Abstract:
BACKGROUND AND PURPOSE:Elevated soluble CD40 ligand (sCD40L) was shown to be related to cardiovascular events, but the role of sCD40L in predicting recurrent stroke remains unclear. METHODS:Baseline sCD40L levels were measured in 3044 consecutive patients with acute minor stroke and transient ischemic attack, who had previously been enrolled in the Clopidogrel in High-Risk Patients With Acute Nondisabling Cerebrovascular Events (CHANCE) trial. Cox proportional-hazards model was used to assess the association of sCD40L with recurrent stroke. RESULTS:Patients in the top tertile of sCD40L levels had increased risk of recurrent stroke comparing with those in the bottom tertile, after adjusted for conventional confounding factors (hazard ratio, 1.49; 95% confidence interval, 1.11-2.00; P=0.008). The patients with elevated levels of both sCD40L and high-sensitive C-reactive protein also had increased risk of recurrent stroke (hazard ratio, 1.81; 95% confidence interval, 1.23-2.68; P=0.003). CONCLUSIONS:Elevated sCD40L levels independently predict recurrent stroke in patients with minor stroke and transient ischemic attack. CLINICAL TRIAL REGISTRATION:URL: http://www.clinicaltrials.gov. Unique identifier: NCT00979589.
journal_name
Strokejournal_title
Strokeauthors
Li J,Wang Y,Lin J,Wang D,Wang A,Zhao X,Liu L,Wang C,Wang Y,CHANCE Investigators.doi
10.1161/STROKEAHA.115.008685subject
Has Abstractpub_date
2015-07-01 00:00:00pages
1990-2issue
7eissn
0039-2499issn
1524-4628pii
STROKEAHA.115.008685journal_volume
46pub_type
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