Abstract:
:We studied a possible relation between stroke and an enhanced susceptibility to rupture of the arterial internal elastic lamina by comparing stroke-prone spontaneously hypertensive rats with spontaneously hypertensive rats, which have a very low incidence of stroke. We quantified interruptions in the internal elastic lamina in certain arteries and studied the effect of beta-aminopropionitrile, an inhibitor of cross-link formation in collagen and elastic fibers, on rupture of the internal elastic lamina and on mortality in these two substrains. To eliminate any influence of higher blood pressure in the stroke-prone rats on the parameters studied, we used antihypertensive treatment to obtain equivalent blood pressures in the two substrains. Results showed that stroke sensitivity was associated with an enhanced early spontaneous rupture of the internal elastic lamina in the caudal artery, an increased susceptibility to beta-aminopropionitrile-induced rupture of the internal elastic lamina, and earlier mortality, mainly from aortic rupture, under beta-aminopropionitrile treatment. These findings suggest that stroke-prone rats have an enhanced minor connective tissue defect that is expressed by rupture of the internal elastic lamina and may be related, at least in part, to their greater vascular fragility and increased susceptibility to stroke.
journal_name
Strokejournal_title
Strokeauthors
Coutard M,Osborne-Pellegrin Mdoi
10.1161/01.str.22.4.510subject
Has Abstractpub_date
1991-04-01 00:00:00pages
510-5issue
4eissn
0039-2499issn
1524-4628journal_volume
22pub_type
杂志文章相关文献
STROKE文献大全abstract:BACKGROUND AND PURPOSE:The goal of this study was to characterize cortical reorganization after stroke and its relation with the site of the stroke-induced lesion and degree of motor recovery using functional MRI (fMRI). METHODS:Fourteen stroke patients with an affected upper limb were studied longitudinally. Three fM...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.0000017100.68294.52
更新日期:2002-06-01 00:00:00
abstract::Changes of regional cerebral blood flow from rest to mental activation by a visually presented spatial reasoning test were measured during normo- and hypercapnia in 10 healthy subjects. Hypercapnia, elicited by inhalation of 6% CO2, resulted in similar flow increases in all 32 cortical regions measured. Increases of f...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.11.4.342
更新日期:1980-07-01 00:00:00
abstract::Background and Purpose- Several vascular risk factors are known to be associated with the occurrence of intracranial aneurysms (IAs). Coronary artery calcium (CAC), which reflects the atherosclerotic burden of the coronary arteries, is a known predictor of cardiovascular events and stroke. We investigated the relation...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.119.024726
更新日期:2019-06-01 00:00:00
abstract::As part of a prospective study of the neurologic and neuropsychological complications of coronary artery bypass graft surgery, 312 patients were compared with a control group of 50 patients undergoing major surgery for peripheral vascular disease. The purpose of comparing the 2 groups was to determine to what extent n...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.18.4.700
更新日期:1987-07-01 00:00:00
abstract:BACKGROUND AND PURPOSE:To increase the reliability of 99mTc-hexamethyl propyleneamine oxime (HMPAO) single photon emission computed tomography (SPECT) study in the evaluation of hemodynamic change with balloon test occlusion (BTO) of the internal carotid artery, we attempted to clarify the usefulness of additional moni...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.30.2.407
更新日期:1999-02-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Recent evidence suggests that physiological changes in the concentration of endogenous estrogens may influence stroke outcome. The purpose of this study was to determine a menstrual cycle-related profile of blood flow through the carotid arteries and its correlation with estrogen concentration. ...
journal_title:Stroke
pub_type: 临床试验,杂志文章
doi:10.1161/01.str.32.1.30
更新日期:2001-01-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Approximately one fourth of stroke occur during sleep. Despite the clinical and radiological similarities between wake-up stroke (WUS) and non-WUS, the functional outcomes of WUS are largely unknown. METHODS:This retrospective analysis reviewed 2289 consecutive patients with acute ischemic strok...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.110.602243
更新日期:2011-07-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Previous work has shown that rates of cerebral microemboli downstream of high-grade internal carotid artery stenosis are higher in recently symptomatic compared with asymptomatic patients. In addition, microembolic rates decline after carotid endarterectomy. We conducted a prospective investigati...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.26.7.1231
更新日期:1995-07-01 00:00:00
abstract:BACKGROUND AND PURPOSE:This study aims to investigate the association between insulin resistance (IR) and silent lacunar infarction (SLI) in healthy adults. METHODS:We recruited 2326 healthy Korean adults who took health checkups, including a brain magnetic resonance imaging. SLI was defined as an infarction measuring...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.116.014097
更新日期:2016-12-01 00:00:00
abstract:BACKGROUND AND PURPOSE:In acute ischemic stroke patients, diffusion-weighted imaging (DWI)-Alberta Stroke Program Early Computed Tomography Score (ASPECTS) is correlated with infarct volume and is an independent factor of functional outcome. Patients with pretreatment DWI-ASPECTS ≤6 were excluded or under-represented i...
journal_title:Stroke
pub_type: 杂志文章,多中心研究
doi:10.1161/STROKEAHA.116.015202
更新日期:2017-04-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Elevated leukocyte count has been associated with cardiovascular and cerebrovascular disease in several epidemiological studies. We sought to determine whether white blood cell count (WBC) is associated with carotid plaque thickness in a stroke-free, multiethnic cohort. METHODS:For this cross-se...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.32.4.842
更新日期:2001-04-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The antiplatelet agent sarpogrelate is a selective inhibitor of 5-hydroxytryptamine receptors. The purpose of this study was to compare the efficacy and safety of sarpogrelate with those of aspirin in Japanese ischemic stroke patients. METHODS:In total, 1510 patients with recent cerebral infarct...
journal_title:Stroke
pub_type: 杂志文章,随机对照试验
doi:10.1161/STROKEAHA.107.505131
更新日期:2008-06-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Although cerebral penetrating arterioles are main regulators of the brain microcirculation, little is known about the effect of endothelium-derived relaxation factor on these vessels. This study examined the effects of nitric oxide synthase inhibitors on the spontaneous tone of isolated rat cereb...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.25.11.2227
更新日期:1994-11-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Policy makers require evidence on the costs and outcomes of different ways of organizing stroke care. This study compared the costs and survival of different ways of providing stroke care. METHODS:Hospitalized stroke patients from 13 European centers were included, with demographic, case-mix, an...
journal_title:Stroke
pub_type: 杂志文章,多中心研究
doi:10.1161/01.str.32.7.1684
更新日期:2001-07-01 00:00:00
abstract:BACKGROUND AND PURPOSE:We postulated that some abnormalities in cerebrovascular function after subarachnoid hemorrhage (SAH) may involve underlying alterations in K(+) channel function. Thus, using pharmacological inhibitors, we assessed the influence of SAH on function of 2 types of K(+) channel in regulation of basil...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.31.10.2460
更新日期:2000-10-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The efficacy and safety of different antiplatelet regimes for prevention of stroke in patients at high risk were investigated in a systematic review and meta-analysis. METHODS:We searched the Cochrane Central Register of Controlled Trials, MEDLINE, and Web of Science. Twenty-two studies comprisi...
journal_title:Stroke
pub_type: 杂志文章,meta分析,评审
doi:10.1161/STROKEAHA.113.002590
更新日期:2014-02-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Research on the relationship between caffeine-containing medicines (CCMs) and the risk of hemorrhagic stroke (HS) is sparse. The aim of this study is to evaluate the association between CCMs and the risk of HS. METHODS:We performed a multicenter case-control study in South Korea, from 2002 to 20...
journal_title:Stroke
pub_type: 杂志文章,多中心研究
doi:10.1161/STROKEAHA.111.674077
更新日期:2013-08-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is an inherited systemic microangiopathy with prevalently cerebral manifestations. Among the causes of death, sudden unexpected death seems to occur in a significant number of CADASIL patients. Be...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.STR.0000254530.38417.07
更新日期:2007-02-01 00:00:00
abstract::Acute thromboembolic occlusion of the basilar artery accounts for 6% to 10% of large-vessel stroke in humans. Because of the brain region supplied by this artery, the case fatality rate is the highest for all ischemic stroke subtypes, ranging from 40% to 86%. Patients who undergo successful recanalization of the basil...
journal_title:Stroke
pub_type: 杂志文章,评审
doi:10.1161/01.STR.0000247897.33267.42
更新日期:2007-02-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Carotid endarterectomy reduces the risk of carotid territory ischemic stroke ipsilateral to a recently symptomatic severe carotid stenosis. However, the benefit is limited by the risks of stroke and death associated with the operation. Although reported surgical risks vary enormously, there has b...
journal_title:Stroke
pub_type: 杂志文章,评审
doi:10.1161/01.str.27.2.260
更新日期:1996-02-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Striatal GABAergic neuron is known as a key regulator in adult neurogenesis. However, the specific role of striatal GABAergic neuronal activity in the promotion of neurological recovery after ischemic stroke remains unknown. Here, we used optogenetic approach to investigate these effects and mech...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.117.019017
更新日期:2017-12-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Cerebral autoregulation may be impaired in the early days after subarachnoid hemorrhage (SAH). The purpose of this study was to examine the relationship between cerebral autoregulation and angiographic vasospasm (aVSP) and radiographic delayed cerebral ischemia (DCI) in patients with SAH. METHOD...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.113.002630
更新日期:2014-03-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Our aim was to estimate the cost-effectiveness of transferring patients with intracerebral hemorrhage from centers without specialized neurological intensive care units (neuro-ICUs) to centers with neuro-ICUs. METHODS:Decision analytic models were developed for the lifetime horizons. Model input...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.114.006653
更新日期:2015-01-01 00:00:00
abstract:BACKGROUND AND PURPOSE:We assessed the influence of different visual stimuli and the reproducibility and habituation of evoked flow responses using simultaneous two-channel transcranial Doppler monitoring and flow velocity averaging. METHODS:We measured stimulus-related percentage changes in posterior cerebral, basila...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.27.12.2256
更新日期:1996-12-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The aim of the study was to determine the effects of thromboembolism and mechanical thrombectomy on the vessel wall magnetic resonance imaging (VW-MRI) appearance of the intracranial arterial wall. METHODS:This was a cross-sectional study of consecutive patients with acute intracranial arterial ...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.114.005618
更新日期:2014-08-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Endothelins (ETs) are potent vasoconstrictors and may play a role in the pathophysiology of several diseases. Limited and controversial data exist on their role in human ischemic stroke. We planned a prospective, observational, and longitudinal clinical study to test whether ET-1 levels increase ...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.31.3.720
更新日期:2000-03-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Subarachnoid hemorrhage caused by cerebral aneurysm rupture remains a life-threatening emergency despite advances in treatment. However, the mechanisms underlying aneurysm initiation, progression, and rupture remain unclear. We developed a method to induce experimental cerebral aneurysms in rats,...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.STR.0000204028.39783.d9
更新日期:2006-03-01 00:00:00
abstract:BACKGROUND AND PURPOSE:There have been relatively few community-based studies of long-term prognosis after acute stroke. This study aimed to provide precise estimates of the absolute and relative risks of dying in an unselected cohort of patients with a first-ever stroke. METHODS:Six hundred seventy-five patients were...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.24.6.796
更新日期:1993-06-01 00:00:00
abstract:BACKGROUND AND PURPOSE:We aim to investigate whether histopathologic examination of thrombi retrieved from acute ischemic stroke patients undergoing endovascular treatment could distinguish cancer-related stroke from other etiologies. METHODS:Thrombi from patients undergoing endovascular treatment were analyzed. The e...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.120.032069
更新日期:2020-12-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The success of gait rehabilitation after stroke depends on active walking exercises. However, the disabling after-effects of stroke often make such exercises impossible at the onset of therapy. To facilitate treadmill training of paraparetic patients, a robot-driven gait orthosis (Lokomat) was de...
journal_title:Stroke
pub_type: 杂志文章,随机对照试验
doi:10.1161/01.STR.0000254607.48765.cb
更新日期:2007-02-01 00:00:00