Update of the stroke therapy academic industry roundtable preclinical recommendations.

abstract：BACKGROUND AND PURPOSE:The risk of major vascular events after an initial episode of cerebral ischemia in patients with nonrheumatic atrial fibrillation (NRAF) varies from 2% to 15% in the first year and is approximately 5% yearly thereafter. Few studies have reported on risk factors that can be used to identify high-r...

journal_title：Stroke

authors： van Latum JC,Koudstaal PJ,Venables GS,van Gijn J,Kappelle LJ,Algra A

更新日期：1995-05-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The mechanisms of immune reaction involved in the pathogenesis and clinical course of acute vascular incidents are still not completely understood. The aim of this study was to examine the presence of immune complexes (IC) in the acute stroke setting and the first month thereafter and to characte...

journal_title：Stroke

authors： Tarnacka B,Gromadzka G,Członkowska A

更新日期：2002-04-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Victims of air embolism often recover rapidly on hyperbaric treatment then deteriorate again, even if hyperbaric treatment is continued. In previous animal experiments, lidocaine has been shown to improve recovery of somatosensory evoked response amplitude after air embolism. However, animals in ...

journal_title：Stroke

authors： Dutka AJ,Mink R,McDermott J,Clark JB,Hallenbeck JM

更新日期：1992-10-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Despite its high prevalence in stroke survivors, there is little clinical research on bowel dysfunction in this population. This is the first randomized controlled trial to evaluate treatment of constipation and fecal incontinence in stroke survivors. METHODS:Stroke patients with constipation or...

journal_title：Stroke

authors： Harari D,Norton C,Lockwood L,Swift C

更新日期：2004-11-01 00:00:00

abstract：:Background and Purpose- Given inconclusive studies, it is debated whether clinical and imaging characteristics, as well as functional outcome, differ among patients with intracerebral hemorrhage (ICH) related to vitamin K antagonists (VKA) versus non-vitamin K antagonist (NOAC)-related ICH. Notably, clinical character...

journal_title：Stroke

authors： Gerner ST,Kuramatsu JB,Sembill JA,Sprügel MI,Hagen M,Knappe RU,Endres M,Haeusler KG,Sobesky J,Schurig J,Zweynert S,Bauer M,Vajkoczy P,Ringleb PA,Purrucker JC,Rizos T,Volkmann J,Müllges W,Kraft P,Schubert AL,Erbgut

更新日期：2019-06-01 00:00:00

abstract：:The plasma concentrations of protein C, an anticoagulant protein, and fibrinopeptide A were measured in 37 patients with acute hemispheric stroke and in age-matched controls with nonvascular neurologic diseases. In 11 stroke patients who died within 15 days after the onset (nonsurvivors) protein C antigen concentratio...

journal_title：Stroke

authors： D'Angelo A,Landi G,Vigano'D'Angelo S,Nobile Orazio E,Boccardi E,Candelise L,Mannucci PM

更新日期：1988-05-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The bedside clinical assessment of the patient with suspected stroke has not been well studied. Improving clinical skills may accelerate patient progress through the emergency department. We aimed to determine the frequency and nature of stroke mimics and to identify the key clinical features tha...

journal_title：Stroke

authors： Hand PJ,Kwan J,Lindley RI,Dennis MS,Wardlaw JM

更新日期：2006-03-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Neonatal encephalopathy in human babies is a serious condition associated with permanent neurological deficits. Diffusion-weighted MRI (DWI) is increasingly used for early diagnosis of brain injury in human babies. The relationship between the presence of DWI abnormalities and cellular injury, in...

journal_title：Stroke

authors： Wendland MF,Faustino J,West T,Manabat C,Holtzman DM,Vexler ZS

更新日期：2008-06-01 00:00:00

abstract：BACKGROUND AND PURPOSE:We know that significant cardiac involvement can occur in patients with acute intracranial hemorrhage, particularly in those with subarachnoid hemorrhage. These patients may present with electrocardiographic abnormalities that were previously thought to be benign. However, many die of cardiovascu...

journal_title：Stroke

authors： Elrifai AM,Bailes JE,Shih SR,Dianzumba S,Brillman J

更新日期：1996-04-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The present study investigated the influence of the antiplatelet agent acetylsalicylic acid (ASA) on cerebral microembolism as detected by transcranial Doppler sonography (TCD). METHODS:Nine patients with recent transient ischemic attack or minor stroke of arterial origin were investigated. Eigh...

journal_title：Stroke

authors： Goertler M,Baeumer M,Kross R,Blaser T,Lutze G,Jost S,Wallesch CW

更新日期：1999-01-01 00:00:00

abstract：:Contrast-enhanced computed tomography of the neck permits low-risk evaluation of morphologic complications of carotid plaque, including (and foremost) calcification. To investigate the patterns and clinical significance of calcified deposits in the cervical carotid arteries using computed tomography we studied 40 pati...

journal_title：Stroke

authors： Culebras A,Otero C,Toledo JR,Rubin BS

更新日期：1989-11-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Perioperative strokes (POS) are rare but serious complications for which mechanical thrombectomy could be beneficial. We aimed to compare the technical results and patients outcomes in a population of POS versus non-POS (nPOS) treated by mechanical thrombectomy. METHODS:From 2010 to 2017, 25 pat...

journal_title：Stroke

authors： Premat K,Clovet O,Frasca Polara G,Shotar E,Bartolini B,Yger M,Di Maria F,Baronnet F,Pistocchi S,Le Bouc R,Pires C,Sourour N,Alamowitch S,Samson Y,Degos V,Clarençon F

更新日期：2017-11-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The extent of cardiac investigation required in patients with coexistent symptomatic carotid and cardiac disease is unsettled. This study compared the outlook for patients symptomatic from carotid stenosis with and without a history of symptomatic ischemic heart disease (IHD). METHODS:The risk o...

journal_title：Stroke

authors： Gates PC,Eliasziw M,Algra A,Barnett HJ,Gunton RW,North American Symptomatic Carotid Endarterectomy Trial Group.

更新日期：2002-10-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Few cohort studies have examined the association of carotid intima-media thickness (IMT) and plaque characteristics with the risk of stroke in apparently healthy persons. We examined the relationship of carotid IMT and the surface, morphology, and calcification of carotid plaques with the inciden...

journal_title：Stroke

authors： Kitamura A,Iso H,Imano H,Ohira T,Okada T,Sato S,Kiyama M,Tanigawa T,Yamagishi K,Shimamoto T

更新日期：2004-12-01 00:00:00

abstract：:Radiolabelled misonidazole, a radiosensitizing drug that binds to viable hypoxic tumor cells, may be useful in identifying hypoxic cells in cerebrovascular disease. Its potential was investigated in the gerbil stroke model. Biodistribution of [3H]misonidazole was measured in normal gerbils and animals that had been su...

journal_title：Stroke

authors： Hoffman JM,Rasey JS,Spence AM,Shaw DW,Krohn KA

更新日期：1987-01-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The aim of the present study was to investigate cerebral hemodynamics in patients requiring surgical treatment for lobar intracerebral hemorrhage. METHODS:Twenty patients who underwent surgery to remove a lobar spontaneous intracerebral hemorrhage were scanned before and after surgery using perf...

journal_title：Stroke

authors： Etminan N,Beseoglu K,Turowski B,Steiger HJ,Hänggi D

更新日期：2012-03-01 00:00:00

abstract：:The purpose of this study was to develop an animal model that could be used to test the ability of Doppler ultrasound to detect arterial emboli composed of materials that are often involved in cerebral emboli. Emboli introduced into the rabbit aorta via the left renal artery consisted of clotted whole blood, platelets...

journal_title：Stroke

authors： Russell D,Madden KP,Clark WM,Sandset PM,Zivin JA

更新日期：1991-02-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The goal of the Stroke Treatment Academic Industry Roundtable (STAIR) meetings is to advance the development of acute and restorative stroke therapies. Summary of Review- At the STAIR VII recommendations for strategies to maximize the use of intravenous thrombolytics through targeting public educ...

journal_title：Stroke

authors： Albers GW,Goldstein LB,Hess DC,Wechsler LR,Furie KL,Gorelick PB,Hurn P,Liebeskind DS,Nogueira RG,Saver JL,STAIR VII Consortium.

更新日期：2011-09-01 00:00:00

abstract：:Two patients with left middle cerebral artery (MCA) distribution infarctions fulfilled the "hot stroke" criteria on sequential 99m Tc pertechnetate flow and static gamma camera studies. The radioisotopic finding of a paradoxical relative increased flow to the affected hemisphere correlated with serial angiography show...

journal_title：Stroke

authors： Yarnell PR,Earnest MP,Sanders B,Burdick D

更新日期：1975-09-01 00:00:00

abstract：:Functional assessment of animals following experimental cerebral ischemia is often difficult due to the passive nature of many neurologic exams. We attempted to increase the objectivity of motor function evaluation by adapting quantifiable behavioral tests and actively testing rats' motor capability following a cerebr...

journal_title：Stroke

authors： Combs DJ,D'Alecy LG

更新日期：1987-03-01 00:00:00

abstract：BACKGROUND AND PURPOSE:An association between high lipoprotein(a) [Lp(a)] levels and positive Chlamydia pneumoniae IgG titers in coronary artery disease has been described. The possibility of predicting ischemic stroke by measurements of plasma Lp(a) and C pneumoniae antibodies was investigated. METHODS:This incident ...

journal_title：Stroke

authors： Glader CA,Stegmayr B,Boman J,Stenlund H,Weinehall L,Hallmans G,Dahlén GH

更新日期：1999-10-01 00:00:00

abstract：BACKGROUND:Improved neurological outcome with postarrest hypertensive hemodilution in an earlier study could be the result of more homogeneous cerebral perfusion and improved O2 delivery. We explored global, regional, and local cerebral blood flow by stable xenon-enhanced computed tomography and global cerebral metabol...

journal_title：Stroke

authors： Leonov Y,Sterz F,Safar P,Johnson DW,Tisherman SA,Oku K

更新日期：1992-01-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Chronic kidney disease may increase the risk for ischemic stroke or systemic embolism in patients with nonvalular atrial fibrillation (AF). We conducted a meta-analysis to summarize all published studies to investigate the link between chronic kidney disease and risk of thromboembolic events in A...

journal_title：Stroke

authors： Zeng WT,Sun XT,Tang K,Mei WY,Liu LJ,Xu Q,Cheng YJ

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The physiological function of cellular prion protein (PrPc) is not yet understood. Recent findings suggest that PrPc may have neuroprotective properties, and its absence increases susceptibility to neuronal injury. The purpose of this study was to elucidate the role of PrPc in ischemic brain inju...

journal_title：Stroke

authors： Weise J,Sandau R,Schwarting S,Crome O,Wrede A,Schulz-Schaeffer W,Zerr I,Bähr M

更新日期：2006-05-01 00:00:00

abstract：BACKGROUND:Nonaneurysmal perimesencephalic hemorrhage, a distinct form of subarachnoid hemorrhage, is a recently described variant of intracranial hemorrhage. We describe two patients who presented with unusual features of this type of subarachnoid hemorrhage and also two patients who had a perimesencephalic pattern of...

journal_title：Stroke

authors： Schievink WI,Wijdicks EF,Piepgras DG,Nichols DA,Ebersold MJ

更新日期：1994-07-01 00:00:00

abstract：:Background and Purpose- This ARISTOPHANES study (Anticoagulants for Reduction in Stroke: Observational Pooled Analysis on Health Outcomes and Experience of Patients) used multiple data sources to compare stroke/systemic embolism (SE) and major bleeding (MB) among a large number of nonvalvular atrial fibrillation patie...

journal_title：Stroke

authors： Lip GYH,Keshishian A,Li X,Hamilton M,Masseria C,Gupta K,Luo X,Mardekian J,Friend K,Nadkarni A,Pan X,Baser O,Deitelzweig S

更新日期：2018-12-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Patients with cerebral amyloid angiopathy (CAA) are at high risk for intracerebral hemorrhage (ICH), but no effective prevention strategies have been established. The objective is to determine whether lowering of blood pressure (BP) provides protection for this high-risk patient group. METHODS:T...

journal_title：Stroke

authors： Arima H,Tzourio C,Anderson C,Woodward M,Bousser MG,MacMahon S,Neal B,Chalmers J,PROGRESS Collaborative Group.

更新日期：2010-02-01 00:00:00

abstract：BACKGROUND AND PURPOSE:We obtained magnetization transfer imaging (MTI) scans from individuals with cerebral autosomal-dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) (1) to investigate the presence, extent, and nature of pathology in white and gray matter outside proton density (PD)-v...

journal_title：Stroke

authors： Iannucci G,Dichgans M,Rovaris M,Brüning R,Gasser T,Giacomotti L,Yousry TA,Filippi M

更新日期：2001-03-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The ability of therapeutic exercise after stroke to improve daily functioning and quality of life (QOL) remains controversial. We examined treatment effects on these outcomes in a randomized controlled trial (RCT) of exercise in subacute stroke survivors. METHODS:This is a secondary analysis of ...

journal_title：Stroke

authors： Studenski S,Duncan PW,Perera S,Reker D,Lai SM,Richards L

更新日期：2005-08-01 00:00:00

abstract：:To clarify the nature of ischemic striatal dopamine release during the earliest periods of neuronal injury, we used chronoamperometry to measure dopamine levels every 60 seconds during various durations of ischemia in 32 gerbils. Catecholamine-selective electrodes were implanted into the brains of anesthetized gerbils...

journal_title：Stroke

authors： Ahn SS,Blaha CD,Alkire MT,Wood E,Gray-Allan P,Marrocco RT,Moore WS

更新日期：1991-05-01 00:00:00