当前位置： SCI文献检索 > STROKE期刊下所有文献 > A comparison of acute hemorrhagic stroke outcomes in 2 populations: the Crete-Boston study.

A comparison of acute hemorrhagic stroke outcomes in 2 populations: the Crete-Boston study.

Abstract：

BACKGROUND AND PURPOSE:Although corticosteroid use in acute hemorrhagic stroke is not widely adopted, management with intravenous dexamethasone has been standard of care at the University Hospital of Heraklion, Crete with observed outcomes superior to those reported in the literature. To explore this further, we conducted a retrospective, multivariable-adjusted 2-center study. METHODS:We studied 391 acute hemorrhagic stroke cases admitted to the University Hospital of Heraklion, Crete between January 1997 and July 2010 and compared them with 510 acute hemorrhagic stroke cases admitted to Massachusetts General Hospital, Boston, from January 2003 to September 2009. Of the Cretan cases, 340 received a tapering scheme of intravenous dexamethasone, starting with 16 to 32 mg/day, whereas the Boston patients were managed without steroids. RESULTS:The 2 cohorts had comparable demographics and stroke severity on admission, although anticoagulation was more frequent in Boston. The in-hospital mortality was significantly lower on Crete (23.8%, n=340) than in Boston (38.0%, n=510; P<0.001) as was the 30-day mortality (Crete: 25.4%, n=307; Boston: 39.4%, n=510; P<0.001). Exclusion of patients on anticoagulants showed even greater differences (30-day mortality: Crete 20.8%; n=259; Boston 37.0%; n=359; P<0.001). The improved survival on Crete was observed 3 days after initiation of intravenous dexamethasone and was pronounced for deep-seated hemorrhages. After adjusting for acute hemorrhagic stroke volume/location, Glasgow Coma Scale, hypertension, diabetes mellitus, smoking, coronary artery disease and statin, antiplatelet, and anticoagulant use, intravenous dexamethasone treatment was associated with better functional outcomes and significantly lower risk of death at 30 days (OR, 0.357; 95% CI, 0.174-0.732). CONCLUSIONS:This study suggests that intravenous dexamethasone improves outcome in acute hemorrhagic stroke and supports a randomized clinical trial using this approach.

journal_name

Stroke

journal_title

Stroke

authors

Zaganas I,Halpin AP,Oleinik A,Alegakis A,Kotzamani D,Zafiris S,Chlapoutaki C,Tsimoulis D,Giannakoudakis E,Chochlidakis N,Ntailiani A,Valatsou C,Papadaki E,Vakis A,Furie KL,Greenberg SM,Plaitakis A

doi

10.1161/STROKEAHA.111.632174

subject

Has Abstract

pub_date

2011-12-01 00:00:00

pages

3640-2

issue

12

eissn

0039-2499

issn

1524-4628

pii

STROKEAHA.111.632174

journal_volume

42

pub_type

杂志文章,多中心研究

相关文献

STROKE文献大全
  • Revised Framingham Stroke Risk Score, Nontraditional Risk Markers, and Incident Stroke in a Multiethnic Cohort.

    abstract：BACKGROUND AND PURPOSE:Limited data exist on the performance of the revised Framingham Stroke Risk Score (R-FSRS) and the R-FSRS in conjunction with nontraditional risk markers. We compared the R-FSRS, original FSRS, and the Pooled Cohort Equation for stroke prediction and assessed the improvement in discrimination by ...

    journal_title：Stroke

    pub_type： 杂志文章

    doi：10.1161/STROKEAHA.117.018928

    authors： Flueckiger P,Longstreth W,Herrington D,Yeboah J

    更新日期：2018-02-01 00:00:00

  • Endogenous platelet activating factor does not modulate blood flow and metabolism in normal rat brain.

    abstract：:Both platelet activating factor and eicosanoids participate in the cerebrovascular response to ischemia. Eicosanoids also modulate cerebrovascular tone under normal physiologic circumstances, but a similar role for platelet activating factor has not been investigated. Therefore, using 16 rats, we studied the effects o...

    journal_title：Stroke

    pub_type： 杂志文章

    doi：10.1161/01.str.21.3.459

    authors： Kochanek PM,Melick JA,Schoettle RJ,Magargee MJ,Evans RW,Nemoto EM

    更新日期：1990-03-01 00:00:00

  • Occurrence and Predictors of Falls in People With Stroke: Six-Year Prospective Study.

    abstract：BACKGROUND AND PURPOSE:The purpose was to investigate the occurrence of self-reported falls in people with stroke at 3, 6, and 12 months and 6 years post stroke and predictors for falls during 6 years. METHODS:A prospective study involving 121 people with stroke. Data were obtained through structured interviews and as...

    journal_title：Stroke

    pub_type： 杂志文章

    doi：10.1161/STROKEAHA.115.010496

    authors： Minet LR,Peterson E,von Koch L,Ytterberg C

    更新日期：2015-09-01 00:00:00

  • Hemostatic therapy in experimental intracerebral hemorrhage associated with the direct thrombin inhibitor dabigatran.

    abstract：BACKGROUND AND PURPOSE:Dabigatran-etexilate (DE) recently has been approved for stroke prevention in atrial fibrillation. However, lack of effective antagonists represents a major concern in the event of intracerebral hemorrhage (ICH). The aims of the present study were to establish a murine model of ICH associated wit...

    journal_title：Stroke

    pub_type： 杂志文章

    doi：10.1161/STROKEAHA.111.624650

    authors： Zhou W,Schwarting S,Illanes S,Liesz A,Middelhoff M,Zorn M,Bendszus M,Heiland S,van Ryn J,Veltkamp R

    更新日期：2011-12-01 00:00:00

  • Relation of laboratory and clinical variables to the grade of carotid atherosclerosis.

    abstract：BACKGROUND AND PURPOSE:To clarify diagnostic entities in ischemic stroke we analyzed the relation between the severity of carotid atherosclerosis, coagulation parameters, lipoproteins, neurological status, and risk factors in 232 patients. METHODS:Duplex ultrasonography, computed tomography scan, and laboratory invest...

    journal_title：Stroke

    pub_type： 杂志文章

    doi：10.1161/01.str.24.12.1811

    authors： Szirmai IG,Kamondi A,Magyar H,Juhász C

    更新日期：1993-12-01 00:00:00

  • Association of plasma homocysteine concentration with atherosclerotic carotid plaques and lacunar infarction.

    abstract：BACKGROUND AND PURPOSE:Higher plasma total homocysteine (tHcy) levels have been associated with carotid atherosclerosis and cerebral infarction in whites. However, data regarding such associations are limited for Asians. This study examined associations between tHcy levels and severity of carotid atherosclerosis in Jap...

    journal_title：Stroke

    pub_type： 杂志文章

    doi：10.1161/01.str.0000016463.01398.d0

    authors： Sasaki T,Watanabe M,Nagai Y,Hoshi T,Takasawa M,Nukata M,Taguchi A,Kitagawa K,Kinoshita N,Matsumoto M

    更新日期：2002-06-01 00:00:00

  • Longitudinal study of regional cerebral blood flow changes in depression after stroke.

    abstract：BACKGROUND:We studied 60 patients longitudinally to examine relations between regional cerebral blood flow and depressive states after stroke. METHODS:Poststroke depressive states were assessed by the Zung Self-Rating Depression Scale (SDS). Regional cerebral blood flow was measured using the 133xenon inhalation metho...

    journal_title：Stroke

    pub_type： 杂志文章

    doi：10.1161/01.str.23.12.1716

    authors： Yamaguchi S,Kobayashi S,Koide H,Tsunematsu T

    更新日期：1992-12-01 00:00:00

  • Late stroke: comparison of percutaneous coronary intervention versus coronary artery bypass grafting in patients with multivessel disease and unprotected left main disease: a meta-analysis and review of literature.

    abstract：BACKGROUND AND PURPOSE:Studies have suggested that the early excess risk of stroke in coronary artery bypass grafting (CABG) may be compensated for by a slow but progressive catch-up phenomenon in patients undergoing percutaneous coronary intervention (PCI). We therefore undertook this analysis to compare the temporal ...

    journal_title：Stroke

    pub_type： 杂志文章,meta分析,评审

    doi：10.1161/STROKEAHA.113.003323

    authors： Athappan G,Chacko P,Patvardhan E,Gajulapalli RD,Tuzcu EM,Kapadia SR

    更新日期：2014-01-01 00:00:00

  • Early recurrent embolism associated with nonvalvular atrial fibrillation: a retrospective study.

    abstract：:Nonvalvular atrial fibrillation (NVAF) can be a source of cardiogenic brain embolism. We retrospectively reviewed the clinical features of 56 patients with acute brain infarction and NVAF. Based on clinical criteria, 35 infarcts (63%) were classified as probably embolic, 13 infarcts (23%) as probably nonembolic and 8 ...

    journal_title：Stroke

    pub_type： 杂志文章

    doi：10.1161/01.str.14.5.688

    authors： Hart RG,Coull BM,Hart D

    更新日期：1983-09-01 00:00:00

  • Use of a decibel threshold in detecting Doppler embolic signals.

    abstract：BACKGROUND AND PURPOSE:To improve reproducibility and reliability in the identification of embolic signals detected with the use of Doppler ultrasound, many studies have used an intensity threshold. However, variable thresholds between 3 and 12 dB have been used, and often the method of measurement of intensity is not ...

    journal_title：Stroke

    pub_type： 杂志文章

    doi：10.1161/01.str.28.4.692

    authors： Markus HS,Molloy J

    更新日期：1997-04-01 00:00:00

  • Heritability of carotid artery distensibility in Hispanics: the Northern Manhattan Family Study.

    abstract：BACKGROUND AND PURPOSE:Reduced arterial distensibility has been introduced as a novel risk factor for atherosclerosis. The importance of the genetic contribution to variation in distensibility is largely unknown. The purpose of this study was to estimate heritability of carotid distensibility. METHODS:The ongoing Nort...

    journal_title：Stroke

    pub_type： 杂志文章

    doi：10.1161/01.STR.0000185926.05011.72

    authors： Juo SH,Rundek T,Lin HF,Cheng R,Lan MY,Huang JS,Boden-Albala B,Sacco RL

    更新日期：2005-11-01 00:00:00

  • Grading scale for prediction of outcome in primary intracerebral hemorrhages.

    abstract：BACKGROUND AND PURPOSE:This study aimed to independently derive an intracerebral hemorrhage grading scale (ICH-GS) for prediction of 3 outcome measures. METHODS:We evaluated 378 patients with primary ICH at hospital arrival and during the next 30 days. Independent predictors were identified by multivariate models of i...

    journal_title：Stroke

    pub_type： 杂志文章

    doi：10.1161/STROKEAHA.106.478222

    authors： Ruiz-Sandoval JL,Chiquete E,Romero-Vargas S,Padilla-Martínez JJ,González-Cornejo S

    更新日期：2007-05-01 00:00:00

  • Factors Associated With Time to Site Activation, Randomization, and Enrollment Performance in a Stroke Prevention Trial.

    abstract：BACKGROUND AND PURPOSE:Multicenter clinical trials attempt to select sites that can move rapidly to randomization and enroll sufficient numbers of patients. However, there are few assessments of the success of site selection. METHODS:In the CREST-2 (Carotid Revascularization and Medical Management for Asymptomatic Car...

    journal_title：Stroke

    pub_type： 杂志文章

    doi：10.1161/STROKEAHA.117.016976

    authors： Demaerschalk BM,Brown RD Jr,Roubin GS,Howard VJ,Cesko E,Barrett KM,Longbottom ME,Voeks JH,Chaturvedi S,Brott TG,Lal BK,Meschia JF,Howard G,CREST-2 Investigators.

    更新日期：2017-09-01 00:00:00

  • Ambient fine particulate matter alters cerebral hemodynamics in the elderly.

    abstract：BACKGROUND AND PURPOSE:Short-term elevations in fine particulate matter air pollution (PM2.5) are associated with increased risk of acute cerebrovascular events. Evidence from the peripheral circulation suggests that vascular dysfunction may be a central mechanism. However, the effects of PM2.5 on cerebrovascular funct...

    journal_title：Stroke

    pub_type： 杂志文章

    doi：10.1161/STROKEAHA.111.000395

    authors： Wellenius GA,Boyle LD,Wilker EH,Sorond FA,Coull BA,Koutrakis P,Mittleman MA,Lipsitz LA

    更新日期：2013-06-01 00:00:00

  • Copeptin for the prediction of recurrent cerebrovascular events after transient ischemic attack: results from the CoRisk study.

    abstract：BACKGROUND AND PURPOSE:Copeptin has been associated with recurrent cerebrovascular events after transient ischemic attack (TIA). In an independent cohort, we evaluated copeptin for the prediction of recurrent cerebrovascular events within 3 months after TIA and assessed the incremental value of copeptin compared with t...

    journal_title：Stroke

    pub_type： 临床试验,杂志文章,多中心研究

    doi：10.1161/STROKEAHA.114.005584

    authors： De Marchis GM,Weck A,Audebert H,Benik S,Foerch C,Buhl D,Schuetz P,Jung S,Seiler M,Morgenthaler NG,Mattle HP,Mueller B,Christ-Crain M,Arnold M,Katan M

    更新日期：2014-10-01 00:00:00

  • Sonographic monitoring of midline shift in space-occupying stroke: an early outcome predictor.

    abstract：BACKGROUND AND PURPOSE:Transcranial color-coded duplex sonography (TCCS) allows bedside imaging of intracranial hemodynamics and parenchymal structures. It provides reliable information regarding midline shift (MLS) in space-occupying hemispheric stroke. We studied the value of MLS measurement to predict fatal outcome ...

    journal_title：Stroke

    pub_type： 临床试验,杂志文章

    doi：10.1161/01.str.32.2.442

    authors： Gerriets T,Stolz E,König S,Babacan S,Fiss I,Jauss M,Kaps M

    更新日期：2001-02-01 00:00:00

  • Cerebral hypoperfusion generates cortical watershed microinfarcts in Alzheimer disease.

    abstract：BACKGROUND AND PURPOSE:The watershed cortical areas are the first to be deprived of sufficient blood flow in the event of cerebral hypoperfusion and will be the sites of watershed microinfarcts. Cerebral hypoperfusion is associated with Alzheimer disease (AD), but information regarding the occurrence of watershed corti...

    journal_title：Stroke

    pub_type： 杂志文章

    doi：10.1161/01.str.0000024523.82311.77

    authors： Suter OC,Sunthorn T,Kraftsik R,Straubel J,Darekar P,Khalili K,Miklossy J

    更新日期：2002-08-01 00:00:00

  • Perinatal nicotine exposure increases vulnerability of hypoxic-ischemic brain injury in neonatal rats: role of angiotensin II receptors.

    abstract：BACKGROUND AND PURPOSE:Maternal cigarette smoking increases the risk of neonatal morbidity. We tested the hypothesis that perinatal nicotine exposure causes heightened brain vulnerability to hypoxic-ischemic (HI) injury in neonatal rats through aberrant expression patterns of angiotensin II type 1 (AT(1)R) and type 2 (...

    journal_title：Stroke

    pub_type： 杂志文章

    doi：10.1161/STROKEAHA.112.664698

    authors： Li Y,Xiao D,Dasgupta C,Xiong F,Tong W,Yang S,Zhang L

    更新日期：2012-09-01 00:00:00

  • Isolated and borderline isolated systolic hypertension relative to long-term risk and type of stroke: a 20-year follow-up of the national health and nutrition survey.

    abstract：BACKGROUND AND PURPOSE:Although the short-term risks of stroke and types of stroke associated with isolated systolic hypertension (ISH) and borderline isolated systolic hypertension (BISH) have been described, the long-term effects of these hypertensive conditions, particularly in younger individuals, are unclear. We p...

    journal_title：Stroke

    pub_type： 杂志文章

    doi：10.1161/01.str.0000039402.05613.0f

    authors： Qureshi AI,Suri MF,Mohammad Y,Guterman LR,Hopkins LN

    更新日期：2002-12-01 00:00:00

  • Assessment of cerebral autoregulation using carotid artery compression.

    abstract：BACKGROUND AND PURPOSE:A simple method of testing cerebral autoregulation by observing transcranial Doppler changes in middle cerebral artery flow velocity (FV) during a brief ipsilateral carotid artery compression (the transient hyperemic response test) was studied in 11 normal healthy volunteers. The aim of this stud...

    journal_title：Stroke

    pub_type： 杂志文章

    doi：10.1161/01.str.27.12.2197

    authors： Smielewski P,Czosnyka M,Kirkpatrick P,McEroy H,Rutkowska H,Pickard JD

    更新日期：1996-12-01 00:00:00

  • Lung function as a risk factor for subarachnoid hemorrhage: a prospective cohort study.

    abstract：BACKGROUND AND PURPOSE:The etiology of subarachnoid hemorrhage (SAH) is poorly understood. Reduced lung function, expressed as low forced expiratory volume in 1 second (FEV(1)) and low forced vital capacity (FVC), is a predictor of cardiovascular disease, but whether reduced lung function is a risk factor for SAH is no...

    journal_title：Stroke

    pub_type： 杂志文章

    doi：10.1161/STROKEAHA.112.658427

    authors： Söderholm M,Zia E,Hedblad B,Engström G

    更新日期：2012-10-01 00:00:00

  • Association of intraoperative transcranial doppler monitoring variables with stroke from carotid endarterectomy.

    abstract：BACKGROUND AND PURPOSE:The outcomes of carotid endarterectomy (CEA) are, in addition to patient baseline characteristics, highly dependent on the safety of the surgical procedure. During the successive stages of the operation, transcranial Doppler (TCD) monitoring of the middle cerebral artery (MCA) was used to assess ...

    journal_title：Stroke

    pub_type： 杂志文章,多中心研究

    doi：10.1161/01.str.31.8.1817

    authors： Ackerstaff RG,Moons KG,van de Vlasakker CJ,Moll FL,Vermeulen FE,Algra A,Spencer MP

    更新日期：2000-08-01 00:00:00

  • Rupture of the internal elastic lamina and vascular fragility in stroke-prone spontaneously hypertensive rats.

    abstract：:We studied a possible relation between stroke and an enhanced susceptibility to rupture of the arterial internal elastic lamina by comparing stroke-prone spontaneously hypertensive rats with spontaneously hypertensive rats, which have a very low incidence of stroke. We quantified interruptions in the internal elastic ...

    journal_title：Stroke

    pub_type： 杂志文章

    doi：10.1161/01.str.22.4.510

    authors： Coutard M,Osborne-Pellegrin M

    更新日期：1991-04-01 00:00:00

  • Do Clinicians Overestimate the Severity of Intracerebral Hemorrhage?

    abstract：:Background and Purpose- Intracerebral hemorrhage (ICH) has a poorer prognosis than acute ischemic stroke (AIS). However, clinician perception of prognosis may influence treatment decisions and adversely affect outcome. On acute CT, the conspicuity of ICH compared with AIS may lead clinicians to overestimate severity a...

    journal_title：Stroke

    pub_type： 杂志文章

    doi：10.1161/STROKEAHA.118.022606

    authors： Tilling EJ,El Tawil S,Muir KW

    更新日期：2019-02-01 00:00:00

  • Evidence for embolization from a posterior cerebral artery thrombus by transcranial Doppler monitoring.

    abstract：BACKGROUND:Transcranial Doppler monitoring enables the detection of emboli passing through intracranial arteries. Comparison of the different intracranial vessels with respect to emboli detection can be of use in identifying the source of embolism. CASE DESCRIPTION:We report the case of a patient with an acute posteri...

    journal_title：Stroke

    pub_type： 杂志文章

    doi：10.1161/01.str.24.4.606

    authors： Diehl RR,Sliwka U,Rautenberg W,Schwartz A

    更新日期：1993-04-01 00:00:00

  • Does acupuncture improve motor recovery after stroke? A meta-analysis of randomized controlled trials.

    abstract：BACKGROUND AND PURPOSE:Acupuncture may be a promising treatment for poststroke paralysis. We conducted a meta-analysis, assessing the efficacy of acupuncture with and without stroke rehabilitation. METHODS:We identified randomized trials comparing acupuncture with no acupuncture within 6 months of stroke by searching ...

    journal_title：Stroke

    pub_type： 杂志文章,meta分析

    doi：10.1161/01.str.0000035908.74261.c9

    authors： Sze FK,Wong E,Or KK,Lau J,Woo J

    更新日期：2002-11-01 00:00:00

  • Linkage of ischemic stroke to the PDE4D region on 5q in a Swedish population.

    abstract：BACKGROUND AND PURPOSE:Recent Icelandic studies have demonstrated linkage for common forms of stroke to chromosome 5q12 and association between phosphodiesterase4D (PDE4D) and ischemic stroke. Using a candidate region approach, we wanted to test the validity of these findings in a different population from northern Swe...

    journal_title：Stroke

    pub_type： 杂志文章

    doi：10.1161/01.STR.0000174188.04716.8d

    authors： Nilsson-Ardnor S,Wiklund PG,Lindgren P,Nilsson AK,Janunger T,Escher SA,Hallbeck B,Stegmayr B,Asplund K,Holmberg D

    更新日期：2005-08-01 00:00:00

  • Early assessments of dysphagia and aspiration risk in acute stroke patients.

    abstract：BACKGROUND AND PURPOSE:Dysphagia is common after stroke and is a marker of poor prognosis. Early identification is important. This article reviews the merits and limitations of various assessment methods available to clinicians. METHODS:An electronic database search was performed of MEDLINE, EMBASE, and the Cochrane d...

    journal_title：Stroke

    pub_type： 杂志文章,评审

    doi：10.1161/01.STR.0000066309.06490.B8

    authors： Ramsey DJ,Smithard DG,Kalra L

    更新日期：2003-05-01 00:00:00

  • Nicardipine reduces calcium accumulation and electrolyte derangements in regional cerebral ischemia in rats.

    abstract：:We studied the effects of the calcium channel blocker nicardipine on regional tissue Ca2+, Na+, K+, and water shifts in the brains of seven Sprague-Dawley rats after permanent occlusions of the middle cerebral artery. We also assessed the entry of [14C]nicardipine into the brains of five rats; the highest concentratio...

    journal_title：Stroke

    pub_type： 杂志文章

    doi：10.1161/01.str.19.9.1125

    authors： Hadani M,Young W,Flamm ES

    更新日期：1988-09-01 00:00:00

  • Relation of coronary atherosclerosis and apolipoprotein E genotypes in Alzheimer patients.

    abstract：BACKGROUND AND PURPOSE:Apolipoprotein E (apoE) epsilon 4 allele has been associated with a high risk for coronary heart disease. Increased frequency of the epsilon 4 allele has also been reported in patients with late-onset familial and sporadic Alzheimer's disease (AD). The aim of this study was to investigate the deg...

    journal_title：Stroke

    pub_type： 杂志文章

    doi：10.1161/01.str.26.5.743

    authors： Kosunen O,Talasniemi S,Lehtovirta M,Heinonen O,Helisalmi S,Mannermaa A,Paljärvi L,Ryynänen M,Riekkinen PJ Sr,Soininen H

    更新日期：1995-05-01 00:00:00