Abstract:
BACKGROUND AND PURPOSE:Intracerebral hemorrhage (ICH) growth predicts mortality and functional outcome. We hypothesized that irregular hematoma shape and density heterogeneity, reflecting active, multifocal bleeding or a variable bleeding time course, would predict ICH growth. METHODS:Three raters examined baseline sub-3-hour CT brain scans of 90 patients in the placebo arm of a Phase IIb trial of recombinant activated Factor VII in ICH. Each rater, blinded to growth data, independently applied novel 5-point categorical scales of density and shape to randomly presented baseline CT images of ICH. Density and shape were defined as either homogeneous/regular (Category 1 to 2) or heterogeneous/irregular (Category 3 to 5). Within- and between-rater reliability was determined for these scales. Growth was assessed as a continuous variable and using 3 binary definitions: (1) any ICH growth; (2) >or=33% or >or=12.5 mL ICH growth; and (3) radial growth >1 mm between baseline and 24-hour CT scan. Patients were divided into tertiles of baseline ICH volume: "small" (0 to 10 mL), "medium" (10 to 25 mL), and "large" (25 to 106 mL). RESULTS:Inter- and intrarater agreements for the novel scales exceeded 85% (+/-1 category). Median growth was significantly higher in the large-volume group compared with the small group (P<0.001) and in heterogeneous compared with homogeneous ICH (P=0.008). Median growth trended higher in irregular ICHs compared with regular ICHs (P=0.084). Small ICHs were more regularly shaped (43%) than medium (17%) and large (3%) ICHs (P<0.001). Small ICHs were more homogeneous (73%) compared with medium (37%) and large (17%) ICHs (P<0.001). Adjusting for baseline ICH volume and time to scan, density heterogeneity, but not shape irregularity, independently predicted ICH growth (P=0.046) on a continuous growth scale. CONCLUSIONS:Large ICHs were significantly more irregular in shape, heterogeneous in density, and had greater growth. Density heterogeneity independently predicted ICH growth using some definitions.
journal_name
Strokejournal_title
Strokeauthors
Barras CD,Tress BM,Christensen S,MacGregor L,Collins M,Desmond PM,Skolnick BE,Mayer SA,Broderick JP,Diringer MN,Steiner T,Davis SM,Recombinant Activated Factor VII Intracerebral Hemorrhage Trial Investigators.doi
10.1161/STROKEAHA.108.536888subject
Has Abstractpub_date
2009-04-01 00:00:00pages
1325-31issue
4eissn
0039-2499issn
1524-4628pii
STROKEAHA.108.536888journal_volume
40pub_type
杂志文章,随机对照试验相关文献
STROKE文献大全abstract:BACKGROUND AND PURPOSE:Transcranial direct current stimulation is emerging as a promising tool for the treatment of several neurological conditions, including cerebral ischemia. The therapeutic role of this noninvasive treatment is, however, limited to chronic phases of stroke. We thus ought to investigate whether diff...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.113.001687
更新日期:2013-11-01 00:00:00
abstract:BACKGROUND:Mechanisms involved in stroke progression are incompletely understood. Ischemic brain injury is characterized by acute local inflammatory response mediated by cytokines. Anti-inflammatory cytokines act in a feedback loop to inhibit continued proinflammatory cytokine production. We assessed the implication of...
journal_title:Stroke
pub_type: 临床试验,杂志文章
doi:10.1161/01.STR.0000057976.53301.69
更新日期:2003-03-01 00:00:00
abstract::The media cross-sectional area, the media thickness, the internal radius and the ratio between media thickness and internal radius were determined in consecutive sections of extraparenchymal cerebral arteries of 7- and 12-month-old normotensive and spontaneously hypertensive rats. The study included intracranial pial ...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.16.2.313
更新日期:1985-03-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Several studies have reported poor outcomes in patients too good to treat with intravenous thrombolysis because of mild or rapidly improving symptoms. We sought to determine baseline clinical and imaging predictors of poor outcome in these patients. METHODS:Among 3950 consecutive stroke admissio...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.116.014871
更新日期:2016-12-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Inflammatory and immune mechanisms can precipitate cerebrovascular thrombosis and hemorrhage. Immunologic tolerance can be induced to a specific antigen by intranasal instillation of that antigen. Lymphocytes tolerized in this way provide local immunosuppression on restimulation with the same ant...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.0000029821.82531.8b
更新日期:2002-09-01 00:00:00
abstract:BACKGROUND AND PURPOSE:We aimed to clarify the association of chronic kidney disease (CKD) with carotid atherosclerosis and the impact of CKD on carotid atherosclerosis according to blood pressure categories in an urban general population. METHODS:We studied 3466 Japanese individuals (35-93 years old) in the Suita Stu...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.113.002957
更新日期:2013-12-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Ischemic postconditioning, a brief episode of ischemia after a prolonged ischemic insult, has been found to reduce the delayed neuronal loss after stroke. However, the mechanisms underlying such endogenous neuroprotective strategy remain obscure. In this study, we try to explore the excitatory po...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.113.680181
更新日期:2013-07-01 00:00:00
abstract::In a postasphyxia neonatal lamb model, the responses of the cerebral circulation to hypoxic hypoxia and changes in systemic arterial blood pressure were examined. Ventilated newborn lambs (n = 14) were subjected to a gradual asphyxial insult, resuscitated, and returned to control ventilator settings. During the time 2...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.19.2.239
更新日期:1988-02-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Subarachnoid hemorrhage caused by cerebral aneurysm rupture remains a life-threatening emergency despite advances in treatment. However, the mechanisms underlying aneurysm initiation, progression, and rupture remain unclear. We developed a method to induce experimental cerebral aneurysms in rats,...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.STR.0000204028.39783.d9
更新日期:2006-03-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Prediction of stroke in healthy individuals is challenging and there is a diurnal variation of stroke onset. We hypothesized that heart rate variability with a focus on nighttime heart rate variability will predict the risk of stroke in apparently healthy middle-age and elderly subjects. METHODS...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.110.607697
更新日期:2011-11-01 00:00:00
abstract::In a group of 48 patients with completed stroke, 8 patients had viable collaterally perfused brain tissue which was accessible for rCBF recordings with a two dimensional technique. All 8 had deep subcortical infarcts on CT-scan, and angiographic occlusion of the arteries normally supplying the infarcted territory. The...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.14.3.332
更新日期:1983-05-01 00:00:00
abstract:BACKGROUND AND PURPOSE:To establish a less invasive and reproducible focal ischemia model in the rat, we adopted a 2-laser system (ie, photothrombosis and YAG laser-induced reperfusion). METHODS:The distal middle cerebral artery (MCA) of spontaneously hypertensive rats was occluded by 568-nm krypton laser and intraven...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.STR.0000094730.38343.73
更新日期:2003-11-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Symptomatic hemorrhage contributes to an increased risk of repeated bleeding and morbidity in cerebral cavernous malformation (CCM). A better understanding of morbidity after CCM hemorrhage would be helpful to identify patients of higher risk for unfavorable outcome and tailor individualized mana...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.120.029942
更新日期:2020-10-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The EuroQol and Medical Outcome Survey 36-item short-form health survey (SF-36) questionnaires have both been validated for the assessment of health-related quality of life after stroke. However, the relationship between these instruments has not been studied after stroke. We therefore sought to ...
journal_title:Stroke
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1161/01.str.30.10.2146
更新日期:1999-10-01 00:00:00
abstract::Contrast-enhanced computed tomography of the neck permits low-risk evaluation of morphologic complications of carotid plaque, including (and foremost) calcification. To investigate the patterns and clinical significance of calcified deposits in the cervical carotid arteries using computed tomography we studied 40 pati...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.20.11.1472
更新日期:1989-11-01 00:00:00
abstract::To elucidate the connection between blood flow and the localized genesis and development of atherosclerosis and thrombosis at the human carotid artery bifurcation, detailed studies of the flow patterns and distributions of fluid velocity and wall shear rate in this region were carried out using a transparent segment o...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.15.1.50
更新日期:1984-01-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The rarity of intracranial vascular malformations (IVMs) and the infrequency of their outcomes make large, prolonged cohort studies the best means to evaluate their frequency and prognosis. METHODS:The Scottish Intracranial Vascular Malformation Study (SIVMS) is a prototype prospective, populati...
journal_title:Stroke
pub_type: 杂志文章,多中心研究
doi:10.1161/01.STR.0000069012.23858.69
更新日期:2003-05-01 00:00:00
abstract:BACKGROUND AND PURPOSE:In an inner-London teaching hospital, a randomized trial of "conventional" care versus early discharge to community-based therapy found no significant differences in clinical outcomes between patient groups. This report examines the economic consequences of the alternative strategies. METHODS:On...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.30.4.729
更新日期:1999-04-01 00:00:00
abstract:BACKGROUND AND PURPOSE:South Asians are the most prevalent ethnic group in the world. Intracranial disease is the most common vascular lesion worldwide. METHODS:We prospectively studied 200 consecutive ethnic South Asian patients with acute ischemic stroke in Singapore. RESULTS:Intracranial large-artery disease was p...
journal_title:Stroke
pub_type: 信件
doi:10.1161/STROKEAHA.107.484584
更新日期:2007-09-01 00:00:00
abstract::Experimental subarachnoid hemorrhage was induced in 52 adult male Wistar rats by microsurgical transclival basilar artery puncture. Telencephalic blood flow measured in 24 rats with subarachnoid hemorrhage was compared with that in 23 sham-operated rats and 10 unoperated control rats using the [14C]butanol indicator f...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.21.4.577
更新日期:1990-04-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Intraventricular thrombolysis (IVT) is a promising treatment in facilitating intraventricular clot resolution after intraventricular hemorrhage. We examined in-hospital outcomes and resource utilization after thrombolysis in patients with intraventricular hemorrhage requiring ventriculostomy in a...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.114.006067
更新日期:2014-09-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Stroke community surveillance projects often focus on hospital data rates. We hypothesized that not including strokes which occurred in nursing homes or at home would differentially affect race/ethnic stroke rates. METHODS:Texas vital statistics data were studied to compare age-specific (45 to 5...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.30.8.1501
更新日期:1999-08-01 00:00:00
abstract::Background and Purpose- We aimed to define the neuroimaging determinants of poststroke cognitive performance and their relative contributions among a spectrum of magnetic resonance imaging markers, including lesion burden and strategic locations. Methods- We prospectively included patients with stroke from the GRECogV...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.118.021981
更新日期:2018-11-01 00:00:00
abstract:BACKGROUND AND PURPOSE:A variety of primary end points have been used in acute stroke trials. We focus on the modified Rankin Scale, a reliable and valid ordinal outcome measure that assesses disability on a 7-point scale. METHODS:We provide an abbreviated discussion of analytical methods for ordinal scales, and relat...
journal_title:Stroke
pub_type: 杂志文章,评审
doi:10.1161/01.STR.0000241106.81293.2b
更新日期:2006-10-01 00:00:00
abstract:BACKGROUND AND PURPOSE:MRI characterization of carotid plaque has been studied recently as a potential tool to predict stroke caused by carotid atherosclerosis. We performed a systematic review and meta-analysis to summarize the association of MRI-determined intraplaque hemorrhage, lipid-rich necrotic core, and thinnin...
journal_title:Stroke
pub_type: 杂志文章,meta分析,评审
doi:10.1161/STROKEAHA.113.002551
更新日期:2013-11-01 00:00:00
abstract:BACKGROUND:The method described provides a rational means for determining whether to institute chronic anticoagulation to prevent stroke in patients with chronic atrial fibrillation under a variety of clinical circumstances. SUMMARY OF COMMENT:The concept of expected value is used in conjunction with data from clinica...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.24.12.2128
更新日期:1993-12-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Treatment of cerebral sinus thrombosis with heparin is controversial. We conducted a double-blind, placebo-controlled multicenter trial to examine whether anticoagulant treatment improves outcome in patients with sinus thrombosis. METHODS:Patients were randomized between body weight-adjusted sub...
journal_title:Stroke
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1161/01.str.30.3.484
更新日期:1999-03-01 00:00:00
abstract::We investigated seasonal variation in the incidence of cerebral stroke among the general population aged greater than or equal to 40 years in November of 1961 in Hisayama, Japan. During the 24-year follow-up period, 311 cases of cerebrovascular diseases occurred. The date or month of onset was determined in 308 cases,...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.21.9.1262
更新日期:1990-09-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Although our previous study demonstrated that dementia of the Binswanger type may be a disconnection dementia caused by leukoaraiosis, some hypertensive patients with marked leukoaraiosis do not develop dementia. The goal of the present study is to elucidate the pathophysiology of nondemented hyp...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.23.11.1673
更新日期:1992-11-01 00:00:00
abstract:BACKGROUND AND PURPOSE:In acute ischemic stroke, fast and complete recanalization of the occluded vessel is associated with improved outcomes. We describe a novel measure for newer generation devices: the first pass effect (FPE). FPE is defined as achieving a complete recanalization with a single thrombectomy device pa...
journal_title:Stroke
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1161/STROKEAHA.117.020315
更新日期:2018-03-01 00:00:00