Abstract:
BACKGROUND AND PURPOSE:To assess the association of lesion location and risk of aspiration and to establish predictors of transient versus extended risk of aspiration after supratentorial ischemic stroke. METHODS:Atlas-based localization analysis was performed in consecutive patients with MRI-proven first-time acute supratentorial ischemic stroke. Standardized swallowing assessment was carried out within 8±18 hours and 7.8±1.2 days after admission. RESULTS:In a prospective, longitudinal analysis, 34 of 94 patients (36%) were classified as having acute risk of aspiration, which was extended (≥7 days) or transient (<7 days) in 17 cases. There were no between-group differences in age, sex, cause of stroke, risk factors, prestroke disability, lesion side, or the degree of age-related white-matter changes. Correcting for stroke volume and National Institutes of Health Stroke Scale with a multiple logistic regression model, significant adjusted odds ratios in favor of acute risk of aspiration were demonstrated for the internal capsule (adjusted odds ratio, 6.2; P<0.002) and the insular cortex (adjusted odds ratio, 4.8; P<0.003). In a multivariate model of extended versus transient risk of aspiration, combined lesions of the frontal operculum and insular cortex was the only significant independent predictor of poor recovery (adjusted odds ratio, 33.8; P<0.008). CONCLUSIONS:Lesions of the insular cortex and the internal capsule are significantly associated with acute risk of aspiration after stroke. Combined ischemic infarctions of the frontal operculum and the insular cortex are likely to cause extended risk of aspiration in stroke patients, whereas risk of aspiration tends to be transient in subcortical stroke.
journal_name
Strokejournal_title
Strokeauthors
Galovic M,Leisi N,Müller M,Weber J,Abela E,Kägi G,Weder Bdoi
10.1161/STROKEAHA.113.001690subject
Has Abstractpub_date
2013-10-01 00:00:00pages
2760-7issue
10eissn
0039-2499issn
1524-4628pii
STROKEAHA.113.001690journal_volume
44pub_type
临床试验,杂志文章相关文献
STROKE文献大全abstract::Background and Purpose- Intraluminal thrombus (ILT) is an uncommon finding among patients with ischemic stroke. We report clinical-imaging manifestations, treatment offered, and outcome among patients with ischemic stroke/transient ischemic attack and ILT in their cervico-cephalic arteries. Methods- Sixty-one of 3750 ...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.118.023015
更新日期:2019-02-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Patients with carotid occlusive disease and stage 2 cerebral hemodynamic failure, characterized by an increased oxygen extraction fraction (OEF) as measured by positron emission tomography (PET) and otherwise known as misery perfusion, have a high risk of cerebral ischemia and subsequent stroke. ...
journal_title:Stroke
pub_type: 临床试验,杂志文章
doi:10.1161/01.str.0000027638.19392.7e
更新日期:2002-09-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The Thrombolytic Therapy in Acute Ischemic Stroke Study, which started in August of 1991, was designed to assess the efficacy and safety of intravenous rtPA (alteplase) in patients with acute (0 to 6 hours) ischemic stroke. In October 1993 enrollment was halted because of Safety Committee (DMSB) ...
journal_title:Stroke
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1161/01.str.31.4.811
更新日期:2000-04-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The risk of major vascular events after an initial episode of cerebral ischemia in patients with nonrheumatic atrial fibrillation (NRAF) varies from 2% to 15% in the first year and is approximately 5% yearly thereafter. Few studies have reported on risk factors that can be used to identify high-r...
journal_title:Stroke
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1161/01.str.26.5.801
更新日期:1995-05-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Different distributions of cerebral microbleeds (CMBs) are associated with distinct pathological mechanisms. Lobar CMBs are thought to be related to cerebral amyloid angiopathy, whereas deep or infratentorial CMBs are related to hypertensive vasculopathy. The present study aimed to evaluate the e...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.116.014166
更新日期:2016-10-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Chlamydia pneumoniae infection has recently become noteworthy in relation to atherosclerosis. We investigated by immunohistochemistry the distribution of C pneumoniae infection in the atherosclerotic carotid artery. METHODS:Twenty carotid atherosclerotic lesions that were resected during carotid...
journal_title:Stroke
pub_type: 临床试验,杂志文章
doi:10.1161/01.str.29.4.773
更新日期:1998-04-01 00:00:00
abstract:BACKGROUND AND PURPOSE:A full appreciation of the presence of cerebral vascular lesions in cognitively impaired patients can be ultimately reached at the neuropathological level. However, there are no detailed guidelines regarding what neuropathologists should look for at autopsy in cases of suspected vascular dementia...
journal_title:Stroke
pub_type: 杂志文章,多中心研究
doi:10.1161/01.STR.0000206445.97511.ae
更新日期:2006-04-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The antiplatelet agent sarpogrelate is a selective inhibitor of 5-hydroxytryptamine receptors. The purpose of this study was to compare the efficacy and safety of sarpogrelate with those of aspirin in Japanese ischemic stroke patients. METHODS:In total, 1510 patients with recent cerebral infarct...
journal_title:Stroke
pub_type: 杂志文章,随机对照试验
doi:10.1161/STROKEAHA.107.505131
更新日期:2008-06-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Increased amount of therapy seems to be beneficial for motor recovery after stroke. The primary aim of the present study was to evaluate the effect of a 4-week community-based intensive motor training program combined with early supported discharge after initial treatment in a comprehensive strok...
journal_title:Stroke
pub_type: 杂志文章,随机对照试验
doi:10.1161/STROKEAHA.110.584284
更新日期:2010-08-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Elevated leukocyte count has been associated with cardiovascular and cerebrovascular disease in several epidemiological studies. We sought to determine whether white blood cell count (WBC) is associated with carotid plaque thickness in a stroke-free, multiethnic cohort. METHODS:For this cross-se...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.32.4.842
更新日期:2001-04-01 00:00:00
abstract:BACKGROUND AND PURPOSE:In acute ischemic stroke, fast and complete recanalization of the occluded vessel is associated with improved outcomes. We describe a novel measure for newer generation devices: the first pass effect (FPE). FPE is defined as achieving a complete recanalization with a single thrombectomy device pa...
journal_title:Stroke
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1161/STROKEAHA.117.020315
更新日期:2018-03-01 00:00:00
abstract::Background and Purpose- The complexity and heterogeneity of stroke, as well as the associated comorbidities, may render neuroprotective drugs less efficacious in clinical practice. Therefore, the development of targeted therapies to specific patient subsets has become a high priority in translational stroke research. ...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.118.022119
更新日期:2018-12-01 00:00:00
abstract:BACKGROUND AND PURPOSE:White matter hyperintensities (WMH) are frequently seen on neuroimaging of elderly and are associated with cognitive decline and the development of dementia. Yet, the temporal dynamics of conversion of normal-appearing white matter (NAWM) into WMH remains unknown. We examined whether and when pro...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.118.020980
更新日期:2018-06-01 00:00:00
abstract::Mild hypothermia is an established neuroprotectant in the laboratory, showing remarkable and consistent effects across multiple laboratories and models of brain injury. At the clinical level, mild hypothermia has shown benefits in patients who have experienced cardiac arrest and in some pediatric populations experienc...
journal_title:Stroke
pub_type: 杂志文章,评审
doi:10.1161/STROKEAHA.110.595371
更新日期:2010-10-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Recent studies have shown the antiapoptotic neuroprotective effects of lecithinized superoxide dismutase (PC-SOD) in different forms of brain injury. We tested the effects of PC-SOD in focal cerebral ischemia in the rat middle cerebral artery occlusion model (MCAO). METHODS:Adult male Sprague-Da...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.STR.0000257978.70312.1d
更新日期:2007-03-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Computed tomography is now routinely used in many hospitals to investigate cerebrovascular disease. The purpose of our prospective study was to determine whether cranial computed tomography in connection with neurological assessment was useful in prognostic evaluation of survival after acute stro...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.23.4.506
更新日期:1992-04-01 00:00:00
abstract::Background and Purpose- Aneurysmal subarachnoid hemorrhage (aSAH) has a high healthcare cost burden. Methods- We performed a cross-sectional analysis of the costs of clipping and coiling of aSAH using the National Inpatient Sample and Vizient databases. We conducted multiple regression analyses to estimate national co...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.118.023079
更新日期:2018-12-03 00:00:00
abstract:BACKGROUND:We sought to determine interrater agreement in evaluation of stroke patients with the Unified Form for Neurological Stroke Scales (UFNSS). SUMMARY OF REPORT:Fifty inpatients were independently examined by three neurologists. Kendall coefficients of concordance were computed for the different items of the UF...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.25.6.1263
更新日期:1994-06-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The etiology of subarachnoid hemorrhage (SAH) is poorly understood. Reduced lung function, expressed as low forced expiratory volume in 1 second (FEV(1)) and low forced vital capacity (FVC), is a predictor of cardiovascular disease, but whether reduced lung function is a risk factor for SAH is no...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.112.658427
更新日期:2012-10-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Brain iron overload plays a detrimental role in brain injury after intracerebral hemorrhage (ICH). A recent study found that minocycline acts as an iron chelator and reduces iron-induced neuronal death in vitro. The present study investigated if minocycline reduces iron overload after ICH and iro...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.111.623926
更新日期:2011-12-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Stroke symptoms in the absence of recognized stroke are common, but potential associated dysfunctions have not been described. METHODS:We assessed quality-of-life measures using the Physical and Mental Component Summary scores of the Short Form 12 (PCS-12 and MCS-12) in the REasons for Geographi...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.106.478032
更新日期:2007-09-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Fibrocartilaginous embolism from the nucleus pulposus has been reported as a rare cause of spinal cord ischemia. We were unable to find previous reports of embolism from this source to cerebral arteries. CASE DESCRIPTION:A previously healthy 17-year-old girl fell during a basketball game. Left h...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.24.5.738
更新日期:1993-05-01 00:00:00
abstract::Leukoaraiosis is a common finding in stroke patients and has been strongly associated with risk of incident stroke and dementia. Leukoaraiosis may also be an independent predictor of stroke outcomes. There is increasing evidence from neuroimaging to support the concept that some leukoaraiosis is caused by white matter...
journal_title:Stroke
pub_type: 杂志文章,评审
doi:10.1161/STROKEAHA.110.596056
更新日期:2010-10-01 00:00:00
abstract::Serum dopamine-beta-hydroxylase (DBH) activity was measured in 34 patients with acute cerebrovascular disease. The serum level of DBH activity showed its highest value soon after the onset of stroke and then gradually decreased over the next few days. After reaching its lowest level, the DBH activity again showed a sl...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.10.2.168
更新日期:1979-03-01 00:00:00
abstract::Background and Purpose- We aimed to determine whether low-frequency electric field navigated repetitive transcranial magnetic stimulation to noninjured motor cortex versus sham repetitive transcranial magnetic stimulation avoiding motor cortex could improve arm motor function in hemiplegic stroke patients when combine...
journal_title:Stroke
pub_type: 杂志文章,随机对照试验
doi:10.1161/STROKEAHA.117.020607
更新日期:2018-09-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Exogenous delivery of vascular endothelial growth factor gene (VEGF) may provide a useful approach to the treatment of brain ischemia. We investigated the use of a hypoxia-responsive element to control VEGF expression given for neuroprotection. METHODS:Three groups (n=36) of mice received AAVH9-...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.STR.0000240407.14765.e8
更新日期:2006-10-01 00:00:00
abstract::The angiographic, clinical, and genetic characteristics of fibromuscular dysplasia (FMD) are reviewed in 37 patients (mean age 48 years) selected from a pool of 4000 angiograms of carotid or vertebral arteries. FMD was a neglected pathogenic factor in 28 patients with hemorrhagic or ischemic cerebral lesions. The aneu...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.13.1.46
更新日期:1982-01-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Controlled multicenter studies have demonstrated the efficacy of systemic recombinant tissue-type plasminogen activator (rtPA) treatment in selected cases of acute ischemic stroke. The feasibility of this therapeutic option in clinical practice was assessed in a community-based approach. METHODS...
journal_title:Stroke
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1161/01.str.29.8.1544
更新日期:1998-08-01 00:00:00
abstract:BACKGROUND AND PURPOSE:There has been a nonstandard surgical procedure and extensive international controversy in minimally invasive surgery (MIS) for the management of spontaneous supratentorial intracerebral hemorrhage. This meta-analysis assessed the effectiveness of MIS as compared with other treatment options, inc...
journal_title:Stroke
pub_type: 杂志文章,meta分析
doi:10.1161/STROKEAHA.112.667535
更新日期:2012-11-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The cerebrovascular contribution to ischemic preconditioning (IPC) has been scarcely explored. Using in vivo and in vitro approaches, we investigated the involvement of the blood-brain barrier and the role of its cellular components. METHODS:Seven-minute occlusion of the right middle cerebral ar...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.110.603266
更新日期:2011-05-01 00:00:00