Cerebral oxygen metabolism and neuronal integrity in patients with impaired vasoreactivity attributable to occlusive carotid artery disease.

abstract：BACKGROUND AND PURPOSE:Stroke is the leading cause of disability in the Western world; however, few therapies are at hand to decrease this burden. SUMMARY OF REVIEW:Endothelial progenitor cells (EPCs) have been introduced in cardiovascular medicine as factotums. EPCs can repair damaged endothelium and attenuate the de...

journal_title：Stroke

authors： Rouhl RP,van Oostenbrugge RJ,Damoiseaux J,Tervaert JW,Lodder J

更新日期：2008-07-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The objective of this study was to determine the clinical features, angiographic findings, and response to treatment with thrombolytic therapy in patients with ischemic stroke caused by acute occlusion of the distal internal carotid artery. METHODS:This is a retrospective case series from a pros...

journal_title：Stroke

authors： Zaidat OO,Suarez JI,Santillan C,Sunshine JL,Tarr RW,Paras VH,Selman WR,Landis DM

更新日期：2002-07-01 00:00:00

abstract：:Various concentrations of acetylcholine (ACh) produced dose dependent relaxations of isolated, helical preparations of human cerebral arteries and these responses were blocked by atropine. The median effective concentration (EC50) of ACh was 6.1 +/- 0.2 X 10(-6)M. ACh produced dual responses in isolated dog cerebral a...

journal_title：Stroke

authors： Tsukahara T,Usui H,Taniguchi T,Shimohama S,Fujiwara M,Handa H

更新日期：1986-03-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Dabigatran-etexilate (DE) recently has been approved for stroke prevention in atrial fibrillation. However, lack of effective antagonists represents a major concern in the event of intracerebral hemorrhage (ICH). The aims of the present study were to establish a murine model of ICH associated wit...

journal_title：Stroke

authors： Zhou W,Schwarting S,Illanes S,Liesz A,Middelhoff M,Zorn M,Bendszus M,Heiland S,van Ryn J,Veltkamp R

更新日期：2011-12-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The cerebral vasodilating effect of acetazolamide (ACZ) injection has been used as an index of the autoregulatory vasodilation (or cerebral perfusion reserve). The question of whether the ACZ test assesses the maximal autoregulatory vasodilating capacity is not definitely resolved. The effects of...

journal_title：Stroke

authors： Démolis P,Florence G,Thomas L,Tran Dinh YR,Giudicelli JF,Seylaz J,Alkayed NJ

更新日期：2000-02-01 00:00:00

abstract：:Five patients with nonseptic cerebral embolism of cardiac origin are reported in whom early anticoagulant therapy resulted in clinical deterioration or death from frank hemorrhage into the acute infarct. In each patient an initial CT scan excluded the presence of intracerebral hemorrhage and a second CT scan, after cl...

journal_title：Stroke

authors： Shields RW Jr,Laureno R,Lachman T,Victor M

更新日期：1984-05-01 00:00:00

abstract：:Using transesophageal echocardiography, cardiac structures can be imaged with high resolution. The aim of our study was to evaluate whether transesophageal echocardiography is superior in detecting mitral valve prolapse and other cardiac abnormalities compared with transthoracic echocardiography in an age-matched cont...

journal_title：Stroke

authors： Zenker G,Erbel R,Krämer G,Mohr-Kahaly S,Drexler M,Harnoncourt K,Meyer J

更新日期：1988-03-01 00:00:00

abstract：:Platinum microelectrodes were used to measure H2 clearance in mouse brain, and the clearance curves were used to calculate regional cerebral blood flow (rCBF). The curves were usually biexponential, whether or not electrode placement was confined to the cortex. When calculated by the height over area method, rCBF in a...

journal_title：Stroke

authors： Rosenblum WI

更新日期：1977-01-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The cerebrovascular contribution to ischemic preconditioning (IPC) has been scarcely explored. Using in vivo and in vitro approaches, we investigated the involvement of the blood-brain barrier and the role of its cellular components. METHODS:Seven-minute occlusion of the right middle cerebral ar...

journal_title：Stroke

authors： Gesuete R,Orsini F,Zanier ER,Albani D,Deli MA,Bazzoni G,De Simoni MG

更新日期：2011-05-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Systemic administration of Toll-like receptor (TLR) 4 and TLR9 agonists before cerebral ischemia have been shown to reduce ischemic injury by reprogramming the response of the brain to stroke. Our goal was to explore the mechanism of TLR-induced neuroprotection by determining whether a TLR7 agoni...

journal_title：Stroke

authors： Leung PY,Stevens SL,Packard AE,Lessov NS,Yang T,Conrad VK,van den Dungen NN,Simon RP,Stenzel-Poore MP

更新日期：2012-05-01 00:00:00

abstract：BACKGROUND AND PURPOSE:ASCOD phenotyping (A, atherosclerosis; S, small vessel disease; C, cardiac pathology; O, other causes; and D, dissection) assigns a degree of likelihood to every potential cause (1 for potentially causal, 2 for causality is uncertain, 3 for unlikely causal but disease is present, 0 for absence of...

journal_title：Stroke

authors： Sirimarco G,Lavallée PC,Labreuche J,Meseguer E,Cabrejo L,Guidoux C,Klein IF,Olivot JM,Abboud H,Adraï V,Kusmierek J,Ratani S,Touboul PJ,Mazighi M,Steg PG,Amarenco P

更新日期：2013-09-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Transcranial Doppler (TCD) and carotid duplex (CD) provide rapid and safe screening for stroke patients but are highly operator dependent. We explored the feasibility of telemedicine (TM)-guided TCD/CD administered by a health care provider inexperienced with ultrasound. METHODS:Dual video scree...

journal_title：Stroke

authors： Mikulik R,Alexandrov AV,Ribo M,Garami Z,Porche NA,Fulep E,Grotta JC,Wojner-Alexandrov AW,Choi JY

更新日期：2006-01-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Angiotensin II produces oxidative stress and endothelial dysfunction in cerebral arteries, and angiotensin II type I receptors may play a role in longevity and vascular aging. Angiotensin-converting enzyme type 2 (ACE2) converts angiotensin II to angiotensin (1-7) and thus, may protect against ef...

journal_title：Stroke

authors： Peña Silva RA,Chu Y,Miller JD,Mitchell IJ,Penninger JM,Faraci FM,Heistad DD

更新日期：2012-12-01 00:00:00

abstract：BACKGROUND AND PURPOSE:5' adenosine monophosphate-dependent protein kinase (AMPK) acts as a metabolic sensor. AMPK is elevated under ischemic conditions, but the role of AMPK in ischemic brain remains controversial. In this study, we examined the effects of AMPK inhibition using both pharmacological and genetic approac...

journal_title：Stroke

authors： Li J,Zeng Z,Viollet B,Ronnett GV,McCullough LD

更新日期：2007-11-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Disturbed cerebral autoregulation has been reported to correlate with an unfavorable outcome after head injury. Using transcranial Doppler ultrasonography, we investigated whether hemodynamic responses to spontaneous variations of cerebral perfusion pressure (CPP) provide reliable information on ...

journal_title：Stroke

authors： Czosnyka M,Smielewski P,Kirkpatrick P,Menon DK,Pickard JD

更新日期：1996-10-01 00:00:00

abstract：:The occurrence of epileptic seizures was investigated in 141 patients with angiographically proven carotid or MCA occlusive disease. Epileptic seizures occurred some time during the clinical course of the disease in 17.3% of carotid patients and in 10.8% of MCA patients, being mainly represented by partial motor seizu...

journal_title：Stroke

authors： Cocito L,Favale E,Reni L

更新日期：1982-03-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Endothelin receptor antagonists such as clazosentan decrease large-artery vasospasm after experimental and clinical subarachnoid hemorrhage. We used clazosentan to gain insight into the pathophysiology of subarachnoid hemorrhage by determining if decreasing vasospasm is associated with alleviatio...

journal_title：Stroke

authors： Sabri M,Ai J,Macdonald RL

更新日期：2011-05-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The aim of this study was to investigate by means of transcranial Doppler (TCD) ultrasonography how many spontaneous reperfusions of the middle cerebral artery (MCA) occurred during the first week after onset of acute ischemic stroke in the carotid territory. METHODS:TCD examination, computed to...

journal_title：Stroke

authors： Zanette EM,Roberti C,Mancini G,Pozzilli C,Bragoni M,Toni D

更新日期：1995-03-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The presence of white-matter hyperintensities (WMHs) has been linked to intracerebral hemorrhage (ICH). We sought to determine whether the severity of WMHs influences hematoma growth and ICH volume. METHODS:We retrospectively reviewed prospectively collected clinical, laboratory, and radiologic ...

journal_title：Stroke

authors： Lou M,Al-Hazzani A,Goddeau RP Jr,Novak V,Selim M

更新日期：2010-01-01 00:00:00

abstract：:We investigated the temporal threshold for focal cerebral infarction in the spontaneously hypertensive rat. The right middle cerebral artery and common carotid artery were occluded for 0, 1, 2, 3, 4, or 24 hours, and all the animals were sacrificed 24 hours after the onset of ischemia. Cortical infarct volumes and ede...

journal_title：Stroke

authors： Kaplan B,Brint S,Tanabe J,Jacewicz M,Wang XJ,Pulsinelli W

更新日期：1991-08-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Aphasia can result in an inability to communicate the presence, location, or intensity of pain. Although visual analogue scales (VASs) exist, it is unknown whether they are useful in assessing pain in individuals with aphasia. The objective was to determine whether those with poststroke aphasia c...

journal_title：Stroke

authors： Korner-Bitensky N,Kehayia E,Tremblay N,Mazer B,Singer F,Tarasuk J

更新日期：2006-02-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Stroke is associated with increased risk of dementia. There has been a decline in mortality from stroke among persons 65 and over in recent decades in the US. It is not clear, however, how this process has affected incidence of various dementias. METHODS:We evaluated over time changes in stroke ...

journal_title：Stroke

authors： Ukraintseva S,Sloan F,Arbeev K,Yashin A

更新日期：2006-05-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Apraxia of speech (AOS) is a motor speech disorder, which is clinically characterized by the combination of phonemic segmental changes and articulatory distortions. AOS has been believed to arise from impairment in motor speech planning/programming and differentiated from both aphasia and dysarth...

journal_title：Stroke

authors： Itabashi R,Nishio Y,Kataoka Y,Yazawa Y,Furui E,Matsuda M,Mori E

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Large falls in blood pressure after meals have been demonstrated in fit and frail elderly subjects; these changes may be associated with an increased incidence of stroke. Postprandial falls in BP may be particularly deleterious after acute stroke, when normal baroreflex mechanisms and cerebral au...

journal_title：Stroke

authors： Robinson TG,Potter JF

更新日期：1995-10-01 00:00:00

abstract：:Feline pial arteries larger than 100 mu in diameter constricted in response to cervical sympathetic nerve stimulation suggests or in response to topical application of norepinephrine. Smaller pial arteries were unresponsive to norepinephrine. This unresponsiveness persisted when norepinephrine was dissolved in CSF wit...

journal_title：Stroke

authors： Wei EP,Raper AJ,Kontos HA,Patterson JL Jr

更新日期：1975-11-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Mild hypothermia is possibly the single most effective method of cerebroprotection developed to date. However, many questions regarding mild hypothermia remain to be addressed before its potential implementation in the treatment of human stroke. Here we report the results of 2 studies designed to...

journal_title：Stroke

authors： Maier CM,Ahern Kv,Cheng ML,Lee JE,Yenari MA,Steinberg GK

更新日期：1998-10-01 00:00:00

abstract：:Background and Purpose- In this era of endovascular therapy (EVT) with early, complete recanalization and reperfusion, we have observed an even more rapid apparent diffusion coefficient (ADC) normalization within the acute ischemic lesion compared with the natural history or IV-tPA-treated patient. In this study, we a...

journal_title：Stroke

authors： Hsia AW,Luby M,Cullison K,Burton S,Armonda R,Liu AH,Leigh R,Nadareishvili Z,Benson RT,Lynch JK,Latour LL

更新日期：2019-08-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Depression after stroke is common. Like stroke, transient ischemic attack (TIA) is a manifestation of long-term atherosclerotic damage to the brain. However, the risk of depression developing after a TIA is uncertain. We studied whether TIA increases the risk of incident late-life depression. ME...

journal_title：Stroke

authors： Luijendijk HJ,Stricker BH,Wieberdink RG,Koudstaal PJ,Hofman A,Breteler MM,Tiemeier H

更新日期：2011-07-01 00:00:00

abstract：:Background and Purpose- Enhancement of erythrophagocytosis by macrophages in a timely manner can limit the toxic effects of erythrocyte metabolites and promote brain recovery after intracerebral hemorrhage (ICH). In the current study, we investigated the therapeutic effect of retinoid X receptor agonist, bexarotene, i...

journal_title：Stroke

authors： Chang CF,Massey J,Osherov A,Angenendt da Costa LH,Sansing LH

更新日期：2020-02-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Symptomatic intracranial hemorrhage (SICH) is the most feared complication after tissue plasminogen activator (tPA) stroke treatment. Endogenous fibrinolysis inhibitors play an essential role in the coagulation/fibrinolysis balance and may be involved in the bleeding process. We aim to determine ...

journal_title：Stroke

authors： Ribo M,Montaner J,Molina CA,Arenillas JF,Santamarina E,Quintana M,Alvarez-Sabín J

更新日期：2004-09-01 00:00:00