Posttraumatic stress disorder and adherence to medications in survivors of strokes and transient ischemic attacks.

Abstract:

BACKGROUND AND PURPOSE:Posttraumatic stress disorder (PTSD) can be triggered by life-threatening medical events such as strokes and transient ischemic attacks (TIAs). Little is known regarding how PTSD triggered by medical events affects patients' adherence to medications. METHODS:We surveyed 535 participants, age ≥40 years old, who had at least 1 stroke or TIA in the previous 5 years. PTSD was assessed using the PTSD Checklist-Specific for stroke; a score ≥50 on this scale is highly specific for PTSD diagnosis. Medication adherence was measured using the 8-item Morisky scale. Logistic regression was used to test whether PTSD after stroke/TIA was associated with increased risk of medication nonadherence. Covariates for adjusted analyses included sociodemographics, Charlson comorbidity index, modified Rankin Scale score, years since last stroke/TIA, and depression. RESULTS:Eighteen percent of participants had likely PTSD (PTSD Checklist-Specific for stroke ≥50), and 41% were nonadherent to medications according to the Morisky scale. A greater proportion of participants with likely PTSD were nonadherent to medications than other participants (67% versus 35%, P<0.001). In the adjusted model, participants with likely PTSD were nearly 3 times more likely (relative risk, 2.7; 95% CI, 1.7-4.2) to be nonadherent compared with participants without PTSD (PTSD Checklist-Specific for stroke <25) even after controlling for depression, and there was a graded association between PTSD severity and medication nonadherence. CONCLUSION:PTSD is common after stroke/TIA. Patients who have PTSD after stroke or TIA are at increased risk for medication nonadherence.

journal_name

Stroke

journal_title

Stroke

authors

Kronish IM,Edmondson D,Goldfinger JZ,Fei K,Horowitz CR

doi

10.1161/STROKEAHA.112.655209

subject

Has Abstract

pub_date

2012-08-01 00:00:00

pages

2192-7

issue

8

eissn

0039-2499

issn

1524-4628

pii

STROKEAHA.112.655209

journal_volume

43

pub_type

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