Endothelial dysfunction and arterial stiffness in ischemic stroke: the role of sleep-disordered breathing.

Abstract:

BACKGROUND AND PURPOSE:Sleep-disordered breathing (SDB) represents a risk factor for cardiovascular morbidity after a cerebral ischemic event (acute ischemic event, ischemic stroke, or transient ischemic attack). In the present study, endothelial function and arterial stiffness were analyzed in patients who experienced a postacute ischemic event with relation to SDB, sleep disruption, and nocturnal oxygenation parameters. METHODS:SDB was assessed by full polysomnography in patients with acute ischemic event 3 months after the admission at our stroke unit. Moderate-severe SDB was defined according to the apnea-hypopnea index as apnea-hypopnea index ≥ 20. Endothelial function and arterial stiffness were assessed by peripheral arterial tonometry using Endo-PAT 2000. RESULTS:Thirty-seven patients were included. The augmentation index was significantly different between patients with apnea-hypopnea index <20 and apnea-hypopnea index ≥ 20 (22.4 ± 15.6% versus 34.6 ± 21.6%; P=0.042), whereas reactive hyperemia index level was not (2.02 ± 0.65 versus 2.31 ± 0.61; P=0.127). Patients with apnea-hypopnea index ≥ 20 showed an increased risk for arterial stiffness (odds ratio, 5.98 [95% CI, 1.11-41.72]) even when controlling for age, sex, body mass index, hypertension, and diabetes mellitus. The augmentation index was correlated with the arousal index (P=0.010) and with mean O2 saturation (P = 0.043). CONCLUSIONS:Poststroke patients with moderate-severe SDB were more prone to have increased arterial stiffness, although we did not find significant differences in endothelial function. Arterial stiffness also correlated with sleep disruption (arousal index) and mean O2 saturation.

journal_name

Stroke

journal_title

Stroke

authors

Cereda CW,Tamisier R,Manconi M,Andreotti J,Frangi J,Pifferini V,Bassetti CL

doi

10.1161/STROKEAHA.111.000112

subject

Has Abstract

pub_date

2013-04-01 00:00:00

pages

1175-8

issue

4

eissn

0039-2499

issn

1524-4628

pii

STROKEAHA.111.000112

journal_volume

44

pub_type

临床试验,杂志文章,多中心研究

相关文献

STROKE文献大全
  • Incidence of Atrial Fibrillation in Patients With Recent Ischemic Stroke Versus Matched Controls.

    abstract::Background and Purpose- It is unclear whether atrial fibrillation/flutter (AF) newly diagnosed after ischemic stroke represents a preexisting risk factor that led to stroke, an arrhythmia triggered by poststroke autonomic dysfunction, or an incidental finding. Methods- We compared AF incidence after hospitalizations f...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/STROKEAHA.118.022826

    authors: Witsch J,Merkler AE,Chen ML,Navi BB,Sheth KN,Freedman B,Schwamm LH,Kamel H

    更新日期:2018-10-01 00:00:00

  • Increased body iron stores are associated with poor outcome after thrombolytic treatment in acute stroke.

    abstract:BACKGROUND AND PURPOSE:Iron overload has been associated with greater oxidative stress and brain injury in experimental cerebral ischemia and reperfusion. This study investigates whether high serum ferritin levels, as an index of increased cellular iron stores, are associated with poor outcome, hemorrhagic transformati...

    journal_title:Stroke

    pub_type: 杂志文章,多中心研究

    doi:10.1161/01.STR.0000251798.25803.e0

    authors: Millan M,Sobrino T,Castellanos M,Nombela F,Arenillas JF,Riva E,Cristobo I,García MM,Vivancos J,Serena J,Moro MA,Castillo J,Dávalos A

    更新日期:2007-01-01 00:00:00

  • Cerebral hemodynamic evaluation using perfusion-weighted magnetic resonance imaging: comparison with positron emission tomography values in chronic occlusive carotid disease.

    abstract:BACKGROUND AND PURPOSE:Perfusion-weighted magnetic resonance imaging (PWI) is a reliable and semiquantitative method for estimating cerebral hemodynamics. We sought to evaluate the potential of PWI for assessing cerebral blood flow (CBF) and metabolism compared with positron emission tomography (PET) in patients with c...

    journal_title:Stroke

    pub_type: 临床试验,杂志文章

    doi:10.1161/01.STR.0000076014.60026.45

    authors: Kajimoto K,Moriwaki H,Yamada N,Hayashida K,Kobayashi J,Miyashita K,Naritomi H

    更新日期:2003-07-01 00:00:00

  • Effects of locomotion training with assistance of a robot-driven gait orthosis in hemiparetic patients after stroke: a randomized controlled pilot study.

    abstract:BACKGROUND AND PURPOSE:The success of gait rehabilitation after stroke depends on active walking exercises. However, the disabling after-effects of stroke often make such exercises impossible at the onset of therapy. To facilitate treadmill training of paraparetic patients, a robot-driven gait orthosis (Lokomat) was de...

    journal_title:Stroke

    pub_type: 杂志文章,随机对照试验

    doi:10.1161/01.STR.0000254607.48765.cb

    authors: Husemann B,Müller F,Krewer C,Heller S,Koenig E

    更新日期:2007-02-01 00:00:00

  • Baseline National Institutes of Health stroke scale-adjusted time window for intravenous tissue-type plasminogen activator in acute ischemic stroke.

    abstract:BACKGROUND AND PURPOSE:The effect of tissue-type plasminogen activator on functional outcome decreases progressively over time. However, given the differential pattern of arterial occlusion, stroke severity, and speed of ischemic lesion growth among candidates for reperfusion, the time window should be adjusted accordi...

    journal_title:Stroke

    pub_type: 临床试验,杂志文章

    doi:10.1161/STROKEAHA.113.004307

    authors: Muchada M,Rubiera M,Rodriguez-Luna D,Pagola J,Flores A,Kallas J,Sanjuan E,Meler P,Alvarez-Sabin J,Ribo M,Molina CA

    更新日期:2014-04-01 00:00:00

  • Cerebral microemboli and brain injury during carotid artery endarterectomy and stenting.

    abstract:BACKGROUND AND PURPOSE:Cerebral microembolic signals detected by transcranial Doppler are frequent during carotid angioplasty with stenting and carotid endarterectomy (CEA). Their potential harmful effects on the brain are, however, unclear. The aim of this study was to relate the frequency and type of per-procedural m...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/STROKEAHA.107.513341

    authors: Skjelland M,Krohg-Sørensen K,Tennøe B,Bakke SJ,Brucher R,Russell D

    更新日期:2009-01-01 00:00:00

  • Quantitative carotid phonoangiography.

    abstract::One hundred and sixteen carotid artery bruits were assessed using quantitative phonoangiography (spectral bruit analysis - SBA). This technique uses the averaged break frequency of the bruit to calculate the diameter of he residual lumen at the site of stenosis. Biplanar contrast arteriography was performed on 43 (37%...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.12.6.798

    authors: Knox R,Breslau P,Strandness DE Jr

    更新日期:1981-11-01 00:00:00

  • Compliance with antiplatelet therapy in patients with ischemic cerebrovascular disease. Assessment by platelet aggregation testing.

    abstract:BACKGROUND AND PURPOSE:Antiplatelet therapy is currently one of the methods for preventing transient ischemic attacks and cerebral thrombosis. Because antiplatelet agents are generally administered on a long-term basis, patient compliance is an important factor. The purpose of this study was to determine the compliance...

    journal_title:Stroke

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1161/01.str.25.12.2337

    authors: Komiya T,Kudo M,Urabe T,Mizuno Y

    更新日期:1994-12-01 00:00:00

  • Macrophage-derived matrix metalloproteinase-2 and -9 promote the progression of cerebral aneurysms in rats.

    abstract:BACKGROUND AND PURPOSE:Mechanisms of initiation, progression and rupture of cerebral aneurysms have not yet been fully understood despite its clinical significance. Matrix metalloproteinases (MMPs) are a family of proteinases which are involved in the remodeling of vascular walls. In the present study, we investigated ...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.STR.0000252129.18605.c8

    authors: Aoki T,Kataoka H,Morimoto M,Nozaki K,Hashimoto N

    更新日期:2007-01-01 00:00:00

  • Sensory symptoms and signs and results of quantitative sensory thermal testing in patients with lacunar infarct syndromes.

    abstract:BACKGROUND AND PURPOSE:Quantitative data on sensory impairment in stroke patients are limited. We measured the perception thresholds for temperature and thermal pain in patients with different lacunar syndromes, correlated the results with clinical and magnetic resonance imaging (MRI) findings, and studied the long-ter...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.25.11.2165

    authors: Samuelsson M,Samuelsson L,Lindell D

    更新日期:1994-11-01 00:00:00

  • Pathogenetical subtypes of recurrent intracerebral hemorrhage: designations by SMASH-U classification system.

    abstract:BACKGROUND AND PURPOSE:Pathogenetic classification of intracerebral hemorrhage (ICH), using systems such as SMASH-U (structural vascular lesions, medication, cerebral amyloid angiopathy [CAA], systemic disease, hypertension, or undetermined), is important in predicting functional outcomes and mortality in patients with...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/STROKEAHA.114.005598

    authors: Yeh SJ,Tang SC,Tsai LK,Jeng JS

    更新日期:2014-09-01 00:00:00

  • Vascular disease: the tsunami of health care.

    abstract::The gap between existing knowledge and the patient care provided in stroke has become more apparent. The translational gap is evidence of our scientific progress, but the sheer magnitude of our implementation gap is astounding. For instance, almost 5 decades ago we recognized the risk factors for stroke, yet in Canada...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/STROKEAHA.107.492793

    authors: Hakim AM

    更新日期:2007-12-01 00:00:00

  • Electrocardiographic changes and myocardial damage in patients with acute cerebrovascular accidents.

    abstract::In 100 consecutive patients with acute cerebrovascular accident, due to cerebral thrombosis in 72, cerebral hemorrhage in 12, embolus in 6, and subarachnoid hemorrhage in 10, there were 90 who had electrocardiographic abnormalities during the first three days after admission, compared to 50% in a control group. The pa...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.8.4.448

    authors: Dimant J,Grob D

    更新日期:1977-07-01 00:00:00

  • Leukocyte accumulation and hemodynamic changes in the cerebral microcirculation during early reperfusion after stroke.

    abstract:BACKGROUND AND PURPOSE:Leukocytes contribute to cerebral ischemia-reperfusion injury. However, few experimental models examine both in vivo behavior of leukocytes and microvascular rheology after stroke. The purpose of the present study was to characterize patterns of leukocyte accumulation in the cerebral microcircula...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.31.5.1153

    authors: Ritter LS,Orozco JA,Coull BM,McDonagh PF,Rosenblum WI

    更新日期:2000-05-01 00:00:00

  • Inhibition of NADPH oxidase attenuates vasospasm after experimental subarachnoid hemorrhage in rats.

    abstract:BACKGROUND AND PURPOSE:The purpose of this study is to investigate whether apocynin, an NADPH oxidase inhibitor, attenuates vasospasm after experimental subarachnoid hemorrhage (SAH) in rats. METHODS:Rats were subjected to endovascular perforation of the right anterior cerebral artery or sham surgery. Beginning 2 hour...

    journal_title:Stroke

    pub_type: 杂志文章,收录出版

    doi:10.1161/01.STR.0000163102.49888.b7

    authors: Zheng JS,Zhan RY,Zheng SS,Zhou YQ,Tong Y,Wan S

    更新日期:2005-05-01 00:00:00

  • Toll-like receptor 7 preconditioning induces robust neuroprotection against stroke by a novel type I interferon-mediated mechanism.

    abstract:BACKGROUND AND PURPOSE:Systemic administration of Toll-like receptor (TLR) 4 and TLR9 agonists before cerebral ischemia have been shown to reduce ischemic injury by reprogramming the response of the brain to stroke. Our goal was to explore the mechanism of TLR-induced neuroprotection by determining whether a TLR7 agoni...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/STROKEAHA.111.641522

    authors: Leung PY,Stevens SL,Packard AE,Lessov NS,Yang T,Conrad VK,van den Dungen NN,Simon RP,Stenzel-Poore MP

    更新日期:2012-05-01 00:00:00

  • Recombinant milk fat globule-EGF factor-8 reduces oxidative stress via integrin β3/nuclear factor erythroid 2-related factor 2/heme oxygenase pathway in subarachnoid hemorrhage rats.

    abstract:BACKGROUND AND PURPOSE:Milk fat globule-EGF factor-8 (MFGE8) has been reported to be neuroprotective in ischemic stroke. However, the effects of MFGE8 in early brain injury after subarachnoid hemorrhage (SAH) have not been investigated. We investigated the role of MFGE8 in early brain injury and the potential mechanism...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/STROKEAHA.114.006635

    authors: Liu F,Hu Q,Li B,Manaenko A,Chen Y,Tang J,Guo Z,Tang J,Zhang JH

    更新日期:2014-12-01 00:00:00

  • Stroke in the People's Republic of China. I. Geographic variations in incidence and risk factors.

    abstract:BACKGROUND AND PURPOSE:Stroke is a major cause of death in the People's Republic of China (PRC), and the geographic distribution of stroke death varies substantially. We conducted an ecological analysis to investigate the relationship of prevalence of hypertension and other risk factors with stroke incidence and mortal...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:

    authors: He J,Klag MJ,Wu Z,Whelton PK

    更新日期:1995-12-01 00:00:00

  • Diffusion-Weighted Imaging Hyperintensities in Subtypes of Acute Intracerebral Hemorrhage.

    abstract::Background and Purpose- Diffusion-weighted imaging (DWI) hyperintensities in intracerebral hemorrhage (ICH) are associated with increased risk of recurrent ICH, cognitive impairment, and death, but whether these lesions are specific to a subtype of ICH remains uncertain. We investigated the association between DWI les...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/STROKEAHA.118.021407

    authors: Boulanger M,Schneckenburger R,Join-Lambert C,Werring DJ,Wilson D,Hodel J,Zuber M,Touzé E

    更新日期:2018-12-07 00:00:00

  • Anterior choroidal artery territory infarcts. Study of presumed mechanisms.

    abstract:BACKGROUND AND PURPOSE:A previous study suggested that occlusive diseases of small penetrating arteries account for most anterior choroidal artery (AChA) territory infarcts, but half of the patients did not have an echocardiogram. Cases of AChA territory infarcts associated with internal carotid artery stenosis or atri...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.25.4.837

    authors: Leys D,Mounier-Vehier F,Lavenu I,Rondepierre P,Pruvo JP

    更新日期:1994-04-01 00:00:00

  • Prevalence and causes of early-onset dementia in Japan: a population-based study.

    abstract:BACKGROUND AND PURPOSE:Few studies are available that have addressed the prevalence of early-onset dementia (EOD), including early-onset Alzheimer disease and other forms of dementia in Japan. METHODS:A 2-step postal survey was sent to all of the 2475 institutions providing medical or care services for individuals wit...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/STROKEAHA.108.542308

    authors: Ikejima C,Yasuno F,Mizukami K,Sasaki M,Tanimukai S,Asada T

    更新日期:2009-08-01 00:00:00

  • Distinguishing between stroke and mimic at the bedside: the brain attack study.

    abstract:BACKGROUND AND PURPOSE:The bedside clinical assessment of the patient with suspected stroke has not been well studied. Improving clinical skills may accelerate patient progress through the emergency department. We aimed to determine the frequency and nature of stroke mimics and to identify the key clinical features tha...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.STR.0000204041.13466.4c

    authors: Hand PJ,Kwan J,Lindley RI,Dennis MS,Wardlaw JM

    更新日期:2006-03-01 00:00:00

  • Impact of pretreatment noncontrast CT Alberta Stroke Program Early CT Score on clinical outcome after intra-arterial stroke therapy.

    abstract:BACKGROUND AND PURPOSE:The efficacy of intra-arterial treatment remains uncertain. Because most centers performing IAT use noncontrast CT (NCCT) imaging, it is critical to understand the impact of NCCT findings on treatment outcomes. This study aimed to compare functional independence and safety among patients undergoi...

    journal_title:Stroke

    pub_type: 杂志文章,多中心研究

    doi:10.1161/STROKEAHA.113.004260

    authors: Yoo AJ,Zaidat OO,Chaudhry ZA,Berkhemer OA,González RG,Goyal M,Demchuk AM,Menon BK,Mualem E,Ueda D,Buell H,Sit SP,Bose A,Penumbra Pivotal and Penumbra Imaging Collaborative Study (PICS) Investigators.

    更新日期:2014-03-01 00:00:00

  • Altered Fibrin Clot Properties in Patients With Cerebral Venous Sinus Thrombosis: Association With the Risk of Recurrence.

    abstract:BACKGROUND AND PURPOSE:Venous thromboembolism and ischemic stroke are associated with unfavorable fibrin clot structure and function. We hypothesized that denser fibrin networks displaying impaired lysability characterize patients with cerebral venous sinus thrombosis (CVST). METHODS:We assessed plasma fibrin clot pro...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/STROKEAHA.115.009528

    authors: Siudut J,Świat M,Undas A

    更新日期:2015-09-01 00:00:00

  • Effects of reduced regional or body temperatures on responses of pial arterioles.

    abstract::We have investigated the effects of a reduced regional or a reduced body temperature, on pial arteriolar response to a variety of vasoactive stimuli. This has been done by studying the effects of these stimuli on groups of mice with different body temperatures, or with different temperatures of the artificial cerebros...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.9.6.580

    authors: Rosenblum WI,Segreti AC

    更新日期:1978-11-01 00:00:00

  • Efficacy of Endovascular Therapy in Acute Ischemic Stroke Depends on Age and Clinical Severity.

    abstract:BACKGROUND AND PURPOSE:Efficacy of endovascular treatment (EVT) for ischemic stroke because of large vessel occlusion may depend on patients' age and stroke severity; we, therefore, developed a prognosis score based on these variables and examined whether EVT efficacy differs between patients with good, intermediate, o...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/STROKEAHA.117.020511

    authors: Le Bouc R,Clarençon F,Meseguer E,Lapergue B,Consoli A,Turc G,Naggara O,Duong DL,Servan J,Reiner P,Labeyrie MA,Fisselier M,Blanc R,Farhat W,Pires C,Zuber M,Obadia M,Mazighi M,Pico F,Mas JL,Amarenco P,Samson Y,P

    更新日期:2018-07-01 00:00:00

  • Correlations between clinical findings and magnetization transfer imaging metrics of tissue damage in individuals with cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy.

    abstract:BACKGROUND AND PURPOSE:We obtained magnetization transfer imaging (MTI) scans from individuals with cerebral autosomal-dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) (1) to investigate the presence, extent, and nature of pathology in white and gray matter outside proton density (PD)-v...

    journal_title:Stroke

    pub_type: 临床试验,杂志文章

    doi:10.1161/01.str.32.3.643

    authors: Iannucci G,Dichgans M,Rovaris M,Brüning R,Gasser T,Giacomotti L,Yousry TA,Filippi M

    更新日期:2001-03-01 00:00:00

  • Sex differences in first-ever acute stroke.

    abstract:BACKGROUND AND PURPOSE:There are few studies analyzing stroke in women, taking into account the vascular risk factors, cause of stroke, clinical picture, and outcome. The purpose of this study was to analyze possible sex differences in patients suffering first-ever acute stroke. METHODS:From December 1995 to January 2...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.STR.0000078562.82918.F6

    authors: Roquer J,Campello AR,Gomis M

    更新日期:2003-07-01 00:00:00

  • Interrater reliability of the Pediatric National Institutes of Health Stroke Scale (PedNIHSS) in a multicenter study.

    abstract:BACKGROUND AND PURPOSE:Stroke is an important cause of death and disability among children. Clinical trials for childhood stroke require a valid and reliable acute clinical stroke scale. We evaluated interrater reliability (IRR) of a pediatric adaptation of the National Institutes of Health Stroke Scale. METHODS:The p...

    journal_title:Stroke

    pub_type: 杂志文章,多中心研究

    doi:10.1161/STROKEAHA.110.607192

    authors: Ichord RN,Bastian R,Abraham L,Askalan R,Benedict S,Bernard TJ,Beslow L,Deveber G,Dowling M,Friedman N,Fullerton H,Jordan L,Kan L,Kirton A,Amlie-Lefond C,Licht D,Lo W,McClure C,Pavlakis S,Smith SE,Tan M,Kasner S

    更新日期:2011-03-01 00:00:00

  • The Virtual International Stroke Trials Archive.

    abstract:BACKGROUND AND PURPOSE:Stroke has global importance and it causes an increasing amount of human suffering and economic burden, but its management is far from optimal. The unsuccessful outcome of several research programs highlights the need for reliable data on which to plan future clinical trials. The Virtual Internat...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/STROKEAHA.106.473579

    authors: Ali M,Bath PM,Curram J,Davis SM,Diener HC,Donnan GA,Fisher M,Gregson BA,Grotta J,Hacke W,Hennerici MG,Hommel M,Kaste M,Marler JR,Sacco RL,Teal P,Wahlgren NG,Warach S,Weir CJ,Lees KR

    更新日期:2007-06-01 00:00:00