Auditory discrimination after left-hemisphere stroke: a mismatch negativity follow-up study.

Abstract:

BACKGROUND AND PURPOSE:We sought to determine the recovery of cortical auditory discrimination in aphasic, left-hemisphere-stroke patients by using an electrophysiological response called mismatch negativity (MMN) and speech-comprehension tests. METHODS:MMN in 8 left-hemisphere stroke patients was recorded in response to duration and frequency changes in a repetitive, harmonically rich tone 4 and 10 days and again 3 and 6 months after their first unilateral stroke. Eight age-matched, healthy persons served as control subjects. RESULTS:At 4 days after stroke onset, patients' sound discrimination was impaired in their left hemisphere, as suggested by attenuated MMNs, especially to right-ear stimuli. At 3 months after stroke, however, MMN to the right-ear duration change had significantly increased and was of normal size. A significant change for the frequency MMN was found for left-ear stimuli between 3 and 6 months after stroke. During the follow-up period, progressive improvement in speech-comprehension tests was also observed. Furthermore, there was a significant correlation between the change in the duration MMN amplitude and the Boston Diagnostic Aphasia Examination speech-comprehension test from 10 days to 3 months after stroke. CONCLUSIONS:These results suggest that the MMN can be used as an index of the recovery of auditory discrimination.

journal_name

Stroke

journal_title

Stroke

authors

Ilvonen TM,Kujala T,Kiesiläinen A,Salonen O,Kozou H,Pekkonen E,Roine RO,Kaste M,Näätänen R

doi

10.1161/01.STR.0000078836.26328.3B

subject

Has Abstract

pub_date

2003-07-01 00:00:00

pages

1746-51

issue

7

eissn

0039-2499

issn

1524-4628

pii

01.STR.0000078836.26328.3B

journal_volume

34

pub_type

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