Delayed paraplegia after spinal cord ischemic injury requires caspase-3 activation in mice.

Abstract:

BACKGROUND AND PURPOSE:Delayed paraplegia remains a devastating complication after ischemic spinal cord injury associated with aortic surgery and trauma. Although apoptosis has been implicated in the pathogenesis of delayed neurodegeneration, mechanisms responsible for the delayed paraplegia remain incompletely understood. The aim of this study was to elucidate the role of apoptosis in delayed motor neuron degeneration after spinal cord ischemia. METHODS:Mice were subjected to spinal cord ischemia induced by occlusion of the aortic arch and left subclavian artery for 5 or 9 minutes. Motor function in the hind limb was evaluated up to 72 hours after spinal cord ischemia. Histological studies were performed to detect caspase-3 activation, glial activation, and motor neuron survival in the serial spinal cord sections. To investigate the impact of caspase-3 activation on spinal cord ischemia, outcome of the spinal cord ischemia was examined in mice deficient for caspase-3. RESULTS:In wild-type mice, 9 minutes of spinal cord ischemia caused immediate paraplegia, whereas 5 minutes of ischemia caused delayed paraplegia. Delayed paraplegia after 5 minutes of spinal cord ischemia was associated with histological evidence of caspase-3 activation, reactive astrogliosis, microglial activation, and motor neuron loss starting at approximately 24 to 48 hours after spinal cord ischemia. Caspase-3 deficiency prevented delayed paraplegia and motor neuron loss after 5 minutes of spinal cord ischemia, but not immediate paraplegia after 9 minutes of ischemia. CONCLUSIONS:The present results suggest that caspase-3 activation is required for delayed paraplegia and motor neuron degeneration after spinal cord ischemia.

journal_name

Stroke

journal_title

Stroke

authors

Kakinohana M,Kida K,Minamishima S,Atochin DN,Huang PL,Kaneki M,Ichinose F

doi

10.1161/STROKEAHA.110.600429

subject

Has Abstract

pub_date

2011-08-01 00:00:00

pages

2302-7

issue

8

eissn

0039-2499

issn

1524-4628

pii

STROKEAHA.110.600429

journal_volume

42

pub_type

杂志文章

相关文献

STROKE文献大全
  • Diffusion-weighted magnetic resonance imaging in a case of cerebral venous thrombosis.

    abstract:BACKGROUND:Diffusion-weighted imaging (DWI) is the most sensitive MR sequence in acute arterial ischemic stroke but has not yet been evaluated in venous cerebral ischemia. We describe a patient with DWI performed at the acute phase of a venous ischemic stroke. CASE DESCRIPTION:A rapid cerebral MRI including DWI and fa...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.29.12.2649

    authors: Corvol JC,Oppenheim C,Manaï R,Logak M,Dormont D,Samson Y,Marsault C,Rancurel G

    更新日期:1998-12-01 00:00:00

  • Trial of secondary prevention with atenolol after transient ischemic attack or nondisabling ischemic stroke. The Dutch TIA Trial Study Group.

    abstract:BACKGROUND AND PURPOSE:beta-Blockers prevent vascular events in patients after myocardial infarction and lower blood pressure, the main risk factor for stroke. Hence, we assessed the effects of atenolol on the occurrence of death from vascular causes, stroke, or myocardial infarction and on blood pressure in patients a...

    journal_title:Stroke

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1161/01.str.24.4.543

    authors:

    更新日期:1993-04-01 00:00:00

  • Effect of hemorrhagic hypotension on cerebrovascular reactivity and ultrastructure in the cat.

    abstract:BACKGROUND AND PURPOSE:The goal of this study was to determine the alterations in contractile and dilatory responses and ultrastructure of the feline middle cerebral artery after hemorrhagic hypotension. METHODS:In the sodium pentobarbital anesthetized cats, a steady 50 mm Hg level of hypotension was reached by bleedi...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.22.12.1541

    authors: Kovách AG,Szabó C,Faragó M,Lohinai Z,Fehér E

    更新日期:1991-12-01 00:00:00

  • Urgent carotid surgery and stenting may be safe after systemic thrombolysis for stroke.

    abstract:BACKGROUND AND PURPOSE:Early carotid surgery or stenting after thrombolytic treatment for stroke has become more common during recent years. It is unclear whether this carries an increased risk of postoperative complications and death. The aim of this nationwide population-based study was, therefore, to investigate the...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/STROKEAHA.113.003763

    authors: Koraen-Smith L,Troëng T,Björck M,Kragsterman B,Wahlgren CM,Swedish Vascular Registry and the Riks-Stroke Collaboration.

    更新日期:2014-03-01 00:00:00

  • Platelet accumulation in regions of low blood flow during the postischemic period.

    abstract::Various studies indicate that after a latent interval, a progressive focal deterioration of microvascular perfusion can develop in zones of acute damage to the central nervous system (CNS). In order to obtain reliable information concerning the possibility of platelet participation in this phenomenon, platelet deposit...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.16.2.224

    authors: Obrenovitch TP,Hallenbeck JM

    更新日期:1985-03-01 00:00:00

  • Fluoxetine treatment in poststroke depression, emotional incontinence, and anger proneness: a double-blind, placebo-controlled study.

    abstract:BACKGROUND AND PURPOSE:The efficacy and safety of the selective serotonin reuptake inhibitor fluoxetine have rarely been studied in the treatment of poststroke emotional disturbances. METHODS:Stroke patients (152) who had poststroke depression (PSD), emotional incontinence (PSEI), or anger proneness (PSAP) were studie...

    journal_title:Stroke

    pub_type: 杂志文章,随机对照试验

    doi:10.1161/01.STR.0000190892.93663.e2

    authors: Choi-Kwon S,Han SW,Kwon SU,Kang DW,Choi JM,Kim JS

    更新日期:2006-01-01 00:00:00

  • Effect of lidocaine on somatosensory evoked response and cerebral blood flow after canine cerebral air embolism.

    abstract:BACKGROUND AND PURPOSE:Victims of air embolism often recover rapidly on hyperbaric treatment then deteriorate again, even if hyperbaric treatment is continued. In previous animal experiments, lidocaine has been shown to improve recovery of somatosensory evoked response amplitude after air embolism. However, animals in ...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.23.10.1515

    authors: Dutka AJ,Mink R,McDermott J,Clark JB,Hallenbeck JM

    更新日期:1992-10-01 00:00:00

  • IL-23 (Interleukin-23)-Producing Conventional Dendritic Cells Control the Detrimental IL-17 (Interleukin-17) Response in Stroke.

    abstract:BACKGROUND AND PURPOSE:Inflammatory mechanisms can exacerbate ischemic tissue damage and worsen clinical outcome in patients with stroke. Both αβ and γδ T cells are established mediators of tissue damage in stroke, and the role of dendritic cells (DCs) in inducing the early events of T cell activation and differentiati...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/STROKEAHA.117.019101

    authors: Gelderblom M,Gallizioli M,Ludewig P,Thom V,Arunachalam P,Rissiek B,Bernreuther C,Glatzel M,Korn T,Arumugam TV,Sedlacik J,Gerloff C,Tolosa E,Planas AM,Magnus T

    更新日期:2018-01-01 00:00:00

  • Grading scale for prediction of outcome in primary intracerebral hemorrhages.

    abstract:BACKGROUND AND PURPOSE:This study aimed to independently derive an intracerebral hemorrhage grading scale (ICH-GS) for prediction of 3 outcome measures. METHODS:We evaluated 378 patients with primary ICH at hospital arrival and during the next 30 days. Independent predictors were identified by multivariate models of i...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/STROKEAHA.106.478222

    authors: Ruiz-Sandoval JL,Chiquete E,Romero-Vargas S,Padilla-Martínez JJ,González-Cornejo S

    更新日期:2007-05-01 00:00:00

  • Auditory discrimination after left-hemisphere stroke: a mismatch negativity follow-up study.

    abstract:BACKGROUND AND PURPOSE:We sought to determine the recovery of cortical auditory discrimination in aphasic, left-hemisphere-stroke patients by using an electrophysiological response called mismatch negativity (MMN) and speech-comprehension tests. METHODS:MMN in 8 left-hemisphere stroke patients was recorded in response...

    journal_title:Stroke

    pub_type: 临床试验,杂志文章

    doi:10.1161/01.STR.0000078836.26328.3B

    authors: Ilvonen TM,Kujala T,Kiesiläinen A,Salonen O,Kozou H,Pekkonen E,Roine RO,Kaste M,Näätänen R

    更新日期:2003-07-01 00:00:00

  • Serum calcium as prognosticator in ischemic stroke.

    abstract:BACKGROUND AND PURPOSE:Calcium (Ca(2+)) plays a role in the cellular and molecular pathways of ischemic neuronal death. We evaluated the impact of both early and delayed Ca(2+) levels on clinical outcomes from acute ischemic stroke. METHODS:The relations between blood calcium level obtained early (<4.5 hours), and del...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/STROKEAHA.107.513499

    authors: Ovbiagele B,Starkman S,Teal P,Lyden P,Kaste M,Davis SM,Hacke W,Fierus M,Saver JL,VISTA Investigators.

    更新日期:2008-08-01 00:00:00

  • Association between interleukin-1A polymorphism and cerebral amyloid angiopathy-related hemorrhage.

    abstract:BACKGROUND AND PURPOSE:It has been suggested that the interleukin-1A (IL-1A) allele 2 is a risk factor for Alzheimer's disease (AD). Because cerebral amyloid angiopathy-related hemorrhage (CAAH) often coexists with AD, we examined the IL-1A polymorphism in CAAH. METHODS:In a case-control study, patients with pathologi...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.STR.0000089294.85447.1E

    authors: McCarron MO,Stewart J,McCarron P,Love S,Vinters HV,Ironside JW,Mann DM,Graham DI,Nicoll JA

    更新日期:2003-10-01 00:00:00

  • Accuracy of ICD-9-CM coding for the identification of patients with acute ischemic stroke: effect of modifier codes.

    abstract:BACKGROUND AND PURPOSE:Discharge ICD-9-CM (International Classification of Diseases, 9th Revision, Clinical Modification) codes have been used to identify patients with acute stroke for epidemiological, quality of care, and cost studies. The aim of this study was to determine if the accuracy of the primary ICD-9-CM cod...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.29.8.1602

    authors: Goldstein LB

    更新日期:1998-08-01 00:00:00

  • First Pass Effect: A New Measure for Stroke Thrombectomy Devices.

    abstract:BACKGROUND AND PURPOSE:In acute ischemic stroke, fast and complete recanalization of the occluded vessel is associated with improved outcomes. We describe a novel measure for newer generation devices: the first pass effect (FPE). FPE is defined as achieving a complete recanalization with a single thrombectomy device pa...

    journal_title:Stroke

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1161/STROKEAHA.117.020315

    authors: Zaidat OO,Castonguay AC,Linfante I,Gupta R,Martin CO,Holloway WE,Mueller-Kronast N,English JD,Dabus G,Malisch TW,Marden FA,Bozorgchami H,Xavier A,Rai AT,Froehler MT,Badruddin A,Nguyen TN,Taqi MA,Abraham MG,Yoo AJ,

    更新日期:2018-03-01 00:00:00

  • Mice expressing a bovine basic fibroblast growth factor transgene in the brain show increased resistance to hypoxemic-ischemic cerebral damage.

    abstract:BACKGROUND AND PURPOSE:Cerebral intraventricular infusion of acidic or basic fibroblast growth factor has been shown to attenuate ischemic damage to hippocampal CA1 neurons in the gerbil. The purpose of the present study was to determine if the basic fibroblast growth factor transgenic mouse has an enhanced ability to ...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.24.11.1735

    authors: MacMillan V,Judge D,Wiseman A,Settles D,Swain J,Davis J

    更新日期:1993-11-01 00:00:00

  • Anesthetic modulation of cerebral hemodynamic and evoked responses to transient middle cerebral artery occlusion in cats.

    abstract::We measured cerebral blood flow and somatosensory evoked potentials during transient focal cerebral ischemia in cats to compare the effects of four commonly used anesthetic regimens: ketamine/fentanyl/N2O (fentanyl), pentobarbital, ketamine/alpha-chloralose (alpha-chloralose), and ketamine/halothane/N2O (halothane). S...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.21.5.795

    authors: Helfaer MA,Kirsch JR,Traystman RJ

    更新日期:1990-05-01 00:00:00

  • Anesthesia Technique and Outcomes of Mechanical Thrombectomy in Patients With Acute Ischemic Stroke.

    abstract:BACKGROUND AND PURPOSE:The impact of anesthesia technique on the outcomes of mechanical thrombectomy for acute ischemic stroke remains an issue of debate. We investigated the association of general anesthesia with outcomes in patients undergoing mechanical thrombectomy for ischemic stroke. METHODS:We performed a cohor...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/STROKEAHA.116.015343

    authors: Bekelis K,Missios S,MacKenzie TA,Tjoumakaris S,Jabbour P

    更新日期:2017-02-01 00:00:00

  • Novel Oral Anticoagulants for Primary Stroke Prevention in Hypertrophic Cardiomyopathy Patients With Atrial Fibrillation.

    abstract::Background and Purpose- Hypertrophic cardiomyopathy patients with atrial fibrillation are at increased risk of stroke, and anticoagulation is strongly recommended. However, limited data are available regarding the safety and effectiveness of non-vitamin K antagonist oral anticoagulants (NOACs) for primary prevention o...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/STROKEAHA.119.026048

    authors: Lee HJ,Kim HK,Jung JH,Han KD,Lee H,Park JB,Kim HM,Kim YJ,Ommen SR

    更新日期:2019-09-01 00:00:00

  • Accuracy of transcranial Doppler compared with CT angiography in diagnosing arterial obstructions in acute ischemic strokes.

    abstract:BACKGROUND AND PURPOSE:Patients with acute ischemic stroke and intracranial arterial obstructions have a poor prognosis and a high probability of deteriorating at 24 hours. We aimed to evaluate the diagnostic accuracy of power motion mode Doppler (PMD-TCD) compared with CT angiography as standard in diagnosing intracra...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/STROKEAHA.108.542704

    authors: Brunser AM,Lavados PM,Hoppe A,Lopez J,Valenzuela M,Rivas R

    更新日期:2009-06-01 00:00:00

  • Long-Term Effect of Pravastatin on Carotid Intima-Media Complex Thickness: The J-STARS Echo Study (Japan Statin Treatment Against Recurrent Stroke).

    abstract:BACKGROUND AND PURPOSE:The effect of statins on progression of carotid intima-media complex thickness (IMT) has been shown exclusively in nonstroke Western patients. This study aimed to determine the effect of low-dose pravastatin on carotid IMT in Japanese patients with noncardioembolic ischemic stroke. METHODS:This ...

    journal_title:Stroke

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1161/STROKEAHA.117.018387

    authors: Koga M,Toyoda K,Minematsu K,Yasaka M,Nagai Y,Aoki S,Nezu T,Hosomi N,Kagimura T,Origasa H,Kamiyama K,Suzuki R,Ohtsuki T,Maruyama H,Kitagawa K,Uchiyama S,Matsumoto M,J-STARS Investigators.

    更新日期:2018-01-01 00:00:00

  • MicroRNA cluster miR-17-92 Cluster in Exosomes Enhance Neuroplasticity and Functional Recovery After Stroke in Rats.

    abstract:BACKGROUND AND PURPOSE:Multipotent mesenchymal stromal cell (MSC) harvested exosomes are hypothesized as the major paracrine effectors of MSCs. In vitro, the miR-17-92 cluster promotes oligodendrogenesis, neurogenesis, and axonal outgrowth. We, therefore, investigated whether the miR-17-92 cluster-enriched exosomes har...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/STROKEAHA.116.015204

    authors: Xin H,Katakowski M,Wang F,Qian JY,Liu XS,Ali MM,Buller B,Zhang ZG,Chopp M

    更新日期:2017-03-01 00:00:00

  • Tissue-Selective Salvage of the White Matter by Successful Endovascular Stroke Therapy.

    abstract:BACKGROUND AND PURPOSE:White matter (WM) is less vulnerable to ischemia than gray matter. In ischemic stroke caused by acute large-vessel occlusion, successful recanalization might therefore sometimes selectively salvage the WM, leading to infarct patterns confined to gray matter. This study examines occurrence, determ...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/STROKEAHA.117.017903

    authors: Kleine JF,Kaesmacher M,Wiestler B,Kaesmacher J

    更新日期:2017-10-01 00:00:00

  • Burden of Intracranial Atherosclerosis Is Associated With Long-Term Vascular Outcome in Patients With Ischemic Stroke.

    abstract:BACKGROUND AND PURPOSE:Ischemic stroke patients often have intracranial atherosclerosis (ICAS), despite heterogeneity in the cause of stroke. We tested the hypothesis that ICAS burden can independently reflect the risk of long-term vascular outcome. METHODS:This was a retrospective cohort study analyzing data from a p...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/STROKEAHA.117.017806

    authors: Kim BS,Chung PW,Park KY,Won HH,Bang OY,Chung CS,Lee KH,Kim GM

    更新日期:2017-10-01 00:00:00

  • Genetic heritability of ischemic stroke and the contribution of previously reported candidate gene and genomewide associations.

    abstract:BACKGROUND AND PURPOSE:The contribution of genetics to stroke risk, and whether this differs for different stroke subtypes, remainsuncertain. Genomewide complex trait analysis allows heritability to be assessed from genomewide association study (GWAS) data. Previous candidate gene studies have identified many associati...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/STROKEAHA.112.665760

    authors: Bevan S,Traylor M,Adib-Samii P,Malik R,Paul NL,Jackson C,Farrall M,Rothwell PM,Sudlow C,Dichgans M,Markus HS

    更新日期:2012-12-01 00:00:00

  • Pathogenic ischemic stroke phenotypes in the NINDS-stroke genetics network.

    abstract:BACKGROUND AND PURPOSE:NINDS (National Institute of Neurological Disorders and Stroke)-SiGN (Stroke Genetics Network) is an international consortium of ischemic stroke studies that aims to generate high-quality phenotype data to identify the genetic basis of pathogenic stroke subtypes. This analysis characterizes the e...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/STROKEAHA.114.007362

    authors: Ay H,Arsava EM,Andsberg G,Benner T,Brown RD Jr,Chapman SN,Cole JW,Delavaran H,Dichgans M,Engström G,Giralt-Steinhauer E,Grewal RP,Gwinn K,Jern C,Jimenez-Conde J,Jood K,Katsnelson M,Kissela B,Kittner SJ,Kleindorfer D

    更新日期:2014-12-01 00:00:00

  • Intracranial Arterial Dolichoectasia and Stenosis: Risk Factors and Relation to Cerebral Small Vessel Disease.

    abstract:BACKGROUND AND PURPOSE:Intracranial arterial dolichoectasia (IADE) is a poorly understood arteriopathy compared with intracranial atherosclerotic stenosis (ICAS). We aimed to investigate the risk factors of IADE and ICAS and their relationship with neuroimaging markers of cerebral small vessel disease in a population-b...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/STROKEAHA.117.020130

    authors: Zhai FF,Yan S,Li ML,Han F,Wang Q,Zhou LX,Ni J,Yao M,Zhang SY,Cui LY,Jin ZY,Zhu YC

    更新日期:2018-05-01 00:00:00

  • Tumor-Like Presentation of Primary Angiitis of the Central Nervous System.

    abstract:BACKGROUND AND PURPOSE:We aimed to describe the clinical and imaging features of patients with tumor-like presentation of primary angiitis of the central nervous system. METHODS:We retrospectively analyzed 10 patients enrolled in the French primary angiitis of the central nervous system cohort, who initially presented...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/STROKEAHA.116.013917

    authors: de Boysson H,Boulouis G,Dequatre N,Godard S,Néel A,Arquizan C,Detante O,Bloch-Queyrat C,Zuber M,Touzé E,Bienvenu B,Aouba A,Guillevin L,Naggara O,Pagnoux C,French Vasculitis Study Group.

    更新日期:2016-09-01 00:00:00

  • Diffusion-Weighted Imaging Hyperintensities in Subtypes of Acute Intracerebral Hemorrhage.

    abstract::Background and Purpose- Diffusion-weighted imaging (DWI) hyperintensities in intracerebral hemorrhage (ICH) are associated with increased risk of recurrent ICH, cognitive impairment, and death, but whether these lesions are specific to a subtype of ICH remains uncertain. We investigated the association between DWI les...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/STROKEAHA.118.021407

    authors: Boulanger M,Schneckenburger R,Join-Lambert C,Werring DJ,Wilson D,Hodel J,Zuber M,Touzé E

    更新日期:2018-12-07 00:00:00

  • Comparison of hypertension management after stroke and myocardial infarction: results from ECLAT1--a French nationwide study.

    abstract:BACKGROUND AND PURPOSE:Hypertension control is a cornerstone of preventive treatment in patients at risk for cerebral attack. The aim of this study was to analyze hypertension management in secondary prevention of stroke as compared with patients in secondary prevention of myocardial infarction (MI). METHODS:The ECLAT...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.STR.0000131547.71502.81

    authors: Amar J,Cambou JP,Touzé E,Bongard V,Jullien G,Vahanian A,Coppé G,Mas JL,ECLAT1 Study Investigators.

    更新日期:2004-07-01 00:00:00

  • Feeding artery pressure and venous drainage pattern are primary determinants of hemorrhage from cerebral arteriovenous malformations.

    abstract:PURPOSE:The purpose of this study was to define the influence of feeding mean arterial pressure (FMAP) in conjunction with other morphological or clinical risk factors in determining the probability of hemorrhagic presentation in patients with cerebral arteriovenous malformations (AVMs). METHODS:Clinical and angiograp...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.29.6.1167

    authors: Duong DH,Young WL,Vang MC,Sciacca RR,Mast H,Koennecke HC,Hartmann A,Joshi S,Mohr JP,Pile-Spellman J

    更新日期:1998-06-01 00:00:00