Preexisting Heart Disease Underlies Newly Diagnosed Atrial Fibrillation After Acute Ischemic Stroke.

Abstract:

BACKGROUND AND PURPOSE:Whether newly diagnosed atrial fibrillation (nAF) after stroke reflects underlying heart disease and represents an increased risk of cardioembolic stroke, or whether it is triggered by neurogenic mechanisms remains uncertain. We investigated, whether cardiovascular risk factors and echocardiographic parameters in patients with nAF are similar to patients with known AF (kAF) and differ from patients without AF. METHODS:Consecutive acute ischemic stroke patients were enrolled into a prospective stroke database. All patients with echocardiography were included and univariable and multivariable testing was applied to compare clinical characteristics and echocardiographic findings among patients with nAF, kAF, and no AF. RESULTS:A total of 1397 patients were included (male, 62.3%; median age, 71 years). AF was present in 320 (22.9%) patients. Of those, nAF was present in 36.2% (116/320) and kAF in 63.8% (204/320). No clinical or echocardiographic factor was independently associated with detection of nAF compared with kAF but a trend toward larger left atrial diameters in patients with kAF was observed (P=0.070). In contrast, patients with nAF were more often female (P<0.001), older (P<0.001) and had a larger left atrial diameters (P<0.001) compared with patients without AF. While stroke severity in patients with nAF and kAF was similar, patients without AF had less severe strokes. CONCLUSIONS:Stroke patients with nAF and with kAF share common cardiovascular risk factors, have similar echocardiographic findings and suffer equally severe strokes. We conclude that preexisting heart disease is the major cause of AF that is first diagnosed after stroke.

journal_name

Stroke

journal_title

Stroke

authors

Rizos T,Horstmann S,Dittgen F,Täger T,Jenetzky E,Heuschmann P,Veltkamp R

doi

10.1161/STROKEAHA.115.011465

subject

Has Abstract

pub_date

2016-02-01 00:00:00

pages

336-41

issue

2

eissn

0039-2499

issn

1524-4628

pii

STROKEAHA.115.011465

journal_volume

47

pub_type

杂志文章

相关文献

STROKE文献大全
  • Cognitive consequences of thalamic, basal ganglia, and deep white matter lacunes in brain aging and dementia.

    abstract:BACKGROUND AND PURPOSE:Most previous studies addressed the cognitive impact of lacunar infarcts using radiologic correlations that are known to correlate poorly with neuropathological data. Moreover, absence of systematic bilateral assessment of vascular lesions and masking effects of Alzheimer disease pathology and ma...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.STR.0000166052.89772.b5

    authors: Gold G,Kövari E,Herrmann FR,Canuto A,Hof PR,Michel JP,Bouras C,Giannakopoulos P

    更新日期:2005-06-01 00:00:00

  • Early component changes in corticomotor evoked potentials following experimental stroke.

    abstract::Corticomotor evoked potentials have recently been used in experimental animals and patients as a measure of neurologic function after stroke. However, little is known about the fundamental electrophysiologic properties contributing to the formation of these potentials. To define some of these properties, corticomotor ...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.18.6.1141

    authors: Simpson RK Jr,Baskin DS

    更新日期:1987-11-01 00:00:00

  • Effect of hemorrhagic hypotension on cerebrovascular reactivity and ultrastructure in the cat.

    abstract:BACKGROUND AND PURPOSE:The goal of this study was to determine the alterations in contractile and dilatory responses and ultrastructure of the feline middle cerebral artery after hemorrhagic hypotension. METHODS:In the sodium pentobarbital anesthetized cats, a steady 50 mm Hg level of hypotension was reached by bleedi...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.22.12.1541

    authors: Kovách AG,Szabó C,Faragó M,Lohinai Z,Fehér E

    更新日期:1991-12-01 00:00:00

  • Cochrane report: A systematic review of mannitol therapy for acute ischemic stroke and cerebral parenchymal hemorrhage.

    abstract:BACKGROUND:Mannitol was reported to decrease cerebral edema associated with tissue damage and is used to treat acute stroke in many countries. SUMMARY OF REVIEW:We tested whether there is any evidence from unconfounded randomized clinical trials that treatment with mannitol reduces short- and long-term case fatality a...

    journal_title:Stroke

    pub_type: 杂志文章,评审

    doi:10.1161/01.str.31.11.2719

    authors: Bereczki D,Liu M,Prado GF,Fekete I

    更新日期:2000-11-01 00:00:00

  • Dietary Protein Intake and Stroke Risk in a General Japanese Population: The Hisayama Study.

    abstract:BACKGROUND AND PURPOSE:The influence of dietary protein intake on stroke risk is an area of interest. We investigated the association between dietary protein intake and stroke risk in Japanese, considering sources of protein. METHODS:A total of 2400 subjects aged 40 to 79 years were followed up for 19 years. Dietary p...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/STROKEAHA.116.016059

    authors: Ozawa M,Yoshida D,Hata J,Ohara T,Mukai N,Shibata M,Uchida K,Nagata M,Kitazono T,Kiyohara Y,Ninomiya T

    更新日期:2017-06-01 00:00:00

  • Perinatal nicotine exposure increases vulnerability of hypoxic-ischemic brain injury in neonatal rats: role of angiotensin II receptors.

    abstract:BACKGROUND AND PURPOSE:Maternal cigarette smoking increases the risk of neonatal morbidity. We tested the hypothesis that perinatal nicotine exposure causes heightened brain vulnerability to hypoxic-ischemic (HI) injury in neonatal rats through aberrant expression patterns of angiotensin II type 1 (AT(1)R) and type 2 (...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/STROKEAHA.112.664698

    authors: Li Y,Xiao D,Dasgupta C,Xiong F,Tong W,Yang S,Zhang L

    更新日期:2012-09-01 00:00:00

  • Relationship between white-matter hyperintensities and hematoma volume and growth in patients with intracerebral hemorrhage.

    abstract:BACKGROUND AND PURPOSE:The presence of white-matter hyperintensities (WMHs) has been linked to intracerebral hemorrhage (ICH). We sought to determine whether the severity of WMHs influences hematoma growth and ICH volume. METHODS:We retrospectively reviewed prospectively collected clinical, laboratory, and radiologic ...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/STROKEAHA.109.564955

    authors: Lou M,Al-Hazzani A,Goddeau RP Jr,Novak V,Selim M

    更新日期:2010-01-01 00:00:00

  • Tetrahydrobiopterin, a cofactor for nitric oxide synthase, produces endothelium-dependent dilation of mouse pial arterioles.

    abstract:BACKGROUND AND PURPOSE:Tetrahydrobiopterin (THBP) is an essential cofactor for nitric oxide synthase (NOS), which is responsible for the synthesis of the endothelium-derived relaxing factor (EDRF) responsible for mediating the vasorelaxation produced by acetylcholine (ACh). Previous publications suggest that EDRFACh is...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.28.1.186

    authors: Rosenblum WI

    更新日期:1997-01-01 00:00:00

  • Leukoaraiosis in relation to prognosis for patients with lacunar infarction.

    abstract:BACKGROUND AND PURPOSE:Close relations between leukoaraiosis detected by computed tomography or magnetic resonance imaging and stroke, particularly lacunar infarction, have been reported. We studied whether leukoaraiosis is related to long-term prognosis for patients with lacunar infarction. METHODS:We examined monthl...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.23.10.1434

    authors: Miyao S,Takano A,Teramoto J,Takahashi A

    更新日期:1992-10-01 00:00:00

  • Stroke in Commercial Flights.

    abstract:BACKGROUND AND PURPOSE:Stroke on board aircraft has been reported in retrospective case series, mainly focusing on economy class stroke syndrome. Data on the actual incidence, pathogenesis, and prognosis of stroke in commercial flights are lacking. METHODS:A prospective registry was designed to include all consecutive...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/STROKEAHA.115.012637

    authors: Álvarez-Velasco R,Masjuan J,DeFelipe A,Corral I,Estévez-Fraga C,Crespo L,Alonso-Cánovas A

    更新日期:2016-04-01 00:00:00

  • Embolic stroke after smoking "crack" cocaine.

    abstract::A 39-year-old woman had an embolic upper division middle cerebral artery branch occlusion 3 hours after smoking the free base of cocaine ("crack"). Radionuclide ventriculography demonstrated cardiomyopathy, and echocardiography documented a left atrial thrombus. This case demonstrates that embolism is one mechanism of...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.21.11.1632

    authors: Petty GW,Brust JC,Tatemichi TK,Barr ML

    更新日期:1990-11-01 00:00:00

  • Distribution of the blood flow supplied by the vertebral artery in humans as assessed by emission CT.

    abstract::Though unilateral blood distribution of the vertebral artery has not been studied in humans, it is significant when considering the ischemic events especially embolic occlusion in vertebrobasilar system. To clarify the blood distribution, Krypton-81m was continuously infused into the vertebral arteries of 10 patients....

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.15.3.469

    authors: Taki W,Handa H,Higa T,Tanada S,Fukuyama H,Fujita T,Yonekawa Y,Kameyama M,Torizuka K

    更新日期:1984-05-01 00:00:00

  • Survival and recurrence following stroke. The Framingham study.

    abstract::Survival and recurrences after stroke were assessed prospectively in a general population sample of 5184 subjects followed biennially for 26 years. Initial strokes occurred in 198 men and 196 women. There were 84 second and 27 third strokes and 223 deaths reported. Thirty day case-fatality rates for initial strokes we...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.13.3.290

    authors: Sacco RL,Wolf PA,Kannel WB,McNamara PM

    更新日期:1982-05-01 00:00:00

  • Detection of mitral valve abnormalities by carotid Doppler flow study: implications for the management of patients with cerebrovascular disease.

    abstract::Patients with symptoms of cerebral ischemia are often evaluated with non-invasive carotid artery testing. An abnormal carotid Doppler ultrasound frequency shift pattern of early systolic flutter (ESF) was demonstrated by auscultation and velocity wave form analysis in patients with normal carotid bifurcations. Ten of ...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.16.6.977

    authors: Weinberger J,Goldman M

    更新日期:1985-11-01 00:00:00

  • Lesion location predicts transient and extended risk of aspiration after supratentorial ischemic stroke.

    abstract:BACKGROUND AND PURPOSE:To assess the association of lesion location and risk of aspiration and to establish predictors of transient versus extended risk of aspiration after supratentorial ischemic stroke. METHODS:Atlas-based localization analysis was performed in consecutive patients with MRI-proven first-time acute s...

    journal_title:Stroke

    pub_type: 临床试验,杂志文章

    doi:10.1161/STROKEAHA.113.001690

    authors: Galovic M,Leisi N,Müller M,Weber J,Abela E,Kägi G,Weder B

    更新日期:2013-10-01 00:00:00

  • Tumor necrosis factor-alpha-238G>A promoter polymorphism is associated with increased risk of new hemorrhage in the natural course of patients with brain arteriovenous malformations.

    abstract:BACKGROUND AND PURPOSE:Identification of single-nucleotide polymorphisms (SNPs) associated with increased risk of new intracranial hemorrhage (ICH) after brain arteriovenous malformation (BAVM) diagnosis would facilitate risk stratification and identify potential targets for therapeutic intervention. METHODS:Patients ...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.STR.0000195133.98378.4b

    authors: Achrol AS,Pawlikowska L,McCulloch CE,Poon KY,Ha C,Zaroff JG,Johnston SC,Lee C,Lawton MT,Sidney S,Marchuk DA,Kwok PY,Young WL,UCSF BAVM Study Project.

    更新日期:2006-01-01 00:00:00

  • Low-Dose Tirofiban Improves Functional Outcome in Acute Ischemic Stroke Patients Treated With Endovascular Thrombectomy.

    abstract:BACKGROUND AND PURPOSE:Chinese patients largely experience acute ischemic stroke (AIS) because of large artery atherosclerosis rather than cardioembolism, and whether tirofiban is safe and effective in these patients treated with endovascular thrombectomy (ET) is unknown. This study evaluated the safety and efficacy of...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/STROKEAHA.117.019193

    authors: Zhao W,Che R,Shang S,Wu C,Li C,Wu L,Chen J,Duan J,Song H,Zhang H,Ling F,Wang Y,Liebeskind D,Feng W,Ji X

    更新日期:2017-12-01 00:00:00

  • Minimally invasive surgery for spontaneous supratentorial intracerebral hemorrhage: a meta-analysis of randomized controlled trials.

    abstract:BACKGROUND AND PURPOSE:There has been a nonstandard surgical procedure and extensive international controversy in minimally invasive surgery (MIS) for the management of spontaneous supratentorial intracerebral hemorrhage. This meta-analysis assessed the effectiveness of MIS as compared with other treatment options, inc...

    journal_title:Stroke

    pub_type: 杂志文章,meta分析

    doi:10.1161/STROKEAHA.112.667535

    authors: Zhou X,Chen J,Li Q,Ren G,Yao G,Liu M,Dong Q,Guo J,Li L,Guo J,Xie P

    更新日期:2012-11-01 00:00:00

  • Association of prestroke statin use and lipid levels with outcome of intracerebral hemorrhage.

    abstract:BACKGROUND AND PURPOSE:It is unclear whether blood lipid profiles and statin use before intracerebral hemorrhage (ICH) are associated with its outcome. METHODS:The Helsinki ICH Study, a single-center observational registry of consecutive ICH patients, was used to study the associations between premorbid statin use, ba...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/STROKEAHA.113.001829

    authors: Mustanoja S,Strbian D,Putaala J,Meretoja A,Curtze S,Haapaniemi E,Sairanen T,Hietikko R,Sirén J,Kaste M,Tatlisumak T

    更新日期:2013-08-01 00:00:00

  • Thromboxane prostaglandin receptor antagonist and carotid atherosclerosis progression in patients with cerebrovascular disease of ischemic origin: a randomized controlled trial.

    abstract:BACKGROUND AND PURPOSE:Thromboxane prostaglandin receptors have been implicated to be involved in the atherosclerotic process. We assessed whether Terutroban, a thromboxane prostaglandin receptor antagonist, affects the progression of atherosclerosis, as measured by common carotid intima-media thickness and carotid pla...

    journal_title:Stroke

    pub_type: 杂志文章,随机对照试验

    doi:10.1161/STROKEAHA.114.004775

    authors: Bots ML,Ford I,Lloyd SM,Laurent S,Touboul PJ,Hennerici MG,Prevention of Cerebrovascular and Cardiovascular Events of Ischemic Origin With Terutroban in Patients With a History of Ischemic Stroke or Transient Ischemic Attack Vascular Ultrasou

    更新日期:2014-08-01 00:00:00

  • Dysregulated RANK ligand/RANK axis in hyperhomocysteinemic subjects: effect of treatment with B-vitamins.

    abstract:BACKGROUND AND PURPOSE:Homocysteine has been linked to increased risk of ischemic stroke and other cardiovascular events. Matrix degradation and inflammation play an important role in these disorders, and we have demonstrated increased levels of matrix-degrading enzymes and inflammatory cytokines in hyperhomocysteinemi...

    journal_title:Stroke

    pub_type: 杂志文章,随机对照试验

    doi:10.1161/STROKEAHA.108.522995

    authors: Nenseter MS,Ueland T,Retterstøl K,Strøm E,Mørkrid L,Landaas S,Ose L,Aukrust P,Holven KB

    更新日期:2009-01-01 00:00:00

  • Vertebrobasilar stenosis predicts high early recurrent stroke risk in posterior circulation stroke and TIA.

    abstract:BACKGROUND AND PURPOSE:20% of ischemic stroke is in the posterior circulation, but there is little prospective data on early recurrent stroke risk and whether vertebrobasilar stenosis predicts a high recurrence risk. This natural history data are important as it is technically possible to stent such lesions. Contrast e...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/STROKEAHA.109.553859

    authors: Gulli G,Khan S,Markus HS

    更新日期:2009-08-01 00:00:00

  • Safety and efficacy of endovascular cooling and rewarming for induction and reversal of hypothermia in human-sized pigs.

    abstract:BACKGROUND AND PURPOSE:Numerous studies indicate that mild hypothermia provides substantial neuroprotection. However, current systems transfer insufficient heat to rapidly vary core temperature. We thus evaluated the safety and efficacy of endovascular cooling and rewarming for the induction and reversal of hypothermia...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.STR.0000057461.56040.FE

    authors: Dae MW,Gao DW,Ursell PC,Stillson CA,Sessler DI

    更新日期:2003-03-01 00:00:00

  • Impact of early blood pressure variability on stroke outcomes after thrombolysis: the SAMURAI rt-PA Registry.

    abstract:BACKGROUND AND PURPOSE:The present study determines associations between early blood pressure (BP) variability and stroke outcomes after intravenous thrombolysis. METHODS:In 527 stroke patients receiving intravenous alteplase (0.6 mg/kg), BP was measured 8 times within the first 25 hours. BP variability was determined...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/STROKEAHA.112.681007

    authors: Endo K,Kario K,Koga M,Nakagawara J,Shiokawa Y,Yamagami H,Furui E,Kimura K,Hasegawa Y,Okada Y,Okuda S,Namekawa M,Miyagi T,Osaki M,Minematsu K,Toyoda K

    更新日期:2013-03-01 00:00:00

  • Thrombolysis-related hemorrhagic infarction: a marker of early reperfusion, reduced infarct size, and improved outcome in patients with proximal middle cerebral artery occlusion.

    abstract:BACKGROUND AND PURPOSE:The role of early and delayed recanalization after thrombolysis in the development of hemorrhagic transformation (HT) subtypes remains uncertain. We sought to explore the association between the timing of recanalization and HT risk in patients with proximal middle cerebral artery (MCA) occlusion ...

    journal_title:Stroke

    pub_type: 临床试验,杂志文章

    doi:10.1161/01.str.0000016323.13456.e5

    authors: Molina CA,Alvarez-Sabín J,Montaner J,Abilleira S,Arenillas JF,Coscojuela P,Romero F,Codina A

    更新日期:2002-06-01 00:00:00

  • Increases in cerebral atherosclerosis according to CHADS2 scores in patients with stroke with nonvalvular atrial fibrillation.

    abstract:BACKGROUND AND PURPOSE:The CHADS(2) score is used for risk stratification of ischemic stroke in patients with nonvalvular atrial fibrillation and high CHADS(2) scores are associated with increased risk of stroke. Most components of the CHADS(2) score are also risk factors for atherosclerosis. Therefore, high CHADS(2) s...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/STROKEAHA.110.602987

    authors: Kim YD,Cha MJ,Kim J,Lee DH,Lee HS,Nam CM,Nam HS,Heo JH

    更新日期:2011-04-01 00:00:00

  • Parity and carotid artery atherosclerosis in elderly women: The Rotterdam Study.

    abstract:BACKGROUND AND PURPOSE:It has been postulated that physiological changes in the cardiovascular system, lipids, and glucose metabolism during pregnancy may increase subsequent risk of cardiovascular disease. Examination of the association between parity and risk factors for atherosclerosis may contribute information reg...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/hs1001.097224

    authors: Humphries KH,Westendorp IC,Bots ML,Spinelli JJ,Carere RG,Hofman A,Witteman JC

    更新日期:2001-10-01 00:00:00

  • Relation of coronary atherosclerosis and apolipoprotein E genotypes in Alzheimer patients.

    abstract:BACKGROUND AND PURPOSE:Apolipoprotein E (apoE) epsilon 4 allele has been associated with a high risk for coronary heart disease. Increased frequency of the epsilon 4 allele has also been reported in patients with late-onset familial and sporadic Alzheimer's disease (AD). The aim of this study was to investigate the deg...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.26.5.743

    authors: Kosunen O,Talasniemi S,Lehtovirta M,Heinonen O,Helisalmi S,Mannermaa A,Paljärvi L,Ryynänen M,Riekkinen PJ Sr,Soininen H

    更新日期:1995-05-01 00:00:00

  • A double blind trial of naloxone in the treatment of acute stroke.

    abstract::Naloxone has been reported to have potential benefit in the treatment of stroke. We evaluated the effect of naloxone in a double-blind trial conducted with 15 stroke patients whose deficits ranged from 8 to 60 hours in duration. All but one patient sustained a cerebral infarction. Neurologic function was assessed befo...

    journal_title:Stroke

    pub_type: 临床试验,杂志文章

    doi:10.1161/01.str.15.4.627

    authors: Fallis RJ,Fisher M,Lobo RA

    更新日期:1984-07-01 00:00:00

  • Prophylactic but not delayed administration of simvastatin protects against long-lasting cognitive and morphological consequences of neonatal hypoxic-ischemic brain injury, reduces interleukin-1beta and tumor necrosis factor-alpha mRNA induction, and does

    abstract:BACKGROUND AND PURPOSE:Prophylactic administration of simvastatin has been shown to protect against brain damage and its long-lasting behavioral consequences in neonatal rats. To establish the drug treatment window, we evaluated the effectiveness of simvastatin administered at different intervals before and after strok...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.STR.0000080677.24419.88

    authors: Balduini W,Mazzoni E,Carloni S,De Simoni MG,Perego C,Sironi L,Cimino M

    更新日期:2003-08-01 00:00:00