Cyclosporine A reduces cerebral vasospasm after subarachnoid hemorrhage in dogs.

Abstract:

:The double subarachnoid hemorrhage canine model was used to test the prophylactic value of immunosuppression in the prevention of cerebral vasospasm after subarachnoid hemorrhage. Dogs treated with cyclosporine A following the regimen prescribed for organ transplant procedures in patients showed a significant reduction in the severity of angiographic constriction of cerebral arteries. While basilar artery diameter after double experimental subarachnoid hemorrhage in a series of untreated dogs (n = 34) averaged 65% of baseline diameter, arterial diameter in dogs treated prophylactically (n = 18) with 6 mg/kg/day cyclosporine A and adjunct low-dose steroid averaged 80% of baseline diameter, for a mean reduction in the severity of chronic arterial constriction of 42%. More important than the average effect, however, is the statistical observation that this mean improvement was obtained primarily by a dramatic reduction in the incidence of severe cerebral vasospasm, the situation most likely to account for morbidity and mortality after aneurysmal rupture.

journal_name

Stroke

journal_title

Stroke

authors

Peterson JW,Nishizawa S,Hackett JD,Bun T,Teramura A,Zervas NT

doi

10.1161/01.str.21.1.133

subject

Has Abstract

pub_date

1990-01-01 00:00:00

pages

133-7

issue

1

eissn

0039-2499

issn

1524-4628

journal_volume

21

pub_type

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