Genetics of cerebrovascular disease.

abstract：:Background and Purpose- Besides the established spot sign (SS) in computed tomography angiography (CTA), there is growing evidence that different imaging markers in noncontrast CT offer great value for outcome prediction in patients with intracerebral hemorrhage (ICH). However, it is unclear how the concurrent presenc...

journal_title：Stroke

authors： Sporns PB,Kemmling A,Schwake M,Minnerup J,Nawabi J,Broocks G,Wildgruber M,Fiehler J,Heindel W,Hanning U

更新日期：2018-10-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The Intravenous Nimodipine West European Stroke Trial (INWEST) found a correlation between nimodipine-induced reduction in blood pressure (BP) and an unfavorable outcome in acute stroke. We sought to confirm this correlation with and without adjustment for prognostic variables and to investigate ...

journal_title：Stroke

authors： Ahmed N,Näsman P,Wahlgren NG

更新日期：2000-06-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Milk fat globule-EGF factor-8 (MFGE8) has been reported to be neuroprotective in ischemic stroke. However, the effects of MFGE8 in early brain injury after subarachnoid hemorrhage (SAH) have not been investigated. We investigated the role of MFGE8 in early brain injury and the potential mechanism...

journal_title：Stroke

authors： Liu F,Hu Q,Li B,Manaenko A,Chen Y,Tang J,Guo Z,Tang J,Zhang JH

更新日期：2014-12-01 00:00:00

abstract：BACKGROUND AND PURPOSE:We aimed to determine clinical and hemodynamic predictors of early reocclusion (RO) in stroke patients treated with intravenous tissue plasminogen activator (tPA). METHODS:We studied 142 consecutive stroke patients with a documented middle cerebral artery (MCA) occlusion treated with intravenous...

journal_title：Stroke

authors： Rubiera M,Alvarez-Sabín J,Ribo M,Montaner J,Santamarina E,Arenillas JF,Huertas R,Delgado P,Purroy F,Molina CA

更新日期：2005-07-01 00:00:00

abstract：:To determine the efficacy of calcium channel blockers in preserving neurologic function after central nervous system ischemia, we studied three such agents in two animal models. We treated rabbits after inducing ischemia in the brain with intra-arterial microspheres and in the spinal cord using a removable aortic occl...

journal_title：Stroke

authors： Lyden PD,Zivin JA,Kochhar A,Mazzarella V

更新日期：1988-08-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The independent contribution of insulin resistance to atherosclerosis is still under debate. We compared associations of 2 different indices of insulin resistance, the Homeostasis Model Assessment (HOMA) index and kITT from a short insulin tolerance test with carotid atherosclerosis. METHODS:A t...

journal_title：Stroke

authors： Sourij H,Schmoelzer I,Dittrich P,Paulweber B,Iglseder B,Wascher TC

更新日期：2008-04-01 00:00:00

abstract：BACKGROUND AND PURPOSE:High-sensitivity C-reactive protein (hsCRP) and lipoprotein-associated phospholipase A2 (Lp-PLA2) are hypothesized to be biomarkers of systemic inflammation and risk of myocardial infarction (MI) and stroke. Little is known, however, about the stability of these markers over time, and in particul...

journal_title：Stroke

authors： Elkind MS,Leon V,Moon YP,Paik MC,Sacco RL

更新日期：2009-10-01 00:00:00

abstract：BACKGROUND AND PURPOSE:While it has been widely reported that the vasospasm following subarachnoid hemorrhage (SAH) is prevented/reversed by endothelin (ET) receptor antagonists selective for the ET(A) receptor and by nonselective ET receptor antagonists, ie, antagonists of both the ET(A) and ET(B) receptors, there are...

journal_title：Stroke

authors： Zuccarello M,Boccaletti R,Romano A,Rapoport RM

更新日期：1998-09-01 00:00:00

abstract：:Background and Purpose- Diffusion-weighted imaging (DWI) hyperintensities in intracerebral hemorrhage (ICH) are associated with increased risk of recurrent ICH, cognitive impairment, and death, but whether these lesions are specific to a subtype of ICH remains uncertain. We investigated the association between DWI les...

journal_title：Stroke

authors： Boulanger M,Schneckenburger R,Join-Lambert C,Werring DJ,Wilson D,Hodel J,Zuber M,Touzé E

更新日期：2018-12-07 00:00:00

abstract：:A patient developed a cerebellar infarction five weeks after a car accident. The pathophysiology and the medico-legal implications are discussed. ...

journal_title：Stroke

authors： Nichelli P,Gibertoni M,Guerzoni C

更新日期：1983-07-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The significance of structural changes associated with cerebral small-vessel disease (SVD), including white matter lesions (WML), lacunes, and brain atrophy, to outcome from acute intracerebral hemorrhage is uncertain. We determined associations of computed tomographic radiological manifestations...

journal_title：Stroke

authors： Sato S,Delcourt C,Heeley E,Arima H,Zhang S,Al-Shahi Salman R,Stapf C,Woo D,Flaherty ML,Vagal A,Levi C,Davies L,Wang J,Robinson T,Lavados PM,Lindley RI,Chalmers J,Anderson CS,INTERACT2 Investigators.

更新日期：2016-03-01 00:00:00

abstract：:We reviewed demographic data on patients having 2,256 carotid endarterectomies in eight large hospitals in North Carolina to determine the frequency of blacks among these patients. Blacks comprised only 4.6% of the patients having carotid endarterectomy even though they comprised 26% of all patients discharged and 22%...

journal_title：Stroke

authors： Maxwell JG,Rutherford EJ,Covington D,Clancy TV,Tackett AD,Robinson N,Johnson G Jr

更新日期：1989-01-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The aim of this study was to assess the prevalence of extracranial carotid artery atherosclerosis and its relation to principal cardiovascular risk factors at different ages in a sample of the general population. METHODS:B-mode ultrasonography was used to investigate the carotid district in 457 ...

journal_title：Stroke

authors： Fabris F,Zanocchi M,Bo M,Fonte G,Poli L,Bergoglio I,Ferrario E,Pernigotti L

更新日期：1994-06-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Visit-to-visit and day-to-day variability in systolic blood pressure (SBP) are associated with an increased risk of stroke, more strongly than variability on 24-hour ambulatory BP monitoring, but underlying physiological mechanisms are unclear. We related potentially relevant physiological charac...

journal_title：Stroke

authors： Webb AJ,Rothwell PM

更新日期：2014-02-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Iron overload has been associated with greater oxidative stress and brain injury in experimental cerebral ischemia and reperfusion. This study investigates whether high serum ferritin levels, as an index of increased cellular iron stores, are associated with poor outcome, hemorrhagic transformati...

journal_title：Stroke

authors： Millan M,Sobrino T,Castellanos M,Nombela F,Arenillas JF,Riva E,Cristobo I,García MM,Vivancos J,Serena J,Moro MA,Castillo J,Dávalos A

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND AND PURPOSE:We tested the hypothesis that fibrin structure/function is unfavorably altered in patients with cryptogenic ischemic stroke. METHODS:Ex vivo plasma fibrin clot permeability, turbidimetry, and efficiency of fibrinolysis were determined in 89 patients with patent foramen ovale (PFO) and a history ...

journal_title：Stroke

authors： Undas A,Podolec P,Zawilska K,Pieculewicz M,Jedliński I,Stepień E,Konarska-Kuszewska E,Weglarz P,Duszyńska M,Hanschke E,Przewlocki T,Tracz W

更新日期：2009-04-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Develop achievable benchmarks for 9 stroke performance measures (PM) and to identify organizational factors associated with adherence. METHODS:Adherence rates and achievable benchmarks were determined for 9 PM within a study of patients (n=2294) admitted with acute ischemic stroke at 17 hospital...

journal_title：Stroke

authors： Hinchey JA,Shephard T,Tonn ST,Ruthazer R,Selker HP,Kent DM

更新日期：2008-05-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Although the efficacy of angiotensin-converting enzyme inhibitors and angiotensin receptor blockers in reducing future vascular events for patients with coronary heart disease is established, less is known about the precise benefit of these agents among patients with stroke. We evaluated whether ...

journal_title：Stroke

authors： Lee M,Saver JL,Hong KS,Hao Q,Chow J,Ovbiagele B

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Although our previous study demonstrated that dementia of the Binswanger type may be a disconnection dementia caused by leukoaraiosis, some hypertensive patients with marked leukoaraiosis do not develop dementia. The goal of the present study is to elucidate the pathophysiology of nondemented hyp...

journal_title：Stroke

authors： Yao H,Sadoshima S,Ibayashi S,Kuwabara Y,Ichiya Y,Fujishima M

更新日期：1992-11-01 00:00:00

abstract：:The hydrogen clearance method was used to measure local and total cerebral blood flow (CBF) in the rhesus monkey before and for five hours after a simulated subarachnoid hemorrhage (SAH). CBF remained stable after SAH unless SAH was associated with a fall in cerebral perfusion pressure. In addition, cerebrovascular re...

journal_title：Stroke

authors： Martins AN,Doyle TF,Newby N,Kobrine AI,Ramirez A

更新日期：1975-11-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Purinergic nucleoside inosine elicits protection and regeneration during various injuries. The purpose of this study was to examine the protective effects of inosine against cerebral ischemia. METHODS:Adult Sprague-Dawley rats were anesthetized. Inosine, hypoxathine, or vehicle was administered ...

journal_title：Stroke

authors： Shen H,Chen GJ,Harvey BK,Bickford PC,Wang Y

更新日期：2005-03-01 00:00:00

abstract：:Background and Purpose- Identifying the etiology of acute ischemic stroke is essential for effective secondary prevention. However, in at least one third of ischemic strokes, existing investigative protocols fail to determine the underlying cause. Establishing etiology is complicated by variation in clinical practice,...

journal_title：Stroke

authors： McMahon NE,Bangee M,Benedetto V,Bray EP,Georgiou RF,Gibson JME,Lane DA,Al-Khalidi AH,Chatterjee K,Chauhan U,Clegg AJ,Lightbody CE,Lip GYH,Sekhar A,Watkins CL

更新日期：2020-05-01 00:00:00

abstract：:Background and Purpose- We aimed to define the neuroimaging determinants of poststroke cognitive performance and their relative contributions among a spectrum of magnetic resonance imaging markers, including lesion burden and strategic locations. Methods- We prospectively included patients with stroke from the GRECogV...

journal_title：Stroke

authors： Puy L,Barbay M,Roussel M,Canaple S,Lamy C,Arnoux A,Leclercq C,Mas JL,Tasseel-Ponche S,Constans JM,Godefroy O,GRECogVASC Study Group.

更新日期：2018-11-01 00:00:00

abstract：:We mapped average age-adjusted stroke mortality rates for white men and white women aged 35-74 years for state economic areas (counties or groups of counties) in the continental United States for three 7-year periods between 1962 and 1982. Despite the decline of national stroke mortality rates, rates in some areas fai...

journal_title：Stroke

authors： Wing S,Casper M,Davis WB,Pellom A,Riggan W,Tyroler HA

更新日期：1988-12-01 00:00:00

abstract：:Internal carotid blood flow, taken as an index of cerebral blood flow (CBF); arterial pressure; and respiratory O2 and CO2 concentrations, were measured in halothane (1%)-anesthetized, paralyzed and mechanically ventilated rabbits. CBF was determined at end-tidal CO2 of 4% (normocapnia) and 8%, as inspired O2 [O2]I) w...

journal_title：Stroke

authors： Quint SR,Scremin OU,Sonnenschein RR,Rubinstein EH

更新日期：1980-05-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Carotid artery intima-media thickness (IMT) is a marker of cardiovascular disease associated with incident stroke. We studied whether IMT rate of change is associated with stroke. METHODS:We studied 5028 participants of the Multi-Ethnic Study of Atherosclerosis (MESA) comprising white, Chinese, ...

journal_title：Stroke

authors： Polak JF,Pencina MJ,O'Leary DH,D'Agostino RB

更新日期：2011-11-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Pretreatment lesion size on diffusion-weighted imaging (DWI) is a risk factor for symptomatic intracerebral hemorrhage (sICH) associated with thrombolytic treatment. Here, we investigated whether the Alberta Stroke Programme Early CT Score (ASPECTS) applied to DWI images (DWI-ASPECTS) predicts sI...

journal_title：Stroke

authors： Singer OC,Kurre W,Humpich MC,Lorenz MW,Kastrup A,Liebeskind DS,Thomalla G,Fiehler J,Berkefeld J,Neumann-Haefelin T,MR Stroke Study Group Investigators.

更新日期：2009-08-01 00:00:00

abstract：BACKGROUND AND PURPOSE:We have previously shown that 17beta-estradiol reduces infarction volume in female rats. The present study determined whether single injection or chronic implantation of estrogen confers neuroprotection in male animals with middle cerebral artery occlusion (MCAO) and whether there is an interacti...

journal_title：Stroke

authors： Toung TJ,Traystman RJ,Hurn PD

更新日期：1998-08-01 00:00:00

abstract：:The goal of this study was to test the hypothesis that atherosclerosis alters responses of cerebral arteries and the ocular circulation to the activation in vivo of leukocytes and platelets. We measured blood flow to the brain and eye using microspheres and pressure in the cerebral microvessels of normal and atheroscl...

journal_title：Stroke

authors： Faraci FM,Lopez AG,Breese K,Armstrong ML,Heistad DD

更新日期：1991-06-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Because thromboembolic events are frequently observed in primary antiphospholipid syndrome (PAPS), we assessed the risk factors for new thrombotic episodes. METHODS:Fifty-six PAPS patients (mean age, 37+/-10 years) were prospectively studied for 5 years. The preliminary Sapporo classification cr...

journal_title：Stroke

authors： Turiel M,Sarzi-Puttini P,Peretti R,Rossi E,Atzeni F,Parsons W,Doria A

更新日期：2005-07-01 00:00:00