Trained Immunity Characteristics Are Associated With Progressive Cerebral Small Vessel Disease.

Abstract:

:Background and Purpose- Cerebral small vessel disease (cSVD) is the major vascular cause of cognitive decline and dementia. The pathogenesis of cSVD remains largely unknown, although several studies suggest a role for systemic inflammation. In certain pathophysiological situations, monocytes can reprogram toward a long-term proinflammatory phenotype, which has been termed trained immunity. We hypothesize that trained immunity contributes to the progression of cSVD. Methods- Individuals with mild-to-severe cSVD participated in the study. Severity of cSVD was determined by the white matter hyperintensities (WMH) volume (mL) on magnetic resonance imaging in 2006, 2015, and the progression between 2006 and 2015 (ΔWMH). Cytokine production was assessed after ex vivo stimulation of peripheral blood mononuclear cells and monocytes. Additionally, monocyte subsets were identified by flow cytometry. Results- Fifty-one subjects (70±6 years, 60% men, 5.1±6.4 mL ΔWMH) were included. Circulating hsIL (high-sensitivity interleukin)-6 correlated with cSVD ( P=0.005, rs=0.40). Cytokine production capacity by monocytes was associated with cSVD progression. Basal IL-8 and IL-17 production ( P=0.08, rs=0.25; P=0.03, rs=0.30) and IL-6 production after Pam3Cys stimulation in monocytes was associated with cSVD (n=35: P=0.008, rs=0.44). Conversely, interferon (IFN)-γ production in Candida albicans stimulated peripheral blood mononuclear cells was negatively correlated with cSVD ( P=0.009, rs=-0.36). Flow cytometry revealed a correlation of the intermediate monocyte subset with cSVD ( P=0.01, rs=0.36). Conclusions- Severity and progression of cSVD are not only correlated with systemic inflammation (hsIL-6) but also with trained immunity characteristics of circulating monocytes, in terms of an altered cytokine production capacity and a shift toward the proinflammatory intermediate monocyte subset.

journal_name

Stroke

journal_title

Stroke

authors

Noz MP,Ter Telgte A,Wiegertjes K,Joosten LAB,Netea MG,de Leeuw FE,Riksen NP

doi

10.1161/STROKEAHA.118.023192

subject

Has Abstract

pub_date

2018-12-01 00:00:00

pages

2910-2917

issue

12

eissn

0039-2499

issn

1524-4628

journal_volume

49

pub_type

杂志文章

相关文献

STROKE文献大全
  • Impaired progression of cerebral aneurysms in interleukin-1beta-deficient mice.

    abstract:BACKGROUND AND PURPOSE:Subarachnoid hemorrhage caused by cerebral aneurysm rupture remains a life-threatening emergency despite advances in treatment. However, the mechanisms underlying aneurysm initiation, progression, and rupture remain unclear. We developed a method to induce experimental cerebral aneurysms in rats,...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.STR.0000204028.39783.d9

    authors: Moriwaki T,Takagi Y,Sadamasa N,Aoki T,Nozaki K,Hashimoto N

    更新日期:2006-03-01 00:00:00

  • Increases in cerebral blood flow in rat hippocampus after medial septal injection of naloxone.

    abstract:BACKGROUND AND PURPOSE:In a previous study, we occasionally found that the rat given naloxone in the preoptic region develops behavioral seizures. In view of knowledge that the forebrain including the medial septal nucleus provides cholinergic projections to the hippocampal formation, the present study examined the eff...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.23.9.1325

    authors: Nishimura J,Endo Y,Kimura F

    更新日期:1992-09-01 00:00:00

  • Osteogenic protein-1 protects against cerebral infarction induced by MCA ligation in adult rats.

    abstract:BACKGROUND AND PURPOSE:Osteogenic protein-1 (OP1) not only possesses trophic activity on bone tissue but also influences neuronal survival and differentiation in vitro. Specific receptors for OP1 are present in brain and spinal cord and can be upregulated during cerebral contusion. OP1 is a member of the transforming g...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.30.1.126

    authors: Lin SZ,Hoffer BJ,Kaplan P,Wang Y

    更新日期:1999-01-01 00:00:00

  • Assessment of scales of disability and handicap for stroke patients.

    abstract:BACKGROUND AND PURPOSE:The purpose of the study is to compare the reliability of the Barthel activities of daily living score, which assesses disability, with the Rankin scale, which assesses handicap, and to determine their mutual agreement. METHODS:Fifty patients with stroke of varying severity were identified by a ...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.22.10.1242

    authors: Wolfe CD,Taub NA,Woodrow EJ,Burney PG

    更新日期:1991-10-01 00:00:00

  • Reduction in incident stroke risk with vigorous physical activity: evidence from 7.7-year follow-up of the national runners' health study.

    abstract:BACKGROUND AND PURPOSE:The purpose of this study was to assess the dose-response relationship between vigorous physical activity (running distance, km/d) and the participant-reported physician-diagnosed stroke. METHODS:Age-adjusted survival analysis of 29 279 men and 12 123 women followed prospectively for 7.7 years. ...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/STROKEAHA.108.535427

    authors: Williams PT

    更新日期:2009-05-01 00:00:00

  • Preoperative assessment of the carotid bifurcation. Can magnetic resonance angiography and duplex ultrasonography replace contrast arteriography?

    abstract:BACKGROUND AND PURPOSE:Noninvasive studies are used with increasing frequency to assess the carotid bifurcation before endarterectomy. Therefore, assessment of their diagnostic accuracies is essential for appropriate patient management. We prospectively evaluate two noninvasive tests, magnetic resonance angiography (MR...

    journal_title:Stroke

    pub_type: 临床试验,杂志文章

    doi:10.1161/01.str.26.10.1753

    authors: Patel MR,Kuntz KM,Klufas RA,Kim D,Kramer J,Polak JF,Skillman JJ,Whittemore AD,Edelman RR,Kent KC

    更新日期:1995-10-01 00:00:00

  • Impact of Goal-Directed Therapy on Delayed Ischemia After Aneurysmal Subarachnoid Hemorrhage: Randomized Controlled Trial.

    abstract:BACKGROUND AND PURPOSE:Delayed cerebral ischemia (DCI) is the most important cause for a poor clinical outcome after a subarachnoid hemorrhage. The aim of this study was to assess whether goal-directed hemodynamic therapy (GDHT), as compared to standard clinical care, reduces the rate of DCI after subarachnoid hemorrha...

    journal_title:Stroke

    pub_type: 杂志文章,随机对照试验

    doi:10.1161/STROKEAHA.120.029279

    authors: Anetsberger A,Gempt J,Blobner M,Ringel F,Bogdanski R,Heim M,Schneider G,Meyer B,Schmid S,Ryang YM,Wostrack M,Schneider J,Martin J,Ehrhardt M,Jungwirth B

    更新日期:2020-08-01 00:00:00

  • Genetics of cerebrovascular disease.

    abstract::Stroke is a complex disease, with both genetic and environmental factors having a role in its pathogenesis. A review of past studies shows some evidence of genetic influences in the development of stroke. This is supported by studies of cardiovascular disease, which indicate major genetic influences at several levels ...

    journal_title:Stroke

    pub_type: 杂志文章,评审

    doi:

    authors: Alberts MJ

    更新日期:1990-11-01 00:00:00

  • Transesophageal echocardiography in the detection of potential cardiac source of embolism in stroke patients.

    abstract::To compare the diagnostic yields of transesophageal and transthoracic echocardiography in the detection of potential cardiac sources of embolism, 63 patients (mean +/- SD age 63 +/- 15 [range 18-87] years) with transient ischemic attacks or stroke underwent both procedures. Transthoracic echocardiography revealed a po...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.22.6.727

    authors: Cujec B,Polasek P,Voll C,Shuaib A

    更新日期:1991-06-01 00:00:00

  • Ultrasonic evaluation of early carotid atherosclerosis.

    abstract::We investigated the prevalence of carotid atherosclerosis, including mild early lesions, and its association with cervical bruits and various risk factors (age, male sex, hypertension, hyperlipidemia, diabetes mellitus, obesity, and cigarette smoking) in 232 consecutive Japanese patients. High-resolution real-time B-m...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.21.11.1567

    authors: Handa N,Matsumoto M,Maeda H,Hougaku H,Ogawa S,Fukunaga R,Yoneda S,Kimura K,Kamada T

    更新日期:1990-11-01 00:00:00

  • Changes in cerebral blood flow and metabolism following intraarterial or local administration of nimodipine, before and after experimental subarachnoid hemorrhage in baboons.

    abstract::Experimental subarachnoid hemorrhage (SAH) was induced in baboons by repeated injections of autologous blood into cisterna chiasmatis and cisterna magna, a total of 14-33 ml being injected over 3-4 days. Cerebral blood flow (CBF; 133xenon clearance) and cerebral metabolic rate of oxygen (CMRO2) were measured before, a...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.17.2.220

    authors: Sahlin C,Delgado T,Owman C,Svendgaard NA

    更新日期:1986-03-01 00:00:00

  • Age dependence of risk factors for stroke and death in young patients with atrial fibrillation: a nationwide study.

    abstract:BACKGROUND AND PURPOSE:The risk of stroke and death in patients with atrial fibrillation is strongly associated with age and concomitant comorbidities. The aim of this study was to examine the age dependence of risk factors for stroke and mortality in young patients with atrial fibrillation. METHODS:This study is a po...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/STROKEAHA.114.004903

    authors: Melgaard L,Rasmussen LH,Skjøth F,Lip GY,Larsen TB

    更新日期:2014-05-01 00:00:00

  • Vegetable and fruit intake and stroke mortality in the Hiroshima/Nagasaki Life Span Study.

    abstract:BACKGROUND AND PURPOSE:Fruits and vegetables are known for their beneficial effects on chronic diseases. The purpose of the present study was to investigate the protective effect of a diet rich in fruits and vegetables on total stroke mortality and its 2 main subtypes in men and women separately. METHODS:A prospective...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.STR.0000089293.29739.97

    authors: Sauvaget C,Nagano J,Allen N,Kodama K

    更新日期:2003-10-01 00:00:00

  • Age-related changes in release of endothelium-derived relaxing factor from the carotid artery.

    abstract:BACKGROUND AND PURPOSE:The goal of this study was to determine whether release of endothelium-derived relaxing factor (EDRF) from carotid artery in response to acetylcholine is altered by aging. METHODS:Responses were examined in arteries from Wistar rats 6 to 8 months old (young rats), 24 to 26 months old (old rats),...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.25.12.2457

    authors: Paternò R,Faraci FM,Heistad DD

    更新日期:1994-12-01 00:00:00

  • Preischemic but not postischemic zinc protoporphyrin treatment reduces infarct size and edema accumulation after temporary focal cerebral ischemia in rats.

    abstract:BACKGROUND AND PURPOSE:Zinc protoporphyrin (ZnPP) has multiple actions. It is an interleukin-1 antagonist as well as a hemeoxygenase inhibitor. Interleukin-1 is produced in ischemic brain and probably contributes to ischemic injury, although the role of heme oxygenase during ischemia is unknown. Whether ZnPP treatment ...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.26.6.1035

    authors: Kadoya C,Domino EF,Yang GY,Stern JD,Betz AL

    更新日期:1995-06-01 00:00:00

  • Clinical Outcomes of Transplanted Modified Bone Marrow-Derived Mesenchymal Stem Cells in Stroke: A Phase 1/2a Study.

    abstract:BACKGROUND AND PURPOSE:Preclinical data suggest that cell-based therapies have the potential to improve stroke outcomes. METHODS:Eighteen patients with stable, chronic stroke were enrolled in a 2-year, open-label, single-arm study to evaluate the safety and clinical outcomes of surgical transplantation of modified bon...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/STROKEAHA.116.012995

    authors: Steinberg GK,Kondziolka D,Wechsler LR,Lunsford LD,Coburn ML,Billigen JB,Kim AS,Johnson JN,Bates D,King B,Case C,McGrogan M,Yankee EW,Schwartz NE

    更新日期:2016-07-01 00:00:00

  • Report of the substudy assessing the impact of neurocognitive function on quality of life 5 years after cardiac surgery.

    abstract:BACKGROUND AND PURPOSE:The importance of perioperative cognitive decline has long been debated. We recently demonstrated a significant correlation between perioperative cognitive decline and long-term cognitive dysfunction. Despite this association, some still question the importance of these changes in cognitive funct...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/hs1201.099803

    authors: Newman MF,Grocott HP,Mathew JP,White WD,Landolfo K,Reves JG,Laskowitz DT,Mark DB,Blumenthal JA,Neurologic Outcome Research Group and the Cardiothoracic Anesthesia Research Endeavors (CARE) Investigators of the Duke Heart Center.

    更新日期:2001-12-01 00:00:00

  • Predictors and Outcomes of Dysphagia Screening After Acute Ischemic Stroke.

    abstract:BACKGROUND AND PURPOSE:Guidelines advocate screening all acute stroke patients for dysphagia. However, limited data are available regarding how many and which patients are screened and how failing a swallowing screen affects patient outcomes. We sought to evaluate predictors of receiving dysphagia screening after acute...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/STROKEAHA.116.015332

    authors: Joundi RA,Martino R,Saposnik G,Giannakeas V,Fang J,Kapral MK

    更新日期:2017-04-01 00:00:00

  • Effects of formaldehyde fixation on basilar artery caliber.

    abstract::The external diameters of rat and rabbit basilar arteries were determined before and after formaldehyde fixation in relaxed and drug constricted vessels. Fixation usually resulted in an immediate vessel constriction followed by partial relaxation after several hours. However, the results were inconstant from vessel to...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.11.1.99

    authors: Hart MN,O'Donnell SL

    更新日期:1980-01-01 00:00:00

  • Thrombotic risk factors in primary antiphospholipid syndrome: a 5-year prospective study.

    abstract:BACKGROUND AND PURPOSE:Because thromboembolic events are frequently observed in primary antiphospholipid syndrome (PAPS), we assessed the risk factors for new thrombotic episodes. METHODS:Fifty-six PAPS patients (mean age, 37+/-10 years) were prospectively studied for 5 years. The preliminary Sapporo classification cr...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.STR.0000170645.40562.09

    authors: Turiel M,Sarzi-Puttini P,Peretti R,Rossi E,Atzeni F,Parsons W,Doria A

    更新日期:2005-07-01 00:00:00

  • Distinct Short-Term Outcomes in Patients With Mild Versus Rapidly Improving Stroke Not Treated With Thrombolytics.

    abstract:BACKGROUND AND PURPOSE:Mild stroke (MS) and rapidly improving stroke (RIS) symptoms are common stroke presentations. Our objective is to describe the short-term outcomes in this population. METHODS:A retrospective analysis of patients with ischemic stroke in the Get With The Guidelines-Stroke registry who arrived ≤4.5...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/STROKEAHA.115.011528

    authors: Romano JG,Smith EE,Liang L,Gardener H,Campo-Bustillo I,Khatri P,Bhatt DL,Fonarow GC,Sacco RL,Schwamm LH

    更新日期:2016-05-01 00:00:00

  • Decompressive Surgery for the Treatment of Malignant Infarction of the Middle Cerebral Artery (DESTINY): a randomized, controlled trial.

    abstract:BACKGROUND AND PURPOSE:Decompressive surgery (hemicraniectomy) for life-threatening massive cerebral infarction represents a controversial issue in neurocritical care medicine. We report here the 30-day mortality and 6- and 12-month functional outcomes from the DESTINY trial. METHODS:DESTINY (ISRCTN01258591) is a pros...

    journal_title:Stroke

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1161/STROKEAHA.107.485649

    authors: Jüttler E,Schwab S,Schmiedek P,Unterberg A,Hennerici M,Woitzik J,Witte S,Jenetzky E,Hacke W,DESTINY Study Group.

    更新日期:2007-09-01 00:00:00

  • Glutamate-induced cerebral vasodilation is mediated by nitric oxide through N-methyl-D-aspartate receptors.

    abstract:BACKGROUND AND PURPOSE:It was found that glutamate, a major neurotransmitter, is vasoactive in the cerebral circulation. However, the mechanism is unclear. This study was designed to investigate the role of nitric oxide (NO) and N-methyl-D-aspartate (NMDA) receptors in cerebral arteriolar dilation to glutamate. METHOD...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.26.5.857

    authors: Meng W,Tobin JR,Busija DW

    更新日期:1995-05-01 00:00:00

  • Soluble CD40L Is a Useful Marker to Predict Future Strokes in Patients With Minor Stroke and Transient Ischemic Attack.

    abstract:BACKGROUND AND PURPOSE:Elevated soluble CD40 ligand (sCD40L) was shown to be related to cardiovascular events, but the role of sCD40L in predicting recurrent stroke remains unclear. METHODS:Baseline sCD40L levels were measured in 3044 consecutive patients with acute minor stroke and transient ischemic attack, who had ...

    journal_title:Stroke

    pub_type: 杂志文章,随机对照试验

    doi:10.1161/STROKEAHA.115.008685

    authors: Li J,Wang Y,Lin J,Wang D,Wang A,Zhao X,Liu L,Wang C,Wang Y,CHANCE Investigators.

    更新日期:2015-07-01 00:00:00

  • NMR-neuropathologic correlation in stroke.

    abstract::True, three-dimensional proton nuclear magnetic resonance imaging at 0.147 tesla was performed postmortem on 2 patients embodying various stroke syndromes, including chronic (4 and 15 years) infarction, subacute (within 1 week) bland infarction, acute (2 days) hemorrhagic infarction, and hematoma secondary to ruptured...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.18.2.342

    authors: DeWitt LD,Kistler JP,Miller DC,Richardson EP Jr,Buonanno FS

    更新日期:1987-03-01 00:00:00

  • Racial disparities in awareness and treatment of atrial fibrillation: the REasons for Geographic and Racial Differences in Stroke (REGARDS) study.

    abstract:BACKGROUND AND PURPOSE:Warfarin reduces stroke risk by approximately 60% in patients with atrial fibrillation (AF). Differences in awareness and treatment of AF may contribute to racial and geographic disparities in stroke mortality. The objective was to examine predictors of awareness of the diagnosis of AF and treatm...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/STROKEAHA.109.573907

    authors: Meschia JF,Merrill P,Soliman EZ,Howard VJ,Barrett KM,Zakai NA,Kleindorfer D,Safford M,Howard G

    更新日期:2010-04-01 00:00:00

  • Dissociation of vasospasm and secondary effects of experimental subarachnoid hemorrhage by clazosentan.

    abstract:BACKGROUND AND PURPOSE:Endothelin receptor antagonists such as clazosentan decrease large-artery vasospasm after experimental and clinical subarachnoid hemorrhage. We used clazosentan to gain insight into the pathophysiology of subarachnoid hemorrhage by determining if decreasing vasospasm is associated with alleviatio...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/STROKEAHA.110.604728

    authors: Sabri M,Ai J,Macdonald RL

    更新日期:2011-05-01 00:00:00

  • Right-left propensity and lesion patterns between cardiogenic and aortogenic cerebral embolisms.

    abstract:BACKGROUND AND PURPOSE:Based on thrombus location and nature and anatomic features of aorta and cerebral arteries, we hypothesized that cardiogenic embolisms (CE) and aortogenic embolisms (AE) might have different right-left propensity and lesion patterns. METHODS:We retrospectively reviewed patients with acute ischem...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/STROKEAHA.111.616573

    authors: Kim HJ,Song JM,Kwon SU,Kim BJ,Kang DH,Song JK,Kim JS,Kang DW

    更新日期:2011-08-01 00:00:00

  • Positive scans in angiographically proved cases of recanalized cerebral infarction.

    abstract::In 20 patients with acute major cerebral arterial occlusion, follow-up angiograms were obtained to inspect the occluded artery. These angiograms were compared with brain scans in the fourth week after the stroke. The angiograms revealed that frequent recanalization of the occluded arteries occurred within a week after...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.6.2.132

    authors: Irino T,Taneda M,Minami T

    更新日期:1975-03-01 00:00:00

  • Intraluminal Thrombi in the Cervico-Cephalic Arteries.

    abstract::Background and Purpose- Intraluminal thrombus (ILT) is an uncommon finding among patients with ischemic stroke. We report clinical-imaging manifestations, treatment offered, and outcome among patients with ischemic stroke/transient ischemic attack and ILT in their cervico-cephalic arteries. Methods- Sixty-one of 3750 ...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/STROKEAHA.118.023015

    authors: Singh RJ,Chakraborty D,Dey S,Ganesh A,Al Sultan AS,Eesa M,Wong JH,Goyal M,Hill MD,Menon BK

    更新日期:2019-02-01 00:00:00