Abstract:
BACKGROUND AND PURPOSE:Wall shear stress (WSS) is one of the main pathogenic factors in the development of saccular cerebral aneurysms. The magnitude and distribution of the WSS in and around human middle cerebral artery (MCA) aneurysms were analyzed using the method of computed fluid dynamics (CFD). METHODS:Twenty mathematical models of MCA vessels with aneurysms were created by 3-dimensional computed tomographic angiography. CFD calculations were performed by using our original finite-element solver with the assumption of Newtonian fluid property for blood and the rigid wall property for the vessel and the aneurysm. RESULTS:The maximum WSS in the calculated region tended to occur near the neck of the aneurysm, not in its tip or bleb. The magnitude of the maximum WSS was 14.39+/-6.21 N/m2, which was 4-times higher than the average WSS in the vessel region (3.64+/-1.25 N/m2). The average WSS of the aneurysm region (1.64+/-1.16 N/m2) was significantly lower than that of the vessel region (P<0.05). The WSSs at the tip of ruptured aneurysms were markedly low. CONCLUSIONS:These results suggest that in contrast to the pathogenic effect of a high WSS in the initiating phase, a low WSS may facilitate the growing phase and may trigger the rupture of a cerebral aneurysm by causing degenerative changes in the aneurysm wall. The WSS of the aneurysm region may be of some help for the prediction of rupture.
journal_name
Strokejournal_title
Strokeauthors
Shojima M,Oshima M,Takagi K,Torii R,Hayakawa M,Katada K,Morita A,Kirino Tdoi
10.1161/01.STR.0000144648.89172.0fsubject
Has Abstractpub_date
2004-11-01 00:00:00pages
2500-5issue
11eissn
0039-2499issn
1524-4628pii
35/11/2500journal_volume
35pub_type
杂志文章相关文献
STROKE文献大全abstract:BACKGROUND AND PURPOSE:This study evaluated the safety and efficacy of aggressive mechanical clot disruption (AMCD) in acute stroke patients with persisting middle cerebral artery (MCA) or internal carotid artery (ICA) occlusion after thrombolytic therapy. METHODS:Retrospective case series were used from a prospective...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.STR.0000152331.93770.18
更新日期:2005-02-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Stroke education, 1 of 8 endorsed stroke performance measures, consists of 5 specific subcomponents: risk factors, stroke warning signs, emergency medical service activation, physician follow-up, and discharge medications. We identified predictors of stroke education performance measure complianc...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.111.000763
更新日期:2013-05-01 00:00:00
abstract::The levels of lipid peroxides, determined as thiobarbituric acid reactive substances (TBARS), and the activities of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px), were examined in the blood from stroke-prone spontaneously hypertensive rats (SHRSP), with and without cerebral lesions, and normotensive W...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.10.3.323
更新日期:1979-05-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Brain atrophy, cortical infarction, and subcortical ischemic vasculopathy have all been associated with cognitive dysfunction. The interrelationships between these pathologies and their independent contributions to cognitive function remain unclear. Despite the high frequency of Alzheimer disease...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.107.491936
更新日期:2008-03-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Because the long-term security of endovascular treatments remains uncertain, a follow-up study of the patients treated in the International Subarachnoid Aneurysm Trial was performed to compare the frequency, timing, and consequences of aneurysm recurrence. METHODS:Patient data were reclassified ...
journal_title:Stroke
pub_type: 杂志文章,随机对照试验
doi:10.1161/STROKEAHA.106.466987
更新日期:2007-05-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The majority of patients with spontaneous cerebral artery dissection show ultrastructural alterations in dermal collagen and elastic fibers. METHODS:We studied the gene encoding tropoelastin (ELN) by reverse transcription-polymerase chain reaction and subsequent sequence analysis in 10 patients ...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.31.8.1935
更新日期:2000-08-01 00:00:00
abstract::Recent clinical studies emphasize the importance of early (less than 12 hours after onset) treatment of patients with acute ischemic stroke. Therapies have been proposed as being effective because of early clinical improvement. The frequency and degree of spontaneous improvement in such patients, however, is unknown. ...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.21.7.1008
更新日期:1990-07-01 00:00:00
abstract::Background and Purpose- Despite evidence to support the prescription of antihypertensive medications before hospital discharge to promote medication adherence and prevent recurrent events, many patients with stroke miss out on these medications at discharge. We aimed to examine patient, clinical, and system-level diff...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.119.026823
更新日期:2019-12-01 00:00:00
abstract::As part of the Ni-Hon-San Study, stroke incidence was compared in the Japan and Hawaii cohorts. Stroke cases were classified in two types, intracranial hemorrhage (ICH) and thrombo-embolic stroke (T-E). For each type the incidence in Japan was about three times as great as in Hawaii. The ratio ICH/T-E was 1/2.2 and 1/...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.15.1.15
更新日期:1984-01-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Thrombin is activated in the cerebrospinal fluid (CSF) after a subarachnoid hemorrhage (SAH). However, the relationship between thrombin and cerebral vasospasm has not yet been fully established. The aim of this study was to investigate the possibility of thrombin as a causative factor for cerebr...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.STR.0000070424.38138.30
更新日期:2003-06-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Chronic ocular ischemia is a rare form of ischemia of the eye in patients with carotid artery occlusion (CAO). The early and often asymptomatic stage of chronic ocular ischemia is referred to as venous stasis retinopathy (VSR). The aim of this study was to gain insight into the prevalence, cause,...
journal_title:Stroke
pub_type: 临床试验,杂志文章
doi:10.1161/hs0302.104619
更新日期:2002-03-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Recent evidence suggests that physiological changes in the concentration of endogenous estrogens may influence stroke outcome. The purpose of this study was to determine a menstrual cycle-related profile of blood flow through the carotid arteries and its correlation with estrogen concentration. ...
journal_title:Stroke
pub_type: 临床试验,杂志文章
doi:10.1161/01.str.32.1.30
更新日期:2001-01-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Many studies have reported frequent cognitive deficits associated with subarachnoid hemorrhage (SAH) and aneurysm repair. One study found more severe cognitive deficits after clipping than coiling of aneurysms, raising the possibility that deficits are due to surgery instead of SAH itself. This p...
journal_title:Stroke
pub_type: 临床试验,杂志文章
doi:10.1161/01.STR.0000087787.38080.B8
更新日期:2003-09-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Decompressive surgery (hemicraniectomy) for life-threatening massive cerebral infarction represents a controversial issue in neurocritical care medicine. We report here the 30-day mortality and 6- and 12-month functional outcomes from the DESTINY trial. METHODS:DESTINY (ISRCTN01258591) is a pros...
journal_title:Stroke
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1161/STROKEAHA.107.485649
更新日期:2007-09-01 00:00:00
abstract::Experimental regional cerebral ischemia was produced in the middle cerebral artery (MCA) territory in primates (M. mulatta) by macrosphere embolization. Determinations of percentage tissue dry weight and tissue sodium and potassium concentrations were obtained in samples from the ischemic and non-ischemic hemispheres ...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.9.4.387
更新日期:1978-07-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Subarachnoid hemorrhage (SAH) caused by ruptured intracranial aneurysm affects approximately 16 000 Americans annually, and almost 40% of affected patients die within 30 days despite the best current therapy. Prevention of SAH is therefore of paramount importance. We present a preliminary analysi...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.0000014773.57733.3e
更新日期:2002-05-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The ABCD system was developed to predict early stroke risk after transient ischemic attack. Incorporation of brain imaging findings has been suggested, but reports have used inconsistent methods and been underpowered. We therefore performed an international, multicenter collaborative study of the...
journal_title:Stroke
pub_type: 杂志文章,多中心研究
doi:10.1161/STROKEAHA.110.578971
更新日期:2010-09-01 00:00:00
abstract:BACKGROUND AND PURPOSE:This prospective study was aimed to evaluate the effects of surgical revascularization on cerebral oxygen metabolism in moyamoya disease. METHODS:This study included totally 69 hemispheres of 42 patients who underwent superficial temporal artery to middle cerebral artery anastomosis and indirect...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.114.006009
更新日期:2014-09-01 00:00:00
abstract::Cerebral venous blood gas tensions were correlated with elevated intracranial pressure in spontaneously breathing dogs lightly anesthetized with nitrous oxide/halothane. Intracranial pressure was elevated by infusion of artificial cerebrospinal fluid into a lateral ventricle. Respiration and blood pressure were monito...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.17.5.946
更新日期:1986-09-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Autonomic nervous system diseases affect systemic blood pressure regulation. Patients with autonomic nervous system diseases have consistently larger drops in blood pressure associated with standing than the normal population. Autonomic dysfunction and/or these changes in blood pressure may affec...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.28.9.1686
更新日期:1997-09-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Deteriorating glucose tolerance is associated with an increased cardiovascular disease (CVD) risk. The underlying mechanisms remain unclear. Arterial remodeling is the change in structural properties through time in response to atherogenic and/or hemodynamic alterations and aims to maintain circu...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.STR.0000115752.58601.0B
更新日期:2004-03-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The goal of this study was to characterize cortical reorganization after stroke and its relation with the site of the stroke-induced lesion and degree of motor recovery using functional MRI (fMRI). METHODS:Fourteen stroke patients with an affected upper limb were studied longitudinally. Three fM...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.0000017100.68294.52
更新日期:2002-06-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Intravascular bridges, resulting from developmental anomalies of brain arteries, are now better known as arterial fenestrations. Their tendency to develop aneurysms, similar to arterial bifurcations, makes their anatomy and microstructure important for study. METHODS:Six segments of artery, each...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.25.9.1799
更新日期:1994-09-01 00:00:00
abstract::This study was conducted to determine whether air distributed to the cerebral circulation alone could cause acute cardiovascular dysfunction and thus be a potential mechanism for sudden death following arterial air embolism. Cardiovascular measurements were made in anesthetized, ventilated cats during infusion of air ...
journal_title:Stroke
pub_type: 杂志文章
doi:
更新日期:1981-05-01 00:00:00
abstract::In normothermic anesthetized cats cerebral blood flow was interrupted completely for one hour by arterial clamping and induced hypotension. The effect of ischemia on the ionic gradients of the cerebral cortex was assayed by determining total cortical electrolytes and by recording the activities of extracellular potass...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.8.1.77
更新日期:1977-01-01 00:00:00
abstract::Background and Purpose- Hypertrophic cardiomyopathy patients with atrial fibrillation are at increased risk of stroke, and anticoagulation is strongly recommended. However, limited data are available regarding the safety and effectiveness of non-vitamin K antagonist oral anticoagulants (NOACs) for primary prevention o...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.119.026048
更新日期:2019-09-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The purpose of this study was to determine the incidence of adult cerebral venous thrombosis. METHODS:A retrospective cross-sectional study was conducted among all 19 hospitals located in 2 Dutch provinces serving 3.1 million people. Adult cerebral venous thrombosis cases diagnosed between Janua...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.112.671453
更新日期:2012-12-01 00:00:00
abstract:BACKGROUND AND PURPOSE:This study aims to investigate the association between insulin resistance (IR) and silent lacunar infarction (SLI) in healthy adults. METHODS:We recruited 2326 healthy Korean adults who took health checkups, including a brain magnetic resonance imaging. SLI was defined as an infarction measuring...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.116.014097
更新日期:2016-12-01 00:00:00
abstract:BACKGROUND AND PURPOSE:There has been a nonstandard surgical procedure and extensive international controversy in minimally invasive surgery (MIS) for the management of spontaneous supratentorial intracerebral hemorrhage. This meta-analysis assessed the effectiveness of MIS as compared with other treatment options, inc...
journal_title:Stroke
pub_type: 杂志文章,meta分析
doi:10.1161/STROKEAHA.112.667535
更新日期:2012-11-01 00:00:00
abstract:BACKGROUND AND PURPOSE:We studied prognosis for survival after an initial stroke in 662 patients who survived at least 30 days after onset while taking into account age, sex, the number of neurological deficits from the initial stroke, stroke type, and five selected medical conditions: hypertension, myocardial infarcti...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.26.11.2011
更新日期:1995-11-01 00:00:00