Abstract:
BACKGROUND AND PURPOSE:The importance of perioperative cognitive decline has long been debated. We recently demonstrated a significant correlation between perioperative cognitive decline and long-term cognitive dysfunction. Despite this association, some still question the importance of these changes in cognitive function to the quality of life of patients and their families. The purpose of our investigation was to determine the association between cognitive dysfunction and long-term quality of life after cardiac surgery. METHODS:After institutional review board approval and patient informed consent, 261 patients undergoing cardiac surgery with cardiopulmonary bypass were enrolled and followed for 5 years. Cognitive function was measured with a battery of tests at baseline, discharge, and 6 weeks and 5 years postoperatively. Quality of life was assessed with well-validated, standardized assessments at the 5-year end point. RESULTS:Our results demonstrate significant correlations between cognitive function and quality of life in patients after cardiac surgery. Lower 5-year overall cognitive function scores were associated with lower general health and a less productive working status. Multivariable logistic and linear regression controlling for age, sex, education, and diabetes confirmed this strong association in the majority of areas of quality of life. CONCLUSIONS:Five years after cardiac surgery, there is a strong relationship between neurocognitive functioning and quality of life. This has important social and financial implications for preoperative evaluation and postoperative care of patients undergoing cardiac surgery.
journal_name
Strokejournal_title
Strokeauthors
Newman MF,Grocott HP,Mathew JP,White WD,Landolfo K,Reves JG,Laskowitz DT,Mark DB,Blumenthal JA,Neurologic Outcome Research Group and the Cardiothoracic Anesthesia Research Endeavors (CARE) Investigators of the Duke Heart Center.doi
10.1161/hs1201.099803subject
Has Abstractpub_date
2001-12-01 00:00:00pages
2874-81issue
12eissn
0039-2499issn
1524-4628journal_volume
32pub_type
杂志文章相关文献
STROKE文献大全abstract:BACKGROUND AND PURPOSE:The prevalence of silent brain infarcts varies from 8% to 28% in the general elderly population. Silent brain infarcts are associated with increased risk of subsequent stroke and cognitive dysfunction. By definition, silent strokes lack clinically overt stroke-like symptoms and fail to come to cl...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.112.666461
更新日期:2012-11-01 00:00:00
abstract:BACKGROUND AND PURPOSE:To clarify diagnostic entities in ischemic stroke we analyzed the relation between the severity of carotid atherosclerosis, coagulation parameters, lipoproteins, neurological status, and risk factors in 232 patients. METHODS:Duplex ultrasonography, computed tomography scan, and laboratory invest...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.24.12.1811
更新日期:1993-12-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The Intravenous Nimodipine West European Stroke Trial (INWEST) found a correlation between nimodipine-induced reduction in blood pressure (BP) and an unfavorable outcome in acute stroke. We sought to confirm this correlation with and without adjustment for prognostic variables and to investigate ...
journal_title:Stroke
pub_type: 临床试验,杂志文章
doi:10.1161/01.str.31.6.1250
更新日期:2000-06-01 00:00:00
abstract:BACKGROUND:Urinary incontinence in the acute stage of stroke is seen as a predictor of death, severe disability, and an important factor on hospital discharge destination. Therefore, it is an important measure of stroke severity that not only affects the lives of stroke survivors but also those of caregivers. SUMMARY ...
journal_title:Stroke
pub_type: 杂志文章,评审
doi:10.1161/01.str.29.2.524
更新日期:1998-02-01 00:00:00
abstract:BACKGROUND AND PURPOSE:We hypothesize that reversal in diffusion-weighted imaging (DWI) volume at 24 hours predicts favorable clinical outcome only if accompanied by immediate reperfusion. Our aim was to quantify the immediate DWI and mean transit time changes at 2 and 24 hours after intravenous tissue-type plasminogen...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.114.006082
更新日期:2014-11-01 00:00:00
abstract::We mapped average age-adjusted stroke mortality rates for white men and white women aged 35-74 years for state economic areas (counties or groups of counties) in the continental United States for three 7-year periods between 1962 and 1982. Despite the decline of national stroke mortality rates, rates in some areas fai...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.19.12.1507
更新日期:1988-12-01 00:00:00
abstract::Serum dopamine-beta-hydroxylase (DBH) activity was measured in 34 patients with acute cerebrovascular disease. The serum level of DBH activity showed its highest value soon after the onset of stroke and then gradually decreased over the next few days. After reaching its lowest level, the DBH activity again showed a sl...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.10.2.168
更新日期:1979-03-01 00:00:00
abstract:BACKGROUND:Gene transfer to peripheral arteries has been accomplished with catheter-based approaches. Recently, gene transfer to the carotid artery and intracranial vessels has been achieved both in vitro and in vivo. Although gene therapy for cerebral vascular disease may not be accomplished for years, currently avail...
journal_title:Stroke
pub_type: 杂志文章,评审
doi:10.1161/01.str.27.9.1688
更新日期:1996-09-01 00:00:00
abstract::Recent success with thrombolytic therapy for acute myocardial infarction has stimulated interest in its use for stroke. To determine the hemorrhagic potential of thrombolytic therapy in experimental cerebral infarction, we compared a group of tissue plasminogen activator-treated rabbits (n = 4) with 2 groups of strept...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.18.6.1148
更新日期:1987-11-01 00:00:00
abstract:BACKGROUND AND PURPOSE:To investigate the efficacy of bone marrow mononuclear cell (BMMNC) treatment against ischemic white matter (WM) damage in a hypoperfused brain. METHODS:Mice were administered intravenous treatment of vehicle, spleen-derived marrow mononuclear cells (MNCs), or BMMNCs (5 × 10⁶ cells) obtained fro...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.110.596379
更新日期:2010-12-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The aim of our study was to compare outcome and its determinants in familial subarachnoid hemorrhage and in sporadic subarachnoid hemorrhage in a large and well-documented patient population. METHODS:Patients with aneurysmal subarachnoid hemorrhage (SAH) treated at the Department of Neurosurgery...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.30.5.1099
更新日期:1999-05-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The objective of this study was to determine the clinical features, angiographic findings, and response to treatment with thrombolytic therapy in patients with ischemic stroke caused by acute occlusion of the distal internal carotid artery. METHODS:This is a retrospective case series from a pros...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.0000020363.23725.67
更新日期:2002-07-01 00:00:00
abstract::We describe a patient with transient ischemic attacks secondary to a giant aneurysm who showed increased activity on platelet scintigrams at the origin of the left vertebral artery. This is assumed to be the first report of a presumed embolizing aneurysm with positive activity of labeled platelets. Platelet scintigrap...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.20.5.687
更新日期:1989-05-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The sensitivity of the brain to brief periods of profound ischemia or prolonged periods of modest ischemia mandates an aggressive approach to acute stroke care. Past studies have shown that many stroke patients do not receive acute care in an urgent and timely fashion. The formation of acute stro...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.29.11.2318
更新日期:1998-11-01 00:00:00
abstract::The frequency of clinically significant coronary artery disease (CAD) among stroke patients and the impact of CAD on stroke rehabilitation were studied in 132 patients with first thrombotic or embolic stroke who participated in comprehensive rehabilitation. Sixty-one patients (46%) had a history of CAD, and 16 of the ...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.19.1.42
更新日期:1988-01-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Improvements in cardiac surgery mortality and morbidity have focused interest on the neurological injury such as stroke and cognitive decline that may accompany an otherwise successful operation. We aimed to investigate (1) the rate of stroke, new ischemic change on MRI, and cognitive impairment ...
journal_title:Stroke
pub_type: 临床试验,杂志文章
doi:10.1161/STROKEAHA.107.502989
更新日期:2008-05-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Subarachnoid hemorrhage caused by cerebral aneurysm rupture remains a life-threatening emergency despite advances in treatment. However, the mechanisms underlying aneurysm initiation, progression, and rupture remain unclear. We developed a method to induce experimental cerebral aneurysms in rats,...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.STR.0000204028.39783.d9
更新日期:2006-03-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The National Institute of Neurological Disorders and Stroke-Canadian Stroke Network Vascular Cognitive Impairment Harmonization working group proposed a brief cognitive protocol for screening of vascular cognitive impairment. We investigated the validity, reliability, and feasibility of the Montr...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.114.007253
更新日期:2015-04-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Efforts to increase the availability and shorten the time delivery of intravenous thrombolysis in patients with acute ischemic stroke carry the potential for tissue plasminogen activator administration in patients with diseases other than stroke, that is, stroke mimics (SMs). We aimed to determin...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.110.609339
更新日期:2011-06-01 00:00:00
abstract::Background and Purpose- The optimal antithrombotic strategy to balance thromboembolic and bleeding events, especially acute stroke, for patients with atrial fibrillation following coronary stenting remains a matter of debate. We conducted a network meta-analysis to identify the antithrombotic regimen associated with t...
journal_title:Stroke
pub_type: 杂志文章,meta分析
doi:10.1161/STROKEAHA.119.026078
更新日期:2019-08-01 00:00:00
abstract::Background and Purpose- Many patients with acute ischemic stroke are not eligible for thrombolysis or mechanical reperfusion therapies due to contraindications, inaccessible vascular occlusions, late presentation, or large infarct core. Sphenopalatine ganglion (SPG) stimulation to enhance collateral flow and stabilize...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.118.024582
更新日期:2019-05-23 00:00:00
abstract:BACKGROUND AND PURPOSE:We sought to assess the long-term predictive usefulness of bone mineral density (BMD) for stroke incidence and stroke mortality. METHODS:The First National Health and Nutrition Examination Survey data were obtained from a nationally representative sample of noninstitutionalized civilians. A coho...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.STR.0000065826.23815.A5
更新日期:2003-05-01 00:00:00
abstract::Background and Purpose- Cerebral small vessel disease (cSVD) is the major vascular cause of cognitive decline and dementia. The pathogenesis of cSVD remains largely unknown, although several studies suggest a role for systemic inflammation. In certain pathophysiological situations, monocytes can reprogram toward a lon...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.118.023192
更新日期:2018-12-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Cerebral blood flow is coupled to brain metabolism by means of active modulation of cerebrovascular resistance. This homeostatic vasogenic activity is reflected in slow waves of cerebral blood flow velocities (FV) which can also be detected in intracranial pressure (ICP). However, effects of incr...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.107.485847
更新日期:2007-10-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The purpose of this study was to investigate the periprocedural morbidity, mortality, and long-term clinical and angiographic follow-up using stent-assisted coiling and stenting alone for treatment of cranial fusiform dissecting and atherosclerotic aneurysms. METHODS:The Institutional Review Boa...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.107.512996
更新日期:2008-12-01 00:00:00
abstract:BACKGROUND:We studied 60 patients longitudinally to examine relations between regional cerebral blood flow and depressive states after stroke. METHODS:Poststroke depressive states were assessed by the Zung Self-Rating Depression Scale (SDS). Regional cerebral blood flow was measured using the 133xenon inhalation metho...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.23.12.1716
更新日期:1992-12-01 00:00:00
abstract::The ejection fraction (EF) of the left ventricle was measured by radionuclide ventriculography in 64 patients during an acute cerebrovascular accident. Sixteen patients (12 with coronary artery disease) died within two weeks of the onset of symptoms and had only one EF measurement. In the remaining 48 patients, the EF...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.17.4.613
更新日期:1986-07-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Despite its high prevalence in stroke survivors, there is little clinical research on bowel dysfunction in this population. This is the first randomized controlled trial to evaluate treatment of constipation and fecal incontinence in stroke survivors. METHODS:Stroke patients with constipation or...
journal_title:Stroke
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1161/01.STR.0000144684.46826.62
更新日期:2004-11-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Cerebral autoregulation may be impaired in the early days after subarachnoid hemorrhage (SAH). The purpose of this study was to examine the relationship between cerebral autoregulation and angiographic vasospasm (aVSP) and radiographic delayed cerebral ischemia (DCI) in patients with SAH. METHOD...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.113.002630
更新日期:2014-03-01 00:00:00
abstract::The etiology of cerebrovascular disease (CDV) in young patients is difficult to establish if the common causes of a focal neurological deficit are excluded by appropriate investigations. Since in some observations prolapse of the mitral-valve (MVP), alterations of platelet function, or both have been linked with cereb...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.13.4.454
更新日期:1982-07-01 00:00:00