Vascular disease: the tsunami of health care.

abstract：:We have studied a new high-affinity competitive N-methyl-D-aspartate antagonist, D-CPP-ene (SDZ-EAA 494), in two models of focal cerebral ischemia. In the cat middle cerebral artery occlusion model (6 hours' survival), pretreatment with D-CPP-ene reduced infarct size by 64% (15 mg/kg dose) and 60% (4.5 mg/kg dose). Th...

journal_title：Stroke

authors： Bullock R,McCulloch J,Graham DI,Lowe D,Chen MH,Teasdale GM

更新日期：1990-11-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Intracerebral hemorrhage (ICH) growth predicts mortality and functional outcome. We hypothesized that irregular hematoma shape and density heterogeneity, reflecting active, multifocal bleeding or a variable bleeding time course, would predict ICH growth. METHODS:Three raters examined baseline su...

journal_title：Stroke

authors： Barras CD,Tress BM,Christensen S,MacGregor L,Collins M,Desmond PM,Skolnick BE,Mayer SA,Broderick JP,Diringer MN,Steiner T,Davis SM,Recombinant Activated Factor VII Intracerebral Hemorrhage Trial Investigators.

更新日期：2009-04-01 00:00:00

abstract：BACKGROUND AND PURPOSE:There have not been any new epidemiological studies related to stroke in Tibet for 20 years. This study aimed to collect stroke data from The City Staff Medical Insurance Registry in Lhasa, Tibet, to describe the incidence, clinical subtypes, and associated risk factors of stroke. METHODS:We use...

journal_title：Stroke

authors： Zhao Y,Yao Z,D'Souza W,Zhu C,Chun H,Zhuoga C,Zhang Q,Hu X,Zhou D

更新日期：2010-12-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The use of percutaneous transluminal coronary angioplasty (PTCA) to treat coronary artery disease is now commonplace. The occurrence of microemboli during invasive procedures such as cardiac angiography and bypass surgery is well documented, although neurological complications are relatively unco...

journal_title：Stroke

authors： Bladin CF,Bingham L,Grigg L,Yapanis AG,Gerraty R,Davis SM

更新日期：1998-11-01 00:00:00

abstract：:We studied ultrastructurally cerebral perforating arteries in 60 stroke-prone spontaneously hypertensive rats (SHRSP), which were sequentially killed at 4-52 weeks of age before showing symptoms of stroke. Another 24 SHRSP were killed soon after they showed symptoms of cerebral infarction. The initial vascular lesions...

journal_title：Stroke

authors： Tagami M,Nara Y,Kubota A,Sunaga T,Maezawa H,Fujino H,Yamori Y

更新日期：1987-07-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Understanding on distinct subsets of endothelial progenitor cells may provide insights of endothelial dysfunction or repair in the acute ischemic event. Recent in vitro data have reported the colony-forming unit (CFU) and outgrowth cell population as a subset of endothelial progenitor cells. In t...

journal_title：Stroke

authors： Chu K,Jung KH,Lee ST,Park HK,Sinn DI,Kim JM,Kim DH,Kim JH,Kim SJ,Song EC,Kim M,Lee SK,Roh JK

更新日期：2008-05-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Clear elucidation of the exact pathophysiological mechanisms of motor weakness in patients with subarachnoid hemorrhage has not yet been achieved. We attempted to investigate injury to the corticospinal tract in patients with subarachnoid hemorrhage using diffusion tensor imaging. METHODS:Twenty...

journal_title：Stroke

authors： Yeo SS,Choi BY,Chang CH,Kim SH,Jung YJ,Jang SH

更新日期：2012-08-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Accumulating evidence indicates that inflammatory responses cause secondary injury after intracerebral hemorrhage (ICH). We recently demonstrated the involvement of toll-like receptor 4 (TLR4) signaling in these processes. The purpose of the current study was to investigate the protective effect ...

journal_title：Stroke

authors： Wang YC,Wang PF,Fang H,Chen J,Xiong XY,Yang QW

更新日期：2013-09-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Recovery from hemiparesis due to corticospinal tract infarction is well documented, but the mechanism of recovery is unknown. Functional MRI (fMRI) provides a means of identifying focal brain activity related to movement of a paretic hand. Although prior studies have suggested that supplementary ...

journal_title：Stroke

authors： Marshall RS,Perera GM,Lazar RM,Krakauer JW,Constantine RC,DeLaPaz RL

更新日期：2000-03-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Pneumonia has been estimated to occur in about one third of patients after acute stroke. Only limited data are available on stroke-associated pneumonia (SAP) in specialized neurological intensive care units (NICUs). METHODS:We enrolled 124 patients with acute stroke who were treated at our unive...

journal_title：Stroke

authors： Hilker R,Poetter C,Findeisen N,Sobesky J,Jacobs A,Neveling M,Heiss WD

更新日期：2003-04-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Stroke is a debilitating disease with long-term social and economic consequences. As new therapies for acute ischemic stroke are forthcoming, there is an increasing need to understand their long-term economic implications. To address this need, a stroke economic model was created. METHODS:The mo...

journal_title：Stroke

authors： Caro JJ,Huybrechts KF

更新日期：1999-12-01 00:00:00

abstract：:Background and Purpose- We aimed to determine whether low-frequency electric field navigated repetitive transcranial magnetic stimulation to noninjured motor cortex versus sham repetitive transcranial magnetic stimulation avoiding motor cortex could improve arm motor function in hemiplegic stroke patients when combine...

journal_title：Stroke

authors： Harvey RL,Edwards D,Dunning K,Fregni F,Stein J,Laine J,Rogers LM,Vox F,Durand-Sanchez A,Bockbrader M,Goldstein LB,Francisco GE,Kinney CL,Liu CY,NICHE Trial Investigators *.

更新日期：2018-09-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Little is known about how regions vary in their use of thrombolysis (intravenous tissue-type plasminogen activator and intra-arterial treatment) for acute stroke. We sought to determine regional variation in thrombolysis treatment and investigate the extent to which regional variation is accounte...

journal_title：Stroke

authors： Skolarus LE,Meurer WJ,Shanmugasundaram K,Adelman EE,Scott PA,Burke JF

更新日期：2015-07-01 00:00:00

abstract：:Naloxone has been reported to have potential benefit in the treatment of stroke. We evaluated the effect of naloxone in a double-blind trial conducted with 15 stroke patients whose deficits ranged from 8 to 60 hours in duration. All but one patient sustained a cerebral infarction. Neurologic function was assessed befo...

journal_title：Stroke

authors： Fallis RJ,Fisher M,Lobo RA

更新日期：1984-07-01 00:00:00

abstract：:Regional cerebral blood flow (CBF) was measured (intra-arterial injections of 133Xe) and electroencephalograms (EEG) were recorded periodically before, for two hours during, and for one and one-fourth hours after middle cerebral artery (MCA) occlusion in 20 squirrel monkeys (Saimiri sciureus). A CBF-Paco2 response cur...

journal_title：Stroke

authors： Donley RF,Sundt TM,Anderson RE,Sharbrough FW

更新日期：1975-03-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The diagnosis and quantification of microangiopathy in dementia is difficult. The assessment of small-vessel disease requires expensive and sophisticated nuclear medicine techniques. This study was performed to identify microangiopathy related to the integrity of cerebral microcirculation by sono...

journal_title：Stroke

authors： Puls I,Hauck K,Demuth K,Horowski A,Schliesser M,Dörfler P,Scheel P,Toyka KV,Reiners K,Schöning M,Becker G

更新日期：1999-11-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Familial aggregation of intracranial aneurysms (IAs) indicates a genetic role in the pathogenesis of this disease. Despite a number of reported susceptibility loci, no disease-causing gene variants have been identified. In this study, we used a parametric genomewide linkage approach to search for...

journal_title：Stroke

authors： Santiago-Sim T,Depalma SR,Ju KL,McDonough B,Seidman CE,Seidman JG,Kim DH

更新日期：2009-03-01 00:00:00

abstract：BACKGROUND AND PURPOSE:We evaluated the impact of lifestyle factors on the risk of ischemic stroke. METHODS:We used a nested case-control design. The cases comprised 163 persons (median age 69 years) admitted to a stroke unit and diagnosed with acute cerebral infarction. All cases had earlier participated in the North...

journal_title：Stroke

authors： Ellekjaer EF,Wyller TB,Sverre JM,Holmen J

更新日期：1992-06-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Current US guideline statements regarding primary and secondary cardiovascular risk prediction and prevention use absolute risk estimates to identify patients who are at high risk for vascular disease events and who may benefit from specific preventive interventions. These guidelines do not expli...

journal_title：Stroke

authors： Lackland DT,Elkind MS,D'Agostino R Sr,Dhamoon MS,Goff DC Jr,Higashida RT,McClure LA,Mitchell PH,Sacco RL,Sila CA,Smith SC Jr,Tanne D,Tirschwell DL,Touzé E,Wechsler LR,American Heart Association Stroke Council.,Council on

更新日期：2012-07-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Cerebral amyloid angiopathy (CAA) occasionally coexists with cerebral vasculitis. An immune system may influence deposition or degradation of the amyloid in cerebral blood vessels. The purpose of this study was to elucidate immune reactions associated with CAA. METHODS:In 11 elderly patients wit...

journal_title：Stroke

authors： Yamada M,Itoh Y,Shintaku M,Kawamura J,Jensson O,Thorsteinsson L,Suematsu N,Matsushita M,Otomo E

更新日期：1996-07-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Randomized clinical trials testing aspirin in relatively low-risk, middle-aged people have consistently shown small increases in stroke associated with aspirin use. We analyzed the relationship between the regular use of aspirin and incident ischemic and hemorrhagic stroke among people aged 65 ye...

journal_title：Stroke

authors： Kronmal RA,Hart RG,Manolio TA,Talbert RL,Beauchamp NJ,Newman A

更新日期：1998-05-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Our goal was to compare outcomes of patients with proximal middle cerebral artery occlusions treated with intravenous tissue plasminogen activator (tPA) with those of patients treated with stent-based thrombectomy (SBT). METHODS:Patients with proximal middle cerebral artery occlusions included i...

journal_title：Stroke

authors： Leker RR,Eichel R,Gomori JM,Ramirez de Noriega F,Ben-Hur T,Cohen JE

更新日期：2012-12-01 00:00:00

abstract：:Background and Purpose- Patients with intracerebral hemorrhage (ICH) and atrial fibrillation (AF) are at risk for ischemic events. While risk calculators (CHA2DS2-VASc and HAS-BLED) have been validated to assess risk for ischemic stroke and major bleeding in AF patients, decisions about anticoagulation must consider t...

journal_title：Stroke

authors： Stanton RJ,Eckman MH,Woo D,Moomaw CJ,Haverbusch M,Flaherty ML,Kleindorfer DO

更新日期：2020-03-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Stroke in young adults has a dramatic effect on life; therefore, we investigated the long-term functional outcome after transient ischemic attack, ischemic stroke, or intracerebral hemorrhage in adults aged 18 to 50 years. METHODS:We studied 722 young patients with first-ever stroke admitted bet...

journal_title：Stroke

authors： Synhaeve NE,Arntz RM,Maaijwee NA,Rutten-Jacobs LC,Schoonderwaldt HC,Dorresteijn LD,de Kort PL,van Dijk EJ,de Leeuw FE

更新日期：2014-04-01 00:00:00

abstract：:Background and Purpose- Blood pressure (BP) variability may increase the risk of stroke and dementia. It remains inconclusive whether BP variability is associated with cerebral small vessel disease, a common and potentially devastating subclinical disease that contributes significantly to both stroke and dementia. Met...

journal_title：Stroke

authors： Ma Y,Song A,Viswanathan A,Blacker D,Vernooij MW,Hofman A,Papatheodorou S

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND AND PURPOSE:We used Riks-Stroke, the Swedish Stroke Register, to explore how thrombolysis has been disseminated in Swedish hospitals since it was approved in 2003. METHODS:All 78 hospitals in Sweden admitting patients with acute stroke participate in Riks-Stroke. Between 2003 and 2008, 72 033 adult patients...

journal_title：Stroke

authors： Eriksson M,Jonsson F,Appelros P,Asberg KH,Norrving B,Stegmayr B,Terént A,Asplund K,Riks-Stroke Collaboration.

更新日期：2010-06-01 00:00:00

abstract：:The value of the concomittant use of a real time frequency analyzer along with a continuous wave carotid Doppler scanner is demonstrated in this study of 118 cases. With a colour-coded Doppler scanner alone, internal carotid stenoses greater than 35% were diagnosed with a sensitivity of 95% and a specificity of 82%. W...

journal_title：Stroke

authors： Johnston KW,Brown PM,Kassam M

更新日期：1982-09-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Platelet-rich thrombi are resistant to thrombolytics. Matrix metalloproteinases (MMPs) may be involved in platelet aggregation and contribute to thrombolysis failure in stroke patients. METHODS:Plasma samples from 23 stroke patients who had received thrombolytics and from 47 healthy volunteers w...

journal_title：Stroke

authors： Heo JH,Kim SH,Lee KY,Kim EH,Chu CK,Nam JM

更新日期：2003-06-01 00:00:00

abstract：:Using clinical presentation, angiography, computed tomography, and nuclear magnetic resonance imaging, 7 patients were identified who had strictly unilateral hemispheric infarction and unilateral cerebrovascular disease. In 6, cerebral blood flow measured by fluorine-18-fluoromethane inhalation and positron emission t...

journal_title：Stroke

authors： Lagrèze HL,Levine RL,Pedula KL,Nickles RJ,Sunderland JS,Rowe BR

更新日期：1987-09-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The purpose of this study is to investigate whether apocynin, an NADPH oxidase inhibitor, attenuates vasospasm after experimental subarachnoid hemorrhage (SAH) in rats. METHODS:Rats were subjected to endovascular perforation of the right anterior cerebral artery or sham surgery. Beginning 2 hour...

journal_title：Stroke

authors： Zheng JS,Zhan RY,Zheng SS,Zhou YQ,Tong Y,Wan S

更新日期：2005-05-01 00:00:00