Abstract:
BACKGROUND AND PURPOSE:Neonatal stroke is increasingly recognized with an estimated incidence of one in 4000 live births per year. Pathways involved in the pathophysiology of neonatal stroke are diverse and may include thrombosis and thrombolysis, vascular reactivity, and inflammation. METHODS:We compared frequencies of polymorphisms in genes regulating thrombosis and thrombolysis, nitric oxide, cytokines, vascular tone, and cell adhesion in a hospital-based cohort of 59 newborns with stroke relative to a random sample of 437 California newborns. RESULTS:Of the 31 polymorphisms evaluated, no variant allele was significantly more common than the reference allele in newborns with stroke than in the general population. CONCLUSIONS:Using a series of polymorphisms in pathways implicated in the etiology of stroke, newborns with stroke were not distinguished from a normal control group. Further studies are needed to determine the interaction of genetic polymorphisms with environmental risk factors in the pathogenesis of neonatal stroke.
journal_name
Strokejournal_title
Strokeauthors
Miller SP,Wu YW,Lee J,Lammer EJ,Iovannisci DM,Glidden DV,Bonifacio SL,Collins A,Shaw GM,Barkovich AJ,Ferriero DMdoi
10.1161/01.STR.0000244810.91105.c9subject
Has Abstractpub_date
2006-11-01 00:00:00pages
2678-83issue
11eissn
0039-2499issn
1524-4628pii
01.STR.0000244810.91105.c9journal_volume
37pub_type
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