Abstract:
BACKGROUND AND PURPOSE:Cerebral intraventricular infusion of acidic or basic fibroblast growth factor has been shown to attenuate ischemic damage to hippocampal CA1 neurons in the gerbil. The purpose of the present study was to determine if the basic fibroblast growth factor transgenic mouse has an enhanced ability to resist the effects of severe cerebral hypoxemia-oligemia. METHODS:Mice that were transgenic for bovine basic fibroblast growth factor were exposed to right carotid artery ligation, hyperglycemia, and 20 minutes of 1% carbon monoxide. After 5 days' recovery, brains were examined for histological damage. RESULTS:Counts of CA1 neurons in the right hippocampus showed a significantly higher number of neurons per millimeter CA1 in hypoxic-ischemic transgenic mice compared with nontransgenic controls (transgenic, 260 +/- 33; nontransgenic, 151 +/- 37 neurons per millimeter CA1; P < .05). CONCLUSIONS:The results indicate that basic fibroblast growth factor transgenic mice, as judged by CA1 hippocampal neuronal survival, have an enhanced ability to resist the effects of a complex hypoxic-ischemic cerebral insult.
journal_name
Strokejournal_title
Strokeauthors
MacMillan V,Judge D,Wiseman A,Settles D,Swain J,Davis Jdoi
10.1161/01.str.24.11.1735subject
Has Abstractpub_date
1993-11-01 00:00:00pages
1735-9issue
11eissn
0039-2499issn
1524-4628journal_volume
24pub_type
杂志文章相关文献
STROKE文献大全abstract:BACKGROUND AND PURPOSE:Stroke has global importance and it causes an increasing amount of human suffering and economic burden, but its management is far from optimal. The unsuccessful outcome of several research programs highlights the need for reliable data on which to plan future clinical trials. The Virtual Internat...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.106.473579
更新日期:2007-06-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Many patients with acute basilar artery occlusion may require endotracheal intubation and mechanical ventilation. The circumstances and predictive value for outcome in these patients are not well documented. METHODS:We reviewed the medical records of 25 patients admitted into the intensive care ...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.27.8.1301
更新日期:1996-08-01 00:00:00
abstract::We studied 1,273 patients with ischemic cerebral infarction who were entered into the Stroke Data Bank, a prospective, observational study involving four university hospitals and the Biometry and Field Studies Branch of the National Institute of Neurological Disorders and Stroke. Forty patients had noniatrogenic recur...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.20.8.983
更新日期:1989-08-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Efforts to reduce disparities in recurrent stroke among Black and Latino stroke survivors have met with limited success. We aimed to determine the effect of peer education on secondary stroke prevention among predominantly minority stroke survivors. METHODS:Between 2009 and 2012, we enrolled 600...
journal_title:Stroke
pub_type: 杂志文章,随机对照试验
doi:10.1161/STROKEAHA.114.006623
更新日期:2014-11-01 00:00:00
abstract::The trends in age adjusted and age and sex specific mortality rates for the period 1968-1980 are compared for ischaemic heart disease and cerebrovascular disease. For both sexes and at all ages over 45 the mortality rates for cerebrovascular disease have fallen significantly. However, the mortality rates for ischaemic...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.13.5.582
更新日期:1982-09-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Stroke risk increases with age in patients who have nonvalvular atrial fibrillation. It is uncertain whether the efficacy of stroke prevention therapies in atrial fibrillation changes as patients age. The objective of this study was to determine the effect of age on the relative efficacy of oral ...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.108.526988
更新日期:2009-04-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Efforts to increase the availability and shorten the time delivery of intravenous thrombolysis in patients with acute ischemic stroke carry the potential for tissue plasminogen activator administration in patients with diseases other than stroke, that is, stroke mimics (SMs). We aimed to determin...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.110.609339
更新日期:2011-06-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Time elapsed from last-known well (LKW) and baseline imaging results are influential on endovascular thrombectomy (EVT) outcomes. METHODS:In a prospective multicenter cohort study of imaging selection for endovascular thrombectomy (SELECT [Optimizing Patient's Selection for Endovascular Treatmen...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.120.030912
更新日期:2021-01-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Tacrolimus, an immunosuppressant agent, has been shown to reduce tissue injury and leukocyte accumulation after transient ischemia. This study was designed to evaluate quantitatively the inhibitory effects of tacrolimus on leukocyte rolling and on subsequent leukocyte accumulation in vivo after t...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.29.7.1431
更新日期:1998-07-01 00:00:00
abstract:BACKGROUND AND PURPOSE:It is not known what fraction of patients with symptomatic cerebral aneurysms are misdiagnosed at initial medical presentation. It is also not clear whether misdiagnosed patients more frequently deteriorate before definitive aneurysm diagnosis and therapy or achieve a poorer outcome than correctl...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.27.9.1558
更新日期:1996-09-01 00:00:00
abstract:OBJECTIVES:This systematic review summarizes the effectiveness of mirror therapy for improving motor function, activities of daily living, pain, and visuospatial neglect in patients after stroke. METHODS:We searched the Cochrane Stroke Group’s Trials Register (June 2011), the Cochrane Central Register of Controlled Tr...
journal_title:Stroke
pub_type: 杂志文章,评审
doi:10.1161/strokeaha.112.673087
更新日期:2013-01-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Subarachnoid hemorrhage (SAH) is associated with a temporal pattern of stroke incidence. We hypothesized that natural oscillations in gene expression controlling circadian rhythm affect the severity of neuronal injury. We moreover predict that heme oxygenase-1 (HO-1/Hmox1) and its product carbon ...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.116.016165
更新日期:2017-09-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Subarachnoid hemorrhage (SAH) causes acute vasoconstriction that contributes to ischemic brain injury shortly after the initial bleed. It has been theorized that decreased availability of nitric oxide (NO) may contribute to acute vasoconstriction. Therefore we examined the effect of the NO donor ...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.30.9.1955
更新日期:1999-09-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The purpose of the present study is to determine the effect of mild hypothermia on the synthesis of ubiquitin, an important protein for maintenance of cell viability, in the hippocampal neurons following transient cerebral ischemia. METHODS:Transient ischemia was induced by occluding both common...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.22.12.1574
更新日期:1991-12-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Studies of peripheral arteries in hypercholesterolemic animals suggest that increased generation of superoxide contributes to endothelial dysfunction, especially in the presence of atherosclerotic lesions. We tested the hypothesis that vasomotor function is impaired in cerebral arterioles during ...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.107.481879
更新日期:2007-07-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The impact of asymptomatic coronary artery disease on the risk of major vascular events in patients with cerebral infarction is unknown. METHODS:Four hundred five patients with acute cerebral infarction underwent carotid, femoral artery, thoracic, and abdominal aorta ultrasound examination. Of 3...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.111.000142
更新日期:2013-06-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Abnormalities in endogenous fibrinolysis are associated with an increased risk for stroke in men and older adults. We tested the hypothesis that elevated plasma tissue plasminogen activator (tPA) antigen, a marker for impaired endogenous fibrinolysis, is an independent risk factor for stroke in y...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.30.1.7
更新日期:1999-01-01 00:00:00
abstract::We studied the pattern and outcome of strokes in 200 Saudi patients. Cerebral infarction constituted 87% of strokes, subarachnoid hemorrhage 4.5%, cerebral hemorrhage 6.5%, and venous infarction 2%. The vessel most commonly involved was part or all of the middle cerebral artery, constituting 52% (90) of the 174 arteri...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.22.9.1173
更新日期:1991-09-01 00:00:00
abstract::Cystatin C, a protein inhibitor of lysosomal cysteine proteinases, was demonstrated by immunohistochemical techniques to be present in the birefringent amyloid deposits of the small arteries in the cerebrum, cerebellum, and leptomeninges of 10 Icelandic individuals with hereditary cerebral hemorrhage with amyloidosis....
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.18.2.431
更新日期:1987-03-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The cerebral vasodilating effect of acetazolamide (ACZ) injection has been used as an index of the autoregulatory vasodilation (or cerebral perfusion reserve). The question of whether the ACZ test assesses the maximal autoregulatory vasodilating capacity is not definitely resolved. The effects of...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.31.2.508
更新日期:2000-02-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Although the efficacy of angiotensin-converting enzyme inhibitors and angiotensin receptor blockers in reducing future vascular events for patients with coronary heart disease is established, less is known about the precise benefit of these agents among patients with stroke. We evaluated whether ...
journal_title:Stroke
pub_type: 杂志文章,meta分析
doi:10.1161/STROKEAHA.111.632596
更新日期:2012-01-01 00:00:00
abstract:BACKGROUND AND PURPOSE:ASCOD phenotyping (A, atherosclerosis; S, small vessel disease; C, cardiac pathology; O, other causes; and D, dissection) assigns a degree of likelihood to every potential cause (1 for potentially causal, 2 for causality is uncertain, 3 for unlikely causal but disease is present, 0 for absence of...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.113.001363
更新日期:2013-09-01 00:00:00
abstract::Cerebral autoregulation can be duplicated in vitro using the large middle cerebral arteries from a calf. The limits of autoregulation were between 50 and 150 mm Hg. Excessively high pressures may lead to the appearance of the "sausage- or bead-string" response followed by forced dilation. These results suggest the exi...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.12.5.640
更新日期:1981-09-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The purposes of this study were to assess the relationships between anatomic and technical factors and the 30-day risk of stroke or death after carotid angioplasty and stenting in the Endarterectomy versus Stenting in Patients with Symptomatic Severe Carotid Stenosis (EVA-3S) trial and to perform...
journal_title:Stroke
pub_type: 杂志文章,多中心研究,随机对照试验,评审
doi:10.1161/STROKEAHA.110.588772
更新日期:2011-02-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Patient selection is crucial in the endovascular treatment of acute ischemic stroke patients. Baseline computed tomographic (CT) images, evaluated with the Alberta Stroke Program Early CT Scale (ASPECTS), are considered significant predictors of outcome. In this study, we evaluated CT images and ...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.113.001068
更新日期:2013-08-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The present study was performed to determine the relation between distribution of atherosclerosis and risk factors in Japanese patients with atherothrombotic occlusion. METHODS:We studied 154 patients with atherothrombotic occlusion of the extracranial internal carotid artery (n = 75, ICA group)...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.24.2.206
更新日期:1993-02-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Neuroprotective effects of electric stimulation have been recently shown in ischemic stroke, but the underlying mechanisms remain poorly understood. METHODS:Adult Wistar rats weighing 200 to 250 g received occlusion of the right middle cerebral artery for 90 minutes. At 1 hour after reperfusion,...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.109.563627
更新日期:2009-11-01 00:00:00
abstract::Background and Purpose- The purpose of this study was to conduct a meta-analysis of CVOTs (cardiovascular outcome trials) to evaluate the effect of glucagon-like peptide-1 receptor agonists therapy in reducing the risk of stroke in patients with type 2 diabetes mellitus. Methods- PubMed and other electronic sources we...
journal_title:Stroke
pub_type: 临床试验,杂志文章
doi:10.1161/STROKEAHA.119.027557
更新日期:2020-02-01 00:00:00
abstract:BACKGROUND AND PURPOSE:A previous study suggested that occlusive diseases of small penetrating arteries account for most anterior choroidal artery (AChA) territory infarcts, but half of the patients did not have an echocardiogram. Cases of AChA territory infarcts associated with internal carotid artery stenosis or atri...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.25.4.837
更新日期:1994-04-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Intravascular bridges, resulting from developmental anomalies of brain arteries, are now better known as arterial fenestrations. Their tendency to develop aneurysms, similar to arterial bifurcations, makes their anatomy and microstructure important for study. METHODS:Six segments of artery, each...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.25.9.1799
更新日期:1994-09-01 00:00:00