Abstract:
BACKGROUND AND PURPOSE:The purpose of this study was to assess the dose-response relationship between vigorous physical activity (running distance, km/d) and the participant-reported physician-diagnosed stroke. METHODS:Age-adjusted survival analysis of 29 279 men and 12 123 women followed prospectively for 7.7 years. RESULTS:One hundred men and 19 women reported incident strokes. Per km/d run, the age- and smoking-adjusted risk for stroke decreased 12% in men (P=0.0007), and 11% in men and women combined (P=0.001), which remained significant when further adjusted for baseline diabetes, hypercholesterolemia, hypertension, and BMI (8% and 7% reduction per km/d run, respectively, P=0.03). Men and women who ran >or=2 km/d (ie, exceeded the recommended AHA/CDC and NIH guideline activity level) had significantly lower risk than those who ran less (P=0.05), and those who ran >or=4 km/d had significantly lower risk than those who ran 2 to 3.9 km/d (P=0.02). Men and women who ran >or=8 km/d were at 60% lower risk than those who ran <2 km/d (P=0.00). CONCLUSIONS:The risk for incident stroke is substantially reduced in those who exceed the guideline physical activity level, which cannot be attributed to less hypertension, diabetes, hypercholesterolemia, or body weight.
journal_name
Strokejournal_title
Strokeauthors
Williams PTdoi
10.1161/STROKEAHA.108.535427subject
Has Abstractpub_date
2009-05-01 00:00:00pages
1921-3issue
5eissn
0039-2499issn
1524-4628pii
STROKEAHA.108.535427journal_volume
40pub_type
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