Abstract:
BACKGROUND AND PURPOSE:The mechanisms of immune reaction involved in the pathogenesis and clinical course of acute vascular incidents are still not completely understood. The aim of this study was to examine the presence of immune complexes (IC) in the acute stroke setting and the first month thereafter and to characterize IC by analyzing the contents of chlamydial lipopolysaccharide and anti-cytomegalovirus (CMV) antibodies in IC. METHODS:Serum concentration of IC was investigated in 179 stroke patients, 122 "old" controls and 112 "young" controls, by the precipitation method. The presence of chlamydial lipopolisaccharyde and anti-CMV antibodies was investigated in some IC preparations by the ELISA method after earlier dissociation of IC into components by high pH treatment. RESULTS:Significantly increased serum IC concentration in stroke patients was noticed. Increased serum IC concentration was revealed as an independent strong stroke risk factor and was connected with significantly worse neurological status and increased 30-day mortality rate. A significantly larger proportion of stroke patients than controls had Chlamydia pneumoniae antigen and anti-CMV antibodies in IC. CONCLUSIONS:This study provides the first evidence of an association between increased serum level of IC and the clinical course of cerebral ischemia and identifies a potentially important association of C pneumoniae and CMV-specific IC with stroke incidence.
journal_name
Strokejournal_title
Strokeauthors
Tarnacka B,Gromadzka G,Członkowska Adoi
10.1161/01.str.0000014562.75483.6bsubject
Has Abstractpub_date
2002-04-01 00:00:00pages
936-40issue
4eissn
0039-2499issn
1524-4628journal_volume
33pub_type
临床试验,杂志文章相关文献
STROKE文献大全abstract:BACKGROUND AND PURPOSE:Lipoprotein-associated phospholipase A(2) (Lp-PLA(2)) is a marker of unstable atherosclerotic plaque, and is predictive of both primary and secondary stroke in population-based studies. METHODS:We conducted a prospective study of patients with acute TIA who presented to the ED. Clinical risk sco...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.109.553545
更新日期:2009-07-01 00:00:00
abstract::A 51-yearold man with moderate intermittent hypertension had a rapidly progressive, profound dementia in the absence of significant localizing neurological signs. Postmortem examination disclosed the vascular alterations and diffuse white matter degeneration which characterize subcortical arteriosclerotic encephalopat...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.7.6.626
更新日期:1976-11-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Cerebral amyloid angiopathy (CAA) occurs as a sporadic disorder in aged humans, as a frequent component of Alzheimer's disease, or in hereditary cerebral hemorrhage with amyloidosis (HCHWA). The primary histological locus of cerebral amyloid deposition varies in aged humans and in different speci...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.27.11.2080
更新日期:1996-11-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Patients with intracerebral hemorrhage and intraventricular hemorrhage have a reported mortality of 50% to 80%. We evaluated a clot lytic treatment strategy for these patients in terms of mortality, ventricular infection, and bleeding safety events, and for its effect on the rate of intraventricu...
journal_title:Stroke
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1161/STROKEAHA.110.610949
更新日期:2011-11-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Sulcal effacement with preserved underlying gray-white matter junction (isolated sulcal effacement [ISE]) in acute ischemic stroke may not represent irreversible parenchymal injury. We aimed to evaluate the frequency and significance of ISE in patients with large vessel occlusion acute ischemic s...
journal_title:Stroke
pub_type: 临床试验,杂志文章
doi:10.1161/STROKEAHA.115.009304
更新日期:2015-06-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Studies using animal models of stroke have shown that human serum albumin (HSA) significantly ameliorates cerebral ischemic injury after both transient and permanent ischemia, even when administered after the onset of ischemia or reperfusion. The mechanism of this effect remains uncertain, and pr...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.STR.0000110790.05859.DA
更新日期:2004-02-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Posttraumatic stress disorder (PTSD) can be triggered by life-threatening medical events such as strokes and transient ischemic attacks (TIAs). Little is known regarding how PTSD triggered by medical events affects patients' adherence to medications. METHODS:We surveyed 535 participants, age ≥40...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.112.655209
更新日期:2012-08-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Elevated fibroblast growth factor 23 (FGF23) regulates phosphate homeostasis and is linked with mortality, cardiovascular events, and stroke. However, the role of FGF23 as a risk factor for subclinical cerebrovascular damage is unclear. METHODS:We used multivariable linear and logistic regressio...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.115.012379
更新日期:2016-04-01 00:00:00
abstract::Functional assessment of animals following experimental cerebral ischemia is often difficult due to the passive nature of many neurologic exams. We attempted to increase the objectivity of motor function evaluation by adapting quantifiable behavioral tests and actively testing rats' motor capability following a cerebr...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.18.2.503
更新日期:1987-03-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Patients with acute ischemic stroke and intracranial arterial obstructions have a poor prognosis and a high probability of deteriorating at 24 hours. We aimed to evaluate the diagnostic accuracy of power motion mode Doppler (PMD-TCD) compared with CT angiography as standard in diagnosing intracra...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.108.542704
更新日期:2009-06-01 00:00:00
abstract:BACKGROUND AND PURPOSE:We postulated that some abnormalities in cerebrovascular function after subarachnoid hemorrhage (SAH) may involve underlying alterations in K(+) channel function. Thus, using pharmacological inhibitors, we assessed the influence of SAH on function of 2 types of K(+) channel in regulation of basil...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.31.10.2460
更新日期:2000-10-01 00:00:00
abstract::We compared three self-rating scales (the Geriatric Depression Scale, the Zung Scale, and the Center for Epidemiologic Studies Depression Scale) with three examiner-rating scales (the Hamilton Rating Scale, the Comprehensive Psychopathological Rating Scale-Depression, and the Cornell Scale), to see which was best for ...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.20.9.1190
更新日期:1989-09-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Motor dysfunction after unilateral deafferentation in primates can be overcome by restraining the unaffected limb. We asked whether a constraint-induced movement (CIM) program could be implemented within 2 weeks after stroke and whether CIM is more effective than traditional upper-extremity (UE) ...
journal_title:Stroke
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1161/01.str.31.12.2984
更新日期:2000-12-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The efficacy and safety of the selective serotonin reuptake inhibitor fluoxetine have rarely been studied in the treatment of poststroke emotional disturbances. METHODS:Stroke patients (152) who had poststroke depression (PSD), emotional incontinence (PSEI), or anger proneness (PSAP) were studie...
journal_title:Stroke
pub_type: 杂志文章,随机对照试验
doi:10.1161/01.STR.0000190892.93663.e2
更新日期:2006-01-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Despite the social, health, and economic burdens associated with cognitive impairment poststroke, there is considerable uncertainty about the types of interventions that might preserve or restore cognitive abilities. The objective of this systematic review and meta-analysis was to evaluate the ef...
journal_title:Stroke
pub_type: 杂志文章,meta分析,评审
doi:10.1161/STROKEAHA.117.017319
更新日期:2017-11-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Some stroke patients complain of an unpleasant sensation of coldness in the hemiplegic arm. This study aimed to determine the prevalence of this symptom and any associated features. METHODS:A questionnaire about symptoms in the arms was sent to patients at least 12 months after stroke. Reflex sy...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.26.10.1867
更新日期:1995-10-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Enlarged perivascular spaces in the brain are common but generally overlooked and of uncertain pathophysiology. They may reflect underlying cerebral small vessel disease. We determined whether enlarged perivascular spaces were associated with lacunar stroke subtype and white matter hyperintensiti...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.109.564914
更新日期:2010-03-01 00:00:00
abstract:BACKGROUND AND PURPOSE:We used Riks-Stroke, the Swedish Stroke Register, to explore how thrombolysis has been disseminated in Swedish hospitals since it was approved in 2003. METHODS:All 78 hospitals in Sweden admitting patients with acute stroke participate in Riks-Stroke. Between 2003 and 2008, 72 033 adult patients...
journal_title:Stroke
pub_type: 杂志文章,多中心研究
doi:10.1161/STROKEAHA.109.577106
更新日期:2010-06-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Although chemokines have been implicated in cardiovascular diseases, few studies have addressed the role of these inflammatory mediators in ischemic stroke. This study tested the hypothesis that RANTES (CCL5; regulated on activation, normal T-cell expressed and secreted) mediates the cerebral mic...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.107.513150
更新日期:2008-09-01 00:00:00
abstract::Fundus fluorescein angiography was performed in 10 cases of occlusive carotid artery disease at presentation and after surgery or medical treatment. An improvement in the microcirculation of the retina was observed in 4 cases after carotid endarterectomy and in 1 case after carotid endarterectomy and extracranial-intr...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.18.3.585
更新日期:1987-05-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors (statins) lower serum cholesterol and decrease the incidence of stroke and cardiovascular disease. There is growing evidence that statins exert some of their beneficial effects independent of cholesterol lowering. Indeed, we...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.32.4.980
更新日期:2001-04-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The underlying mechanisms for reductions in cerebral blood flow (CBF) during orthostasis are not completely understood. This study tested the hypothesis that sympathetic activation causes cerebral vasoconstriction leading to reductions in CBF during lower body negative pressure (LBNP). METHODS:C...
journal_title:Stroke
pub_type: 临床试验,杂志文章
doi:10.1161/01.STR.0000260095.94175.d0
更新日期:2007-04-01 00:00:00
abstract::At the same time as the world recognizes the rapid economic development in China, Chinese healthcare system has also had significant improvement. However, this nation of 1.4 billion faces tough challenges in treating stroke, the leading cause of death in China. The recently completed Chinese National Stroke Registry h...
journal_title:Stroke
pub_type: 杂志文章,评审
doi:10.1161/STROKEAHA.111.635755
更新日期:2011-12-01 00:00:00
abstract:BACKGROUND AND PURPOSE:We aimed to determine whether lobar cerebellar microbleeds or concomitant lobar cerebellar and deep microbleeds, in the presence of lobar cerebral microbleeds, attribute to underlying advanced cerebral amyloid angiopathy pathology or hypertensive arteriopathy. METHODS:We categorized 71 patients ...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.119.028487
更新日期:2020-12-01 00:00:00
abstract::Regional cerebral ischemia was produced by common carotid artery occlusion in gerbils and by middle cerebral artery occlusion in dogs, cats, and squirrel monkeys. Anesthesia was induced with either pentobarbital or halothane and maintained for two to three hours after vessel occlusion. In acute studies, the effect of ...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.6.4.405
更新日期:1975-07-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The purpose of this study was to evaluate the impact of new treatments by examining the changes between 1990 to 1991 and 2000 to 2001 in in-hospital mortality rates and hospital charges in adult patients with stroke. METHODS:From the Nationwide Inpatient Survey, the largest all-payer inpatient c...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.106.467506
更新日期:2007-07-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Improved methods of identifying patients at high risk of thromboembolism would allow improved targeting of therapy. One such situation is carotid artery stenosis. This is associated with an increased risk of stroke, which can be reduced by carotid endarterectomy. However, the risk-benefit ratio i...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.30.7.1440
更新日期:1999-07-01 00:00:00
abstract::The authors report an autopsy case with repeated transient ischemic attacks and subsequent strokes demonstrating evidence of artery-to-artery embolism from thrombi generated in the stenotic middle cerebral artery to the distal cortical branches. This case substantiates the existence of intracranial artery-to-artery em...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.18.3.680
更新日期:1987-05-01 00:00:00
abstract::Arteriolar diameters and venular erythrocyte velocities in the small pial vessels on the surface of the cat brain were measured by TV methods during induced epileptic seizures through a cranial window. Grand mal seizures maximally dilated arterioles and increased venular erythrocyte velocity up to 400%. High positive ...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.7.1.83
更新日期:1976-01-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The independent contribution of insulin resistance to atherosclerosis is still under debate. We compared associations of 2 different indices of insulin resistance, the Homeostasis Model Assessment (HOMA) index and kITT from a short insulin tolerance test with carotid atherosclerosis. METHODS:A t...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.107.502799
更新日期:2008-04-01 00:00:00