Altered endothelial Ca2+ regulation after ischemia/reperfusion produces potentiated endothelium-derived hyperpolarizing factor-mediated dilations.

abstract：BACKGROUND AND PURPOSE:The genetic basis of white matter hyperintensities (WMH) is still unknown. This study examines the heritability of WMH in both sexes and in different brain regions, and the influence of age. METHODS:Participants from the Older Australian Twins Study were recruited (n=320; 92 monozygotic and 68 d...

journal_title：Stroke

authors： Sachdev PS,Thalamuthu A,Mather KA,Ames D,Wright MJ,Wen W,OATS Collaborative Research Team.

更新日期：2016-06-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The epsilon4 allele of the apolipoprotein E (apoE) has been related to the occurrence of myocardial infarction, but its association with ischemic stroke is controversial. We have evaluated the relation between apoE alleles and the occurrence of cerebrovascular ischemia. METHODS:The apoE epsilon ...

journal_title：Stroke

authors： Margaglione M,Seripa D,Gravina C,Grandone E,Vecchione G,Cappucci G,Merla G,Papa S,Postiglione A,Di Minno G,Fazio VM

更新日期：1998-02-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Cerebral small vessel disease reflected by white matter lesions (WMLs) in MRI and kidney function reflected by estimated glomerular filtration rate (eGFR) is closely associated in patients without stroke. We studied whether eGFR and WMLs predict long-term survival in patients with acute stroke. ...

journal_title：Stroke

authors： Oksala NK,Salonen T,Strandberg T,Oksala A,Pohjasvaara T,Kaste M,Karhunen PJ,Erkinjuntti T

更新日期：2010-09-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Diffusion-weighted imaging sometimes fails to detect early computed tomography (CT) ischemic lesions in acute ischemic stroke patients, which is termed reversed discrepancy (RD), but its clinical significance remains unclear. The incidence and factors associated with RD in acute ischemic stroke p...

journal_title：Stroke

authors： Kawano H,Hirano T,Nakajima M,Inatomi Y,Yonehara T

更新日期：2013-04-01 00:00:00

abstract：:Background and Purpose- To identify the specific post-endovascular stroke therapy (EVT) peak systolic blood pressure (SBP) threshold that best discriminates good from bad functional outcomes (a priori hypothesized to be 160 mm Hg), we conducted a prospective, multicenter, cohort study with a prespecified analysis plan...

journal_title：Stroke

authors： Mistry EA,Sucharew H,Mistry AM,Mehta T,Arora N,Starosciak AK,De Los Rios La Rosa F,Siegler JE 3rd,Barnhill NR,Patel K,Assad S,Tarboosh A,Dakay K,Salwi S,Cruz AS,Wagner J,Fortuny E,Bennett A,James RF,Jagadeesan B,S

更新日期：2019-12-01 00:00:00

abstract：:U78517F is a novel inhibitor of iron-catalyzed lipid peroxidation that combines the tetramethylchroman antioxidant ring portion of alpha-tocopherol with the amine of the previously described 21-aminosteroids (e.g., U74006F). U78517F inhibited 200 microM FeCl2-initiated lipid peroxidation in rat brain homogenates by 50...

journal_title：Stroke

authors： Hall ED,Pazara KE,Braughler JM,Linseman KL,Jacobsen EJ

更新日期：1990-11-01 00:00:00

abstract：:Five patients with nonseptic cerebral embolism of cardiac origin are reported in whom early anticoagulant therapy resulted in clinical deterioration or death from frank hemorrhage into the acute infarct. In each patient an initial CT scan excluded the presence of intracerebral hemorrhage and a second CT scan, after cl...

journal_title：Stroke

authors： Shields RW Jr,Laureno R,Lachman T,Victor M

更新日期：1984-05-01 00:00:00

abstract：:Blood flow velocity of the middle cerebral artery was monitored during cardiopulmonary bypass procedures by means of transcranial Doppler ultrasonography. Our investigation was carried out in a group of 16 patients with severe carotid stenosis or occlusion and in a control group of 42 patients with no or stenosis of l...

journal_title：Stroke

authors： von Reutern GM,Hetzel A,Birnbaum D,Schlosser V

更新日期：1988-06-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Patients with carotid occlusive disease and stage 2 cerebral hemodynamic failure, characterized by an increased oxygen extraction fraction (OEF) as measured by positron emission tomography (PET) and otherwise known as misery perfusion, have a high risk of cerebral ischemia and subsequent stroke. ...

journal_title：Stroke

authors： Imaizumi M,Kitagawa K,Hashikawa K,Oku N,Teratani T,Takasawa M,Yoshikawa T,Rishu P,Ohtsuki T,Hori M,Matsumoto M,Nishimura T

更新日期：2002-09-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Autosomal dominant hypertension with brachydactyly features severe hypertension that causes stroke usually before the age of 50 years. We recently characterized the hypertension as featuring normal renin, aldosterone, and catecholamine responses and mapped the gene responsible to chromosome 12p. ...

journal_title：Stroke

authors： Naraghi R,Schuster H,Toka HR,Bähring S,Toka O,Oztekin O,Bilginturan N,Knoblauch H,Wienker TF,Busjahn A,Haller H,Fahlbusch R,Luft FC

更新日期：1997-09-01 00:00:00

abstract：BACKGROUND AND PURPOSE:If it could be determined whether cerebral blood flow can be maintained (autoregulated) during transient falls in arterial blood pressure, we might be able to identify patients with carotid stenosis who are at risk of stroke. However, conventional methods of determining autoregulation in such pat...

journal_title：Stroke

authors： White RP,Markus HS

更新日期：1997-07-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Reliable data on the risk of carotid endarterectomy (CEA) in relation to clinical indication and timing of surgery are necessary to target CEA more effectively, to inform patients, to adjust risks for case mix, and to understand the mechanisms of operative stroke. METHODS:We performed a systemat...

journal_title：Stroke

authors： Bond R,Rerkasem K,Rothwell PM

更新日期：2003-09-01 00:00:00

abstract：:Background and Purpose- Emergency medical services (EMSs) are critical for early treatment of patients with ischemic stroke, yet data on EMS utilization and its association with timely treatment in China are still limited. Methods- We examined data from the Chinese Stroke Center Alliance for patients with ischemic str...

journal_title：Stroke

authors： Gu HQ,Rao ZZ,Yang X,Wang CJ,Zhao XQ,Wang YL,Liu LP,Wang CY,Liu C,Li H,Li ZX,Xiao RP,Wang YJ,Chinese Stroke Center Alliance Investigators.

更新日期：2019-04-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Hemorrhagic conversion after tissue plasminogen activator (tPA) stroke therapy has been linked with elevations in matrix metalloproteinase-9 (MMP-9) at the neurovascular interface. Here, we test the idea that statins may directly ameliorate tPA-induced MMP-9 dysregulation. METHODS:Recombinant hu...

journal_title：Stroke

authors： Wang S,Lee SR,Guo SZ,Kim WJ,Montaner J,Wang X,Lo EH

更新日期：2006-07-01 00:00:00

abstract：:The intact omentum of 13 monkeys was lengthened, placed subcutaneously, and laid on the left cerebral hemisphere prior to occluding the left middle cerebral artery. Two of these 13 monkeys developed left cerebral infarct and a right hemiparesis. Nine other monkeys had their left middle cerebral artery occluded without...

journal_title：Stroke

authors： Goldsmith HS,Duckett S,Chen WF

更新日期：1978-05-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The CHA2DS2-VASc score aims to improve risk stratification of ischemic stroke among patients with atrial fibrillation to identify those who can safely forego oral anticoagulation. Oral anticoagulation treatment guidelines remain uncertain for CHA2DS2-VASc score of 1. We conducted a systematic rev...

journal_title：Stroke

authors： Joundi RA,Cipriano LE,Sposato LA,Saposnik G,Stroke Outcomes Research Working Group.

更新日期：2016-05-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Coffee consumption has been inconsistently associated with stroke incidence and mortality in previous studies. We investigated the association between coffee consumption and stroke incidence in the Swedish Mammography Cohort. METHODS:We prospectively followed of 34,670 women without a history of...

journal_title：Stroke

authors： Larsson SC,Virtamo J,Wolk A

更新日期：2011-04-01 00:00:00

abstract：BACKGROUND AND PURPOSE:To clarify hemodynamic risk factors for hemorrhage in arteriovenous malformations (AVMs), the mean transit time (MTT) of feeding arteries and draining veins in AVMs with and without hemorrhage was measured and analyzed. METHODS:Morphological features such as the number and diameter of draining a...

journal_title：Stroke

authors： Todaka T,Hamada J,Kai Y,Morioka M,Ushio Y

更新日期：2003-10-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Brain injury caused by stroke is a frequent cause of perinatal morbidity and mortality with limited therapeutic options. Mesenchymal stem cells (MSC) have been shown to improve outcome after neonatal hypoxic-ischemic brain injury mainly by secretion of growth factors stimulating repair processes....

journal_title：Stroke

authors： van Velthoven CT,Sheldon RA,Kavelaars A,Derugin N,Vexler ZS,Willemen HL,Maas M,Heijnen CJ,Ferriero DM

更新日期：2013-05-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The diagnosis and quantification of microangiopathy in dementia is difficult. The assessment of small-vessel disease requires expensive and sophisticated nuclear medicine techniques. This study was performed to identify microangiopathy related to the integrity of cerebral microcirculation by sono...

journal_title：Stroke

authors： Puls I,Hauck K,Demuth K,Horowski A,Schliesser M,Dörfler P,Scheel P,Toyka KV,Reiners K,Schöning M,Becker G

更新日期：1999-11-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Treatment of cerebral sinus thrombosis with heparin is controversial. We conducted a double-blind, placebo-controlled multicenter trial to examine whether anticoagulant treatment improves outcome in patients with sinus thrombosis. METHODS:Patients were randomized between body weight-adjusted sub...

journal_title：Stroke

authors： de Bruijn SF,Stam J

更新日期：1999-03-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The association between minor ST-T abnormalities and stroke incidence has not been well elucidated. We sought to examine the relationship between nonspecific minor or major ST-T abnormalities and the incidence of stroke among Japanese men and women. METHODS:A 15.4-year prospective study was cond...

journal_title：Stroke

authors： Ohira T,Iso H,Imano H,Kitamura A,Sato S,Nakagawa Y,Naito Y,Sankai T,Tanigawa T,Yamagishi K,Iida M,Shimamoto T

更新日期：2003-12-01 00:00:00

abstract：:Background and Purpose- Preterm neonates with intraventricular hemorrhage (IVH) are at risk for posthemorrhagic hydrocephalus and poor neurological outcomes. Iron has been implicated in ventriculomegaly, hippocampal injury, and poor outcomes following IVH. We hypothesized that levels of cerebrospinal fluid blood break...

journal_title：Stroke

authors： Mahaney KB,Buddhala C,Paturu M,Morales D,Limbrick DD Jr,Strahle JM

更新日期：2020-06-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Little is known about high-signal lesions in magnetic resonance diffusion-weighted imaging (DWI [+]) after stenting for intracranial atherosclerotic stenosis. This study aimed to evaluate the incidence, distribution, risk factors, and clinical implications of DWI (+) after intracranial stenting. ...

journal_title：Stroke

authors： Park KY,Kim BM,Kim DJ,Kim DI,Heo JH,Nam HS,Kim YD,Song D

更新日期：2014-11-01 00:00:00

abstract：:Background and Purpose- Aneurysmal subarachnoid hemorrhage (aSAH) has a high healthcare cost burden. Methods- We performed a cross-sectional analysis of the costs of clipping and coiling of aSAH using the National Inpatient Sample and Vizient databases. We conducted multiple regression analyses to estimate national co...

journal_title：Stroke

authors： Yoon S,Yoon JC,Winkler E,Liu C,Lawton MT

更新日期：2018-12-03 00:00:00

abstract：BACKGROUND AND PURPOSE:Stroke education, 1 of 8 endorsed stroke performance measures, consists of 5 specific subcomponents: risk factors, stroke warning signs, emergency medical service activation, physician follow-up, and discharge medications. We identified predictors of stroke education performance measure complianc...

journal_title：Stroke

authors： Nickles A,Fiedler J,Roberts S,Lyon-Callo S,Hurst R,Reeves M

更新日期：2013-05-01 00:00:00

abstract：BACKGROUND:Diffusion-weighted MRI (DWI) and perfusion-weighted MRI (PWI) are new techniques that can be used for the evaluation of acute ischemic stroke. However, their potential role in the management of patients treated with recombinant tissue plasminogen activator (rtPA) has yet to be determined. CASE DESCRIPTION:T...

journal_title：Stroke

authors： Lansberg MG,Tong DC,Norbash AM,Yenari MA,Moseley ME

更新日期：1999-03-01 00:00:00

abstract：:Background and Purpose- Although intracellular zinc accumulation has been shown to contribute to neuronal death after cerebral ischemia, the mechanism by which zinc keeps on accumulating to cause severe brain damage remains unclear. Herein the dynamic cause-effect relationships between zinc accumulation and reactive o...

journal_title：Stroke

authors： Zhao Y,Yan F,Yin J,Pan R,Shi W,Qi Z,Fang Y,Huang Y,Li S,Luo Y,Ji X,Liu KJ

更新日期：2018-09-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The limited walking ability that follows a stroke restricts the patient's independent mobility about the home and community, a significant social handicap. To improve the in-hospital prediction of functional outcome, the relationships between impairment, disability, and handicap were assessed wit...

journal_title：Stroke

authors： Perry J,Garrett M,Gronley JK,Mulroy SJ

更新日期：1995-06-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Outcome after acute stroke is determined to a large extent by poststroke complications. Nutritional status and metabolic balance may substantially contribute to outcome after stroke. Key mechanisms of stroke pathophysiology can induce systemic catabolic imbalance with impaired metabolic efficienc...

journal_title：Stroke

authors： Scherbakov N,Dirnagl U,Doehner W

更新日期：2011-12-01 00:00:00