Abstract:
BACKGROUND AND PURPOSE:Platelet-rich thrombi are resistant to thrombolytics. Matrix metalloproteinases (MMPs) may be involved in platelet aggregation and contribute to thrombolysis failure in stroke patients. METHODS:Plasma samples from 23 stroke patients who had received thrombolytics and from 47 healthy volunteers were examined for MMP-2 and MMP-9 by both enzyme-linked immunosorbent assays and zymography. RESULTS:The arteries were recanalized in 15 patients but not in the other 8. The MMP-9 plasma level was significantly higher in patients whose arteries were not recanalized. CONCLUSIONS:MMP-9 may be associated with the formation of a thrombolytics-resistant thrombus.
journal_name
Strokejournal_title
Strokeauthors
Heo JH,Kim SH,Lee KY,Kim EH,Chu CK,Nam JMdoi
10.1161/01.STR.0000073788.81170.1Csubject
Has Abstractpub_date
2003-06-01 00:00:00pages
e48-50issue
6eissn
0039-2499issn
1524-4628pii
01.STR.0000073788.81170.1Cjournal_volume
34pub_type
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