Abstract:
BACKGROUND AND PURPOSE:The pressure-flow relation has been characterized in normal cerebrum, but it has not been studied in cerebrum dependent on collateral flow. The purpose of this investigation was to examine the relation between systemic pressure, regional cerebral blood flow, and middle cerebral artery branch pressure in collateral-dependent and normal brain. METHODS:In 10 anesthetized dogs, we cannulated a branch of the middle cerebral artery and identified collateral-dependent tissues using the shadow flow technique. We measured pressure in normal and cannulated branches of the middle cerebral artery and regional cerebral blood flow. The common carotid arteries were occluded, and hemorrhage reduced mean arterial pressure to 50 and 25 mm Hg. RESULTS:When aortic pressure was 25 mm Hg, blood flow to the collateral-dependent zone decreased from a baseline of 87 +/- 5 to 6 +/- 1 ml/100 g per minute (mean +/- SE), and pressure in the cannulated branch of the middle cerebral artery decreased from 49 +/- 4 to 2 +/- 0.4 mm Hg (p less than 0.05). Small-vessel resistance in the collateral-dependent region decreased from 0.56 +/- 0.09 to 0.38 +/- 0.04 mm Hg/ml/100 g per minute (p less than 0.05) after carotid occlusion but did not change significantly during hypotension. In normal brain, however, small-vessel resistance continued to decrease as systemic pressure was reduced. CONCLUSIONS:This study provides pressure-flow relations in normal and collateral-dependent cerebrum during carotid occlusion and progressive hypotension. In collateral-dependent tissue, concurrent occlusion of middle cerebral and carotid arteries produces autoregulatory dilatation of small vessels, resistance fails to decrease as mean arterial pressure is reduced to 25 mm Hg, and profound focal hypoperfusion is produced.
journal_name
Strokejournal_title
Strokeauthors
Muhonen MG,Sawin PD,Loftus CM,Heistad DDdoi
10.1161/01.str.23.7.988subject
Has Abstractpub_date
1992-07-01 00:00:00pages
988-94issue
7eissn
0039-2499issn
1524-4628journal_volume
23pub_type
杂志文章相关文献
STROKE文献大全abstract:BACKGROUND AND PURPOSE:A low ankle-brachial blood pressure index (ABI) is an established risk marker for cardiovascular disease and mortality in the general population, but little is known about its prognostic value in individuals with acute ischemic stroke or transient ischemic attack (TIA). METHODS:An inception coho...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.109.559740
更新日期:2009-12-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Stroke incidence and mortality are declining rapidly in developed countries. Little data on ethnic-specific stroke recurrence trends exist. Fourteen-year stroke recurrence trend estimates were evaluated in Mexican Americans and non-Hispanic whites in a population-based study. METHODS:Recurrent s...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.120.029376
更新日期:2020-08-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Limited data exist on the performance of the revised Framingham Stroke Risk Score (R-FSRS) and the R-FSRS in conjunction with nontraditional risk markers. We compared the R-FSRS, original FSRS, and the Pooled Cohort Equation for stroke prediction and assessed the improvement in discrimination by ...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.117.018928
更新日期:2018-02-01 00:00:00
abstract:BACKGROUND AND PURPOSE:We have shown that acute treatment with candesartan in an experimental model of stroke resulted in vascular protection and improved outcomes at 24 hours poststroke, but the mechanisms are unknown. We now examine effects of candesartan on proangiogenic factors and 7-day outcomes using the same tre...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.108.537225
更新日期:2009-05-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Intracranial internal carotid artery calcification is associated with cerebrovascular risk factors and stroke, but few quantification methods are available. We tested the reliability of visual scoring, semiautomated Agatston score, and calcium volume measurement in patients with recent stroke. M...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.115.009716
更新日期:2015-09-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Adequate control of blood pressure (BP) is a cornerstone in stroke prevention. This study explored the risk of stroke in relation to the quality of BP control in a population-based cohort and whether control of hypertension was related to background characteristics of patients. METHODS:A total o...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.STR.0000158925.12740.87
更新日期:2005-04-01 00:00:00
abstract:BACKGROUND AND PURPOSE:To evaluate the impact of proximal flow control on efficacy and safety of mechanical thrombectomy in an in vitro middle cerebral artery occlusion. METHODS:Three independent variables, including clot type, device (Merci Retriever, Solitaire FR, and Trevo devices), and use of a balloon guide cathe...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.111.670463
更新日期:2013-05-01 00:00:00
abstract::The angiographic, clinical, and genetic characteristics of fibromuscular dysplasia (FMD) are reviewed in 37 patients (mean age 48 years) selected from a pool of 4000 angiograms of carotid or vertebral arteries. FMD was a neglected pathogenic factor in 28 patients with hemorrhagic or ischemic cerebral lesions. The aneu...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.13.1.46
更新日期:1982-01-01 00:00:00
abstract::Contrast-enhanced computed tomography of the neck permits low-risk evaluation of morphologic complications of carotid plaque, including (and foremost) calcification. To investigate the patterns and clinical significance of calcified deposits in the cervical carotid arteries using computed tomography we studied 40 pati...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.20.11.1472
更新日期:1989-11-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Enhanced angiogenesis facilitates neurovascular remodeling processes and promotes brain functional recovery after stroke. Previous studies from our laboratory demonstrated that valproate (VPA), a histone deacetylase inhibitor, protects against experimental brain ischemia. The present study invest...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.112.652545
更新日期:2012-09-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Space-occupying brain edema is a life-threatening complication in patients with large middle cerebral artery (MCA) infarction. To determine predictors of this detrimental process, we investigated alterations of extracellular non-transmitter amino acid concentrations in peri-infarct tissue. METHO...
journal_title:Stroke
pub_type: 临床试验,杂志文章
doi:10.1161/01.STR.0000100158.51986.EB
更新日期:2003-12-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The role of decompressive hemicraniectomy (DC) in malignant cerebral infarction (MCI) has clearly been established, but little is known about the course of intracranial pressure (ICP) in patients undergoing this surgical measure. In this study, we investigated the role of invasive ICP monitoring ...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.120.032390
更新日期:2021-01-01 00:00:00
abstract::Background and Purpose- High-resolution vessel wall magnetic resonance imaging is a promising technique for assessing wall structures of unruptured intracranial aneurysms (UIAs). However, the relationship between aneurysmal high-resolution vessel wall magnetic resonance imaging features and their histopathologic mecha...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.118.024195
更新日期:2019-06-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Enlarged perivascular spaces (EPVS) have been associated with aging, increased stroke risk, decreased cognitive function, and vascular dementia. However, the relationship of EPVS with age-related neuropathologies is not well understood. Therefore, the purpose of this study was to assess the neuro...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.120.029388
更新日期:2020-09-01 00:00:00
abstract::Sixteen acceptably randomized studies of anticoagulant therapy after cerebral or retinal ischemia or infarction are reviewed and the results among 1,046 anticoagulated patients and 1,071 controls are analyzed. The following conclusions are derived. 1) Anticoagulant therapy has not been shown to be better than control ...
journal_title:Stroke
pub_type: 临床试验,杂志文章,评审
doi:10.1161/01.str.19.8.1043
更新日期:1988-08-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Arterial baroreflex is one of the most important mechanisms in the regulation of cardiovascular activities. Arterial baroreflex function can be expressed as baroreflex sensitivity (BRS). The present study was designed to test 2 hypotheses: (1) BRS is a new independent predictor for the incidence ...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.106.480061
更新日期:2007-06-01 00:00:00
abstract::We investigated the effects of phenytoin on the rate of enzymatic release of free fatty acids and on the levels of energy metabolites and nucleoside phosphates in ischemic brain. Phenytoin (10 mg/kg i.v.) was administered 30 minutes before the onset of ischemia induced in 30 male Wistar rats by occluding the basilar a...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.21.9.1326
更新日期:1990-09-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Systemic inflammatory response syndrome (SIRS) is a generalized inflammatory state. The primary goal of the study was to determine whether differences exist in outcomes in SIRS and non-SIRS intravenous tissue-type plasminogen activator-treated patients. METHODS:Consecutive patients were retrospe...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.113.001371
更新日期:2013-08-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Risk-standardized hospital readmission rates are used as publicly reported measures reflecting quality of care. Valid risk-standardized models adjust for differences in patient-level factors across hospitals. We conducted a systematic review of peer-reviewed literature to identify models that com...
journal_title:Stroke
pub_type: 杂志文章,评审
doi:10.1161/STROKEAHA.110.599159
更新日期:2010-11-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The purpose of this study was to assess the association of vitamin D deficiency and indices of mineral metabolism with subclinical carotid markers that predict cardiovascular events. METHODS:Two hundred three community-dwelling adults (Northern Manhattan Study; age, 68 ± 11; age range, 50 to 93 ...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.110.608539
更新日期:2011-08-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Thrombin-induced clots used in experimental thromboembolic stroke differ from clots forming spontaneously under clinical conditions. We investigated whether this difference influences the efficacy and outcome of thrombolytic treatment. METHODS:In rats, the middle cerebral artery was occluded by ...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.STR.0000080941.73934.30
更新日期:2003-08-01 00:00:00
abstract:BACKGROUND AND PURPOSE:the Penumbra Pivotal Stroke Trial reported a 25% good outcome (modified Rankin scale score ≤ 2) despite an 81% recanalization rate. We evaluated the association of a favorable initial noncontrast CT and a short time to recanalization in predicting good outcome. METHODS:data were from the Penumbr...
journal_title:Stroke
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1161/STROKEAHA.110.594481
更新日期:2011-01-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The aim of this study was to validate the diagnosis of self-reported stroke. METHODS:During 1994-1995, 27 159 people attended a population health survey in the community of Tromso, Norway, a response rate of 77%. A total of 418 attenders reported a history of stroke. In 1997, all individuals wit...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.31.7.1602
更新日期:2000-07-01 00:00:00
abstract::Background and Purpose- Hypertrophic cardiomyopathy patients with atrial fibrillation are at increased risk of stroke, and anticoagulation is strongly recommended. However, limited data are available regarding the safety and effectiveness of non-vitamin K antagonist oral anticoagulants (NOACs) for primary prevention o...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.119.026048
更新日期:2019-09-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Brain atrophy can be regarded as an end-organ effect of cumulative cardiovascular risk factors. Accelerated brain atrophy is described following ischemic stroke, but it is not known whether atrophy rates vary over the poststroke period. Examining rates of brain atrophy allows the identification o...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.120.030256
更新日期:2020-09-01 00:00:00
abstract:BACKGROUND AND PURPOSE:A supraphysiological amount of vitamin E in the standard diet of laboratory animals may provide partial protection against cerebral ischemic damage in stroke models. The aim of the present study was to test the effect of dietary vitamin E on infarct volume in rats subjected to permanent focal cer...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.29.5.1002
更新日期:1998-05-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Enhanced thromboxane (TX) biosynthesis has previously been reported in the acute phase after ischemic stroke. We investigated whether enhanced urinary excretion of 11-dehydro-TXB2, a noninvasive index of platelet activation, was present in the chronic phase after a transient ischemic attack (TIA)...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.30.3.546
更新日期:1999-03-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Diffusion magnetic resonance imaging (MRI) can quantitatively detect focal ischemic injury within minutes of onset, and perfusion MRI can evaluate the brain's microcirculation. N-Methyl-D-aspartate (NMDA) antagonists and reperfusion can reduce lesion size in stroke models. We used diffusion and p...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.24.12.2074
更新日期:1993-12-01 00:00:00
abstract:BACKGROUND:Cerebral fat embolism syndrome is a rare, but potentially lethal, complication of long bone fractures. Neurological symptoms are variable, and the clinical diagnosis is difficult. The purpose of this case study is to demonstrate the value of diffusion-weighted MRI of the brain for early diagnosis of fat embo...
journal_title:Stroke
pub_type: 杂志文章
doi:
更新日期:2001-12-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Reliable data on the risk of carotid endarterectomy (CEA) in relation to clinical indication and timing of surgery are necessary to target CEA more effectively, to inform patients, to adjust risks for case mix, and to understand the mechanisms of operative stroke. METHODS:We performed a systemat...
journal_title:Stroke
pub_type: 杂志文章,meta分析,评审
doi:10.1161/01.STR.0000087785.01407.CC
更新日期:2003-09-01 00:00:00