Candidate gene polymorphisms do not differ between newborns with stroke and normal controls.

Abstract:

BACKGROUND AND PURPOSE:Neonatal stroke is increasingly recognized with an estimated incidence of one in 4000 live births per year. Pathways involved in the pathophysiology of neonatal stroke are diverse and may include thrombosis and thrombolysis, vascular reactivity, and inflammation. METHODS:We compared frequencies of polymorphisms in genes regulating thrombosis and thrombolysis, nitric oxide, cytokines, vascular tone, and cell adhesion in a hospital-based cohort of 59 newborns with stroke relative to a random sample of 437 California newborns. RESULTS:Of the 31 polymorphisms evaluated, no variant allele was significantly more common than the reference allele in newborns with stroke than in the general population. CONCLUSIONS:Using a series of polymorphisms in pathways implicated in the etiology of stroke, newborns with stroke were not distinguished from a normal control group. Further studies are needed to determine the interaction of genetic polymorphisms with environmental risk factors in the pathogenesis of neonatal stroke.

journal_name

Stroke

journal_title

Stroke

authors

Miller SP,Wu YW,Lee J,Lammer EJ,Iovannisci DM,Glidden DV,Bonifacio SL,Collins A,Shaw GM,Barkovich AJ,Ferriero DM

doi

10.1161/01.STR.0000244810.91105.c9

subject

Has Abstract

pub_date

2006-11-01 00:00:00

pages

2678-83

issue

11

eissn

0039-2499

issn

1524-4628

pii

01.STR.0000244810.91105.c9

journal_volume

37

pub_type

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