Abstract:
BACKGROUND AND PURPOSE:The cerebral vasodilating effect of acetazolamide (ACZ) injection has been used as an index of the autoregulatory vasodilation (or cerebral perfusion reserve). The question of whether the ACZ test assesses the maximal autoregulatory vasodilating capacity is not definitely resolved. The effects of ACZ injection on this reserve at a dose producing maximal vasodilation have never been evaluated and may help to resolve this problem. METHODS:The effect of ACZ injection on cerebral blood flow (CBF) autoregulation was tested in anesthetized rats. A pilot experiment evaluated the dose-effect relationship of injected ACZ, cumulative doses (n=4, group 1), and independent bolus doses (n=6, group 2). CBF was estimated by laser-Doppler flowmetry, and cerebrovascular resistance (CVR) was calculated from mean arterial blood pressure (MABP) and from CBF (expressed as a percentage of baseline CBF). A bolus of ACZ of 21 mg/kg produced the maximal cerebral vasodilation that could be obtained by ACZ administration. In the main experiment, MABP was lowered from 110 to 20 mm Hg by stepwise bleeding in 3 groups of 6 animals treated 10 minutes before bleeding by injection of saline (group 3), 7 mg/kg ACZ (group 4), or 21 mg/kg ACZ (group 5). RESULTS:The CVR-MABP relationship was linear in all groups, indicating that CBF autoregulation was still effective after ACZ administration. CONCLUSIONS:These results indicate that maximal ACZ-induced cerebral vasodilation is not quantitatively equivalent to maximal autoregulatory vasodilating capacity in anesthetized rats.
journal_name
Strokejournal_title
Strokeauthors
Démolis P,Florence G,Thomas L,Tran Dinh YR,Giudicelli JF,Seylaz J,Alkayed NJdoi
10.1161/01.str.31.2.508subject
Has Abstractpub_date
2000-02-01 00:00:00pages
508-15issue
2eissn
0039-2499issn
1524-4628journal_volume
31pub_type
杂志文章相关文献
STROKE文献大全abstract:BACKGROUND AND PURPOSE:Enhanced thromboxane (TX) biosynthesis has previously been reported in the acute phase after ischemic stroke. We investigated whether enhanced urinary excretion of 11-dehydro-TXB2, a noninvasive index of platelet activation, was present in the chronic phase after a transient ischemic attack (TIA)...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.30.3.546
更新日期:1999-03-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Neuroradiological characteristics and functional outcomes of patients with intracerebral hemorrhage (ICH) during novel oral anticoagulant treatment were not well defined. We examined these in comparison with those during warfarin treatment. METHODS:The consecutive 585 patients with ICH admitted ...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.114.006661
更新日期:2014-09-01 00:00:00
abstract:BACKGROUND AND PURPOSE:An association between high lipoprotein(a) [Lp(a)] levels and positive Chlamydia pneumoniae IgG titers in coronary artery disease has been described. The possibility of predicting ischemic stroke by measurements of plasma Lp(a) and C pneumoniae antibodies was investigated. METHODS:This incident ...
journal_title:Stroke
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1161/01.str.30.10.2013
更新日期:1999-10-01 00:00:00
abstract:BACKGROUND AND PURPOSE:We systematically compared and appraised contemporary guidelines on management of asymptomatic and symptomatic carotid artery stenosis. METHODS:We systematically searched for guideline recommendations on carotid endarterectomy (CEA) or carotid angioplasty/stenting (CAS) published in any language...
journal_title:Stroke
pub_type: 杂志文章,评审
doi:10.1161/STROKEAHA.115.003390
更新日期:2015-11-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Animal studies of cerebral arteries 2 to 3 days after experimental subarachnoid hemorrhage (SAH) provide evidence of arterial change such as hyperresponsiveness to contractile agonists. There is evidence that small arteries, as well as those large enough to be seen on angiography, may be involved...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.29.12.2575
更新日期:1998-12-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Some strokes of unknown etiology may be the result of a paradoxical embolism traversing through a nonfused foramen ovale (patent foramen ovale [PFO]). The utility of percutaneously placed devices for treatment of patients with cryptogenic stroke or transient ischemic attack (TIA) and PFO is unkno...
journal_title:Stroke
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1161/STROKEAHA.110.593376
更新日期:2010-12-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Watershed ischemia is a significant cause of stroke in severe carotid disease, but its pathophysiology is unsettled. Although hemodynamic compromise has long been regarded as the main mechanism-particularly with deep watershed infarction-there is some contradictory evidence from clinical and path...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.110.580415
更新日期:2010-07-01 00:00:00
abstract:BACKGROUND AND PURPOSE:To prevent new cardiovascular events after stroke, prescribed preventive drugs should be used continuously. This study measures persistent use of preventive drugs after stroke and identifies factors associated with persistence. METHODS:A 1-year cohort (21,077 survivors) from Riks-Stroke, the Swe...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.109.566950
更新日期:2010-02-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The purpose of this study was to evaluate the impact of new treatments by examining the changes between 1990 to 1991 and 2000 to 2001 in in-hospital mortality rates and hospital charges in adult patients with stroke. METHODS:From the Nationwide Inpatient Survey, the largest all-payer inpatient c...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.106.467506
更新日期:2007-07-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Many studies associate fever with poor outcome in patients with neurological injury, but this relationship is blurred by divergence in populations and outcome measures. We sought to incorporate all recent scholarship addressing fever in brain-injured patients into a comprehensive meta-analysis to...
journal_title:Stroke
pub_type: 杂志文章,meta分析
doi:10.1161/STROKEAHA.108.521583
更新日期:2008-11-01 00:00:00
abstract::Non-invasive ultrasonic imaging of the carotid bifurcation by duplex scanning and ultrasonic arteriography combined with pulsed Doppler spectrum analysis demonstrated patency of the external and internal carotid arteries distal to a common carotid occlusion in 3 patients. Common carotid occlusion is not invariably ass...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.11.3.249
更新日期:1980-05-01 00:00:00
abstract:BACKGROUND AND PURPOSE:We examined sex-specific relationships of smoking with risk of total stroke and stroke subtypes in Asian populations because of the limited data available. METHODS:A total of 19,782 men and 21,500 women aged 40 to 59 years who were free of prior diagnosis of stroke, coronary heart disease, or ca...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.STR.0000128794.30660.e8
更新日期:2004-06-01 00:00:00
abstract:BACKGROUND AND PURPOSE:We examined the relationship of carotid artery lesions (CALs), with and without acoustic shadowing (AS), to incident ischemic stroke events in the Atherosclerosis Risk in Communities study cohort. METHODS:The study population consisted of 13 123 men and women aged 45 to 64 years, and free of str...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.32.5.1120
更新日期:2001-05-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The natural history of stroke is worse in women than in men. Controversial data have been published on the efficacy of thrombolysis with recombinant tissue plasminogen activator (rtPA) according to gender. We evaluated gender differences in the efficacy and safety outcomes of intravenous rtPA usi...
journal_title:Stroke
pub_type: 杂志文章,评审
doi:10.1161/STROKEAHA.108.546325
更新日期:2009-06-01 00:00:00
abstract:BACKGROUND:Infantile polyarteritis nodosa usually presents in children under 2 years of age as a multiorgan system disease with signs of congestive heart failure or renal failure. This disease and Kawasaki disease may share certain clinical and pathological features. CASE DESCRIPTION:We describe a child who first pres...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.26.4.699
更新日期:1995-04-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Depression after stroke is common. Like stroke, transient ischemic attack (TIA) is a manifestation of long-term atherosclerotic damage to the brain. However, the risk of depression developing after a TIA is uncertain. We studied whether TIA increases the risk of incident late-life depression. ME...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.110.604405
更新日期:2011-07-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The consequences of stroke are a major health concern. This study was conducted to compare the health-related quality of life among long-term survivors of stroke with that of the general population. METHODS:Our data are taken from a population-based case-control study of all 6-year survivors of ...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.31.2.440
更新日期:2000-02-01 00:00:00
abstract::The effect of very-low-dose aspirin as an antithrombotic agent was evaluated blindly in 301 patients who had recently undergone carotid endarterectomy. After randomization, 150 patients received aspirin and 151 received placebo. The two groups were comparable with regard to age, sex, blood pressure, previous cerebrova...
journal_title:Stroke
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1161/01.str.19.10.1211
更新日期:1988-10-01 00:00:00
abstract:BACKGROUND AND PURPOSE:A right-to-left shunt can be identified by contrast transcranial Doppler ultrasonography (c-TCD) at rest and/or after a Valsalva maneuver (VM) or by arterial blood gas (ABG) measurement. We assessed the influence of controlled strain pressures and durations during VM on the right-to-left passage ...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.STR.0000119384.28376.EB
更新日期:2004-04-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Potassium intake has been inconsistently associated with risk of stroke. Our aim was to conduct a meta-analysis of prospective studies to assess the relation between potassium intake and stroke risk. METHODS:Pertinent studies were identified by a search of PubMed from January 1966 through March ...
journal_title:Stroke
pub_type: 杂志文章,meta分析
doi:10.1161/STROKEAHA.111.622142
更新日期:2011-10-01 00:00:00
abstract::Acute thromboembolic occlusion of the basilar artery accounts for 6% to 10% of large-vessel stroke in humans. Because of the brain region supplied by this artery, the case fatality rate is the highest for all ischemic stroke subtypes, ranging from 40% to 86%. Patients who undergo successful recanalization of the basil...
journal_title:Stroke
pub_type: 杂志文章,评审
doi:10.1161/01.STR.0000247897.33267.42
更新日期:2007-02-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The typical magnetic resonance imaging picture of arterial dissection, namely, a narrowed eccentric signal void surrounded by a semilunar signal hyper-intensity (corresponding to the mural hematoma) on T1- and T2-weighted images, has been repeatedly reported, but the sensitivity of magnetic reson...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.25.3.576
更新日期:1994-03-01 00:00:00
abstract::Perforating branches of the middle cerebral arteries (MCA) were examined on the forebrain hemispheres of fourteen human brains. It was noticed that their intracerebral segments arose from the MCA main trunk, and its terminal and collateral (cortical) branches. They terminated in certain parts of the basal ganglia and ...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.16.6.1022
更新日期:1985-11-01 00:00:00
abstract:BACKGROUND AND PURPOSE:It has been proposed that spin trap agents such as N:-t-butyl-phenylnitrone (PBN) may be useful as neuroprotective agents in the treatment of ischemia and stroke. However, to date, there is little information concerning the effectiveness of spin trap agents when administered in combination with t...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.32.1.147
更新日期:2001-01-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Multiple studies have shown that negative computed tomographic angiograms (CTAs) are reliable in excluding aneurysms in patients with isolated perimesencephalic subarachnoid hemorrhage (pSAH). We evaluate the use of digital subtraction angiography versus CTA for initial diagnosis and of angiograp...
journal_title:Stroke
pub_type: 杂志文章,meta分析
doi:10.1161/STROKEAHA.114.007370
更新日期:2015-02-01 00:00:00
abstract:BACKGROUND AND PURPOSE:We found age-related vulnerability to cerebral ischemia in the hippocampus and striatum in spontaneously hypertensive rats. Further study revealed that ischemia-induced release of hippocampal taurine, an inhibitory amino acid, was reduced by 40% in aged rats compared with adult rats, which sugges...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.24.4.577
更新日期:1993-04-01 00:00:00
abstract::Visually apparent EEG changes associated with clamping the internal carotid artery appeared in 55 of 176 consecutive patients (31%) undergoing carotid endarterectomy without shunt. Attenuation of higher frequency activity was the most common change. Changes were moderate in 33 patients (19%) and major in 22 (12.5%). M...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.17.5.891
更新日期:1986-09-01 00:00:00
abstract::The goal of this study was to test the hypothesis that atherosclerosis alters responses of cerebral arteries and the ocular circulation to the activation in vivo of leukocytes and platelets. We measured blood flow to the brain and eye using microspheres and pressure in the cerebral microvessels of normal and atheroscl...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.22.6.790
更新日期:1991-06-01 00:00:00
abstract::In an attempt to elucidate the mechanism by which hypertension acts as a risk factor for major non-haemorrhagic stroke, its effect on the prevalence of carotid atheroma has been studied angiographically. The carotid angiograms of 269 patients with cerebral tumours have been reviewed for evidence of coincidental athero...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.14.4.550
更新日期:1983-07-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Recent studies have shown that the cerebral arteriolar dilation from hypercapnic acidosis is blocked by agents which inhibit KATP channels. These findings suggested that this response is due to opening of KATP channels. Because the repose to CO2 is a continuum, with hypercapnic acidosis causing v...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.30.4.851
更新日期:1999-04-01 00:00:00