Tumor-Like Presentation of Primary Angiitis of the Central Nervous System.

Abstract:

BACKGROUND AND PURPOSE:We aimed to describe the clinical and imaging features of patients with tumor-like presentation of primary angiitis of the central nervous system. METHODS:We retrospectively analyzed 10 patients enrolled in the French primary angiitis of the central nervous system cohort, who initially presented tumor-like brain lesions and compared them with other patients within the cohort. RESULTS:The 10 patients with tumor-like presentation in the cohort were younger and had more seizures at diagnosis than the other 75 patients (median of 37 [30-48] years versus 46 [18-79] years; P=0.008; 9 [90%] with seizures versus 22 [29%], P<0.001; respectively). All 10 patients had a biopsy (stereotactic procedure in 7 and open-wedge surgery in 3). Histological findings suggestive of vasculitis were observed in 9 patients in whom conventional cerebral angiography and magnetic resonance angiography were negative. In the remaining patient, vascular imaging demonstrated diffuse bilateral large- and medium-sized vessel involvement (biopsy did not reveal vasculitis). All patients with tumor-like presentation received glucocorticoids, combined with cyclophosphamide in 9 cases. With a median follow-up of 27 (12-130) months, 5 (50%) patients relapsed, but achieved remission again after treatment intensification. CONCLUSIONS:Patients with tumor-like presentation of primary angiitis of the central nervous system represent a subgroup characterized with mainly small-sized vessel disease that requires histological confirmation because vascular imaging is often normal. Although relapses are not uncommon, global outcomes are good under treatment with glucocorticoids and cyclophosphamide.

journal_name

Stroke

journal_title

Stroke

authors

de Boysson H,Boulouis G,Dequatre N,Godard S,Néel A,Arquizan C,Detante O,Bloch-Queyrat C,Zuber M,Touzé E,Bienvenu B,Aouba A,Guillevin L,Naggara O,Pagnoux C,French Vasculitis Study Group.

doi

10.1161/STROKEAHA.116.013917

subject

Has Abstract

pub_date

2016-09-01 00:00:00

pages

2401-4

issue

9

eissn

0039-2499

issn

1524-4628

pii

STROKEAHA.116.013917

journal_volume

47

pub_type

杂志文章

相关文献

STROKE文献大全
  • B vitamin plasma levels and the risk of ischemic stroke and transient ischemic attack in a German cohort.

    abstract:BACKGROUND AND PURPOSE:Data from prospective studies on the associations between B vitamin plasma levels and the risk of stroke are limited. We investigated the individual and combined effects of plasma folate, vitamin B12, and pyridoxal 5-phosphate (PLP) levels on the risk of ischemic stroke and transient ischemic att...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/STROKEAHA.107.486068

    authors: Weikert C,Dierkes J,Hoffmann K,Berger K,Drogan D,Klipstein-Grobusch K,Spranger J,Möhlig M,Luley C,Boeing H

    更新日期:2007-11-01 00:00:00

  • ICES (Intraoperative Stereotactic Computed Tomography-Guided Endoscopic Surgery) for Brain Hemorrhage: A Multicenter Randomized Controlled Trial.

    abstract:BACKGROUND AND PURPOSE:Intracerebral hemorrhage (ICH) is a devastating disease without a proven therapy to improve long-term outcome. Considerable controversy about the role of surgery remains. Minimally invasive endoscopic surgery for ICH offers the potential of improved neurological outcome. METHODS:We tested the hy...

    journal_title:Stroke

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1161/STROKEAHA.116.013837

    authors: Vespa P,Hanley D,Betz J,Hoffer A,Engh J,Carter R,Nakaji P,Ogilvy C,Jallo J,Selman W,Bistran-Hall A,Lane K,McBee N,Saver J,Thompson RE,Martin N,ICES Investigators.

    更新日期:2016-11-01 00:00:00

  • Epidemiologic studies of stroke in Shibata, a Japanese provincial city: preliminary report on risk factors for cerebral infarction.

    abstract::A 6.5-year prospective study of cerebral infarction among residents 40 years and older was conducted at the Akadani-Ijimino district in Shibata City, Niigata Prefecture, Japan. The response rate for the initial examination was 85% of 1,182 males and 93% of 1,469 females. Nine hundred and sixty males and 1,339 females ...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.16.5.773

    authors: Tanaka H,Hayashi M,Date C,Imai K,Asada M,Shoji H,Okazaki K,Yamamoto H,Yoshikawa K,Shimada T

    更新日期:1985-09-01 00:00:00

  • The cost of pediatric stroke care and rehabilitation.

    abstract:BACKGROUND AND PURPOSE:There is little data regarding the cost of pediatric stroke care or the elements that contribute to these costs. We examined costs for poststroke care during the first year after diagnosis and compared these costs with the volume of the cerebral infarct and the level of neurological and functiona...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/STROKEAHA.107.497420

    authors: Lo W,Zamel K,Ponnappa K,Allen A,Chisolm D,Tang M,Kerlin B,Yeates KO

    更新日期:2008-01-01 00:00:00

  • Effect of white matter changes on cognitive impairment in patients with lacunar infarcts.

    abstract:BACKGROUND AND PURPOSE:Cerebral white matter changes (WMC) and lacunar infarct are both believed to be consequence of small vessel disease. Whether the extent of WMC affect the type and degree of cognitive impairment in patients with lacunar infarct is not clear. The study was undertaken to determine if WMC influences ...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.STR.0000133686.29320.58

    authors: Wen HM,Mok VC,Fan YH,Lam WW,Tang WK,Wong A,Huang RX,Wong KS

    更新日期:2004-08-01 00:00:00

  • Calcium antagonists and vasoconstrictor effects in intracerebral microarterioles.

    abstract::The purpose of this work was to study the contractile activity of intracerebral microarterioles and their sensitivity to the calcium antagonist nimodipine. Potassium depolarization evoked contraction and rhythmic activity that was blocked by nimodipine (IC50 0.08 nM). High concentrations of noradrenaline and prostagla...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:

    authors: Godfraind T,Morel N,Dessy C

    更新日期:1990-12-01 00:00:00

  • Localized retinal nerve fiber layer defects and stroke.

    abstract:BACKGROUND AND PURPOSE:Because the blood circulation system of retina and brain are closely related to each other, we examined whether stroke is associated with localized retinal nerve fiber layer defects (RNFLDs). METHODS:Patients with acute ischemic stroke as part of a hospital-based study group were compared with t...

    journal_title:Stroke

    pub_type: 杂志文章,随机对照试验

    doi:10.1161/STROKEAHA.113.004629

    authors: Wang D,Li Y,Wang C,Xu L,You QS,Wang YX,Zhao L,Wei WB,Zhao X,Jonas JB

    更新日期:2014-06-01 00:00:00

  • Targeted Infarction of the Internal Capsule in the Rat Using Microstimulation Guidance.

    abstract::Background and Purpose- Lacunar strokes are subcortical infarcts with small size and high disability rates, largely due to injury of the corticospinal tract in the internal capsule (IC). Current rodent models of lacunar infarcts are created based on stereotactic coordinates. We tested the hypothesis that better unders...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/STROKEAHA.119.025646

    authors: Wen TC,Sindhurakar A,Ramirez VC,Park H,Gupta D,Carmel JB

    更新日期:2019-09-01 00:00:00

  • Predictive genomics of cardioembolic stroke.

    abstract::Cardioembolic stroke is a complex disease resulting from the interaction of numerous factors. Using data from Genes Affecting Stroke Risk and Outcome Study (GASROS), we show that a multivariate predictive model built using Bayesian networks is able to achieve a predictive accuracy of 86% on the fitted values as comput...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/STROKEAHA.108.533273

    authors: Ramoni RB,Himes BE,Sale MM,Furie KL,Ramoni MF

    更新日期:2009-03-01 00:00:00

  • Effect of thrombin inhibition in vascular dementia and silent cerebrovascular disease. An MR spectroscopy study.

    abstract:BACKGROUND AND PURPOSE:Silent cerebrovascular disease (CVD) has been proposed as a predisposing condition for clinically overt stroke and vascular dementia. Recently, we found increased thrombin generation in silent CVD patients. Here, we report the effect of thrombin inhibition using a potent selective thrombin inhibi...

    journal_title:Stroke

    pub_type: 临床试验,杂志文章

    doi:10.1161/01.str.30.5.1033

    authors: Kario K,Matsuo T,Hoshide S,Umeda Y,Shimada K

    更新日期:1999-05-01 00:00:00

  • First-Ever Stroke and Transient Ischemic Attack Incidence and 30-Day Case-Fatality Rates in a Population-Based Study in Argentina.

    abstract:BACKGROUND AND PURPOSE:Epidemiological data about stroke are scarce in low- and middle-income Latin-American countries. We investigated annual incidence of first-ever stroke and transient ischemic attack (TIA) and 30-day case-fatality rates in a population-based setting in Tandil, Argentina. METHODS:We prospectively i...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/STROKEAHA.116.013637

    authors: Bahit MC,Coppola ML,Riccio PM,Cipriano LE,Roth GA,Lopes RD,Feigin VL,Borrego Guerrero B,De Martino M,Díaz A,Ferrante D,Funaro F,Lavados P,Lewin ML,López DH,Macarrone P,Marciello R,Marino D,Martens C,Martínez P,Odr

    更新日期:2016-06-01 00:00:00

  • Sonographic monitoring of midline shift in space-occupying stroke: an early outcome predictor.

    abstract:BACKGROUND AND PURPOSE:Transcranial color-coded duplex sonography (TCCS) allows bedside imaging of intracranial hemodynamics and parenchymal structures. It provides reliable information regarding midline shift (MLS) in space-occupying hemispheric stroke. We studied the value of MLS measurement to predict fatal outcome ...

    journal_title:Stroke

    pub_type: 临床试验,杂志文章

    doi:10.1161/01.str.32.2.442

    authors: Gerriets T,Stolz E,König S,Babacan S,Fiss I,Jauss M,Kaps M

    更新日期:2001-02-01 00:00:00

  • Racial disparities in stroke risk factors: the impact of socioeconomic status.

    abstract:BACKGROUND AND PURPOSE:In the US, blacks have a higher incidence of stroke and more severe strokes than whites. Our objective was to determine if differences in income, education, and insurance, as well as differences in the prevalence of stroke risk factors, accounted for the association between ethnicity and stroke. ...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.STR.0000170991.63594.b6

    authors: Bravata DM,Wells CK,Gulanski B,Kernan WN,Brass LM,Long J,Concato J

    更新日期:2005-07-01 00:00:00

  • Utility of Computed Tomographic Perfusion in Thrombolysis for Minor Stroke.

    abstract:BACKGROUND AND PURPOSE:The use of thrombolysis in acute minor ischemic stroke (MIS) remains controversial. We sought to determine the safety and efficacy of intravenous tissue-type plasminogen activator (IV-tPA) in acute MIS patients with demonstrable penumbra on computed tomographic perfusion study. METHODS:Consecuti...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/STROKEAHA.116.013021

    authors: Ng FC,Coote S,Frost T,Bladin C,Choi PM

    更新日期:2016-07-01 00:00:00

  • Comparative effectiveness of unruptured cerebral aneurysm therapies: propensity score analysis of clipping versus coiling.

    abstract:BACKGROUND AND PURPOSE:Endovascular therapy has increasingly become the most common treatment for unruptured cerebral aneurysms in the United States. We evaluated a national, multi-hospital database to examine recent utilization trends and compare periprocedural outcomes between clipping and coiling treatments of unrup...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/STROKEAHA.111.000196

    authors: McDonald JS,McDonald RJ,Fan J,Kallmes DF,Lanzino G,Cloft HJ

    更新日期:2013-04-01 00:00:00

  • Exaggeration of focal cerebral ischemia in transgenic mice carrying human Renin and human angiotensinogen genes.

    abstract:BACKGROUND AND PURPOSE:We examined the possibility that activation of the human brain renin-angiotensin system is involved in enhancement of ischemic brain damage using chimeric transgenic mice with human renin (hRN) and human angiotensinogen (hANG) genes. METHODS:Chimeric (hRN/hANG-Tg) mice were generated by mating o...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/STROKEAHA.108.519801

    authors: Inaba S,Iwai M,Tomono Y,Senba I,Furuno M,Kanno H,Okayama H,Mogi M,Higaki J,Horiuchi M

    更新日期:2009-02-01 00:00:00

  • Detection of mitral valve abnormalities by carotid Doppler flow study: implications for the management of patients with cerebrovascular disease.

    abstract::Patients with symptoms of cerebral ischemia are often evaluated with non-invasive carotid artery testing. An abnormal carotid Doppler ultrasound frequency shift pattern of early systolic flutter (ESF) was demonstrated by auscultation and velocity wave form analysis in patients with normal carotid bifurcations. Ten of ...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.16.6.977

    authors: Weinberger J,Goldman M

    更新日期:1985-11-01 00:00:00

  • Minimally invasive surgery for spontaneous supratentorial intracerebral hemorrhage: a meta-analysis of randomized controlled trials.

    abstract:BACKGROUND AND PURPOSE:There has been a nonstandard surgical procedure and extensive international controversy in minimally invasive surgery (MIS) for the management of spontaneous supratentorial intracerebral hemorrhage. This meta-analysis assessed the effectiveness of MIS as compared with other treatment options, inc...

    journal_title:Stroke

    pub_type: 杂志文章,meta分析

    doi:10.1161/STROKEAHA.112.667535

    authors: Zhou X,Chen J,Li Q,Ren G,Yao G,Liu M,Dong Q,Guo J,Li L,Guo J,Xie P

    更新日期:2012-11-01 00:00:00

  • Continuation or Discontinuation of Anticoagulation in the Early Phase After Acute Ischemic Stroke.

    abstract:BACKGROUND AND PURPOSE:There is no consensus on whether anticoagulation should be continued or temporarily stopped in patients suffering acute ischemic stroke while using anticoagulation. We assessed treatment variations and outcomes in these patients. METHODS:Post hoc analysis of PASS (Preventive Antibiotics in Strok...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/STROKEAHA.118.021514

    authors: Groot AE,Vermeij JM,Westendorp WF,Nederkoorn PJ,van de Beek D,Coutinho JM

    更新日期:2018-07-01 00:00:00

  • Reduction in distal emboli with proximal flow control during mechanical thrombectomy: a quantitative in vitro study.

    abstract:BACKGROUND AND PURPOSE:To evaluate the impact of proximal flow control on efficacy and safety of mechanical thrombectomy in an in vitro middle cerebral artery occlusion. METHODS:Three independent variables, including clot type, device (Merci Retriever, Solitaire FR, and Trevo devices), and use of a balloon guide cathe...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/STROKEAHA.111.670463

    authors: Chueh JY,Kühn AL,Puri AS,Wilson SD,Wakhloo AK,Gounis MJ

    更新日期:2013-05-01 00:00:00

  • Addition of brain infarction to the ABCD2 Score (ABCD2I): a collaborative analysis of unpublished data on 4574 patients.

    abstract:BACKGROUND AND PURPOSE:The ABCD system was developed to predict early stroke risk after transient ischemic attack. Incorporation of brain imaging findings has been suggested, but reports have used inconsistent methods and been underpowered. We therefore performed an international, multicenter collaborative study of the...

    journal_title:Stroke

    pub_type: 杂志文章,多中心研究

    doi:10.1161/STROKEAHA.110.578971

    authors: Giles MF,Albers GW,Amarenco P,Arsava MM,Asimos A,Ay H,Calvet D,Coutts S,Cucchiara BL,Demchuk AM,Johnston SC,Kelly PJ,Kim AS,Labreuche J,Lavallee PC,Mas JL,Merwick A,Olivot JM,Purroy F,Rosamond WD,Sciolla R,Rothw

    更新日期:2010-09-01 00:00:00

  • Brain Arteriovenous Malformation Recurrence After Apparent Microsurgical Cure: Increased Risk in Children Who Present With Arteriovenous Malformation Rupture.

    abstract:BACKGROUND AND PURPOSE:Do children have an increased risk for brain arteriovenous malformation (AVM) recurrence compared with adults and does this risk vary depending on initial presentation with AVM rupture? METHODS:We retrospectively studied 115 patients initially presenting with brain AVM under age 25 years who und...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/STROKEAHA.120.030135

    authors: Copelan A,Drocton G,Caton MT,Smith ER,Cooke DL,Nelson J,Abla AA,Fox C,Amans MR,Dowd CF,Halbach VV,Higashida RT,Lawton MT,Kim H,Fullerton HJ,Gupta N,Hetts SW,UCSF Center For Cerebrovascular Research and UCSF Pediatric Br

    更新日期:2020-10-01 00:00:00

  • Drip, ship, and retrieve: cooperative recanalization therapy in acute basilar artery occlusion.

    abstract:BACKGROUND AND PURPOSE:In acute basilar artery occlusion, intra-arterial thrombolysis or endovascular mechanical recanalization may result in higher recanalization rates than intravenous thrombolysis. However, many patients are admitted to community hospitals, where endovascular therapy is usually not readily available...

    journal_title:Stroke

    pub_type: 临床试验,杂志文章

    doi:10.1161/STROKEAHA.109.567552

    authors: Pfefferkorn T,Holtmannspötter M,Schmidt C,Bender A,Pfister HW,Straube A,Mayer TE,Brückmann H,Dichgans M,Fesl G

    更新日期:2010-04-01 00:00:00

  • Blockade of ATP-sensitive potassium channels in cerebral arterioles inhibits vasoconstriction from hypocapnic alkalosis in cats.

    abstract:BACKGROUND AND PURPOSE:Recent studies have shown that the cerebral arteriolar dilation from hypercapnic acidosis is blocked by agents which inhibit KATP channels. These findings suggested that this response is due to opening of KATP channels. Because the repose to CO2 is a continuum, with hypercapnic acidosis causing v...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.30.4.851

    authors: Wei EP,Kontos HA

    更新日期:1999-04-01 00:00:00

  • Regional Comparison of Multiphase Computed Tomographic Angiography and Computed Tomographic Perfusion for Prediction of Tissue Fate in Ischemic Stroke.

    abstract:BACKGROUND AND PURPOSE:Within different brain regions, we determine the comparative value of multiphase computed tomographic angiography (mCTA) and computed tomographic perfusion (CTP) in predicting follow-up infarction. METHODS:Patients with M1-middle cerebral artery occlusions were prospectively included in this mul...

    journal_title:Stroke

    pub_type: 杂志文章,多中心研究

    doi:10.1161/STROKEAHA.116.015969

    authors: d'Esterre CD,Trivedi A,Pordeli P,Boesen M,Patil S,Hwan Ahn S,Najm M,Fainardi E,Shankar JJ,Rubiera M,Almekhlafi MA,Mandzia J,Khaw AV,Barber P,Coutts S,Hill MD,Demchuk AM,Sajobi T,Forkert ND,Goyal M,Lee TY,Menon B

    更新日期:2017-04-01 00:00:00

  • Variations in case fatality and dependency from stroke in western and central Europe. The European BIOMED Study of Stroke Care Group.

    abstract:BACKGROUND AND PURPOSE:There are significant variations in mortality rates from stroke in Europe. A European Union BIOMED Concerted Action was established to assess and determine the reasons for the variations in case fatality and disability after stroke. METHODS:Hospital-based stroke registers were established in 12 ...

    journal_title:Stroke

    pub_type: 杂志文章,多中心研究

    doi:10.1161/01.str.30.2.350

    authors: Wolfe CD,Tilling K,Beech R,Rudd AG

    更新日期:1999-02-01 00:00:00

  • Epidemiology and costs of acute hospital care for cerebrovascular disease in diabetic and nondiabetic populations.

    abstract:BACKGROUND AND PURPOSE:Little is known about the pattern of cerebrovascular disease (CVD) for diabetic and nondiabetic patients or about the cost of treatment for CVD in the United Kingdom. The purpose of this study was to extend previous work to describe the epidemiology and cost of acute care of CVD as a frequent com...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.28.6.1142

    authors: Currie CJ,Morgan CL,Gill L,Stott NC,Peters JR

    更新日期:1997-06-01 00:00:00

  • Anesthetic modulation of cerebral hemodynamic and evoked responses to transient middle cerebral artery occlusion in cats.

    abstract::We measured cerebral blood flow and somatosensory evoked potentials during transient focal cerebral ischemia in cats to compare the effects of four commonly used anesthetic regimens: ketamine/fentanyl/N2O (fentanyl), pentobarbital, ketamine/alpha-chloralose (alpha-chloralose), and ketamine/halothane/N2O (halothane). S...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.21.5.795

    authors: Helfaer MA,Kirsch JR,Traystman RJ

    更新日期:1990-05-01 00:00:00

  • Deferoxamine attenuates white matter injury in a piglet intracerebral hemorrhage model.

    abstract:BACKGROUND AND PURPOSE:Deferoxamine reduces neuronal death in a piglet model of intracerebral hemorrhage (ICH). This study examined the effect of deferoxamine on perihematomal white matter edema in piglets. METHODS:ICH was induced by an injection of autologous blood into the right frontal lobe of piglets. In the first...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/STROKEAHA.113.003033

    authors: Xie Q,Gu Y,Hua Y,Liu W,Keep RF,Xi G

    更新日期:2014-01-01 00:00:00

  • Is diabetic retinopathy an independent risk factor for ischemic stroke?

    abstract:BACKGROUND AND PURPOSE:The relationship between diabetic retinopathy and ischemic stroke is uncertain and examined in this study. METHODS:A population-based, prospective cohort study of 1617 middle-aged persons with diabetes. Diabetic retinopathy signs were ascertained from retinal photographs, and incident ischemic s...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.STR.0000254547.91276.50

    authors: Cheung N,Rogers S,Couper DJ,Klein R,Sharrett AR,Wong TY

    更新日期:2007-02-01 00:00:00