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Regional Comparison of Multiphase Computed Tomographic Angiography and Computed Tomographic Perfusion for Prediction of Tissue Fate in Ischemic Stroke.

Abstract：

BACKGROUND AND PURPOSE:Within different brain regions, we determine the comparative value of multiphase computed tomographic angiography (mCTA) and computed tomographic perfusion (CTP) in predicting follow-up infarction. METHODS:Patients with M1-middle cerebral artery occlusions were prospectively included in this multicenter study. Regional analysis was performed for each patient within Alberta Stroke Program Early CT Score regions M2 to M6. Regional pial vessel filling was assessed on mCTA in 3 ways: (1) Washout of contrast within pial vessels; (2) Extent of maximal pial vessel enhancement compared with contralateral hemisphere; (3) Delay in maximal pial vessel enhancement compared with contralateral hemisphere. Cerebral blood flow, cerebral blood volume, and Tmax data were extracted within these Alberta Stroke Program Early CT Score regions. Twenty-four- to 36-hour magnetic resonance imaging/CT was assessed for infarct in each Alberta Stroke Program Early CT Score region (defined as >20% infarction within that region). Mixed effects logistic regression models were used to compare mCTA and CTP parameters when predicting brain infarction. Area under the receiver operating characteristics was used to assess discriminative value of statistical models. RESULTS:Seventy-seven patients were included. mCTA parameter washout and CTP parameter Tmax were significantly associated with follow-up infarction in all models (P<0.05). The area under the receiver operating characteristic for mCTA models ranged from 92% to 94% and was not different compared with all CTP models (P>0.05). Mean Tmax and cerebral blood volume values were significantly different between each washout score (P<0.01) and each delay score category (P<0.01). Mean Tmax, cerebral blood flow, and cerebral blood volume values were significantly different between each extent score category (P<0.05). CONCLUSIONS:Similar to CTP, multiphase CTA can be used to predict tissue fate regionally in acute ischemic stroke patients.

journal_name

Stroke

journal_title

Stroke

authors

d'Esterre CD,Trivedi A,Pordeli P,Boesen M,Patil S,Hwan Ahn S,Najm M,Fainardi E,Shankar JJ,Rubiera M,Almekhlafi MA,Mandzia J,Khaw AV,Barber P,Coutts S,Hill MD,Demchuk AM,Sajobi T,Forkert ND,Goyal M,Lee TY,Menon B

doi

10.1161/STROKEAHA.116.015969

subject

Has Abstract

pub_date

2017-04-01 00:00:00

pages

939-945

issue

eissn

0039-2499

issn

1524-4628

pii

STROKEAHA.116.015969

journal_volume

pub_type

杂志文章,多中心研究

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Regional Comparison of Multiphase Computed Tomographic Angiography and Computed Tomographic Perfusion for Prediction of Tissue Fate in Ischemic Stroke.