Impact of early blood pressure variability on stroke outcomes after thrombolysis: the SAMURAI rt-PA Registry.

abstract：BACKGROUND AND PURPOSE:Stroke produces diaschisis in adjacent and connected regions. The sequential changes in diaschisis over time and the relationship of regions of diaschisis to functional cortical areas and regions of poststroke neuroplasticity have not been determined. METHODS:Small cortical strokes were produced...

journal_title：Stroke

authors： Carmichael ST,Tatsukawa K,Katsman D,Tsuyuguchi N,Kornblum HI

更新日期：2004-03-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Matrix metalloproteinases (MMPs) and cysteine proteases (calpain and cathepsin B) play an important role in cell death and are upregulated after focal cerebral ischemia. Because there is a significant interaction between MMP-9 with calpain and cathepsin B, we investigated the role of E64d (a calp...

journal_title：Stroke

authors： Tsubokawa T,Solaroglu I,Yatsushige H,Cahill J,Yata K,Zhang JH

更新日期：2006-07-01 00:00:00

abstract：:The levels of lipid peroxides, determined as thiobarbituric acid reactive substances (TBARS), and the activities of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px), were examined in the blood from stroke-prone spontaneously hypertensive rats (SHRSP), with and without cerebral lesions, and normotensive W...

journal_title：Stroke

authors： Tomita I,Sano M,Serizawa S,Ohta K,Katou M

更新日期：1979-05-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Oxidative damage of mitochondrial DNA (mtDNA) in the ischemic brain is expected after ischemia/reperfusion injury. A recent study demonstrated limited patterns of mtDNA deletion in the brain after ischemia/reperfusion. We studied the ischemia/reperfusion-induced global changes of mtDNA integrity ...

journal_title：Stroke

authors： Chen H,Hu CJ,He YY,Yang DI,Xu J,Hsu CY

更新日期：2001-10-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Physiologically, it appears plausible for physical activity to decrease stroke risk; however, epidemiological studies have produced mixed findings. Furthermore, few studies have examined specific kinds and intensities of activities. The purpose of this study was to examine the association between...

journal_title：Stroke

authors： Lee IM,Paffenbarger RS Jr

更新日期：1998-10-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Risk factors for stroke recurrence have usually been evaluated as single variables. This study is a multivariate analysis of five risk factors (hypertension, myocardial infarction, cardiac arrhythmia, diabetes mellitus, and transient ischemic attacks) for second stroke after an initial ischemic s...

journal_title：Stroke

authors： Lai SM,Alter M,Friday G,Sobel E

更新日期：1994-05-01 00:00:00

abstract：:To elucidate the role of the internal elastic lamina in the development of cerebral aneurysm, the bifurcation of the anterior cerebral artery and olfactory artery was histologically studied in control and experimental rats treated with unilateral carotid ligation and renal hypertension. Various stages of aneurysm form...

journal_title：Stroke

authors： Kim C,Kikuchi H,Hashimoto N,Kojima M,Kang Y,Hazama F

更新日期：1988-04-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Adequate control of blood pressure (BP) is a cornerstone in stroke prevention. This study explored the risk of stroke in relation to the quality of BP control in a population-based cohort and whether control of hypertension was related to background characteristics of patients. METHODS:A total o...

journal_title：Stroke

authors： Li C,Engström G,Hedblad B,Berglund G,Janzon L

更新日期：2005-04-01 00:00:00

abstract：:Stroke is a complex disease, with both genetic and environmental factors having a role in its pathogenesis. A review of past studies shows some evidence of genetic influences in the development of stroke. This is supported by studies of cardiovascular disease, which indicate major genetic influences at several levels ...

journal_title：Stroke

authors： Alberts MJ

更新日期：1990-11-01 00:00:00

abstract：BACKGROUND AND PURPOSE:We assessed whether the load of cerebral small vessel disease (cSVD) and its individual markers, including lacunes, white matter hyperintensities, microbleeds, and enlarged perivascular spaces (EPVS), are associated with arterial stiffness. METHODS:We evaluated cSVD markers in a cohort of 782 hy...

journal_title：Stroke

authors： Riba-Llena I,Jiménez-Balado J,Castañé X,Girona A,López-Rueda A,Mundet X,Jarca CI,Álvarez-Sabin J,Montaner J,Delgado P

更新日期：2018-05-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The absence of a widely available and sensitive diagnostic test for acute cerebral ischemia remains a significant limitation in the diagnosis and management of stroke. The objective of this study was to examine the feasibility of developing a diagnostic panel of blood-borne biochemical markers of...

journal_title：Stroke

authors： Lynch JR,Blessing R,White WD,Grocott HP,Newman MF,Laskowitz DT

更新日期：2004-01-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Global cerebral blood flow (CBF) is an important yet largely unknown quantity in the treatment of neurological intensive care patients. Color duplex sonography of the extracranial cerebral arteries can be used to measure global CBF volume directly at the bedside. To establish reference data on gl...

journal_title：Stroke

authors： Scheel P,Ruge C,Petruch UR,Schöning M

更新日期：2000-01-01 00:00:00

abstract：:Background and Purpose- The complexity and heterogeneity of stroke, as well as the associated comorbidities, may render neuroprotective drugs less efficacious in clinical practice. Therefore, the development of targeted therapies to specific patient subsets has become a high priority in translational stroke research. ...

journal_title：Stroke

authors： Jiang Y,Liu N,Wang Q,Yu Z,Lin L,Yuan J,Guo S,Ahn BJ,Wang XJ,Li X,Lo EH,Sun X,Wang X

更新日期：2018-12-01 00:00:00

abstract：BACKGROUND AND PURPOSE:In most European societies and in the United States, the percentage of patients ≥80 years has been rising over the past century. The present study was conducted to observe this demographic change and its impact on patients with intracerebral hemorrhage (ICH). METHODS:We reviewed patients' data w...

journal_title：Stroke

authors： Stein M,Misselwitz B,Hamann GF,Scharbrodt W,Schummer DI,Oertel MF

更新日期：2012-04-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Extracorporeal rheopheresis is a safe method to optimize hemorheology. Our aim was to determine whether treatment with extracorporeal rheopheresis in patients with acute ischemic hemispheric stroke improves cerebral perfusion as assessed with serial 99mTc-ethyl-cysteinate-dimer single-photon emis...

journal_title：Stroke

authors： Berrouschot J,Barthel H,Köster J,Hesse S,Rössler A,Knapp WH,Schneider D

更新日期：1999-04-01 00:00:00

abstract：BACKGROUND AND PURPOSE:We investigated the intra- and interrater reliability of ischemic lesion volumes measurements assessed by different MRI sequences at various times from onset. METHODS:Ischemic lesion volumes were measured for intrarater reliability using diffusion-weighted (DWI), mean transit time (MTT) perfusio...

journal_title：Stroke

authors： Luby M,Bykowski JL,Schellinger PD,Merino JG,Warach S

更新日期：2006-12-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The sensitivity of the brain to brief periods of profound ischemia or prolonged periods of modest ischemia mandates an aggressive approach to acute stroke care. Past studies have shown that many stroke patients do not receive acute care in an urgent and timely fashion. The formation of acute stro...

journal_title：Stroke

authors： Alberts MJ,Chaturvedi S,Graham G,Hughes RL,Jamieson DG,Krakowski F,Raps E,Scott P

更新日期：1998-11-01 00:00:00

abstract：:The double subarachnoid hemorrhage canine model was used to test the prophylactic value of immunosuppression in the prevention of cerebral vasospasm after subarachnoid hemorrhage. Dogs treated with cyclosporine A following the regimen prescribed for organ transplant procedures in patients showed a significant reductio...

journal_title：Stroke

authors： Peterson JW,Nishizawa S,Hackett JD,Bun T,Teramura A,Zervas NT

更新日期：1990-01-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Noninvasive studies are used with increasing frequency to assess the carotid bifurcation before endarterectomy. Therefore, assessment of their diagnostic accuracies is essential for appropriate patient management. We prospectively evaluate two noninvasive tests, magnetic resonance angiography (MR...

journal_title：Stroke

authors： Patel MR,Kuntz KM,Klufas RA,Kim D,Kramer J,Polak JF,Skillman JJ,Whittemore AD,Edelman RR,Kent KC

更新日期：1995-10-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Quality of life (QoL) is important to stroke survivors yet is often recorded as a secondary measure in acute stroke randomized controlled trials. We examined whether commonly used stroke outcome measures captured aspects of QoL. METHODS:We examined primary outcomes by National Institutes of Heal...

journal_title：Stroke

authors： Ali M,Fulton R,Quinn T,Brady M,VISTA Collaboration.

更新日期：2013-11-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Subfebrile body temperature and fever in the first days after stroke are strongly associated with unfavorable outcome. A subgroup analysis of a previous trial suggested that early treatment with paracetamol may improve functional outcome in patients with acute stroke and a body temperature of ≥36...

journal_title：Stroke

authors： de Ridder IR,den Hertog HM,van Gemert HM,Schreuder AH,Ruitenberg A,Maasland EL,Saxena R,van Tuijl JH,Jansen BP,Van den Berg-Vos RM,Vermeij F,Koudstaal PJ,Kappelle LJ,Algra A,van der Worp HB,Dippel DW,Trial Organization.

更新日期：2017-04-01 00:00:00

abstract：BACKGROUND AND PURPOSE:We have previously shown that 17beta-estradiol reduces infarction volume in female rats. The present study determined whether single injection or chronic implantation of estrogen confers neuroprotection in male animals with middle cerebral artery occlusion (MCAO) and whether there is an interacti...

journal_title：Stroke

authors： Toung TJ,Traystman RJ,Hurn PD

更新日期：1998-08-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Microembolic signals (MESs) are detectable within the transcranial Doppler frequency spectrum downstream from vascular atherothrombotic or cardiothrombotic lesions. A frequent occurrence of MESs has also been shown during bypass surgery or after mechanical valve implantation. We sought to compile...

journal_title：Stroke

authors： Dittrich R,Ringelstein EB

更新日期：2008-02-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Previous studies reported that Tat-NR2B9c, a peptide disrupting the N-methyl-d-aspartate receptor-postsynaptic density protein-95 interaction, reduced ischemic damage in the acute phase after stroke. However, its effect in the subacute phase is unknown. The aim of this study is to determine wheth...

journal_title：Stroke

authors： Zhou HH,Tang Y,Zhang XY,Luo CX,Gao LY,Wu HY,Chang L,Zhu DY

更新日期：2015-05-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Stroke is a major healthcare problem in both the United States (US) and the United Kingdom (UK). Little comparative data are available concerning how generalist physicians in the two countries approach the management of patients at high risk of stroke. METHODS:Contemporaneous surveys of random s...

journal_title：Stroke

authors： Goldstein LB,Farmer A,Matchar DB

更新日期：1997-04-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Ultrasound of carotid arteries provides measures of intima media thickness (IMT) and plaque, both widely used as surrogate measures of cardiovascular disease. Although IMT and plaques are highly intercorrelated, the relationship between carotid plaque and IMT and cardiovascular disease has been c...

journal_title：Stroke

authors： Johnsen SH,Mathiesen EB,Joakimsen O,Stensland E,Wilsgaard T,Løchen ML,Njølstad I,Arnesen E

更新日期：2007-11-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Admission infarct core lesion size is an important determinant of management and outcome in acute (<9 hours) stroke. Our purposes were to: (1) determine the optimal CT perfusion parameter to define infarct core using various postprocessing platforms; and (2) establish the degree of variability in...

journal_title：Stroke

authors： Kamalian S,Kamalian S,Maas MB,Goldmacher GV,Payabvash S,Akbar A,Schaefer PW,Furie KL,Gonzalez RG,Lev MH

更新日期：2011-07-01 00:00:00

abstract：:A 51-yearold man with moderate intermittent hypertension had a rapidly progressive, profound dementia in the absence of significant localizing neurological signs. Postmortem examination disclosed the vascular alterations and diffuse white matter degeneration which characterize subcortical arteriosclerotic encephalopat...

journal_title：Stroke

authors： Burger PC,Burch JG,Kunze U

更新日期：1976-11-01 00:00:00

abstract：:Among 21 patients with angiographically demonstrated stenosis of the middle cerebral artery (MCA) 14 presented with a stroke and 7 with transient ischaemic attacks (TIAs). Of the former 4 had further strokes (3 fatal); of the latter one had a fatal stroke. Only 2 of the 21 patients had TIAs during the follow-up period...

journal_title：Stroke

authors： Corston RN,Kendall BE,Marshall J

更新日期：1984-03-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Ipsilateral thalamic diaschisis (ITD) describes the reduction of thalamic function, metabolism, and perfusion resulting from a distant lesion of the ipsilateral hemisphere. Our aim was to evaluate the perfusion characteristics and clinical impact of ITD in acute middle cerebral artery stroke, whi...

journal_title：Stroke

authors： Reidler P,Thierfelder KM,Fabritius MP,Sommer WH,Meinel FG,Dorn F,Wollenweber FA,Duering M,Kunz WG

更新日期：2018-04-01 00:00:00