Abstract:
BACKGROUND AND PURPOSE:Diffusion magnetic resonance imaging (MRI) can quantitatively detect focal ischemic injury within minutes of onset, and perfusion MRI can evaluate the brain's microcirculation. N-Methyl-D-aspartate (NMDA) antagonists and reperfusion can reduce lesion size in stroke models. We used diffusion and perfusion MRI to evaluate the in vivo effects of a noncompetitive NMDA antagonist, CNS 1102, in a temporary ischemia model. METHODS:Sixteen Sprague-Dawley rats underwent suture occlusion of the middle cerebral artery. Fifteen minutes after occlusion, animals were randomly assigned to treatment with CNS 1102 (n = 10) or placebo (n = 6), receiving a bolus of 1.13 mg/kg at that time and an infusion of 0.785 mg.kg-1.h-1 for the next 165 minutes. The placebo group received a saline bolus and infusion. Diffusion MRI studies by a spin-echo technique were initiated 30 minutes after occlusion and repeated every 30 minutes for the next 3 hours. Perfusion MRI studies were obtained using echo-planar imaging after injection of superparamagnetic iron oxide particles, immediately before and 15 minutes after withdrawal of the occluder at 3 hours after middle cerebral artery occlusion. At 24 hours, the animals were clinically evaluated (scale of 0 to 5) and electively killed, and the brain was stained with triphenyltetrazolium chloride to evaluate infarct size. RESULTS:Diffusion imaging demonstrated markedly reduced ischemic lesion area in the CNS 1102 group during occlusion--10.5 +/- 7.3% (mean +/- SEM) of the ischemic hemisphere (optic chiasm slice) at 30 minutes after occlusion versus 50.0 +/- 2.7% of the hemisphere in controls (P < .02). With reperfusion after 3 hours of temporary ischemia, diffusion imaging documented an additional 29% reduction of the ischemic lesion area in the CNS 1102-treated group (P < .01) compared with the prereperfusion ischemic lesion area, with no change in the placebo group. During occlusion, perfusion imaging demonstrated a relative signal intensity decline of 31.5 +/- 7.7% in controls and 83.4 +/- 7.6% in the CNS 1102 group (P < .005), indicating better perfusion in the latter group. After removal of the occluder, perfusion improved in both groups and was not significantly different. Post mortem infarct volume was 53.8 +/- 20.0 mm3 in the CNS 1102 group and 216.8 +/- 16.1 mm3 in the controls (P < .0001). Clinical outcome at 24 hours was 1.1 +/- 0.4 in the CNS 1102 group and 4.0 +/- 0.5 (scale of 0 to 5) in the controls (P < .005). CONCLUSIONS:This study demonstrates that CNS 1102 reduces early postischemic injury as documented by diffusion MRI and improves perfusion as documented by perfusion MRI and that reperfusion confers additional reduction of ischemic lesion size.
journal_name
Strokejournal_title
Strokeauthors
Minematsu K,Fisher M,Li L,Sotak CHdoi
10.1161/01.str.24.12.2074subject
Has Abstractpub_date
1993-12-01 00:00:00pages
2074-81issue
12eissn
0039-2499issn
1524-4628journal_volume
24pub_type
杂志文章相关文献
STROKE文献大全abstract::Adenylate cyclase activity was investigated in either homogenate or particulate fractions from the frontal cerebral cortex of the gerbil following five experimental conditions of bilateral ischemia. After periods of 15 min ischemia, 15 min ischemia plus 15 min of recirculation or 60 min ischemia the enzyme generally d...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.15.2.329
更新日期:1984-03-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Aneurysmal subarachnoid hemorrhage (SAH) is a cerebrovascular disease with a high mortality rate and severe disability. Longitudinal studies investigating health-economic costs in SAH are scare and only one of them analyzed cost-driving factors. The objective was to evaluate first-year costs in G...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.110.586826
更新日期:2010-12-01 00:00:00
abstract::Acute thromboembolic occlusion of the basilar artery accounts for 6% to 10% of large-vessel stroke in humans. Because of the brain region supplied by this artery, the case fatality rate is the highest for all ischemic stroke subtypes, ranging from 40% to 86%. Patients who undergo successful recanalization of the basil...
journal_title:Stroke
pub_type: 杂志文章,评审
doi:10.1161/01.STR.0000247897.33267.42
更新日期:2007-02-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Subarachnoid hemorrhage (SAH) is the only type of stroke with female predominance, suggesting that reproductive factors may play a role in the etiology. We conducted a population-based study to examine the influence of parity on the risk of SAH in women. METHODS:We linked data from 3 national Sw...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.STR.0000105933.16654.B4
更新日期:2004-01-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Studies of peripheral arteries in hypercholesterolemic animals suggest that increased generation of superoxide contributes to endothelial dysfunction, especially in the presence of atherosclerotic lesions. We tested the hypothesis that vasomotor function is impaired in cerebral arterioles during ...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.107.481879
更新日期:2007-07-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The presence of known restriction fragment length polymorphisms in the apoprotein A-I-C-III gene cluster, which encodes their respective apoproteins, was investigated using the restriction enzymes Sac I and Pst I to determine the potential role of genetic variations for stroke risk in an American...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.23.9.1257
更新日期:1992-09-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Although the short-term risks of stroke and types of stroke associated with isolated systolic hypertension (ISH) and borderline isolated systolic hypertension (BISH) have been described, the long-term effects of these hypertensive conditions, particularly in younger individuals, are unclear. We p...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.0000039402.05613.0f
更新日期:2002-12-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Some studies have suggested a link between impaired cerebral hemodynamics and stroke in patients with carotid stenosis. The aim of this study was to assess the effects of severe carotid stenosis on cerebrovascular reactivity and the possible changes after endarterectomy. METHODS:Using bilateral ...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.27.11.1970
更新日期:1996-11-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The ABC/2 method for calculating intracerebral hemorrhage (ICH) volume has been well validated. However, the formula, derived from the volume of an ellipse, assumes the shape of ICH is elliptical. We sought to compare the agreement of the ABC/2 formula with other methods through retrospective ana...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.117.016677
更新日期:2018-02-01 00:00:00
abstract:BACKGROUND AND PURPOSE:We assessed whether the load of cerebral small vessel disease (cSVD) and its individual markers, including lacunes, white matter hyperintensities, microbleeds, and enlarged perivascular spaces (EPVS), are associated with arterial stiffness. METHODS:We evaluated cSVD markers in a cohort of 782 hy...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.118.020163
更新日期:2018-05-01 00:00:00
abstract:BACKGROUND AND PURPOSE:In Asian populations, few studies investigated the association between stroke and common carotid artery intima-media thickness (IMT). Our previous case-control studies showed that low end-diastolic velocity (EDV) in common carotid artery, a potential hemodynamic marker of intracranial resistance,...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.110.605477
更新日期:2011-05-01 00:00:00
abstract:BACKGROUND AND PURPOSE:There is inconclusive evidence of the effectiveness of psychological interventions for depression after stroke. We report the results from a randomized controlled trial of cognitive behavioral therapy (CBT). METHODS:Stroke patients admitted to hospital were invited to complete mood questionnaire...
journal_title:Stroke
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1161/01.str.0000044167.44670.55
更新日期:2003-01-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The objective of this study was to determine the prevalence of intracranial plaques and stenoses and their causal role in patients with fatal stroke. Intracranial atherosclerosis is considered to be a rare condition with a severe prognosis. However, disease prevalence may be underestimated due to...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.107.496513
更新日期:2008-04-01 00:00:00
abstract::Platinum microelectrodes were used to measure H2 clearance in mouse brain, and the clearance curves were used to calculate regional cerebral blood flow (rCBF). The curves were usually biexponential, whether or not electrode placement was confined to the cortex. When calculated by the height over area method, rCBF in a...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.8.1.103
更新日期:1977-01-01 00:00:00
abstract::Regional cerebral blood flow, blood volume, fractional oxygen extraction, and oxygen consumption were measured by positron emission tomography in 4 stroke patients prior to and 6 months following omental transposition surgery. Preoperatively, 3 patients showed the typical picture of established infarction with a match...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.18.1.46
更新日期:1987-01-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The watershed cortical areas are the first to be deprived of sufficient blood flow in the event of cerebral hypoperfusion and will be the sites of watershed microinfarcts. Cerebral hypoperfusion is associated with Alzheimer disease (AD), but information regarding the occurrence of watershed corti...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.0000024523.82311.77
更新日期:2002-08-01 00:00:00
abstract::Background and Purpose- The aim of the present study was to evaluate the relationship between normal-appearing white matter (NAWM) integrity and postischemic stroke recovery in 4 main domains including cognition, mood, gait, and dependency. Methods- A prospective study was conducted, including patients diagnosed for a...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.119.026886
更新日期:2020-02-01 00:00:00
abstract:BACKGROUND AND PURPOSE:It is unclear which harmonic imaging mode (power Doppler or gray-scale imaging) is superior and which measuring method is the most robust for the description of brain perfusion. METHODS:We performed an animal study on 6 beagles through the intact skull using a SONOS 5500 device and Optison injec...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.31.7.1728
更新日期:2000-07-01 00:00:00
abstract::In the rat an intracisternal injection of blood induces an angiographically demonstrable biphasic cerebral arterial vasospasm. Chemical destruction of the central serotoninergic and dopaminergic pathways prior to the cisternal blood injection does not affect the spasm pattern after the subarachnoid haemorrhage. It is ...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.17.1.86
更新日期:1986-01-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The aim of this study is to assess whether the PHASES score allows to (1) match decisions taken by multidisciplinary team whether to observe or intervene, (2) classify patients being diagnosed with a ruptured versus unruptured intracranial aneurysm (UIA), and (3) discriminate patients at low risk...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.117.017391
更新日期:2017-08-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Leukocytes contribute to cerebral ischemia-reperfusion injury. However, few experimental models examine both in vivo behavior of leukocytes and microvascular rheology after stroke. The purpose of the present study was to characterize patterns of leukocyte accumulation in the cerebral microcircula...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.31.5.1153
更新日期:2000-05-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Astrocytes are potent regulators of brain capillary endothelial cell function. Recently, astrocytes were shown to regulate brain capillary endothelial expression of the fibrinolytic enzyme tissue plasminogen activator (tPA) and the anticoagulant thrombomodulin (TM). To study the mechanism of this...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.30.8.1671
更新日期:1999-08-01 00:00:00
abstract::During the 5-year period from 1980 to 1984, the incidence of subarachnoid hemorrhage due only to rupture of aneurysms was investigated in Izumo City, a small city with a population of 79,026. Additionally, to ascertain the relation of incidence to the size of the geographic area and/or population, a similar analysis w...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.19.2.170
更新日期:1988-02-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The natural history of stroke is still incompletely understood. The aim of this study was to present detailed data on survival, recurrence, and all types of healthcare utilization before and after a stroke event in patients with stroke. METHODS:Three hundred ninety stroke survivors constituted t...
journal_title:Stroke
pub_type: 杂志文章,多中心研究
doi:10.1161/STROKEAHA.109.556720
更新日期:2009-11-01 00:00:00
abstract::Brief episodes of ischemia can protect against subsequent damaging ischemic events; however, the molecular mechanisms responsible for protection are poorly understood. Identifying genes involved in this process could provide insight into cell survival and treatment of stroke. We developed a murine model of ischemic pr...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.STR.0000143735.89281.bb
更新日期:2004-11-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Dysphagia is common after stroke and is a marker of poor prognosis. Early identification is important. This article reviews the merits and limitations of various assessment methods available to clinicians. METHODS:An electronic database search was performed of MEDLINE, EMBASE, and the Cochrane d...
journal_title:Stroke
pub_type: 杂志文章,评审
doi:10.1161/01.STR.0000066309.06490.B8
更新日期:2003-05-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The Stroke Health and Risk Education Project was a cluster-randomized, faith-based, culturally sensitive, theory-based multicomponent behavioral intervention trial to reduce key stroke risk factor behaviors in Hispanics/Latinos and European Americans. METHODS:Ten Catholic churches were randomize...
journal_title:Stroke
pub_type: 杂志文章,随机对照试验
doi:10.1161/STROKEAHA.115.010678
更新日期:2015-10-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Animal data suggest the use of beta-human chorionic gonadotropin followed by erythropoietin to promote brain repair after stroke. The current study directly translated these results by evaluating safety of this sequential growth factor therapy through a 3-center, single-dose, open-label, noncontr...
journal_title:Stroke
pub_type: 杂志文章,多中心研究
doi:10.1161/STROKEAHA.109.574343
更新日期:2010-05-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Oxidative stress is known to be involved in ischemic stroke. Intense interest is drawn to the therapeutic potential of Chinese herbs on ischemic stroke because many of them contain antioxidant properties. Leonurine, 1 of the active compounds from purified Herba Leonuri, was studied to evaluate it...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.110.589895
更新日期:2010-11-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Variations in blood-brain barrier (BBB) opening after ischemia have been suggested by some tracer and magnetization transfer studies, although direct in vivo proof is still lacking. Contrast-enhanced magnetic resonance imaging (MRI) is also often used to visualize BBB damage in stroke. We hypothe...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.107.496059
更新日期:2008-02-01 00:00:00