Abstract:
BACKGROUND AND PURPOSE:Deferoxamine reduces neuronal death in a piglet model of intracerebral hemorrhage (ICH). This study examined the effect of deferoxamine on perihematomal white matter edema in piglets. METHODS:ICH was induced by an injection of autologous blood into the right frontal lobe of piglets. In the first part of study, the time course of edema formation was determined. In the second part, the effects of deferoxamine on ICH-induced white matter edema, tumor necrosis factor α, and receptor-interacting protein kinase 1 were examined. RESULTS:ICH resulted in marked brain edema and increased tumor necrosis factor α and receptor-interacting protein kinase 1 levels in white matter. Systemic treatment with deferoxamine markedly reduced white matter tumor necrosis factor α and receptor-interacting protein kinase 1 levels and attenuated white matter edema after ICH. CONCLUSIONS:Deferoxamine reduces white matter edema, tumor necrosis factor α, and receptor-interacting protein kinase 1 levels after ICH in piglets, suggesting deferoxamine is a potential effective therapeutic agent for patients with ICH.
journal_name
Strokejournal_title
Strokeauthors
Xie Q,Gu Y,Hua Y,Liu W,Keep RF,Xi Gdoi
10.1161/STROKEAHA.113.003033subject
Has Abstractpub_date
2014-01-01 00:00:00pages
290-2issue
1eissn
0039-2499issn
1524-4628pii
STROKEAHA.113.003033journal_volume
45pub_type
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