Abstract:
BACKGROUND AND PURPOSE:Few cohort studies have examined the association of carotid intima-media thickness (IMT) and plaque characteristics with the risk of stroke in apparently healthy persons. We examined the relationship of carotid IMT and the surface, morphology, and calcification of carotid plaques with the incidence of stroke among Japanese men. METHODS:Carotid IMT and plaque were evaluated bilaterally with ultrasonography in 1289 men aged 60 to 74 years without a previous stroke or coronary heart disease. In this cohort, the subsequent incidence of stroke was investigated. RESULTS:During the 4.5-year follow-up, 34 strokes occurred. The multivariate-adjusted relative risk (95% CI) for the highest versus lowest quartiles of maximum IMT of the common carotid artery (CCA; > or =1.07 versus < or =0.77 mm) was 3.0 (1.1 to 8.3) for stroke. The combination of CCA and internal carotid artery (ICA) wall thickness was a better predictor of the risk of stroke than was CCA wall thickness alone. Men with a plaque, defined as a focal wall thickness of > or =1.5 mm, in the ICA had a 3-fold higher risk of stroke than those without a plaque, and the plaque surface irregularity further increased the stroke risk. A significant excess risk of stroke was confined to men with an uncalcified plaque. CONCLUSIONS:Increased IMT of the CCA and an uncalcified plaque in the ICA, as assessed by ultrasonography, are risk factors for stroke in elderly Japanese men.
journal_name
Strokejournal_title
Strokeauthors
Kitamura A,Iso H,Imano H,Ohira T,Okada T,Sato S,Kiyama M,Tanigawa T,Yamagishi K,Shimamoto Tdoi
10.1161/01.STR.0000147723.52033.9esubject
Has Abstractpub_date
2004-12-01 00:00:00pages
2788-94issue
12eissn
0039-2499issn
1524-4628pii
01.STR.0000147723.52033.9ejournal_volume
35pub_type
杂志文章相关文献
STROKE文献大全abstract:BACKGROUND AND PURPOSE:We examined sex-specific relationships of smoking with risk of total stroke and stroke subtypes in Asian populations because of the limited data available. METHODS:A total of 19,782 men and 21,500 women aged 40 to 59 years who were free of prior diagnosis of stroke, coronary heart disease, or ca...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.STR.0000128794.30660.e8
更新日期:2004-06-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Cysteine could potentially lower the risk of stroke through antihypertensive and antioxidant effects. Our aim was to evaluate the hypothesis that cysteine intake is inversely associated with stroke incidence. METHODS:We used data from the Swedish Mammography Cohort, a population-based prospectiv...
journal_title:Stroke
pub_type: 临床试验,杂志文章
doi:10.1161/STROKEAHA.114.008022
更新日期:2015-04-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Prompt recognition of stroke symptoms is critical to timely treatment and women have increased delay to treatment. Women may be more likely to present with atypical symptoms, but this hypothesis has not been extensively evaluated. METHODS:We examined gender differences in the prevalence of prese...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.108.543371
更新日期:2009-04-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Large falls in blood pressure after meals have been demonstrated in fit and frail elderly subjects; these changes may be associated with an increased incidence of stroke. Postprandial falls in BP may be particularly deleterious after acute stroke, when normal baroreflex mechanisms and cerebral au...
journal_title:Stroke
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1161/01.str.26.10.1811
更新日期:1995-10-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The majority of patients enrolled in SWIFT PRIME trial (Solitaire FR With the Intention for Thrombectomy as Primary Endovascular Treatment for Acute Ischemic Stroke) had computed tomographic perfusion (CTP) imaging before randomization; 34 patients were randomized after magnetic resonance imaging...
journal_title:Stroke
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1161/STROKEAHA.117.016669
更新日期:2017-06-01 00:00:00
abstract::A new micro T-tube, 0.6 mm in outer diameter, has been constructed. Use of this tube has allowed 1-mm common carotid artery (CCA) bypass ofr periods of time up to 22 minutes. After bypass, scanning electron microscopic observation of sutured CCA endothelium showed widespread destruction, scattered attached platelets a...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.7.5.476
更新日期:1976-09-01 00:00:00
abstract:BACKGROUND AND PURPOSE:We report on trends in poststroke survival, both in the early period after stroke and over the long term. We examine these trends by stroke subtype. METHODS:The Minnesota Stroke Survey is a study of all hospitalized patients with acute stroke aged 30 to 74 years in the Minneapolis-St Paul metrop...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.114.005512
更新日期:2014-09-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Patients with atrial fibrillation have a high risk of stroke and other vascular events even if anticoagulated. The primary objective here is to determine whether routine blood pressure-lowering provides additional protection for this high-risk patient group. METHODS:This study was a subsidiary a...
journal_title:Stroke
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1161/01.STR.0000181115.59173.42
更新日期:2005-10-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Efforts to increase the availability and shorten the time delivery of intravenous thrombolysis in patients with acute ischemic stroke carry the potential for tissue plasminogen activator administration in patients with diseases other than stroke, that is, stroke mimics (SMs). We aimed to determin...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.110.609339
更新日期:2011-06-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The objective of this study was to determine the clinical features, angiographic findings, and response to treatment with thrombolytic therapy in patients with ischemic stroke caused by acute occlusion of the distal internal carotid artery. METHODS:This is a retrospective case series from a pros...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.0000020363.23725.67
更新日期:2002-07-01 00:00:00
abstract:BACKGROUND AND PURPOSE:With the exception of atrial fibrillation (AF), little scientific attention has been given the associations between cardiac arrhythmias and incidence of stroke. We sought to study whether atrial and ventricular arrhythmias assessed during a 24-hour ambulatory ECG registration are associated with ...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.31.12.2925
更新日期:2000-12-01 00:00:00
abstract::Patients with chronic aphasia were assigned randomly to a group to receive either conventional aphasia therapy or constraint-induced (CI) aphasia therapy, a new therapeutic technique requiring intense practice over a relatively short period of consecutive days. CI aphasia therapy is realized in a communicative therape...
journal_title:Stroke
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1161/01.str.32.7.1621
更新日期:2001-07-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Preceding infection as an important risk factor for ischemic stroke has been reported but neglected for hemorrhagic stroke, especially in young and middle-aged patients. This study investigates whether newly diagnosed leptospirosis is associated with an increased risk of stroke. METHODS:We ident...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.120.029998
更新日期:2021-01-26 00:00:00
abstract:BACKGROUND AND PURPOSE:Proinflammatory cytokines including interleukin-6 (IL-6) are supposed to play a pivotal role in the development of atherosclerosis. A common polymorphism in the promoter of the IL-6 gene (IL-6 -174G>C) affects plasma IL-6 concentrations and has been suggested as a risk factor for cardiovascular d...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.STR.0000151329.84830.37
更新日期:2005-02-01 00:00:00
abstract:BACKGROUND AND PURPOSE:This study reviews the perioperative use of red blood cell transfusion in cerebrovascular neurosurgery. The current algorithm for preoperative ordering of red cells is historical and dated. More blood is ordered than is actually transfused, and considerable variability exists between different in...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/hs0402.105296
更新日期:2002-04-01 00:00:00
abstract::An ocular pneumoplethysmograph was devised to measure the systolic pressure in the ophthalmic artery and to obtain calibrated pulse volume changes from the ocular globe, with simultaneous recording from both eyes. The instrument is self-contained and portable. It can be applied by paramedical personnel, and the graphi...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.7.1.18
更新日期:1976-01-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Although headache is the most common symptom in cerebral venous thrombosis, 5% to 30% of patients do not report headache at baseline. Characteristics of these patients have not been investigated. METHODS:In post hoc analysis of the International Study on Cerebral Vein and Dural Sinus Thrombosis ...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.114.007584
更新日期:2015-01-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Controlled multicenter studies have demonstrated the efficacy of systemic recombinant tissue-type plasminogen activator (rtPA) treatment in selected cases of acute ischemic stroke. The feasibility of this therapeutic option in clinical practice was assessed in a community-based approach. METHODS...
journal_title:Stroke
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1161/01.str.29.8.1544
更新日期:1998-08-01 00:00:00
abstract::The plasma concentrations of protein C, an anticoagulant protein, and fibrinopeptide A were measured in 37 patients with acute hemispheric stroke and in age-matched controls with nonvascular neurologic diseases. In 11 stroke patients who died within 15 days after the onset (nonsurvivors) protein C antigen concentratio...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.19.5.579
更新日期:1988-05-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The role of the sympathetic nervous system in cerebral autoregulation remains poorly characterized. We examined cerebral blood flow responses to augmented arterial pressure oscillations with and without sympathetic blockade and compared them with responses in the forearm circulation. METHODS:An ...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.109.557132
更新日期:2010-01-01 00:00:00
abstract:BACKGROUND AND PURPOSE:In addition to low-density lipoprotein (LDL) cholesterol, small, dense LDL particles and oxidative modification of LDL have been linked to the pathogenesis of atherosclerosis. The present study was aimed at investigating the association between carotid artery intima-media thickness (IMT) and LDL ...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.0000014924.29238.e1
更新日期:2002-05-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Atrial fibrillation (AF) is increasingly recognized as the single most important cause of disabling ischemic stroke in the elderly. We undertook an international survey to characterize the frequency of AF-associated stroke, methods of AF detection, and patient features. METHODS:Consecutive patie...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.116.013378
更新日期:2016-09-01 00:00:00
abstract::The study of focal central nervous system ischemia has been impeded by the lack of animal models that are both reproducible and simulate human ischemic strokes. To circumvent these problems, we have developed a rabbit spinal cord infarction model. Infarction of the caudal lumbar cord is produced by temporary occlusion...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.11.2.200
更新日期:1980-03-01 00:00:00
abstract:BACKGROUND AND PURPOSE:beta-Blockers prevent vascular events in patients after myocardial infarction and lower blood pressure, the main risk factor for stroke. Hence, we assessed the effects of atenolol on the occurrence of death from vascular causes, stroke, or myocardial infarction and on blood pressure in patients a...
journal_title:Stroke
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1161/01.str.24.4.543
更新日期:1993-04-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Motor dysfunction after unilateral deafferentation in primates can be overcome by restraining the unaffected limb. We asked whether a constraint-induced movement (CIM) program could be implemented within 2 weeks after stroke and whether CIM is more effective than traditional upper-extremity (UE) ...
journal_title:Stroke
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1161/01.str.31.12.2984
更新日期:2000-12-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The purpose of this study was to assess individual differences in the pharmacological effects of acetylsalicylic acid (ASA) on bleeding time as measured by in vitro platelet aggregation and to examine the consistency of responses over time. METHODS:We measured template IIR bleeding time and plat...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.31.3.591
更新日期:2000-03-01 00:00:00
abstract::The trends in age adjusted and age and sex specific mortality rates for the period 1968-1980 are compared for ischaemic heart disease and cerebrovascular disease. For both sexes and at all ages over 45 the mortality rates for cerebrovascular disease have fallen significantly. However, the mortality rates for ischaemic...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.13.5.582
更新日期:1982-09-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The mortality and morbidity after aneurysmal subarachnoid hemorrhage has improved because of better diagnosis, early treatment to secure the aneurysm, and better management of disease-specific complications. With these improvements in care, it is not clear if the previously identified independent...
journal_title:Stroke
pub_type: 杂志文章,多中心研究
doi:10.1161/STROKEAHA.117.017777
更新日期:2017-11-01 00:00:00
abstract::Regional cerebral ischemia was produced by common carotid artery occlusion in gerbils and by middle cerebral artery occlusion in dogs, cats, and squirrel monkeys. Anesthesia was induced with either pentobarbital or halothane and maintained for two to three hours after vessel occlusion. In acute studies, the effect of ...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.6.4.405
更新日期:1975-07-01 00:00:00
abstract::U78517F is a novel inhibitor of iron-catalyzed lipid peroxidation that combines the tetramethylchroman antioxidant ring portion of alpha-tocopherol with the amine of the previously described 21-aminosteroids (e.g., U74006F). U78517F inhibited 200 microM FeCl2-initiated lipid peroxidation in rat brain homogenates by 50...
journal_title:Stroke
pub_type: 杂志文章
doi:
更新日期:1990-11-01 00:00:00