Abstract:
BACKGROUND AND PURPOSE:Multifocal signal loss lesions (MSLLs) on T2*-weighted gradient-echo (GE) MRI are believed to be microbleeds histopathologically. Previous epidemiological studies suggested that low serum cholesterol is associated with the increased risk of intracerebral hemorrhage. We investigated risk factors of MSLLs and the relationship between lipid profiles and MSLLs on GE-MRI. METHODS:We included consecutively 172 patients who underwent brain MRI. MSLLs on GE-MRI were counted by 2 neurologists separately and graded by consensus. The concentrations of lipid profiles were categorized as quartiles, and the MSLLs were graded as absent (total count, 0), mild (1 to 2), moderate (3 to 10), and severe (>10). RESULTS:The mean concentrations of total cholesterol and low-density lipoprotein cholesterol were significantly lower in patients with a severe degree of MSLLs than in those without MSLL (P<0.05). By multivariate analysis, MSLLs were significantly correlated with hypertension (odds ratio [OR], 3.42; 95% CI, 1.17 to 9.97), leukoaraiosis (OR, 4.62; 95% CI, 2.87 to 7.41), the lowest quartile of serum total cholesterol (<4.27 mmol/L; OR, 10.91; 95% CI, 3.98 to 25.57), and the highest quartile of high-density lipoprotein (>1.47 mmol/L; OR, 3.5; 95% CI, 1.45 to 8.29). CONCLUSIONS:Our results suggest that both the lipid profile levels and the severity of hypertension may be closely associated with MSLLs on GE-MRI.
journal_name
Strokejournal_title
Strokeauthors
Lee SH,Bae HJ,Yoon BW,Kim H,Kim DE,Roh JKdoi
10.1161/01.str.0000036092.23649.2esubject
Has Abstractpub_date
2002-12-01 00:00:00pages
2845-9issue
12eissn
0039-2499issn
1524-4628journal_volume
33pub_type
临床试验,杂志文章相关文献
STROKE文献大全abstract:BACKGROUND AND PURPOSE:Limited data exist on the frequency and outcome of carotid artery disease in Pakistan. Such information would help guide the usefulness of screening for the condition in this low-middle income health care setting. METHODS:A prospective, descriptive study was conducted among 3 large teaching hosp...
journal_title:Stroke
pub_type: 杂志文章,多中心研究
doi:10.1161/STROKEAHA.108.532960
更新日期:2009-03-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Standard radiographic criteria for hematoma enlargement have not been established. We undertook this investigation to assess the incidence and time course of hematoma growth using objective cutoff values. METHODS:We reviewed the clinical records of 204 patients with spontaneous intracerebral hem...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.27.10.1783
更新日期:1996-10-01 00:00:00
abstract:BACKGROUND AND PURPOSE:This study aims to investigate the association between insulin resistance (IR) and silent lacunar infarction (SLI) in healthy adults. METHODS:We recruited 2326 healthy Korean adults who took health checkups, including a brain magnetic resonance imaging. SLI was defined as an infarction measuring...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.116.014097
更新日期:2016-12-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Endothelins (ETs) are potent vasoconstrictors and may play a role in the pathophysiology of several diseases. Limited and controversial data exist on their role in human ischemic stroke. We planned a prospective, observational, and longitudinal clinical study to test whether ET-1 levels increase ...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.31.3.720
更新日期:2000-03-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Urinary incontinence (UI) is a common and distressing problem after stroke. Although there is evidence of new, effective UI poststroke rehabilitation intervention, it is unknown whether occupational therapists (OTs)' and physical therapists (PTs)' actual practices reflect best practices. We sough...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.107.486035
更新日期:2007-10-01 00:00:00
abstract:BACKGROUND AND PURPOSE:To investigate whether neuroimaging information has added predictive value compared with clinical information for independency in activities of daily living (ADL) 1 year after stroke. METHODS:Seventy-five first-ever middle cerebral artery stroke survivors were evaluated in logistic regression an...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.STR.0000206462.09410.6f
更新日期:2006-04-01 00:00:00
abstract::The methionine analogue methionine sulfoximine was administered to 10 rats 24 hours before occlusion of the proximal left middle cerebral artery. Three days later the rats were decapitated and the brain infarct volumes were compared with those in 10 control rats that received saline before middle cerebral artery occlu...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.21.2.322
更新日期:1990-02-01 00:00:00
abstract::Cardioembolic stroke is a complex disease resulting from the interaction of numerous factors. Using data from Genes Affecting Stroke Risk and Outcome Study (GASROS), we show that a multivariate predictive model built using Bayesian networks is able to achieve a predictive accuracy of 86% on the fitted values as comput...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.108.533273
更新日期:2009-03-01 00:00:00
abstract::Patients with infarctions in the territory of the right middle cerebral artery (RMCA) sometimes present with an agitated confusional state. We reviewed clinical data on 46 patients with RMCA infarcts and compared neurologic findings in patients with and without agitated confusion. Neither of the two patients presentin...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.15.5.883
更新日期:1984-09-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The purpose of the study is to compare the reliability of the Barthel activities of daily living score, which assesses disability, with the Rankin scale, which assesses handicap, and to determine their mutual agreement. METHODS:Fifty patients with stroke of varying severity were identified by a ...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.22.10.1242
更新日期:1991-10-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Stroke in young adults has a dramatic effect on life; therefore, we investigated the long-term functional outcome after transient ischemic attack, ischemic stroke, or intracerebral hemorrhage in adults aged 18 to 50 years. METHODS:We studied 722 young patients with first-ever stroke admitted bet...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.113.004411
更新日期:2014-04-01 00:00:00
abstract:BACKGROUND AND PURPOSE:It is unclear which harmonic imaging mode (power Doppler or gray-scale imaging) is superior and which measuring method is the most robust for the description of brain perfusion. METHODS:We performed an animal study on 6 beagles through the intact skull using a SONOS 5500 device and Optison injec...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.31.7.1728
更新日期:2000-07-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The aim of this study was to investigate by means of transcranial Doppler (TCD) ultrasonography how many spontaneous reperfusions of the middle cerebral artery (MCA) occurred during the first week after onset of acute ischemic stroke in the carotid territory. METHODS:TCD examination, computed to...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.26.3.430
更新日期:1995-03-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Our aim in this study was to assess the incidence and determining factors of angiographic recurrences after endovascular treatment of aneurysms. METHODS:A retrospective analysis of all patients with selective endosaccular coil occlusion of intracranial aneurysms prospectively collected from 1992...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.STR.0000073841.88563.E9
更新日期:2003-06-01 00:00:00
abstract::Mild hypothermia is an established neuroprotectant in the laboratory, showing remarkable and consistent effects across multiple laboratories and models of brain injury. At the clinical level, mild hypothermia has shown benefits in patients who have experienced cardiac arrest and in some pediatric populations experienc...
journal_title:Stroke
pub_type: 杂志文章,评审
doi:10.1161/STROKEAHA.110.595371
更新日期:2010-10-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Subarachnoid hemorrhage (SAH) caused by ruptured intracranial aneurysm affects approximately 16 000 Americans annually, and almost 40% of affected patients die within 30 days despite the best current therapy. Prevention of SAH is therefore of paramount importance. We present a preliminary analysi...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.0000014773.57733.3e
更新日期:2002-05-01 00:00:00
abstract::Intravenously injected metaraminol induced a larger blood pressure increase in spontaneously hypertensive rats (SHR) than in normotensive controls (NR) when the pressure was raised from the same starting level. Cerebral blood flow (CBF) response in NR was either perfect autoregulation, partial autoregulation or "break...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.10.5.572
更新日期:1979-09-01 00:00:00
abstract::Background and Purpose- Carotid web (CW) is a rare form of focal fibromuscular dysplasia defined as an abnormal shelf-like projection of intimal fibrous tissue into the carotid bulb. It is theorized that CW leads to ischemic stroke secondary to blood flow stasis and subsequent embolization. The natural history and opt...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.118.021907
更新日期:2018-12-01 00:00:00
abstract:BACKGROUND:Mechanisms involved in stroke progression are incompletely understood. Ischemic brain injury is characterized by acute local inflammatory response mediated by cytokines. Anti-inflammatory cytokines act in a feedback loop to inhibit continued proinflammatory cytokine production. We assessed the implication of...
journal_title:Stroke
pub_type: 临床试验,杂志文章
doi:10.1161/01.STR.0000057976.53301.69
更新日期:2003-03-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The association between minor ST-T abnormalities and stroke incidence has not been well elucidated. We sought to examine the relationship between nonspecific minor or major ST-T abnormalities and the incidence of stroke among Japanese men and women. METHODS:A 15.4-year prospective study was cond...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.STR.0000103742.83117.FB
更新日期:2003-12-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Glutamate receptor antagonists are protective in animal models of focal cerebral ischemia. Lamotrigine (3,5-diamino-6-[2,3-dichlorophenyl]-1,2,4-triazine) is an anticonvulsant drug that blocks voltage-gated sodium channels and inhibits the ischemia-induced release of glutamate. We describe the ce...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.26.1.117
更新日期:1995-01-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Autonomic dysfunction, including increased sympathetic drive and blunted baroreflex, has repeatedly been observed in acute stroke. Of clinical importance is that the stroke-related autonomic imbalance seems to be linked to worse outcome after stroke. Here, we discuss the role of baroreflex impair...
journal_title:Stroke
pub_type: 杂志文章,评审
doi:10.1161/STROKEAHA.109.565838
更新日期:2009-12-01 00:00:00
abstract::The presence of hyperglycemia prior to stroke or cardiac arrest can increase neuronal damage caused by brain ischemia. Acute hyperglycemia shows this effect in animal models of stroke. However, chronic hyperglycemia and chronic hyperglycemia with additional acute elevation of blood glucose are more common premorbid st...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.18.1.52
更新日期:1987-01-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The Combined Lysis of Thrombus in Brain Ischemia With Transcranial Ultrasound and Systemic T-PA-Hands-Free (CLOTBUST-HF) study is a first-in-human, National Institutes of Health-sponsored, multicenter, open-label, pilot safety trial of tissue-type plasminogen activator (tPA) plus a novel operator...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.113.002713
更新日期:2013-12-01 00:00:00
abstract:BACKGROUND:Timing of carotid endarterectomy after stroke in a patient with a fixed neurological deficit remains an important but unresolved question. Early surgery has been associated with cerebral hemorrhage and infarct extension. Delayed endarterectomy exposes the patient to recurrent stroke and carotid occlusion. Th...
journal_title:Stroke
pub_type: 杂志文章,评审
doi:10.1161/01.str.28.12.2563
更新日期:1997-12-01 00:00:00
abstract:BACKGROUND AND PURPOSE:In acute ischemic stroke patients, diffusion-weighted imaging (DWI)-Alberta Stroke Program Early Computed Tomography Score (ASPECTS) is correlated with infarct volume and is an independent factor of functional outcome. Patients with pretreatment DWI-ASPECTS ≤6 were excluded or under-represented i...
journal_title:Stroke
pub_type: 杂志文章,多中心研究
doi:10.1161/STROKEAHA.116.015202
更新日期:2017-04-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The National Institutes of Health Stroke Scale (NIHSS) is a valid, reproducible scale that measures neurological deficit. Of 42 possible points, 7 points are directly related to measurement of language compared with only 2 points related to neglect. METHODS:We examined the placebo arm of the NIN...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.30.11.2355
更新日期:1999-11-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Autopsy series of patients with AIDS have found a 4% to 29% prevalence of cerebral infarction. Little is known of the prevalence of cerebral infarction when not associated with non-HIV central nervous system (CNS) infection, lymphoma, or cardioembolic sources. Clinical correlation has seldom been...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.31.9.2117
更新日期:2000-09-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Inflammation is thought to be a major contributor to carotid artery disease. Lipopolysaccharide (LPS) activates inflammatory mechanisms thought to contribute to endothelial dysfunction by mechanisms that are not well defined. The goal of this study was to determine whether overexpression of CuZn-...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.STR.0000132764.06878.c5
更新日期:2004-08-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The association among socioeconomic status, quality of care, and clinical outcome after stroke remains poorly understood. In a Danish nationwide follow-up study, we examined whether socioeconomic-related differences in acute stroke care occur and, if so, whether they explain socioeconomic differe...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.110.611871
更新日期:2011-10-01 00:00:00