Reproducibility of computer-quantified carotid plaque echogenicity: can we overcome the subjectivity?

Abstract:

BACKGROUND AND PURPOSE:We sought to assess the reproducibility, interobserver variability, and application to clinical studies of a new method for the quantitative assessment of carotid plaque echogenicity. METHODS:Carotid plaques were scanned with the use of ultrasound, and their images were stored in a computer. They were normalized by assigning certain gray values to blood and adventitia, and the gray scale median (GSM) was used to quantify their echogenicity. The variability between storage media, between degrees of magnification, and between probes was assessed. The method was applied to 232 asymptomatic carotid plaques causing 60% to 99% stenosis in relation to the presence of ipsilateral CT-demonstrated brain infarcts. In all parts of the study the plaque GSM was measured before and after normalization to evaluate its effect. Interobserver agreement for the scanning process was assessed. RESULTS:The GSM mean difference before and after normalization for variability studies of storage media, degrees of magnification, and probes was -14.5 and -0.12, 2.24 and 1.68, and -8.3 and -0.7, respectively. The median GSM of plaques associated with ipsilateral nonlacunar silent CT-demonstrated brain infarcts was 14, and that of plaques that were not so associated was 30 (P:=0.003). The interobserver GSM difference was -0.05 (95% CI, -1.7 to 1.6). CONCLUSIONS:Our method decreases the variability between storage media and between probes but not the variability between degrees of magnification. It separates echomorphologically the carotid plaques associated with silent nonlacunar CT-demonstrated brain infarcts from plaques that are not so associated.

journal_name

Stroke

journal_title

Stroke

authors

Sabetai MM,Tegos TJ,Nicolaides AN,Dhanjil S,Pare GJ,Stevens JM

doi

10.1161/01.str.31.9.2189

subject

Has Abstract

pub_date

2000-09-01 00:00:00

pages

2189-96

issue

9

eissn

0039-2499

issn

1524-4628

journal_volume

31

pub_type

杂志文章

相关文献

STROKE文献大全
  • First Pass Effect: A New Measure for Stroke Thrombectomy Devices.

    abstract:BACKGROUND AND PURPOSE:In acute ischemic stroke, fast and complete recanalization of the occluded vessel is associated with improved outcomes. We describe a novel measure for newer generation devices: the first pass effect (FPE). FPE is defined as achieving a complete recanalization with a single thrombectomy device pa...

    journal_title:Stroke

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1161/STROKEAHA.117.020315

    authors: Zaidat OO,Castonguay AC,Linfante I,Gupta R,Martin CO,Holloway WE,Mueller-Kronast N,English JD,Dabus G,Malisch TW,Marden FA,Bozorgchami H,Xavier A,Rai AT,Froehler MT,Badruddin A,Nguyen TN,Taqi MA,Abraham MG,Yoo AJ,

    更新日期:2018-03-01 00:00:00

  • Neuroimaging Determinants of Poststroke Cognitive Performance.

    abstract::Background and Purpose- We aimed to define the neuroimaging determinants of poststroke cognitive performance and their relative contributions among a spectrum of magnetic resonance imaging markers, including lesion burden and strategic locations. Methods- We prospectively included patients with stroke from the GRECogV...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/STROKEAHA.118.021981

    authors: Puy L,Barbay M,Roussel M,Canaple S,Lamy C,Arnoux A,Leclercq C,Mas JL,Tasseel-Ponche S,Constans JM,Godefroy O,GRECogVASC Study Group.

    更新日期:2018-11-01 00:00:00

  • Randomized controlled trial of acetylsalicylic acid in aneurysmal subarachnoid hemorrhage: the MASH Study.

    abstract:BACKGROUND AND PURPOSE:A previous systematic review of randomized trials suggested a positive effect of antiplatelet therapy in patients with aneurysmal subarachnoid hemorrhage (SAH). We performed a randomized controlled trial to assess whether acetylsalicylic acid (ASA) reduces the risk of delayed ischemic neurologica...

    journal_title:Stroke

    pub_type: 杂志文章,随机对照试验

    doi:10.1161/01.STR.0000236841.16055.0f

    authors: van den Bergh WM,MASH Study Group.,Algra A,Dorhout Mees SM,van Kooten F,Dirven CM,van Gijn J,Vermeulen M,Rinkel GJ

    更新日期:2006-09-01 00:00:00

  • Pressure-flow relations in canine collateral-dependent cerebrum.

    abstract:BACKGROUND AND PURPOSE:The pressure-flow relation has been characterized in normal cerebrum, but it has not been studied in cerebrum dependent on collateral flow. The purpose of this investigation was to examine the relation between systemic pressure, regional cerebral blood flow, and middle cerebral artery branch pres...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.23.7.988

    authors: Muhonen MG,Sawin PD,Loftus CM,Heistad DD

    更新日期:1992-07-01 00:00:00

  • Effect of DPPD (diphenyl-para-phenylenediamine) on stroke and cerebral edema in gerbils.

    abstract::Diphenyl-para-phenylenediamine (DPPD) is an antioxidant that has been shown to decrease liver damage due to the peroxidative process of carbon tetrachloride in rats and to ameliorate cold-induced cerebral edema in cats. Because lipid peroxidation disrupts the integrity of the plasma membrane, a process believed to occ...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.9.5.480

    authors: Butterfield JD,McGraw CP

    更新日期:1978-09-01 00:00:00

  • Early intensive versus minimally invasive approach to postoperative hemodynamic management after subarachnoid hemorrhage.

    abstract:BACKGROUND AND PURPOSE:The results of previous studies suggest that early goal-directed fluid therapy (EGDT) reduces delayed cerebral ischemia (DCI) after aneurysmal subarachnoid hemorrhage, but the effects of EGDT on clinical outcomes are still unclear. This study aimed to determine whether EGDT improves outcomes comp...

    journal_title:Stroke

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1161/STROKEAHA.114.004739

    authors: Mutoh T,Kazumata K,Terasaka S,Taki Y,Suzuki A,Ishikawa T

    更新日期:2014-05-01 00:00:00

  • Hemorrhagic complications of thrombolytic therapy in experimental stroke.

    abstract::Recent success with thrombolytic therapy for acute myocardial infarction has stimulated interest in its use for stroke. To determine the hemorrhagic potential of thrombolytic therapy in experimental cerebral infarction, we compared a group of tissue plasminogen activator-treated rabbits (n = 4) with 2 groups of strept...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.18.6.1148

    authors: Slivka A,Pulsinelli W

    更新日期:1987-11-01 00:00:00

  • Effect of intracarotid prostaglandin E1 on regional cerebral blood flow in man.

    abstract::The effect of prostaglandin E1 on regional cerebral blood flow (rCBF) was studied with the intra-arterial 133Xe method in ten awake patients under local anesthesia. Measurements were taken from 16 areas of a hemisphere in seven patients, from 35 areas of a hemisphere in two patients and from 256 areas of a hemisphere ...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.7.6.566

    authors: Olesen J

    更新日期:1976-11-01 00:00:00

  • Stimulated acoustic emission detected by transcranial color doppler ultrasound : a contrast-specific phenomenon useful for the detection of cerebral tissue perfusion.

    abstract:BACKGROUND AND PURPOSE:Experimental and clinical data suggest that insonation of echo-contrast agents with high acoustical power produces disintegration of microbubbles, resulting in a pseudo-Doppler phenomenon called stimulated acoustic emission (SAE). The purpose of this study was to investigate whether SAE might be ...

    journal_title:Stroke

    pub_type: 临床试验,杂志文章

    doi:10.1161/01.str.31.7.1661

    authors: Pohl C,Tiemann K,Schlosser T,Becher H

    更新日期:2000-07-01 00:00:00

  • Lacunar infarcts and white matter attenuation. Ophthalmologic and microcirculatory aspects of the pathophysiology.

    abstract:BACKGROUND AND PURPOSE:By means of neurological and ophthalmologic examinations we considered whether there is a microcirculatory disorder not related to hypertension and diabetes in patients with lacunar infarcts and whether there are microcirculatory differences in patients with lacunar infarcts compared with those w...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.24.12.1874

    authors: Schneider R,Rademacher M,Wolf S

    更新日期:1993-12-01 00:00:00

  • Efficacy of Endovascular Therapy in Acute Ischemic Stroke Depends on Age and Clinical Severity.

    abstract:BACKGROUND AND PURPOSE:Efficacy of endovascular treatment (EVT) for ischemic stroke because of large vessel occlusion may depend on patients' age and stroke severity; we, therefore, developed a prognosis score based on these variables and examined whether EVT efficacy differs between patients with good, intermediate, o...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/STROKEAHA.117.020511

    authors: Le Bouc R,Clarençon F,Meseguer E,Lapergue B,Consoli A,Turc G,Naggara O,Duong DL,Servan J,Reiner P,Labeyrie MA,Fisselier M,Blanc R,Farhat W,Pires C,Zuber M,Obadia M,Mazighi M,Pico F,Mas JL,Amarenco P,Samson Y,P

    更新日期:2018-07-01 00:00:00

  • Detection of thrombus in acute ischemic stroke: value of thin-section noncontrast-computed tomography.

    abstract:BACKGROUND AND PURPOSE:Previous studies on the hyperdense middle cerebral artery (MCA) sign were conducted using > or =5-mm thickness noncontrast-computed tomography (NCT). The purpose of this study was to compare thin-section NCT with 5-mm NCT in the detection of thrombus in acute ischemic stroke. METHODS:Enrolled we...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.STR.0000185720.03803.41

    authors: Kim EY,Lee SK,Kim DJ,Suh SH,Kim J,Heo JH,Kim DI

    更新日期:2005-12-01 00:00:00

  • Delayed cerebral ischemia following arteriography.

    abstract::Cerebral ischemic events associated with arteriography are usually attributed to catheter-induced emboli. We present three patients with cerebral ischemia occurring 6 to 48 hours post-arteriography. We suspected that alternate pathogenic mechanisms were in effect. To evaluate the possibility that sustained platelet ac...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.16.3.431

    authors: Fisher M,Sandler R,Weiner JM

    更新日期:1985-05-01 00:00:00

  • Stroke Incidence and Outcomes in Northeastern Greece: The Evros Stroke Registry.

    abstract:BACKGROUND AND PURPOSE:Data are scarce on both stroke incidence rates and outcomes in Greece and in rural areas in particular. We performed a prospective population-based study evaluating the incidence of first-ever stroke in the Evros prefecture, a region of a total 147 947 residents located in North Eastern Greece. ...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/STROKEAHA.117.019524

    authors: Tsivgoulis G,Patousi A,Pikilidou M,Birbilis T,Katsanos AH,Mantatzis M,Asimis A,Papanas N,Skendros P,Terzoudi A,Karamanli A,Kouroumichakis I,Zebekakis P,Maltezos E,Piperidou C,Vadikolias K,Heliopoulos I

    更新日期:2018-02-01 00:00:00

  • Stroke awareness and knowledge retention in children: The Brain Child Project.

    abstract:BACKGROUND AND PURPOSE:Efforts at public education to improve adults' response to stroke symptoms continue to be disappointing, and very little has been developed to improve the knowledge base of children regarding brain attacks. Children may be able to exert a positive influence on adult behavior and to learn positive...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/hs0202.102728

    authors: Dressman LA,Hunter J

    更新日期:2002-02-01 00:00:00

  • Linkage of ischemic stroke to the PDE4D region on 5q in a Swedish population.

    abstract:BACKGROUND AND PURPOSE:Recent Icelandic studies have demonstrated linkage for common forms of stroke to chromosome 5q12 and association between phosphodiesterase4D (PDE4D) and ischemic stroke. Using a candidate region approach, we wanted to test the validity of these findings in a different population from northern Swe...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.STR.0000174188.04716.8d

    authors: Nilsson-Ardnor S,Wiklund PG,Lindgren P,Nilsson AK,Janunger T,Escher SA,Hallbeck B,Stegmayr B,Asplund K,Holmberg D

    更新日期:2005-08-01 00:00:00

  • Coffee consumption and risk of stroke in women.

    abstract:BACKGROUND AND PURPOSE:Coffee consumption has been inconsistently associated with stroke incidence and mortality in previous studies. We investigated the association between coffee consumption and stroke incidence in the Swedish Mammography Cohort. METHODS:We prospectively followed of 34,670 women without a history of...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/STROKEAHA.110.603787

    authors: Larsson SC,Virtamo J,Wolk A

    更新日期:2011-04-01 00:00:00

  • Cerebral venous thrombosis in the absence of headache.

    abstract:BACKGROUND AND PURPOSE:Although headache is the most common symptom in cerebral venous thrombosis, 5% to 30% of patients do not report headache at baseline. Characteristics of these patients have not been investigated. METHODS:In post hoc analysis of the International Study on Cerebral Vein and Dural Sinus Thrombosis ...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/STROKEAHA.114.007584

    authors: Coutinho JM,Stam J,Canhão P,Barinagarrementeria F,Bousser MG,Ferro JM,ISCVT Investigators.

    更新日期:2015-01-01 00:00:00

  • Deferral of Consent in Acute Stroke Trials.

    abstract::Background and Purpose- The ESCAPE trial (The Endovascular Treatment for Small Core and Anterior Circulation Proximal Occlusion With Emphasis on Minimizing CT to Recanalization Times) was a multicentre, randomized controlled trial of endovascular thrombectomy versus standard care for patients with acute ischemic strok...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/STROKEAHA.118.024096

    authors: Shamy MCF,Dewar B,Chevrier S,Wang CQ,Page S,Goyal M,Demchuk AM,Hill MD

    更新日期:2019-04-01 00:00:00

  • Change in perfusion in acute nondominant hemisphere stroke may be better estimated by tests of hemispatial neglect than by the National Institutes of Health Stroke Scale.

    abstract:BACKGROUND AND PURPOSE:It has been reported that National Institutes of Health Stroke Scale (NIHSS) scores correlate poorly with hypoperfused tissue measured by perfusion-weighted imaging (PWI) in nondominant hemisphere stroke. We conducted 2 studies to determine whether tests of hemispatial neglect provide a better me...

    journal_title:Stroke

    pub_type: 临床试验,杂志文章

    doi:10.1161/01.STR.0000089681.84041.69

    authors: Hillis AE,Wityk RJ,Barker PB,Ulatowski JA,Jacobs MA

    更新日期:2003-10-01 00:00:00

  • Primary care physician-reported secondary and tertiary stroke prevention practices. A comparison between the United States and the United Kingdom.

    abstract:BACKGROUND AND PURPOSE:Stroke is a major healthcare problem in both the United States (US) and the United Kingdom (UK). Little comparative data are available concerning how generalist physicians in the two countries approach the management of patients at high risk of stroke. METHODS:Contemporaneous surveys of random s...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.28.4.746

    authors: Goldstein LB,Farmer A,Matchar DB

    更新日期:1997-04-01 00:00:00

  • Utility of Computed Tomographic Perfusion in Thrombolysis for Minor Stroke.

    abstract:BACKGROUND AND PURPOSE:The use of thrombolysis in acute minor ischemic stroke (MIS) remains controversial. We sought to determine the safety and efficacy of intravenous tissue-type plasminogen activator (IV-tPA) in acute MIS patients with demonstrable penumbra on computed tomographic perfusion study. METHODS:Consecuti...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/STROKEAHA.116.013021

    authors: Ng FC,Coote S,Frost T,Bladin C,Choi PM

    更新日期:2016-07-01 00:00:00

  • Computed tomographic study of cervical carotid calcification.

    abstract::Contrast-enhanced computed tomography of the neck permits low-risk evaluation of morphologic complications of carotid plaque, including (and foremost) calcification. To investigate the patterns and clinical significance of calcified deposits in the cervical carotid arteries using computed tomography we studied 40 pati...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.20.11.1472

    authors: Culebras A,Otero C,Toledo JR,Rubin BS

    更新日期:1989-11-01 00:00:00

  • Low concentration of serum total cholesterol is associated with multifocal signal loss lesions on gradient-echo magnetic resonance imaging: analysis of risk factors for multifocal signal loss lesions.

    abstract:BACKGROUND AND PURPOSE:Multifocal signal loss lesions (MSLLs) on T2*-weighted gradient-echo (GE) MRI are believed to be microbleeds histopathologically. Previous epidemiological studies suggested that low serum cholesterol is associated with the increased risk of intracerebral hemorrhage. We investigated risk factors o...

    journal_title:Stroke

    pub_type: 临床试验,杂志文章

    doi:10.1161/01.str.0000036092.23649.2e

    authors: Lee SH,Bae HJ,Yoon BW,Kim H,Kim DE,Roh JK

    更新日期:2002-12-01 00:00:00

  • Distinguishing between stroke and mimic at the bedside: the brain attack study.

    abstract:BACKGROUND AND PURPOSE:The bedside clinical assessment of the patient with suspected stroke has not been well studied. Improving clinical skills may accelerate patient progress through the emergency department. We aimed to determine the frequency and nature of stroke mimics and to identify the key clinical features tha...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.STR.0000204041.13466.4c

    authors: Hand PJ,Kwan J,Lindley RI,Dennis MS,Wardlaw JM

    更新日期:2006-03-01 00:00:00

  • Nitric oxide regulates cerebral arteriolar tone in rats.

    abstract:BACKGROUND AND PURPOSE:Although cerebral penetrating arterioles are main regulators of the brain microcirculation, little is known about the effect of endothelium-derived relaxation factor on these vessels. This study examined the effects of nitric oxide synthase inhibitors on the spontaneous tone of isolated rat cereb...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.25.11.2227

    authors: Kimura M,Dietrich HH,Dacey RG Jr

    更新日期:1994-11-01 00:00:00

  • Contrast-enhanced transcranial color-coded sonography in acute hemispheric brain infarction.

    abstract:PURPOSE:The aim of the present study was to investigate the diagnostic potential of contrast-enhanced transcranial color-coded real-time sonography (CE-TCCS) in otherwise ultrasound-refractory acute stroke patients with an ischemia in the territory of the middle cerebral artery (MCA). Furthermore, correlations of CE-TC...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.30.9.1819

    authors: Postert T,Braun B,Meves S,Köster O,Przuntek H,Weber S,Büttner T

    更新日期:1999-09-01 00:00:00

  • Strokes with minor symptoms: an exploratory analysis of the National Institute of Neurological Disorders and Stroke recombinant tissue plasminogen activator trials.

    abstract:BACKGROUND AND PURPOSE:The pivotal National Institute of Neurological Disorders and Stroke recombinant tissue plasminogen activator trials excluded patients with ischemic stroke with specific minor presentations or rapidly improving symptoms. The recombinant tissue plasminogen activator product label notes that its use...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/STROKEAHA.110.593632

    authors: Khatri P,Kleindorfer DO,Yeatts SD,Saver JL,Levine SR,Lyden PD,Moomaw CJ,Palesch YY,Jauch EC,Broderick JP

    更新日期:2010-11-01 00:00:00

  • Posttraumatic stress disorder and adherence to medications in survivors of strokes and transient ischemic attacks.

    abstract:BACKGROUND AND PURPOSE:Posttraumatic stress disorder (PTSD) can be triggered by life-threatening medical events such as strokes and transient ischemic attacks (TIAs). Little is known regarding how PTSD triggered by medical events affects patients' adherence to medications. METHODS:We surveyed 535 participants, age ≥40...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/STROKEAHA.112.655209

    authors: Kronish IM,Edmondson D,Goldfinger JZ,Fei K,Horowitz CR

    更新日期:2012-08-01 00:00:00

  • Correlation between amino acid release and neuropathologic outcome in rat brain following middle cerebral artery occlusion.

    abstract::Using in vivo brain microdialysis, we studied amino acid release in the striatum and cortex of eight rats following permanent middle cerebral artery occlusion. We then processed all brains for histopathologic assessment of the volume of ischemic damage 4 hours after occlusion. Ischemic damage was varied by occlusion o...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.21.12.1727

    authors: Butcher SP,Bullock R,Graham DI,McCulloch J

    更新日期:1990-12-01 00:00:00