Improving modified Rankin Scale assessment with a simplified questionnaire.

abstract：BACKGROUND AND PURPOSE:Hemodynamic insult by bilateral common carotid artery ligation has been shown to induce aneurysmal remodeling at the basilar terminus in a rabbit model. To characterize critical hemodynamics that initiate this remodeling, we applied a novel hemodynamics-histology comapping technique. METHODS:Eig...

journal_title：Stroke

authors： Metaxa E,Tremmel M,Natarajan SK,Xiang J,Paluch RA,Mandelbaum M,Siddiqui AH,Kolega J,Mocco J,Meng H

更新日期：2010-08-01 00:00:00

abstract：BACKGROUND AND PURPOSE:A high rate of postprocedure complications in the Stenting versus Aggressive Medical Therapy for Intracranial Arterial Stenosis (SAMMPRIS) trial has raised concerns whether such results are representative of intracranial stent placement in actual routine practice. METHODS:Using the Nationwide In...

journal_title：Stroke

authors： Siddiq F,Adil MM,Norby K,Qureshi AI

更新日期：2013-12-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Clomethiazole is a neuroprotective drug that enhances gamma-aminobutyrate type A (GABA(A)) receptor activity. Its efficacy and safety were tested in the CLomethiazole Acute Stroke Study (CLASS). The protocol allowed a CT scan to be done after randomization but within 7 days of stroke onset to min...

journal_title：Stroke

authors： Wahlgren NG,Díez-Tejedor E,Teitelbaum J,Arboix A,Leys D,Ashwood T,Grossman E

更新日期：2000-01-01 00:00:00

abstract：:In a consecutive series of 473 patients admitted within 72 hours after a subarachnoid hemorrhage, 91 (19%) had hydrocephalus on the initial computed tomogram. Consciousness was unimpaired in 25 of the 91 (28%). In 11 more patients acute hydrocephalus developed within 1 week after subarachnoid hemorrhage. Thirty-eight ...

journal_title：Stroke

authors： Hasan D,Vermeulen M,Wijdicks EF,Hijdra A,van Gijn J

更新日期：1989-06-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Spreading depressions (SDs) occur in experimental focal ischemia and contribute to lesion evolution. N-Methyl-D-aspartate (NMDA) antagonists inhibit SDs and reduce infarct size. The glycine site on the NMDA receptor complex offers a therapeutic target for acute focal ischemia, potentially devoid ...

journal_title：Stroke

authors： Tatlisumak T,Takano K,Meiler MR,Fisher M

更新日期：1998-01-01 00:00:00

abstract：BACKGROUND:Mechanisms involved in stroke progression are incompletely understood. Ischemic brain injury is characterized by acute local inflammatory response mediated by cytokines. Anti-inflammatory cytokines act in a feedback loop to inhibit continued proinflammatory cytokine production. We assessed the implication of...

journal_title：Stroke

authors： Vila N,Castillo J,Dávalos A,Esteve A,Planas AM,Chamorro A

更新日期：2003-03-01 00:00:00

abstract：:To assess the importance of occult atrial disorder with possible embolization as a cause of non-hemorrhagic stroke, 68 patients with neurologic symptoms lasting 24 hours or more and 18 patients with transient ischemic attacks were examined by long-term electrocardiographic recording (LTER). Lacking matched controls we...

journal_title：Stroke

authors： Abdon NJ,Zettervall O,Carlson J,Berglund S,Sterner G,Tejler L,Turesson I

更新日期：1982-11-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The goal of this study was to determine whether release of endothelium-derived relaxing factor (EDRF) from carotid artery in response to acetylcholine is altered by aging. METHODS:Responses were examined in arteries from Wistar rats 6 to 8 months old (young rats), 24 to 26 months old (old rats),...

journal_title：Stroke

authors： Paternò R,Faraci FM,Heistad DD

更新日期：1994-12-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Vorapaxar is an antiplatelet agent that antagonizes thrombin-mediated activation of the protease-activated receptor-1 on platelets. We tested the efficacy and safety of vorapaxar in a prespecified analysis in the stroke subcohort from a multinational, randomized, placebo-controlled trial. METHOD...

journal_title：Stroke

authors： Morrow DA,Alberts MJ,Mohr JP,Ameriso SF,Bonaca MP,Goto S,Hankey GJ,Murphy SA,Scirica BM,Braunwald E,Thrombin Receptor Antagonist in Secondary Prevention of Atherothrombotic Ischemic Events–TIMI 50 Steering Committee and Investigators

更新日期：2013-03-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Coffee and tea consumption could potentially reduce the risk of stroke because these beverages have antioxidant properties, and coffee may improve insulin sensitivity. We examined the associations of coffee and tea consumption with risk of stroke subtypes. METHODS:We used prospective data from t...

journal_title：Stroke

authors： Larsson SC,Männistö S,Virtanen MJ,Kontto J,Albanes D,Virtamo J

更新日期：2008-06-01 00:00:00

abstract：:Background and Purpose- Hemispheric stroke studies associating lateropulsion (pusher syndrome) with the location of brain lesions have had mixed results from small, unmatched samples. This study was designed to determine whether lateropulsion localizes to specific brain regions across patients with stroke using a case...

journal_title：Stroke

authors： Babyar SR,Smeragliuolo A,Albazron FM,Putrino D,Reding M,Boes AD

更新日期：2019-05-01 00:00:00

abstract：:Survival and recurrences after stroke were assessed prospectively in a general population sample of 5184 subjects followed biennially for 26 years. Initial strokes occurred in 198 men and 196 women. There were 84 second and 27 third strokes and 223 deaths reported. Thirty day case-fatality rates for initial strokes we...

journal_title：Stroke

authors： Sacco RL,Wolf PA,Kannel WB,McNamara PM

更新日期：1982-05-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The incidence, causes, and prognosis of nonhemorrhagic strokes and intraparenchymal hemorrhages occurring in association with pregnancy or puerperium are poorly understood. METHODS:We carried out a retrospective (1989 through 1991) and prospective (1992) study in 63 public maternities (348,295 d...

journal_title：Stroke

authors： Sharshar T,Lamy C,Mas JL

更新日期：1995-06-01 00:00:00

abstract：:The author reviewed electrocardiographic records of 150 patients with acute stroke and 150 age- and sex-matched controls, to assess the relative frequencies of ECG abnormalities among the pathophysiologic categories of stroke, and to distinguish new abnormalities at the time of the stroke from those noted on prior tra...

journal_title：Stroke

authors： Goldstein DS

更新日期：1979-05-01 00:00:00

abstract：:Fundus fluorescein angiography was performed in 10 cases of occlusive carotid artery disease at presentation and after surgery or medical treatment. An improvement in the microcirculation of the retina was observed in 4 cases after carotid endarterectomy and in 1 case after carotid endarterectomy and extracranial-intr...

journal_title：Stroke

authors： Sarkies NJ,Shilling JS,Burnand KG,Browse NL,Russell RW

更新日期：1987-05-01 00:00:00

abstract：BACKGROUND AND PURPOSE:We aimed to determine if ischemia involving Broca area predicts Broca aphasia more reliably in acute or chronic stroke. METHODS:We included consecutive right-hand-dominant patients with left hemisphere ischemic stroke (<48 hours from onset for acute stroke or >6 months after stroke for chronic s...

journal_title：Stroke

authors： Ochfeld E,Newhart M,Molitoris J,Leigh R,Cloutman L,Davis C,Crinion J,Hillis AE

更新日期：2010-02-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Effects of anoxic stress on cerebrovascular responses to calcitonin gene-related peptide (CGRP) have not been examined previously. We determined the effects of total global ischemia on cerebral arteriolar responses to CGRP in newborn pigs. METHODS:Piglets were anesthetized and ventilated with a ...

journal_title：Stroke

authors： Louis TM,Meng W,Bari F,Errico RA,Busija DW

更新日期：1996-01-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Few pediatric reports of thrombolysis exist. We sought to determine national rates of thrombolysis among pediatric ischemic stroke patients using a national database. METHODS:Patients between the ages of 1 and 17 years, entered in the Nationwide Inpatient Sample between 2000 and 2003, with Inter...

journal_title：Stroke

authors： Janjua N,Nasar A,Lynch JK,Qureshi AI

更新日期：2007-06-01 00:00:00

abstract：:In the rat an intracisternal injection of blood induces an angiographically demonstrable biphasic cerebral arterial vasospasm. Chemical destruction of the central serotoninergic and dopaminergic pathways prior to the cisternal blood injection does not affect the spasm pattern after the subarachnoid haemorrhage. It is ...

journal_title：Stroke

authors： Svendgaard NA,Brismar J,Delgado TJ,Rosengren E,Stenevi U

更新日期：1986-01-01 00:00:00

abstract：BACKGROUND AND PURPOSE:There is debate regarding the approach for analysis of modified Rankin scale scores, the most common functional outcome scale used in acute stroke trials. METHODS:We propose to use tests to assess treatment differences addressing the metric, "if a patient is chosen at random from each treatment ...

journal_title：Stroke

authors： Howard G,Waller JL,Voeks JH,Howard VJ,Jauch EC,Lees KR,Nichols FT,Rahlfs VW,Hess DC

更新日期：2012-03-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Outcome after acute stroke is determined to a large extent by poststroke complications. Nutritional status and metabolic balance may substantially contribute to outcome after stroke. Key mechanisms of stroke pathophysiology can induce systemic catabolic imbalance with impaired metabolic efficienc...

journal_title：Stroke

authors： Scherbakov N,Dirnagl U,Doehner W

更新日期：2011-12-01 00:00:00

abstract：:We compared 211 consecutive patients who had acute ischemic hemispheric stroke and atrial fibrillation with 837 consecutive patients who had stroke without atrial fibrillation. The atrial fibrillation group included a higher frequency of women, older subjects, and those with a severe neurologic deficit, abnormal compu...

journal_title：Stroke

authors： Candelise L,Pinardi G,Morabito A

更新日期：1991-02-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Progression of asymptomatic carotid artery stenosis (ACAS) in patients with >50% luminal narrowing is considered a potential risk factor for ischemic stroke; however, subclinical molecular biomarkers of ACAS progression are lacking. Recent studies suggest a regulatory function for several microRN...

journal_title：Stroke

authors： Dolz S,Górriz D,Tembl JI,Sánchez D,Fortea G,Parkhutik V,Lago A

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Increased knowledge of stroke risk factors in the general population may lead to improved prevention of stroke. The objective of the present study was to assess knowledge of stroke risk factors and to determine factors associated with knowledge. METHODS:In a population-based survey, we sent a qu...

journal_title：Stroke

authors： Müller-Nordhorn J,Nolte CH,Rossnagel K,Jungehülsing GJ,Reich A,Roll S,Villringer A,Willich SN

更新日期：2006-04-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Clinical development of novel neuroprotection therapies for the treatment of brain injury has been unsuccessful. One critical limitation is the lack of a viable therapeutic treatment window (TW). In this study, we evaluated the neuroprotection TW for the proteosome inhibitor MLN519 after ischemia...

journal_title：Stroke

authors： Williams AJ,Berti R,Dave JR,Elliot PJ,Adams J,Tortella FC

更新日期：2004-05-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The premotor cortex (PMC) (Brodmann 6) contributes uniquely to proximal upper and lower limb power and plays a role in the organization of motor behaviors. We assessed the degree to which PMC damage affected functional outcome. METHODS:We prospectively compared the functional outcome of patients...

journal_title：Stroke

authors： Miyai I,Suzuki T,Kang J,Kubota K,Volpe BT

更新日期：1999-07-01 00:00:00

abstract：:The etiology of cerebrovascular disease (CDV) in young patients is difficult to establish if the common causes of a focal neurological deficit are excluded by appropriate investigations. Since in some observations prolapse of the mitral-valve (MVP), alterations of platelet function, or both have been linked with cereb...

journal_title：Stroke

authors： Scharf RE,Hennerici M,Bluschke V,Lueck J,Kladetzky RG

更新日期：1982-07-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The contribution of genetics to stroke risk, and whether this differs for different stroke subtypes, remainsuncertain. Genomewide complex trait analysis allows heritability to be assessed from genomewide association study (GWAS) data. Previous candidate gene studies have identified many associati...

journal_title：Stroke

authors： Bevan S,Traylor M,Adib-Samii P,Malik R,Paul NL,Jackson C,Farrall M,Rothwell PM,Sudlow C,Dichgans M,Markus HS

更新日期：2012-12-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Studies using animal models of stroke have shown that human serum albumin (HSA) significantly ameliorates cerebral ischemic injury after both transient and permanent ischemia, even when administered after the onset of ischemia or reperfusion. The mechanism of this effect remains uncertain, and pr...

journal_title：Stroke

authors： Gum ET,Swanson RA,Alano C,Liu J,Hong S,Weinstein PR,Panter SS

更新日期：2004-02-01 00:00:00

abstract：BACKGROUND AND PURPOSE:In animals, drugs that increase brain amine concentrations influence the rate and degree of recovery from cortical lesions. It is therefore conceivable that antidepressants may influence outcome after ischemic brain injury in humans. We evaluated the effects of the norepinephrine reuptake blocker...

journal_title：Stroke

authors： Dam M,Tonin P,De Boni A,Pizzolato G,Casson S,Ermani M,Freo U,Piron L,Battistin L

更新日期：1996-07-01 00:00:00