Abstract:
:To determine the efficacy of calcium channel blockers in preserving neurologic function after central nervous system ischemia, we studied three such agents in two animal models. We treated rabbits after inducing ischemia in the brain with intra-arterial microspheres and in the spinal cord using a removable aortic occluding device. We found no benefit, in terms of neurologic functional outcome, from lidoflazine, nimodipine, or nicardipine. All three agents elevated regional blood flow in the spinal cord. We conclude that calcium antagonists are not likely to prove beneficial if used alone in the treatment of focal central nervous system ischemia.
journal_name
Strokejournal_title
Strokeauthors
Lyden PD,Zivin JA,Kochhar A,Mazzarella Vdoi
10.1161/01.str.19.8.1020subject
Has Abstractpub_date
1988-08-01 00:00:00pages
1020-6issue
8eissn
0039-2499issn
1524-4628journal_volume
19pub_type
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