Abstract:
BACKGROUND AND PURPOSE:The role of athersclerosis in the difference between the pathogenesis of large-vessel disease (LVD) and small-vessel disease (SVD) is a matter of debate. Common carotid artery intima-media thickness (CCA IMT) is a marker of atherosclerosis. Our aim was to compare CCA IMT between SVD and LVD patients. METHODS:Two independent observers classified ischemic stroke or transient ischemic attack as caused by SVD or LVD, primarily based on imaging and in addition on clinical features. Mean CCA IMT was calculated based on 6 measurements for each patient. RESULTS:Four hundred and seventeen patients were classified LVD and 115 SVD. Mean CCA IMT was higher in patients with LVD (1.08 mm) than in patients with SVD (0.92 mm). The crude mean difference was 0.16 mm (95% CI, 0.09 to 0.23). After adjustment for age, sex and hypertension, the mean difference was 0.11 mm (95% CI, 0.05 to 0.18). CONCLUSIONS:CCA IMT is higher in LVD patients than in SVD patients supporting the hypothesis that LVD and SVD have a different pathogenesis.
journal_name
Strokejournal_title
Strokeauthors
Pruissen DM,Gerritsen SA,Prinsen TJ,Dijk JM,Kappelle LJ,Algra A,SMART Study Group.doi
10.1161/01.STR.0000260220.37016.88subject
Has Abstractpub_date
2007-04-01 00:00:00pages
1371-3issue
4eissn
0039-2499issn
1524-4628pii
01.STR.0000260220.37016.88journal_volume
38pub_type
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