Abstract:
:Experimental subarachnoid hemorrhage (SAH) was induced in baboons by repeated injections of autologous blood into cisterna chiasmatis and cisterna magna, a total of 14-33 ml being injected over 3-4 days. Cerebral blood flow (CBF; 133xenon clearance) and cerebral metabolic rate of oxygen (CMRO2) were measured before, and 7 days after, the first blood injection. The effect of the calcium channel blocker, nimodipine, used in a commercially available form for clinical application, was studied following continuous i.a. infusion (0.1 microgram X kg-1 X min-1) for an interval of 45 min, and also 20 and 60 min after intrathecal administration of 1 microgram X kg-1. During the infusion experiments, CBF was increased by 25-30% both before and after the cisternal blood injection. CMRO2 was also enhanced, but much less. Nimodipine in doses given did not alter systemic blood pressure. Following intrathecal application, CBF and CMRO2 slightly increased at 20 min only before experimental SAH.
journal_name
Strokejournal_title
Strokeauthors
Sahlin C,Delgado T,Owman C,Svendgaard NAdoi
10.1161/01.str.17.2.220subject
Has Abstractpub_date
1986-03-01 00:00:00pages
220-4issue
2eissn
0039-2499issn
1524-4628journal_volume
17pub_type
杂志文章相关文献
STROKE文献大全abstract:BACKGROUND AND PURPOSE:We sought to assess the reproducibility, interobserver variability, and application to clinical studies of a new method for the quantitative assessment of carotid plaque echogenicity. METHODS:Carotid plaques were scanned with the use of ultrasound, and their images were stored in a computer. The...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.31.9.2189
更新日期:2000-09-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Randomized clinical trials testing aspirin in relatively low-risk, middle-aged people have consistently shown small increases in stroke associated with aspirin use. We analyzed the relationship between the regular use of aspirin and incident ischemic and hemorrhagic stroke among people aged 65 ye...
journal_title:Stroke
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1161/01.str.29.5.887
更新日期:1998-05-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The Stroke Health and Risk Education Project was a cluster-randomized, faith-based, culturally sensitive, theory-based multicomponent behavioral intervention trial to reduce key stroke risk factor behaviors in Hispanics/Latinos and European Americans. METHODS:Ten Catholic churches were randomize...
journal_title:Stroke
pub_type: 杂志文章,随机对照试验
doi:10.1161/STROKEAHA.115.010678
更新日期:2015-10-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Effects of anoxic stress on cerebrovascular responses to calcitonin gene-related peptide (CGRP) have not been examined previously. We determined the effects of total global ischemia on cerebral arteriolar responses to CGRP in newborn pigs. METHODS:Piglets were anesthetized and ventilated with a ...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.27.1.134
更新日期:1996-01-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Traditional vascular risk factors do not completely explain the asymmetry, racial, and sex differences in carotid artery disease. Carotid anatomy and geometry may play a role in the pathogenesis of internal carotid artery (ICA) stenosis, but their effects are unknown. We hypothesized that carotid...
journal_title:Stroke
pub_type: 临床试验,杂志文章
doi:10.1161/STROKEAHA.111.645499
更新日期:2012-06-01 00:00:00
abstract::Recent clinical studies emphasize the importance of early (less than 12 hours after onset) treatment of patients with acute ischemic stroke. Therapies have been proposed as being effective because of early clinical improvement. The frequency and degree of spontaneous improvement in such patients, however, is unknown. ...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.21.7.1008
更新日期:1990-07-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Chronic ocular ischemia is a rare form of ischemia of the eye in patients with carotid artery occlusion (CAO). The early and often asymptomatic stage of chronic ocular ischemia is referred to as venous stasis retinopathy (VSR). The aim of this study was to gain insight into the prevalence, cause,...
journal_title:Stroke
pub_type: 临床试验,杂志文章
doi:10.1161/hs0302.104619
更新日期:2002-03-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The purposes of this study were to assess the relationships between anatomic and technical factors and the 30-day risk of stroke or death after carotid angioplasty and stenting in the Endarterectomy versus Stenting in Patients with Symptomatic Severe Carotid Stenosis (EVA-3S) trial and to perform...
journal_title:Stroke
pub_type: 杂志文章,多中心研究,随机对照试验,评审
doi:10.1161/STROKEAHA.110.588772
更新日期:2011-02-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Kawasaki disease is a febrile disease of children notable for systemic vasculitis. There have been many previous reports of various complications, including disorders of the central nervous system. We evaluated cerebral perfusion during the acute stage in patients with Kawasaki disease. METHODS:...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.29.7.1320
更新日期:1998-07-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Administration of histamine receptor antagonists has been reported to produce contradictory results, either reducing or increasing neural damage induced by ischemia. In this study, we investigated the neuroprotective effects of histamine H2-receptor antagonists in an "in vitro" model of ischemia....
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.STR.0000141160.66818.24
更新日期:2004-10-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Computed tomography is now routinely used in many hospitals to investigate cerebrovascular disease. The purpose of our prospective study was to determine whether cranial computed tomography in connection with neurological assessment was useful in prognostic evaluation of survival after acute stro...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.23.4.506
更新日期:1992-04-01 00:00:00
abstract::The levels of lipid peroxides, determined as thiobarbituric acid reactive substances (TBARS), and the activities of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px), were examined in the blood from stroke-prone spontaneously hypertensive rats (SHRSP), with and without cerebral lesions, and normotensive W...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.10.3.323
更新日期:1979-05-01 00:00:00
abstract::We studied the pattern and outcome of strokes in 200 Saudi patients. Cerebral infarction constituted 87% of strokes, subarachnoid hemorrhage 4.5%, cerebral hemorrhage 6.5%, and venous infarction 2%. The vessel most commonly involved was part or all of the middle cerebral artery, constituting 52% (90) of the 174 arteri...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.22.9.1173
更新日期:1991-09-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The aim of our study was to clarify the pathophysiology of perioperative cerebral complications during carotid endarterectomy in our series. METHODS:By means of transcranial Doppler ultrasonography and stump pressure measurement, we monitored 112 patients who underwent carotid endarterectomy und...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.28.12.2448
更新日期:1997-12-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The use of lithium as a neuroprotective agent has been demonstrated using various models in which improvements in infarct size, DNA damage, and neurological function were reported. We further investigated neurohemodynamic aspects of the treatment-associated recovery by assessing the therapeutic e...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.107.492215
更新日期:2008-02-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Brain atrophy can be regarded as an end-organ effect of cumulative cardiovascular risk factors. Accelerated brain atrophy is described following ischemic stroke, but it is not known whether atrophy rates vary over the poststroke period. Examining rates of brain atrophy allows the identification o...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.120.030256
更新日期:2020-09-01 00:00:00
abstract::As part of a prospective study of mood disorders in stroke patients, interviews were obtained from 37 patients at 1 year and 48 patients at 2 years follow-up. In-hospital evaluations for these 65 follow-up patients found that 9 patients (14%) had symptom clusters of major depression, 12 patients (18%) had symptom clus...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.18.5.837
更新日期:1987-09-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Anemia is 1 potential mechanism by which the brain receives inadequate oxygenation. The purpose of this study was to determine in acute stroke patients whether lower hemoglobin values were associated with worse hemispatial neglect. METHODS:In 203 subjects, neglect testing batteries were administ...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.110.585265
更新日期:2010-08-01 00:00:00
abstract:BACKGROUND AND PURPOSE:There is controversy about the optimal patient position for the detection of right-to-left shunt (RLS). The study was performed to investigate which patient position best detects RLS during contrast-enhanced transcranial Doppler. METHODS:We prospectively evaluated consecutive patients with ische...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.110.609875
更新日期:2011-08-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The goal of this study was to determine the alterations in contractile and dilatory responses and ultrastructure of the feline middle cerebral artery after hemorrhagic hypotension. METHODS:In the sodium pentobarbital anesthetized cats, a steady 50 mm Hg level of hypotension was reached by bleedi...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.22.12.1541
更新日期:1991-12-01 00:00:00
abstract:BACKGROUND AND PURPOSE:In ACTIVE-W, oral anticoagulation (OAC) was more efficacious than combined clopidogrel plus aspirin (C+A) in preventing vascular events in patients with atrial fibrillation. However, because OAC carries important bleeding complications, risk stratification schemes have been devised to identify pa...
journal_title:Stroke
pub_type: 杂志文章,随机对照试验
doi:10.1161/STROKEAHA.107.500199
更新日期:2008-05-01 00:00:00
abstract:BACKGROUND AND PURPOSE:We tested the hypothesis that sildenafil, a phosphodiesterase type 5 (PDE5) inhibitor, promotes functional recovery and neurogenesis after stroke. METHODS:Male Wistar rats were subjected to embolic middle cerebral artery occlusion. Sildenafil (Viagra) was administered orally for 7 consecutive da...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.0000034399.95249.59
更新日期:2002-11-01 00:00:00
abstract::Non-invasive vascular testing has proven to be an effective means of identifying patients with significant extracranial carotid artery disease. Such tests can yield valuable physiologic data in patients with TIAs and can identify patients with soft signs who may have significant carotid artery disease and who may be c...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.11.4.325
更新日期:1980-07-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Neuroprotective effects of electric stimulation have been recently shown in ischemic stroke, but the underlying mechanisms remain poorly understood. METHODS:Adult Wistar rats weighing 200 to 250 g received occlusion of the right middle cerebral artery for 90 minutes. At 1 hour after reperfusion,...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.109.563627
更新日期:2009-11-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The benefits of chronic disease self-management programs for stroke survivors are uncertain because individuals with severe impairments have been excluded from previous research. We undertook a phase II randomized controlled trial to determine whether a self-management program designed for surviv...
journal_title:Stroke
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1161/STROKEAHA.110.601997
更新日期:2011-06-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Exogenous delivery of vascular endothelial growth factor gene (VEGF) may provide a useful approach to the treatment of brain ischemia. We investigated the use of a hypoxia-responsive element to control VEGF expression given for neuroprotection. METHODS:Three groups (n=36) of mice received AAVH9-...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.STR.0000240407.14765.e8
更新日期:2006-10-01 00:00:00
abstract:BACKGROUND:Cardiac involvement in Whipple's disease is not an uncommon phenomenon in autopsies, but its clinical occurrence is often overshadowed by gastrointestinal symptoms. We report a very atypical manifestation of this disorder. SUMMARY OF REPORT:An extraordinary presentation of an extremely long-lasting, culture...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.31.8.2002
更新日期:2000-08-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The ABCD system was developed to predict early stroke risk after transient ischemic attack. Incorporation of brain imaging findings has been suggested, but reports have used inconsistent methods and been underpowered. We therefore performed an international, multicenter collaborative study of the...
journal_title:Stroke
pub_type: 杂志文章,多中心研究
doi:10.1161/STROKEAHA.110.578971
更新日期:2010-09-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The objectives of the present study were to: (1) noninvasively identify white matter reorganization and monitor its progress within 6 weeks after the onset of stroke; and (2) quantitatively investigate the effect of recombinant human erythropoietin treatment on this structural change using in viv...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.108.527713
更新日期:2009-03-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Carotid angioplasty and stenting (CAS) has a higher incidence of periprocedural stroke compared with endarterectomy. Identifying CAS steps with the highest likelihood of embolization may have important implications. We evaluated CAS safety by correlating the findings of procedural transcranial Do...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.111.000659
更新日期:2013-05-01 00:00:00