Transforming growth factor-beta mediates astrocyte-specific regulation of brain endothelial anticoagulant factors.

abstract：BACKGROUND AND PURPOSE:Cerebral venous thrombosis (CVT) may be a manifestation of underlying autoimmune disease. Antibodies against annexin A2 (anti-A2Ab) coincide with antiphospholipid syndrome, in which antiphospholipid antibodies (aPLA) are associated with thrombosis in any vascular bed. Annexin A2, a profibrinolyti...

journal_title：Stroke

authors： Cesarman-Maus G,Cantú-Brito C,Barinagarrementeria F,Villa R,Reyes E,Sanchez-Guerrero J,Hajjar KA,Latorre EG

更新日期：2011-02-01 00:00:00

abstract：:The protective properties of PY 108-068 against ischemic disturbances in the brain were investigated in vitro and in vivo. The calcium antagonistic effects were demonstrated on isolated, calcium-loaded arterial rings of feline cerebral arteries. Determination of brain tissue oxygenation with pO2 microelectrodes showed...

journal_title：Stroke

authors： Wiernsperger N,Gygax P,Hofmann A

更新日期：1984-07-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Recent Icelandic studies have demonstrated linkage for common forms of stroke to chromosome 5q12 and association between phosphodiesterase4D (PDE4D) and ischemic stroke. Using a candidate region approach, we wanted to test the validity of these findings in a different population from northern Swe...

journal_title：Stroke

authors： Nilsson-Ardnor S,Wiklund PG,Lindgren P,Nilsson AK,Janunger T,Escher SA,Hallbeck B,Stegmayr B,Asplund K,Holmberg D

更新日期：2005-08-01 00:00:00

abstract：:Patients with symptoms of cerebral ischemia are often evaluated with non-invasive carotid artery testing. An abnormal carotid Doppler ultrasound frequency shift pattern of early systolic flutter (ESF) was demonstrated by auscultation and velocity wave form analysis in patients with normal carotid bifurcations. Ten of ...

journal_title：Stroke

authors： Weinberger J,Goldman M

更新日期：1985-11-01 00:00:00

abstract：BACKGROUND AND PURPOSE:In major cerebral arterial steno-occlusive diseases, there can be remarkably decreased hemodynamic reserve without marked neurological impairments. In such settings, it is not known whether the neural activity is well maintained or disturbed according to the severity of cerebral ischemia. The pre...

journal_title：Stroke

authors： Bundo M,Inao S,Nakamura A,Kato T,Ito K,Tadokoro M,Kabeya R,Sugimoto T,Kajita Y,Yoshida J

更新日期：2002-01-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The visual analogue scale is a self-reported, validated tool to measure quality of life (QoL). Our purpose was to determine whether baseline QoL predicted strokes in the ALLHAT study (Antihypertensive and Lipid Lowering Treatment to Prevent Heart Attack Trial) and evaluate determinants of poststr...

journal_title：Stroke

authors： Shams T,Auchus AP,Oparil S,Wright CB,Wright J,Furlan AJ,Sila CA,Davis BR,Pressel S,Yamal JM,Einhorn PT,Lerner AJ,ALLHAT Collaborative Research Group.

更新日期：2017-11-01 00:00:00

abstract：:There have been numerous failures in the field of acute stroke therapy over many years, but the first large clinical trial showing preliminary indications of efficacy and safety of a neuroprotective drug, NXY-059, has now been fully reported. If confirmed, it will mean that a second therapy for acute stroke has been i...

journal_title：Stroke

authors： Zivin JA

更新日期：2007-02-01 00:00:00

abstract：:To evaluate the role of platelet function in the pathogenesis of cerebral vasospasm, we compared sequential changes of platelet aggregability and beta-thromboglobulin and thromboxane B2 concentrations in blood samples from the internal jugular and peripheral vein of 13 patients with aneurysmal subarachnoid hemorrhage....

journal_title：Stroke

authors： Ohkuma H,Suzuki S,Kimura M,Sobata E

更新日期：1991-07-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Transcranial color-coded duplex sonography (TCCS) enables visualization of the intracranial parenchymal structures and measurement of blood flow velocity in the basal cerebral arteries. The present study aims to evaluate prospectively the clinical usefulness of TCCS in patients with acute stroke....

journal_title：Stroke

authors： Seidel G,Kaps M,Gerriets T

更新日期：1995-11-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Clinical development of novel neuroprotection therapies for the treatment of brain injury has been unsuccessful. One critical limitation is the lack of a viable therapeutic treatment window (TW). In this study, we evaluated the neuroprotection TW for the proteosome inhibitor MLN519 after ischemia...

journal_title：Stroke

authors： Williams AJ,Berti R,Dave JR,Elliot PJ,Adams J,Tortella FC

更新日期：2004-05-01 00:00:00

abstract：BACKGROUND AND PURPOSE:[123I]Iomazenil is a specific radioligand for the central benzodiazepine receptor that may be useful as an indicator of the intactness of cortical neurons after focal cerebral ischemia. We evaluated the binding of this receptor in reperfused cortex among patients with ischemic stroke to detect vi...

journal_title：Stroke

authors： Nakagawara J,Sperling B,Lassen NA

更新日期：1997-01-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Spreading depressions (SDs) occur in experimental focal ischemia and contribute to lesion evolution. N-Methyl-D-aspartate (NMDA) antagonists inhibit SDs and reduce infarct size. The glycine site on the NMDA receptor complex offers a therapeutic target for acute focal ischemia, potentially devoid ...

journal_title：Stroke

authors： Tatlisumak T,Takano K,Meiler MR,Fisher M

更新日期：1998-01-01 00:00:00

abstract：:We tested the reproducibility of consecutive measurements of regional cerebral blood flow (rCBF) made in 13 areas of each hemisphere in patients with cerebrovascular diseases by the atraumatic 133Xe intravenous injection method. The data were analysed by a two-compartment model similar to that used in the Obrist inhal...

journal_title：Stroke

authors： Meric P,Luft A,Seylaz J,Mamo H

更新日期：1983-01-01 00:00:00

abstract：BACKGROUND AND PURPOSE:We assessed whether the load of cerebral small vessel disease (cSVD) and its individual markers, including lacunes, white matter hyperintensities, microbleeds, and enlarged perivascular spaces (EPVS), are associated with arterial stiffness. METHODS:We evaluated cSVD markers in a cohort of 782 hy...

journal_title：Stroke

authors： Riba-Llena I,Jiménez-Balado J,Castañé X,Girona A,López-Rueda A,Mundet X,Jarca CI,Álvarez-Sabin J,Montaner J,Delgado P

更新日期：2018-05-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The purpose of our study was to compare lesion location between moyamoya disease-related intracerebral hemorrhage (MMD-ICH) and primary intracerebral hemorrhage (P-ICH). METHODS:Ninety-three patients each with MMD-ICH and P-ICH were compared. In patients with MMD-ICH, angiographic findings were ...

journal_title：Stroke

authors： Nah HW,Kwon SU,Kang DW,Ahn JS,Kwun BD,Kim JS

更新日期：2012-07-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Autonomic nervous system diseases affect systemic blood pressure regulation. Patients with autonomic nervous system diseases have consistently larger drops in blood pressure associated with standing than the normal population. Autonomic dysfunction and/or these changes in blood pressure may affec...

journal_title：Stroke

authors： Blaber AP,Bondar RL,Stein F,Dunphy PT,Moradshahi P,Kassam MS,Freeman R

更新日期：1997-09-01 00:00:00

abstract：BACKGROUND AND PURPOSE:In an inner-London teaching hospital, a randomized trial of "conventional" care versus early discharge to community-based therapy found no significant differences in clinical outcomes between patient groups. This report examines the economic consequences of the alternative strategies. METHODS:On...

journal_title：Stroke

authors： Beech R,Rudd AG,Tilling K,Wolfe CD

更新日期：1999-04-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Loss of movement coordination is the main postacute symptom after cerebellar infarction. Although the course of motor recovery has been described previously, detailed kinematic descriptions of acute stage ataxia are rare and no attempt has been made to link improvements in motor function to measu...

journal_title：Stroke

authors： Konczak J,Pierscianek D,Hirsiger S,Bultmann U,Schoch B,Gizewski ER,Timmann D,Maschke M,Frings M

更新日期：2010-10-01 00:00:00

abstract：BACKGROUND AND PURPOSE:We studied whether the inducible nitric oxide synthase (iNOS) inhibitor aminoguanidine reduces focal cerebral ischemic damage in a relatively noninvasive stroke model in which the rat middle cerebral artery (MCA) is occluded using an intravascular filament. METHODS:In rats anesthetized with halo...

journal_title：Stroke

authors： Zhang F,Casey RM,Ross ME,Iadecola C

更新日期：1996-02-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Calcium (Ca(2+)) plays a role in the cellular and molecular pathways of ischemic neuronal death. We evaluated the impact of both early and delayed Ca(2+) levels on clinical outcomes from acute ischemic stroke. METHODS:The relations between blood calcium level obtained early (<4.5 hours), and del...

journal_title：Stroke

authors： Ovbiagele B,Starkman S,Teal P,Lyden P,Kaste M,Davis SM,Hacke W,Fierus M,Saver JL,VISTA Investigators.

更新日期：2008-08-01 00:00:00

abstract：BACKGROUND:Stroke patients are heterogeneous not only with respect to etiology but also in terms of preexisting clinical conditions. Approximately one fifth of patients with acute stroke are hyperglycemic and/or have had a recent infectious or inflammatory condition. Summary of Review-- Experimental research indicates ...

journal_title：Stroke

authors： Kent TA,Soukup VM,Fabian RH

更新日期：2001-10-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The effect of tissue-type plasminogen activator on functional outcome decreases progressively over time. However, given the differential pattern of arterial occlusion, stroke severity, and speed of ischemic lesion growth among candidates for reperfusion, the time window should be adjusted accordi...

journal_title：Stroke

authors： Muchada M,Rubiera M,Rodriguez-Luna D,Pagola J,Flores A,Kallas J,Sanjuan E,Meler P,Alvarez-Sabin J,Ribo M,Molina CA

更新日期：2014-04-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The association between minor ST-T abnormalities and stroke incidence has not been well elucidated. We sought to examine the relationship between nonspecific minor or major ST-T abnormalities and the incidence of stroke among Japanese men and women. METHODS:A 15.4-year prospective study was cond...

journal_title：Stroke

authors： Ohira T,Iso H,Imano H,Kitamura A,Sato S,Nakagawa Y,Naito Y,Sankai T,Tanigawa T,Yamagishi K,Iida M,Shimamoto T

更新日期：2003-12-01 00:00:00

abstract：:To determine the efficacy of calcium channel blockers in preserving neurologic function after central nervous system ischemia, we studied three such agents in two animal models. We treated rabbits after inducing ischemia in the brain with intra-arterial microspheres and in the spinal cord using a removable aortic occl...

journal_title：Stroke

authors： Lyden PD,Zivin JA,Kochhar A,Mazzarella V

更新日期：1988-08-01 00:00:00

abstract：BACKGROUND AND PURPOSE:A transient ischemic attack (TIA) in the brain is classically considered a syndrome lasting <24 hours. Having previously shown that an experimental challenge with the GABAA agonist midazolam in recovered stroke patients can reinduce the acute clinical state, we determined whether TIA patients wou...

journal_title：Stroke

authors： Lazar RM,Fitzsimmons BF,Marshall RS,Mohr JP,Berman MF

更新日期：2003-03-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The mechanisms of immune reaction involved in the pathogenesis and clinical course of acute vascular incidents are still not completely understood. The aim of this study was to examine the presence of immune complexes (IC) in the acute stroke setting and the first month thereafter and to characte...

journal_title：Stroke

authors： Tarnacka B,Gromadzka G,Członkowska A

更新日期：2002-04-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Elevated cardiac troponin is a marker of cardiac disease and has been recently shown to be associated with embolic stroke risk. We hypothesize that early elevated troponin levels in the acute stroke setting are more prevalent in patients with embolic stroke subtypes (cardioembolic and embolic str...

journal_title：Stroke

authors： Yaghi S,Chang AD,Ricci BA,Jayaraman MV,McTaggart RA,Hemendinger M,Narwal P,Dakay K,Mac Grory B,Cutting SM,Burton TM,Song C,Mehanna E,Siket M,Madsen TE,Reznik M,Merkler AE,Lerario MP,Kamel H,Elkind MSV,Furie KL

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Uric acid (UA) is a neuroprotective antioxidant that improves the benefits of alteplase in experimental ischemia. However, it is unknown whether endogenous UA also influences the response to thrombolysis in patients with stroke. METHODS:A total of 317 consecutive patients treated with thrombolys...

journal_title：Stroke

authors： Amaro S,Urra X,Gómez-Choco M,Obach V,Cervera A,Vargas M,Torres F,Rios J,Planas AM,Chamorro A

更新日期：2011-01-01 00:00:00

abstract：:Endovascular acute ischemic stroke therapy is now proven by randomized controlled trials to produce large, clinically meaningful benefits. In response, stroke systems of care must change to increase timely and equitable access to this therapy. In this review, we provide a North American perspective on implications for...

journal_title：Stroke

authors： Smith EE,Schwamm LH

更新日期：2015-06-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Little is known about how regions vary in their use of thrombolysis (intravenous tissue-type plasminogen activator and intra-arterial treatment) for acute stroke. We sought to determine regional variation in thrombolysis treatment and investigate the extent to which regional variation is accounte...

journal_title：Stroke

authors： Skolarus LE,Meurer WJ,Shanmugasundaram K,Adelman EE,Scott PA,Burke JF

更新日期：2015-07-01 00:00:00