Abstract:
BACKGROUND AND PURPOSE:Efforts to reduce disparities in recurrent stroke among Black and Latino stroke survivors have met with limited success. We aimed to determine the effect of peer education on secondary stroke prevention among predominantly minority stroke survivors. METHODS:Between 2009 and 2012, we enrolled 600 stroke or transient ischemic attack survivors from diverse, low-income communities in New York City into a 2-arm randomized clinical trial that compared a 6 week (1 session/week), peer-led, community-based, stroke prevention self-management group workshop (N=301) to a wait-list control group (N=299). The primary outcome was the proportion with a composite of controlled blood pressure (<140/90 mm Hg), low-density lipoprotein cholesterol <100 mg/dL, and use of antithrombotic medications at 6 months. Secondary outcomes included control of the individual stroke risk factors. All analyses were by intent-to-treat. RESULTS:There was no difference in the proportion of intervention and control group participants achieving the composite outcome (34% versus 34%; P=0.98). The proportion with controlled blood pressure at 6 months was greater in the intervention group than in the control group (76% versus 67%; P=0.02). This corresponded to a greater change in systolic blood pressure in the intervention versus control group (-3.63 SD, 19.81 mm Hg versus +0.34 SD, 23.76 mm Hg; P=0.04). There were no group differences in the control of cholesterol or use of antithrombotics. CONCLUSIONS:A low-cost peer education self-management workshop modestly improved blood pressure, but not low-density lipoprotein cholesterol or antithrombotic use, among stroke and transient ischemic attack survivors from vulnerable, predominantly minority urban communities. CLINICAL TRIAL REGISTRATION URL:http://www.clinicaltrials.gov/show/NCT0102727. Unique identifier: NCT01027273.
journal_name
Strokejournal_title
Strokeauthors
Kronish IM,Goldfinger JZ,Negron R,Fei K,Tuhrim S,Arniella G,Horowitz CRdoi
10.1161/STROKEAHA.114.006623subject
Has Abstractpub_date
2014-11-01 00:00:00pages
3330-6issue
11eissn
0039-2499issn
1524-4628pii
STROKEAHA.114.006623journal_volume
45pub_type
杂志文章,随机对照试验相关文献
STROKE文献大全abstract:BACKGROUND AND PURPOSE:Mild hypothermia has been shown to ameliorate neuronal damage due to cerebral ischemia. In our study, the influence of mild-to-moderate hypothermia was examined in a rabbit model of focal cerebral ischemia. METHODS:After 4 hours of permanent ischemia induced by occlusion of the anterior and midd...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.23.6.889
更新日期:1992-06-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The most powerful predictors of functional recovery and eventual home discharge among stroke survivors are the initial severity of the stroke and the patient's age. We analyzed a large population of stroke rehabilitation admissions by stratifying subgroups with coherent outcomes in an attempt to ...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.25.1.128
更新日期:1994-01-01 00:00:00
abstract::A 55-year-old woman with an aortic arch syndrome of acute onset and dysphasia, resulting from the excessive administration of ergotamine tartrate suppositories, is described. Complete resolution of symptoms and return of upper limb and carotid artery pulses to normal occurred within four days of cessation of the ergot...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.14.5.811
更新日期:1983-09-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Stroke is a debilitating disease with long-term social and economic consequences. As new therapies for acute ischemic stroke are forthcoming, there is an increasing need to understand their long-term economic implications. To address this need, a stroke economic model was created. METHODS:The mo...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.30.12.2574
更新日期:1999-12-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Current guidelines suggest that cardiac arrest (CA) survivors should be ventilated with 100% O(2) after resuscitation. Breathing 100% O(2) may worsen neurological outcome after experimental CA. This study tested the hypothesis that graded reoxygenation, with oximetry guidance, can safely reduce F...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.STR.0000248455.73785.b1
更新日期:2006-12-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Fibrocartilaginous embolism from the nucleus pulposus has been reported as a rare cause of spinal cord ischemia. We were unable to find previous reports of embolism from this source to cerebral arteries. CASE DESCRIPTION:A previously healthy 17-year-old girl fell during a basketball game. Left h...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.24.5.738
更新日期:1993-05-01 00:00:00
abstract::The purpose of this work was to study the contractile activity of intracerebral microarterioles and their sensitivity to the calcium antagonist nimodipine. Potassium depolarization evoked contraction and rhythmic activity that was blocked by nimodipine (IC50 0.08 nM). High concentrations of noradrenaline and prostagla...
journal_title:Stroke
pub_type: 杂志文章
doi:
更新日期:1990-12-01 00:00:00
abstract::It has been recognized that small intracerebral hemorrhage not uncommonly produced lacunar syndromes. In this study, we examined cases of intracerebral hemorrhage presenting as lacunar syndromes. Of 174 cases with recent intracerebral hemorrhage, 19 presented with a lacunar syndrome: 4 presented with pure motor hemipa...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.16.3.454
更新日期:1985-05-01 00:00:00
abstract::Three leukotrienes (LTB4, C4, D4) were locally applied to cerebral arterioles in doses varying from 3 X 10(-8) to 4 X 10(-7) M and each produced a dose related constriction. LTC was tested in the presence and absence of FPL-55712, a relatively specific inhibitor of leukotriene receptors. A low dose (10(-8) M) of FPL-5...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.16.2.262
更新日期:1985-03-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Neuroprotective effects of electric stimulation have been recently shown in ischemic stroke, but the underlying mechanisms remain poorly understood. METHODS:Adult Wistar rats weighing 200 to 250 g received occlusion of the right middle cerebral artery for 90 minutes. At 1 hour after reperfusion,...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.109.563627
更新日期:2009-11-01 00:00:00
abstract:BACKGROUND AND PURPOSE:There is debate regarding the approach for analysis of modified Rankin scale scores, the most common functional outcome scale used in acute stroke trials. METHODS:We propose to use tests to assess treatment differences addressing the metric, "if a patient is chosen at random from each treatment ...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.111.632935
更新日期:2012-03-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The purpose of the present study is to determine the effect of mild hypothermia on the synthesis of ubiquitin, an important protein for maintenance of cell viability, in the hippocampal neurons following transient cerebral ischemia. METHODS:Transient ischemia was induced by occluding both common...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.22.12.1574
更新日期:1991-12-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Intracranial aneurysms and aneurysmal subarachnoid hemorrhage may occur more frequently in sickle-cell disease (SCD), and this could be related to the sickle genotype and moyamoya syndrome seen in SCD. METHODS:Records from a total of 1002 patients with SCD attending 2 specialized adult hematolog...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.116.012664
更新日期:2016-07-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Chronic ocular ischemia is a rare form of ischemia of the eye in patients with carotid artery occlusion (CAO). The early and often asymptomatic stage of chronic ocular ischemia is referred to as venous stasis retinopathy (VSR). The aim of this study was to gain insight into the prevalence, cause,...
journal_title:Stroke
pub_type: 临床试验,杂志文章
doi:10.1161/hs0302.104619
更新日期:2002-03-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Patients with stroke and patients with transient ischemic attack (TIA) are at high risk for vascular events and may not exhibit the signs and symptoms of peripheral arterial disease (PAD). We investigated if asymptomatic PAD detected by ankle brachial index <0.9 is independently associated with r...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.109.559278
更新日期:2009-11-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Chlamydia pneumoniae infection has recently become noteworthy in relation to atherosclerosis. We investigated by immunohistochemistry the distribution of C pneumoniae infection in the atherosclerotic carotid artery. METHODS:Twenty carotid atherosclerotic lesions that were resected during carotid...
journal_title:Stroke
pub_type: 临床试验,杂志文章
doi:10.1161/01.str.29.4.773
更新日期:1998-04-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Thrombolytic treatment of stroke carries the risk of hemorrhagic transformation. Therefore, the potential of MRI for prediction of recombinant tissue plasminogen activator (rtPA)-induced bleeding is explored to identify patients in whom rtPA treatment may provoke such complications. METHODS:Spon...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.0000014619.59851.65
更新日期:2002-05-01 00:00:00
abstract::As a preliminary investigation into the cerebral effects of mechanical cardiac assist devices, using transcranial Doppler ultrasonography I examined the basal cerebral arteries in three patients placed on an intra-aortic balloon pump. Unassisted systoles had normal blood velocities and waveforms. When the pump was in ...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.21.3.484
更新日期:1990-03-01 00:00:00
abstract:BACKGROUND:In the United States, stroke mortality is higher in the south than in other regions. Hypertension is the main risk factor for stroke among older adults; however, few studies have examined group-specific regional and urbanization differences in hypertension prevalence. METHODS:Data from the Third National He...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.31.1.19
更新日期:2000-01-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The clinical syndrome of transient ischemic attacks is accompanied in a significant percentage of patients by brain lesions or neuroimaging abnormalities whose structural counterparts have not been defined. The objective of this study was to analyze, in an experimental model of short-term (< 25 m...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.28.11.2303
更新日期:1997-11-01 00:00:00
abstract::Eighteen patients with recent ischemic stroke were compared with an equal number of matched controls. Standardized suspensions of red cells as well as of red and white cells were filtered in a new filtration apparatus capable of discriminating between cell deformability and filter occlusion. Results show that red cell...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.18.1.59
更新日期:1987-01-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Cerebral microembolic signals detected by transcranial Doppler are frequent during carotid angioplasty with stenting and carotid endarterectomy (CEA). Their potential harmful effects on the brain are, however, unclear. The aim of this study was to relate the frequency and type of per-procedural m...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.107.513341
更新日期:2009-01-01 00:00:00
abstract::Acute thromboembolic occlusion of the basilar artery accounts for 6% to 10% of large-vessel stroke in humans. Because of the brain region supplied by this artery, the case fatality rate is the highest for all ischemic stroke subtypes, ranging from 40% to 86%. Patients who undergo successful recanalization of the basil...
journal_title:Stroke
pub_type: 杂志文章,评审
doi:10.1161/01.STR.0000247897.33267.42
更新日期:2007-02-01 00:00:00
abstract::The methionine analogue methionine sulfoximine was administered to 10 rats 24 hours before occlusion of the proximal left middle cerebral artery. Three days later the rats were decapitated and the brain infarct volumes were compared with those in 10 control rats that received saline before middle cerebral artery occlu...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.21.2.322
更新日期:1990-02-01 00:00:00
abstract:BACKGROUND AND PURPOSE:We assessed whether the load of cerebral small vessel disease (cSVD) and its individual markers, including lacunes, white matter hyperintensities, microbleeds, and enlarged perivascular spaces (EPVS), are associated with arterial stiffness. METHODS:We evaluated cSVD markers in a cohort of 782 hy...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.118.020163
更新日期:2018-05-01 00:00:00
abstract::Exposure of Mongolian gerbils to a 100% oxygen atmosphere after 15 minutes of global brain ischemia resulted in a marked increase in the production of pentane, an in vivo product of lipid peroxidation. Much less pentane production occurred in animals subjected to global brain ischemia then exposed to an air atmosphere...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.18.2.426
更新日期:1987-03-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Screening for dysphagia is essential to the implementation of preventive therapies for patients with stroke. A systematic review was undertaken to determine the evidence-based validity of dysphagia screening items using instrumental evaluation as the reference standard. METHODS:Four databases fr...
journal_title:Stroke
pub_type: 杂志文章,meta分析,评审
doi:10.1161/STROKEAHA.111.640946
更新日期:2012-03-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Findings on transesophageal echocardiography (TEE) after ischemic stroke predict recurrent embolic events and prompt therapy; however, the additive predictive power of TEE findings on long-term mortality is unknown. Our goal was to study the impact of TEE findings on all cause mortality in ischem...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.STR.0000196939.12313.16
更新日期:2006-01-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The genetic basis of white matter hyperintensities (WMH) is still unknown. This study examines the heritability of WMH in both sexes and in different brain regions, and the influence of age. METHODS:Participants from the Older Australian Twins Study were recruited (n=320; 92 monozygotic and 68 d...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.116.012532
更新日期:2016-06-01 00:00:00
abstract:BACKGROUND AND PURPOSE:It remains unknown whether the effects of 0.6 mg/kg alteplase differ with occlusion site of the middle cerebral artery (MCA). We therefore evaluated the effects of 0.6 mg/kg intravenous alteplase in patients with different sites of MCA occlusion. METHODS:An exploratory analysis was made of 57 pa...
journal_title:Stroke
pub_type: 杂志文章,多中心研究
doi:10.1161/STROKEAHA.110.594333
更新日期:2010-12-01 00:00:00