Preliminary findings of external counterpulsation for ischemic stroke patient with large artery occlusive disease.

Abstract:

BACKGROUND AND PURPOSE:We aimed to investigate the feasibility and therapeutic effect of external counterpulsation (ECP) in ischemic stroke. METHODS:The trial was a randomized, crossover, assessment-blinded, proof-of-concept trial. ECP treatment consisted of 35 daily 1-hour sessions. Patients were randomized to either early (ECP weeks 1 to 7 and no ECP weeks 8 to 14) or late group (no ECP weeks 1 to 7 and ECP weeks 8 to 14). Primary outcomes were an overall change in National Institutes of Health Stroke Scale (NIHSS) and cerebral blood flow estimated by color velocity imaging quantification. Secondary outcomes were change in NIHSS, color velocity imaging quantification, favorable functional outcome (modified Rankin scale, 0 to 2), and stroke recurrence at weeks 7 and 14, respectively. RESULTS:Fifty patients were recruited. At week 7, there was a significant change in NIHSS (early 3.5 vs late 1.9; P=0.042). After adjusting for treatment sequence, ECP was associated with a favorable trend of change in NIHSS of 2.1 vs 1.3 for non-ECP (P=0.061). Changes of color velocity imaging quantification were not significant but tended to increase with ECP. At week 14, a favorable functional outcome was found in 100% of early group patients compared to 76% in the late group (P=0.022). CONCLUSIONS:ECP is feasible for ischemic stroke patients with larger artery disease.

journal_name

Stroke

journal_title

Stroke

authors

Han JH,Leung TW,Lam WW,Soo YO,Alexandrov AW,Mok V,Leung YF,Lo R,Wong KS

doi

10.1161/STROKEAHA.107.500132

subject

Has Abstract

pub_date

2008-04-01 00:00:00

pages

1340-3

issue

4

eissn

0039-2499

issn

1524-4628

pii

STROKEAHA.107.500132

journal_volume

39

pub_type

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