: Burnett MG,Shimazu T,Szabados T,Muramatsu H,Detre JA,Greenberg JH

    更新日期:2006-05-01 00:00:00

  • IMPS (intact months of patient survival): an analysis of the results of carotid endarterectomy.

    abstract::The literature on carotid surgery for lesions appropriate to prior episodes of ischemia has been reviewed. Only one randomized study and six non-controlled reports give useful data (this despite more than thirty years of surgical activity in this field). When analyzed by the IMPS (intact months of patient survival) cr...

    journal_title:Stroke

    pub_type: 临床试验,杂志文章

    doi:10.1161/01.str.17.6.1329

    authors: Jonas S

    更新日期:1986-11-01 00:00:00

  • Dynamic Regional Brain Atrophy Rates in the First Year After Ischemic Stroke.

    abstract:BACKGROUND AND PURPOSE:Brain atrophy can be regarded as an end-organ effect of cumulative cardiovascular risk factors. Accelerated brain atrophy is described following ischemic stroke, but it is not known whether atrophy rates vary over the poststroke period. Examining rates of brain atrophy allows the identification o...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/STROKEAHA.120.030256

    authors: Brodtmann A,Khlif MS,Egorova N,Veldsman M,Bird LJ,Werden E

    更新日期:2020-09-01 00:00:00

  • Altered fibrin clot structure/function in patients with cryptogenic ischemic stroke.

    abstract:BACKGROUND AND PURPOSE:We tested the hypothesis that fibrin structure/function is unfavorably altered in patients with cryptogenic ischemic stroke. METHODS:Ex vivo plasma fibrin clot permeability, turbidimetry, and efficiency of fibrinolysis were determined in 89 patients with patent foramen ovale (PFO) and a history ...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/STROKEAHA.108.532812

    authors: Undas A,Podolec P,Zawilska K,Pieculewicz M,Jedliński I,Stepień E,Konarska-Kuszewska E,Weglarz P,Duszyńska M,Hanschke E,Przewlocki T,Tracz W

    更新日期:2009-04-01 00:00:00

  • 111-Indium platelet imaging, Doppler spectral analysis and angiography compared in patients with transient cerebral ischaemia.

    abstract::We have evaluated carotid gamma imaging using 111Indium-labelled platelets in the diagnosis of carotid artery disease and measured the accumulation of labelled platelets on endarterectomy specimens. Autologous 111In labelled platelets were injected in 25 patients with TIA. Gamma images were then taken daily and indepe...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.14.5.752

    authors: Goldman M,Leung JO,Aukland A,Hawker RJ,Drolc Z,McCollum CN

    更新日期:1983-09-01 00:00:00

  • Thrombolysis in stroke mimics: frequency, clinical characteristics, and outcome.

    abstract:BACKGROUND AND PURPOSE:Intravenous thrombolysis for acute ischemic stroke is usually based on clinical assessment, blood test results, and CT findings. Intravenous thrombolysis of stroke mimics may occur but has not been studied in detail. METHODS:We determined frequency, clinical characteristics, and outcome of mimic...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/STROKEAHA.108.530352

    authors: Winkler DT,Fluri F,Fuhr P,Wetzel SG,Lyrer PA,Ruegg S,Engelter ST

    更新日期:2009-04-01 00:00:00

  • Heritability of carotid artery distensibility in Hispanics: the Northern Manhattan Family Study.

    abstract:BACKGROUND AND PURPOSE:Reduced arterial distensibility has been introduced as a novel risk factor for atherosclerosis. The importance of the genetic contribution to variation in distensibility is largely unknown. The purpose of this study was to estimate heritability of carotid distensibility. METHODS:The ongoing Nort...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.STR.0000185926.05011.72

    authors: Juo SH,Rundek T,Lin HF,Cheng R,Lan MY,Huang JS,Boden-Albala B,Sacco RL

    更新日期:2005-11-01 00:00:00

  • PERK (Protein Kinase RNA-Like ER Kinase) Branch of the Unfolded Protein Response Confers Neuroprotection in Ischemic Stroke by Suppressing Protein Synthesis.

    abstract::Background and Purpose- Ischemic stroke impairs endoplasmic reticulum (ER) function, causes ER stress, and activates the unfolded protein response. The unfolded protein response consists of 3 branches controlled by ER stress sensor proteins, which include PERK (protein kinase RNA-like ER kinase). Activated PERK phosph...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/STROKEAHA.120.029071

    authors: Wang YC,Li X,Shen Y,Lyu J,Sheng H,Paschen W,Yang W

    更新日期:2020-05-01 00:00:00

  • Increased vulnerability of the blood-brain barrier to experimental subarachnoid hemorrhage in spontaneously hypertensive rats.

    abstract::The influence of chronic arterial hypertension upon the permeability to albumin of the cerebral capillaries, i.e. the blood-brain barrier, was studied in normotensive Wistar and spontaneously hypertensive Wistar rats with experimental subarachnoid hemorrhage. The blood-brain barrier permeability to albumin was assesse...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.17.3.498

    authors: Dóczi T,Joó F,Sonkodi S,Adám G

    更新日期:1986-05-01 00:00:00

  • Repeated Intravenous Thrombolysis for Early Recurrent Stroke: Challenging the Exclusion Criterion.

    abstract:BACKGROUND AND PURPOSE:Intravenous thrombolysis (IVT) within 4.5 hours from symptom onset improves functional outcome in patients with acute ischemic stroke. Its use in patients with previous stroke within the preceding 3 months is contraindicated because of the assumed higher risk of intracranial hemorrhage. In additi...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/STROKEAHA.116.013599

    authors: Kahles T,Mono ML,Heldner MR,Baumgartner RW,Sarikaya H,Luft A,Bohlhalter S,Traenka C,Engelter ST,Kurka N,Köhrmann M,Curtze S,Michel P,Tatlisumak T,Nedeltchev K

    更新日期:2016-08-01 00:00:00

  • Prevalence of asymptomatic retinal emboli in an Australian urban community.

    abstract:BACKGROUND AND PURPOSE:Because no population-based estimates are available for asymptomatic retinal emboli, we aimed to assess prevalence and associations of this sign in a defined older Australian urban population. METHODS:A total of 3654 persons aged 49 years or older, representing 82% of residents in an urban area ...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.28.1.63

    authors: Mitchell P,Wang JJ,Li W,Leeder SR,Smith W

    更新日期:1997-01-01 00:00:00

  • Comparison of computed tomographic and magnetic resonance perfusion measurements in acute ischemic stroke: back-to-back quantitative analysis.

    abstract:BACKGROUND AND PURPOSE:Magnetic resonance perfusion (MRP) and computed tomographic perfusion (CTP) are being increasingly applied in acute stroke trials and clinical practice, yet the comparability of their perfusion values is not well validated. The aim of this study was to validate the comparability of CTP and MRP me...

    journal_title:Stroke

    pub_type: 杂志文章,随机对照试验

    doi:10.1161/STROKEAHA.114.005419

    authors: Lin L,Bivard A,Levi CR,Parsons MW

    更新日期:2014-06-01 00:00:00

  • Risk of stroke from new carotid artery occlusion in the Asymptomatic Carotid Surgery Trial-1.

    abstract:BACKGROUND AND PURPOSE:In the Asymptomatic Carotid Surgery Trial-1 (ACST-1), 3120 patients with tight asymptomatic carotid stenosis were randomly assigned to medical treatment alone or to carotid endarterectomy and appropriate medication. Successful carotid endarterectomy significantly reduced 10-year stroke risk in yo...

    journal_title:Stroke

    pub_type: 杂志文章,随机对照试验

    doi:10.1161/STROKEAHA.111.000348

    authors: den Hartog AG,Halliday AW,Hayter E,Pan H,Kong X,Moll FL,de Borst GJ,Asymptomatic Carotid Surgery Trial Collaborators.

    更新日期:2013-06-01 00:00:00

  • Stent placement in acute cerebral artery occlusion: use of a self-expandable intracranial stent for acute stroke treatment.

    abstract:BACKGROUND AND PURPOSE:Stent placement has been applied in small case series as a rescue therapy in combination with different thrombolytic agents, percutaneous balloon angioplasty (PTA), and mechanical thromboembolectomy (MT) in acute stroke treatment. These studies report a considerable mortality and a high rate of i...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/STROKEAHA.108.533810

    authors: Brekenfeld C,Schroth G,Mattle HP,Do DD,Remonda L,Mordasini P,Arnold M,Nedeltchev K,Meier N,Gralla J

    更新日期:2009-03-01 00:00:00

  • Cerebrovascular reserve in patients with carotid occlusive disease assessed by stable xenon-enhanced ct cerebral blood flow and transcranial Doppler.

    abstract:BACKGROUND AND PURPOSE:Cerebrovascular reserve (CVR) by both transcranial Doppler ultrasonography (TCD) and quantitative cerebral blood flow (CBF) can identify subgroups of patients at increased risk for stroke. A direct comparison of CVR measurements obtained with both technologies in patients with cerebrovascular occ...

    journal_title:Stroke

    pub_type: 临床试验,杂志文章

    doi:10.1161/01.str.32.8.1811

    authors: Pindzola RR,Balzer JR,Nemoto EM,Goldstein S,Yonas H

    更新日期:2001-08-01 00:00:00

  • Stroke, statins, and cholesterol. A meta-analysis of randomized, placebo-controlled, double-blind trials with HMG-CoA reductase inhibitors.

    abstract:BACKGROUND AND PURPOSE:To estimate the effect of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors ("statins") on stroke ris, we combined the data of the randomized, placebo-controlled, double-blind trials with HMG-CoA reductase inhibitors published so far. METHODS:The studies were identified using ...

    journal_title:Stroke

    pub_type: 杂志文章,meta分析

    doi:10.1161/01.str.28.5.946

    authors: Blauw GJ,Lagaay AM,Smelt AH,Westendorp RG

    更新日期:1997-05-01 00:00:00

  • Treatment in a combined acute and rehabilitation stroke unit: which aspects are most important?

    abstract:BACKGROUND AND PURPOSE:We have previously shown that treatment of acute stroke patients in our stroke unit (SU) compared with treatment in general ward (GWs) improves short- and long-term survival and functional outcome and increases the possibility of earlier discharge to home. The aim of the present study was to iden...

    journal_title:Stroke

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1161/01.str.30.5.917

    authors: Indredavik B,Bakke F,Slordahl SA,Rokseth R,Hâheim LL

    更新日期:1999-05-01 00:00:00

  • ORAI1/STIM1 Interaction Intervenes in Stroke and in Neuroprotection Induced by Ischemic Preconditioning Through Store-Operated Calcium Entry.

    abstract::Background and Purpose- Disturbance of endoplasmic reticulum (ER) Ca2+ homeostasis causes neuronal cell injury in stroke. By contrast, ischemic preconditioning (IPC)-a brief sublethal ischemic episode affording tolerance to a subsequent ischemic insult-restores ER Ca2+ homeostasis. Under physiological conditions, ER c...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/STROKEAHA.118.024115

    authors: Secondo A,Petrozziello T,Tedeschi V,Boscia F,Vinciguerra A,Ciccone R,Pannaccione A,Molinaro P,Pignataro G,Annunziato L

    更新日期:2019-05-01 00:00:00

  • Risk of thromboembolic events in controlled trials of rFVIIa in spontaneous intracerebral hemorrhage.

    abstract:BACKGROUND AND PURPOSE:Recombinant activated factor VII (rFVIIa) reduces hematoma expansion and improves outcome after intracerebral hemorrhage (ICH), with an apparent increase in nonfatal thromboembolic events (TEs) with higher doses. Despite low incidences of such events in rFVIIa-treated hemophiliacs, the frequency ...

    journal_title:Stroke

    pub_type: 杂志文章,meta分析

    doi:10.1161/STROKEAHA.107.493601

    authors: Diringer MN,Skolnick BE,Mayer SA,Steiner T,Davis SM,Brun NC,Broderick JP

    更新日期:2008-03-01 00:00:00