Matrix metalloproteinase expression is related to hemorrhagic transformation after cardioembolic stroke.

Abstract:

BACKGROUND AND PURPOSE:In animal models of cerebral ischemia, matrix metalloproteinase (MMP) expression was significantly increased and related to blood-brain barrier disruption, edema formation, and hemorrhagic transformation (HT). MMP inhibitors reduce HT after embolic ischemia in tissue-type plasminogen activator-treated animals. We aimed to determine the relationship between MMPs and HT after human ischemic stroke. METHODS:Serial MMP-2 and MMP-9 determinations were performed by means of ELISA in 39 cardioembolic strokes in the middle cerebral artery territory. Hemorrhagic events were classified according to clinical and CT criteria (hemorrhagic infarction [HI] and parenchymal hematoma [PH]). HT was evaluated on CT at 48 hours (early HT) and again between day 5 and 7 (late HT). RESULTS:HT was present in 41% of the patients (43.75% early HI, 25% early PH and 31.25% late HI). MMP-2 values were within normal range and were unrelated to HT. Increased expression of MMP-9 (normal range <97 ng/mL) was found among patients with and without HT (159.3+/-82 versus 143.9+/-112.6 ng/mL; P=0.64). According to HT subtypes, the highest baseline MMP-9 levels corresponded to patients with late HI (240.4+/-111.2 versus 102.5+/-76.7 ng/mL for all other patients, P=0.002). Baseline MMP-9 was the only variable associated with late HI in the multiple logistic regression model (OR 9; CI 1.46, 55.24; P=0.010). Peak of MMP-9 at the 24-hour time point (250.6 ng/mL) was found before appearance of PH. CONCLUSIONS:MMPs are involved in some subtypes of HT after human cardioembolic stroke. Baseline MMP-9 level predicts late HI and a 24-hour peak precedes early PH.

journal_name

Stroke

journal_title

Stroke

authors

Montaner J,Alvarez-Sabín J,Molina CA,Anglés A,Abilleira S,Arenillas J,Monasterio J

doi

10.1161/hs1201.99512

subject

Has Abstract

pub_date

2001-12-01 00:00:00

pages

2762-7

issue

12

eissn

0039-2499

issn

1524-4628

journal_volume

32

pub_type

临床试验,杂志文章

相关文献

STROKE文献大全
  • Patent foramen ovale in cryptogenic stroke: incidental or pathogenic?

    abstract:BACKGROUND AND PURPOSE:Patent foramen ovale (PFO) is significantly associated with cryptogenic stroke (CS). However, even in patients with CS, a PFO can be an incidental finding. We sought to estimate the probability that a PFO in a patient with CS is incidental. METHODS:A systematic search identified 23 case-control ...

    journal_title:Stroke

    pub_type: 杂志文章,meta分析

    doi:10.1161/STROKEAHA.109.547828

    authors: Alsheikh-Ali AA,Thaler DE,Kent DM

    更新日期:2009-07-01 00:00:00

  • Delayed Administration of Tat-HA-NR2B9c Promotes Recovery After Stroke in Rats.

    abstract:BACKGROUND AND PURPOSE:Previous studies reported that Tat-NR2B9c, a peptide disrupting the N-methyl-d-aspartate receptor-postsynaptic density protein-95 interaction, reduced ischemic damage in the acute phase after stroke. However, its effect in the subacute phase is unknown. The aim of this study is to determine wheth...

    journal_title:Stroke

    pub_type: 杂志文章,收录出版

    doi:10.1161/STROKEAHA.115.008886

    authors: Zhou HH,Tang Y,Zhang XY,Luo CX,Gao LY,Wu HY,Chang L,Zhu DY

    更新日期:2015-05-01 00:00:00

  • Cerebrovascular ischemic events with high positive anticardiolipin antibodies.

    abstract:BACKGROUND AND PURPOSE:The aim of our study was to characterize the patient profile and prognostic value associated with high positive IgG (>100 GPL) anticardiolipin antibodies (aCL). METHODS:We studied the clinical, laboratory, radiological, and prospective historical features of ischemic cerebrovascular disease in p...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.29.11.2245

    authors: Verro P,Levine SR,Tietjen GE

    更新日期:1998-11-01 00:00:00

  • Stroke and incontinence.

    abstract:BACKGROUND:Urinary incontinence in the acute stage of stroke is seen as a predictor of death, severe disability, and an important factor on hospital discharge destination. Therefore, it is an important measure of stroke severity that not only affects the lives of stroke survivors but also those of caregivers. SUMMARY ...

    journal_title:Stroke

    pub_type: 杂志文章,评审

    doi:10.1161/01.str.29.2.524

    authors: Brittain KR,Peet SM,Castleden CM

    更新日期:1998-02-01 00:00:00

  • Effects of the allosteric modification of hemoglobin on brain oxygen and infarct size in a feline model of stroke.

    abstract:BACKGROUND AND PURPOSE:Cerebral ischemia and stroke are leading causes of morbidity and mortality. An approach to protecting the brain during ischemia is to try to increase the delivery of oxygen via the residual blood flow through and around ischemic tissue. To test this hypothesis, we used a novel oxygen delivery age...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.28.8.1624

    authors: Watson JC,Doppenberg EM,Bullock MR,Zauner A,Rice MR,Abraham D,Young HF

    更新日期:1997-08-01 00:00:00

  • A randomized trial of aspirin or heparin in hospitalized patients with recent transient ischemic attacks. A pilot study.

    abstract::In a randomized pilot study we compared the efficacy of temporary anticoagulation with intravenous heparin sodium to the efficacy of aspirin in preventing cerebral infarction in hospitalized patients with recent (less than 7 days) transient ischemic attacks (TIAs). Fifty-five patients (33 men, 22 women) aged 36-81 (me...

    journal_title:Stroke

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1161/01.str.20.4.441

    authors: Biller J,Bruno A,Adams HP Jr,Godersky JC,Loftus CM,Mitchell VL,Banwart KJ,Jones MP

    更新日期:1989-04-01 00:00:00

  • Occipital bone abnormality causing recurrent posterior circulation strokes.

    abstract::We report the case of a young man with recurrent posterior circulation strokes over the course of 6 years. Standard stroke evaluation was unremarkable until careful review of catheter angiogram and CT angiogram images revealed a bony protuberance from the occiput impinging on the left vertebral artery. Local vessel in...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/STROKEAHA.110.612176

    authors: Cronin CA,Aldrich EF,Kittner SJ

    更新日期:2011-05-01 00:00:00

  • Early Infarct Growth Rate Correlation With Endovascular Thrombectomy Clinical Outcomes: Analysis From the SELECT Study.

    abstract:BACKGROUND AND PURPOSE:Time elapsed from last-known well (LKW) and baseline imaging results are influential on endovascular thrombectomy (EVT) outcomes. METHODS:In a prospective multicenter cohort study of imaging selection for endovascular thrombectomy (SELECT [Optimizing Patient's Selection for Endovascular Treatmen...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/STROKEAHA.120.030912

    authors: Sarraj A,Hassan AE,Grotta J,Blackburn S,Day A,Abraham M,Sitton C,Dannenbaum M,Cai C,Pujara D,Hicks W,Vora N,Budzik R,Shaker F,Arora A,Riascos RF,Kamal H,Martin-Schild S,Lansberg M,Gupta R,Albers GW,SELECT Invest

    更新日期:2021-01-01 00:00:00

  • Clomethiazole Acute Stroke Study in ischemic stroke (CLASS-I): final results.

    abstract:BACKGROUND AND PURPOSE:A previous trial (the Clomethiazole Acute Stroke Study) generated the hypothesis that clomethiazole is effective in patients with a major ischemic stroke (total anterior circulation syndrome), and this was tested in the present study. METHODS:A total of 1198 patients with major ischemic stroke a...

    journal_title:Stroke

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.1161/hs0102.101478

    authors: Lyden P,Shuaib A,Ng K,Levin K,Atkinson RP,Rajput A,Wechsler L,Ashwood T,Claesson L,Odergren T,Salazar-Grueso E,CLASS-I\/H\/T Investigators.

    更新日期:2002-01-01 00:00:00

  • Blood use in cerebrovascular neurosurgery.

    abstract:BACKGROUND AND PURPOSE:This study reviews the perioperative use of red blood cell transfusion in cerebrovascular neurosurgery. The current algorithm for preoperative ordering of red cells is historical and dated. More blood is ordered than is actually transfused, and considerable variability exists between different in...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/hs0402.105296

    authors: Couture DE,Ellegala DB,Dumont AS,Mintz PD,Kassell NF

    更新日期:2002-04-01 00:00:00

  • Changes in locomotor activity and passive avoidance task performance induced by cerebral ischemia in Mongolian gerbils.

    abstract:BACKGROUND AND PURPOSE:We investigated changes in locomotor activity, passive avoidance task performance, and hippocampal CA1 neurons induced by cerebral ischemia in Mongolian gerbils to examine the relation between these behavioral changes and CA1 neuronal damage. METHODS:Spontaneous locomotor activity was measured u...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.25.3.645

    authors: Karasawa Y,Araki H,Otomo S

    更新日期:1994-03-01 00:00:00

  • Reversed intracranial blood flow in patients with an intra-aortic balloon pump.

    abstract::As a preliminary investigation into the cerebral effects of mechanical cardiac assist devices, using transcranial Doppler ultrasonography I examined the basal cerebral arteries in three patients placed on an intra-aortic balloon pump. Unassisted systoles had normal blood velocities and waveforms. When the pump was in ...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.21.3.484

    authors: Brass LM

    更新日期:1990-03-01 00:00:00

  • Prevalence and predictors of paroxysmal atrial fibrillation on Holter monitor in patients with stroke or transient ischemic attack.

    abstract:BACKGROUND AND PURPOSE:Our aims were to quantify the yield of Holter monitor for detection of paroxysmal atrial fibrillation (PAF) in patients with stroke and TIA, and to determine potential predictors of PAF to allow more focused testing. METHODS:We reviewed records of 1128 consecutive patients attending a university...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/STROKEAHA.109.570382

    authors: Alhadramy O,Jeerakathil TJ,Majumdar SR,Najjar E,Choy J,Saqqur M

    更新日期:2010-11-01 00:00:00

  • Anterior spinal artery aneurysm presenting as a subarachnoid hemorrhage.

    abstract::A woman who presented with a subarachnoid hemorrhage secondary to a ruptured anterior spinal artery aneurysm of the spinal cord is reported. While this is the first report of a ruptured aneurysm of the anterior spinal artery with angiographic confirmation, it emphasizes that occasionally subarachnoid hemorrhage may be...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.12.2.230

    authors: Vincent FM

    更新日期:1981-03-01 00:00:00

  • Quantitative carotid phonoangiography.

    abstract::One hundred and sixteen carotid artery bruits were assessed using quantitative phonoangiography (spectral bruit analysis - SBA). This technique uses the averaged break frequency of the bruit to calculate the diameter of he residual lumen at the site of stenosis. Biplanar contrast arteriography was performed on 43 (37%...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.12.6.798

    authors: Knox R,Breslau P,Strandness DE Jr

    更新日期:1981-11-01 00:00:00

  • Stroke associated with antiphospholipid antibodies.

    abstract::There is a strong link between antiphospholipid antibodies and stroke. Retrospective studies indicate that these patients are generally young, often have had prior thrombotic events including stroke, frequently complain of headaches, and often experience amaurosis fugax. Cardiac valvular lesions, particularly involvin...

    journal_title:Stroke

    pub_type: 杂志文章,评审

    doi:

    authors: Hess DC

    更新日期:1992-02-01 00:00:00

  • Compliance with the stroke education performance measure in the Michigan Paul Coverdell National Acute Stroke Registry.

    abstract:BACKGROUND AND PURPOSE:Stroke education, 1 of 8 endorsed stroke performance measures, consists of 5 specific subcomponents: risk factors, stroke warning signs, emergency medical service activation, physician follow-up, and discharge medications. We identified predictors of stroke education performance measure complianc...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/STROKEAHA.111.000763

    authors: Nickles A,Fiedler J,Roberts S,Lyon-Callo S,Hurst R,Reeves M

    更新日期:2013-05-01 00:00:00

  • Differences in clot preparation determine outcome of recombinant tissue plasminogen activator treatment in experimental thromboembolic stroke.

    abstract:BACKGROUND AND PURPOSE:Thrombin-induced clots used in experimental thromboembolic stroke differ from clots forming spontaneously under clinical conditions. We investigated whether this difference influences the efficacy and outcome of thrombolytic treatment. METHODS:In rats, the middle cerebral artery was occluded by ...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.STR.0000080941.73934.30

    authors: Niessen F,Hilger T,Hoehn M,Hossmann KA

    更新日期:2003-08-01 00:00:00

  • Increased lipid peroxidation in vulnerable brain regions after transient forebrain ischemia in rats.

    abstract::We examined cerebral lipid peroxidation, estimated by a thiobarbituric acid test, in rat brain regions after 30 minutes of severe forebrain ischemia and at recirculation periods of up to 72 hours. The lipid peroxide levels remained unaltered in all brain regions during ischemia and during the first hour of recirculati...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.20.7.918

    authors: Bromont C,Marie C,Bralet J

    更新日期:1989-07-01 00:00:00

  • Gene therapy and endovascular treatment of intracranial aneurysms.

    abstract:BACKGROUND:Endovascular treatment of intracranial aneurysms is safe and effective but too often is followed by recurrences. Gene therapy may improve healing after embolization, and endovascular approaches may offer future in situ delivery systems designed to prevent aneurysm rupture. SUMMARY OF REVIEW:Advances in coil...

    journal_title:Stroke

    pub_type: 杂志文章,评审

    doi:10.1161/01.STR.0000117577.94345.CC

    authors: Ribourtout E,Raymond J

    更新日期:2004-03-01 00:00:00

  • Sympathetic nerve activity: a link to stroke?

    abstract::Spontaneously hypertensive rats (SHR) have been shown to have an increased capacity for superior cervical sympathetic nerve activity which may protect against stroke (Mueller et al: Stroke 13: 115, 1982). Sympathetic nerve activity has never been examined in the stroke-prone substrain of SHR (SP). In this study we mea...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.16.1.73

    authors: Mueller SM,Black WL Jr

    更新日期:1985-01-01 00:00:00

  • Gene therapy for cerebral vascular disease.

    abstract:BACKGROUND:Gene transfer to peripheral arteries has been accomplished with catheter-based approaches. Recently, gene transfer to the carotid artery and intracranial vessels has been achieved both in vitro and in vivo. Although gene therapy for cerebral vascular disease may not be accomplished for years, currently avail...

    journal_title:Stroke

    pub_type: 杂志文章,评审

    doi:10.1161/01.str.27.9.1688

    authors: Heistad DD,Faraci FM

    更新日期:1996-09-01 00:00:00

  • Early growth, adult income, and risk of stroke.

    abstract:BACKGROUND AND PURPOSE:A number of studies have shown that reduced intrauterine growth and low birth weight are associated with raised rates of fatal and nonfatal stroke in adult life. Whether this increased risk of stroke is modified by growth in childhood or by socioeconomic status in adult life is not known. METHOD...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.31.4.869

    authors: Eriksson JG,Forsén T,Tuomilehto J,Osmond C,Barker DJ

    更新日期:2000-04-01 00:00:00

  • Combined Multimodal Computed Tomography Score Correlates With Futile Recanalization After Thrombectomy in Patients With Acute Stroke.

    abstract:BACKGROUND AND PURPOSE:Futile recanalization after acute ischemic stroke occurs in almost half of the patients despite optimal angiographic results. Multimodal neuroimaging may help to improve patient's selection but is still dismissed by many interventionalists. Our aim was to evaluate the accuracy of each parameter o...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/STROKEAHA.114.008598

    authors: Espinosa de Rueda M,Parrilla G,Manzano-Fernández S,García-Villalba B,Zamarro J,Hernández-Fernández F,Sánchez-Vizcaino C,Carreón E,Morales A,Moreno A

    更新日期:2015-09-01 00:00:00

  • Early protective effect of bone marrow mononuclear cells against ischemic white matter damage through augmentation of cerebral blood flow.

    abstract:BACKGROUND AND PURPOSE:To investigate the efficacy of bone marrow mononuclear cell (BMMNC) treatment against ischemic white matter (WM) damage in a hypoperfused brain. METHODS:Mice were administered intravenous treatment of vehicle, spleen-derived marrow mononuclear cells (MNCs), or BMMNCs (5 × 10⁶ cells) obtained fro...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/STROKEAHA.110.596379

    authors: Fujita Y,Ihara M,Ushiki T,Hirai H,Kizaka-Kondoh S,Hiraoka M,Ito H,Takahashi R

    更新日期:2010-12-01 00:00:00

  • Intra-arterial thrombolytic therapy for acute basilar occlusion: pro.

    abstract::Acute thromboembolic occlusion of the basilar artery accounts for 6% to 10% of large-vessel stroke in humans. Because of the brain region supplied by this artery, the case fatality rate is the highest for all ischemic stroke subtypes, ranging from 40% to 86%. Patients who undergo successful recanalization of the basil...

    journal_title:Stroke

    pub_type: 杂志文章,评审

    doi:10.1161/01.STR.0000247897.33267.42

    authors: Smith WS

    更新日期:2007-02-01 00:00:00

  • Stroke in Commercial Flights.

    abstract:BACKGROUND AND PURPOSE:Stroke on board aircraft has been reported in retrospective case series, mainly focusing on economy class stroke syndrome. Data on the actual incidence, pathogenesis, and prognosis of stroke in commercial flights are lacking. METHODS:A prospective registry was designed to include all consecutive...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/STROKEAHA.115.012637

    authors: Álvarez-Velasco R,Masjuan J,DeFelipe A,Corral I,Estévez-Fraga C,Crespo L,Alonso-Cánovas A

    更新日期:2016-04-01 00:00:00

  • Endothelial function and carotid intima-media thickness in young healthy subjects among endothelial nitric oxide synthase Glu298-->Asp and T-786-->C polymorphisms.

    abstract:BACKGROUND AND PURPOSE:To assess the role of the endothelial nitric oxide synthase (eNOS) gene variants as risk factors for early atherosclerosis, we sought to investigate whether two polymorphisms located in the exon 7 (Glu298-->Asp) and in the promoter region (T-786-->C) of the eNOS gene were associated with function...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.STR.0000126482.86708.37

    authors: Paradossi U,Ciofini E,Clerico A,Botto N,Biagini A,Colombo MG

    更新日期:2004-06-01 00:00:00

  • Multiple Soluble Components of the Glycocalyx Are Increased in Patient Plasma After Ischemic Stroke.

    abstract::Background and Purpose- The GLX (glycocalyx) is a protein/polysaccharide meshwork at the cellular surface. Consisting largely of glycosaminoglycans and proteoglycans, the GLX can shed in response to stress. In this study, we assay 11 components of the GLX in plasma from patients with ischemic stroke from a longitudina...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/STROKEAHA.119.025953

    authors: DellaValle B,Hasseldam H,Johansen FF,Iversen HK,Rungby J,Hempel C

    更新日期:2019-10-01 00:00:00

  • Predictors of Mortality in Acute Ischemic Stroke Intervention: Analysis of the North American Solitaire Acute Stroke Registry.

    abstract:BACKGROUND AND PURPOSE:Failure to recanalize predicts mortality in acute ischemic stroke. In the North American Solitaire Acute Stroke registry, we investigated parameters associated with mortality in successfully recanalized patients. METHODS:Logistic regression was used to evaluate baseline characteristics and recan...

    journal_title:Stroke

    pub_type: 杂志文章,多中心研究

    doi:10.1161/STROKEAHA.115.009530

    authors: Linfante I,Walker GR,Castonguay AC,Dabus G,Starosciak AK,Yoo AJ,Abou-Chebl A,Britz GW,Marden FA,Alvarez A,Gupta R,Sun CH,Martin C,Holloway WE,Mueller-Kronast N,English JD,Malisch TW,Bozorgchami H,Xavier A,Rai AT,F

    更新日期:2015-08-01 00:00:00