Parity and carotid artery atherosclerosis in elderly women: The Rotterdam Study.

Abstract:

BACKGROUND AND PURPOSE:It has been postulated that physiological changes in the cardiovascular system, lipids, and glucose metabolism during pregnancy may increase subsequent risk of cardiovascular disease. Examination of the association between parity and risk factors for atherosclerosis may contribute information regarding possible mechanisms. METHODS:The relationship of parity with cardiovascular risk factors and the presence of carotid atherosclerosis was examined in the Rotterdam Study, a population-based study comprising 4878 women aged 55 years and older. Carotid atherosclerosis was assessed by ultrasonographic detection of plaques in the common carotid artery and bifurcation. Logistic regression models were used to compute odds ratios and 95% confidence intervals, adjusted for confounding factors. RESULTS:Parity was inversely associated with high-density lipoprotein cholesterol, and alcohol intake. Parity was positively associated with body mass index, total/HDL cholesterol ratio, insulin resistance, age at menopause, and socioeconomic status. Relative to nulliparous women, parous women had 36% (9% to 71%) greater risk of carotid atherosclerosis, rising to 64% in women with >/=4 children (19% to 127%). Adjustment for known cardiovascular risk factors, including insulin resistance and current lipid levels, did not diminish the magnitude of this association. CONCLUSIONS:Data demonstrated that there is a positive association between parity and risk of carotid artery plaques in elderly women and, further, that high parity is associated with lower HDL cholesterol levels and higher glucose/insulin ratios long after childbearing has ceased.

journal_name

Stroke

journal_title

Stroke

authors

Humphries KH,Westendorp IC,Bots ML,Spinelli JJ,Carere RG,Hofman A,Witteman JC

doi

10.1161/hs1001.097224

subject

Has Abstract

pub_date

2001-10-01 00:00:00

pages

2259-64

issue

10

eissn

0039-2499

issn

1524-4628

journal_volume

32

pub_type

杂志文章

相关文献

STROKE文献大全
  • Shunt-associated migraine responds favorably to atrial septal repair: a case-control study.

    abstract:BACKGROUND AND PURPOSE:Transcatheter closure of patent foramen ovale (PFO) has been reported to improve migraine in patients with cerebrovascular disorders in noncontrolled studies. The aim of the study was to compare the course of migraine assessed prospectively over a 12-month period in symptomatic (for cerebrovascul...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.STR.0000199082.07317.43

    authors: Anzola GP,Frisoni GB,Morandi E,Casilli F,Onorato E

    更新日期:2006-02-01 00:00:00

  • Mobile Stroke Unit Computed Tomography Angiography Substantially Shortens Door-to-Puncture Time.

    abstract::Background and Purpose- Endovascular thrombectomy (ET) door-to-puncture time (DTPT) is a modifiable metric. One of the most important, yet time-consuming steps, is documentation of large vessel occlusion by computed tomography angiography (CTA). We hypothesized that obtaining CTA on board a Mobile Stroke Unit and dire...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/STROKEAHA.119.028626

    authors: Czap AL,Singh N,Bowry R,Jagolino-Cole A,Parker SA,Phan K,Wang M,Sheth SA,Rajan SS,Yamal JM,Grotta JC

    更新日期:2020-05-01 00:00:00

  • Homocysteine-lowering treatment with folic acid, cobalamin, and pyridoxine does not reduce blood markers of inflammation, endothelial dysfunction, or hypercoagulability in patients with previous transient ischemic attack or stroke: a randomized substudy o

    abstract:BACKGROUND AND PURPOSE:Epidemiological and laboratory studies suggest that increasing concentrations of plasma homocysteine (total homocysteine [tHcy]) accelerate cardiovascular disease by promoting vascular inflammation, endothelial dysfunction, and hypercoagulability. METHODS:We conducted a randomized controlled tri...

    journal_title:Stroke

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1161/01.STR.0000150494.91762.70

    authors: Dusitanond P,Eikelboom JW,Hankey GJ,Thom J,Gilmore G,Loh K,Yi Q,Klijn CJ,Langton P,van Bockxmeer FM,Baker R,Jamrozik K

    更新日期:2005-01-01 00:00:00

  • Reduced risk of intracerebral hemorrhage with dynamic recreational exercise but not with heavy work activity.

    abstract:BACKGROUND AND PURPOSE:It is unclear whether intracerebral hemorrhage (ICH) is associated with dynamic or static exercise. Our aim was to assess whether such an association exists. METHODS:A case-control study was undertaken involving 331 consecutive cases of primary ICH and 331 age- and sex-matched community-based ne...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/hs0202.102878

    authors: Thrift AG,Donnan GA,McNeil JJ

    更新日期:2002-02-01 00:00:00

  • A comparison of acute hemorrhagic stroke outcomes in 2 populations: the Crete-Boston study.

    abstract:BACKGROUND AND PURPOSE:Although corticosteroid use in acute hemorrhagic stroke is not widely adopted, management with intravenous dexamethasone has been standard of care at the University Hospital of Heraklion, Crete with observed outcomes superior to those reported in the literature. To explore this further, we conduc...

    journal_title:Stroke

    pub_type: 杂志文章,多中心研究

    doi:10.1161/STROKEAHA.111.632174

    authors: Zaganas I,Halpin AP,Oleinik A,Alegakis A,Kotzamani D,Zafiris S,Chlapoutaki C,Tsimoulis D,Giannakoudakis E,Chochlidakis N,Ntailiani A,Valatsou C,Papadaki E,Vakis A,Furie KL,Greenberg SM,Plaitakis A

    更新日期:2011-12-01 00:00:00

  • Retreatment of ruptured cerebral aneurysms in patients randomized by coiling or clipping in the International Subarachnoid Aneurysm Trial (ISAT).

    abstract:BACKGROUND AND PURPOSE:Because the long-term security of endovascular treatments remains uncertain, a follow-up study of the patients treated in the International Subarachnoid Aneurysm Trial was performed to compare the frequency, timing, and consequences of aneurysm recurrence. METHODS:Patient data were reclassified ...

    journal_title:Stroke

    pub_type: 杂志文章,随机对照试验

    doi:10.1161/STROKEAHA.106.466987

    authors: Campi A,Ramzi N,Molyneux AJ,Summers PE,Kerr RS,Sneade M,Yarnold JA,Rischmiller J,Byrne JV

    更新日期:2007-05-01 00:00:00

  • Early Imaging Prediction of Malignant Cerebellar Edema Development in Acute Ischemic Stroke.

    abstract:BACKGROUND AND PURPOSE:Malignant cerebellar edema (MCE) is a life-threatening complication of acute ischemic stroke that requires timely diagnosis and management. Aim of this study was to identify imaging predictors in initial multiparametric computed tomography (CT), including whole-brain CT perfusion (WB-CTP). METHO...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/STROKEAHA.117.018237

    authors: Fabritius MP,Thierfelder KM,Meinel FG,Othman AE,Dorn F,Sabel BO,Scheffler P,Ertl-Wagner B,Sommer WH,Kunz WG

    更新日期:2017-09-01 00:00:00

  • Endothelial function and carotid intima-media thickness in young healthy subjects among endothelial nitric oxide synthase Glu298-->Asp and T-786-->C polymorphisms.

    abstract:BACKGROUND AND PURPOSE:To assess the role of the endothelial nitric oxide synthase (eNOS) gene variants as risk factors for early atherosclerosis, we sought to investigate whether two polymorphisms located in the exon 7 (Glu298-->Asp) and in the promoter region (T-786-->C) of the eNOS gene were associated with function...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.STR.0000126482.86708.37

    authors: Paradossi U,Ciofini E,Clerico A,Botto N,Biagini A,Colombo MG

    更新日期:2004-06-01 00:00:00

  • Familial subarachnoid hemorrhage. Outcome study.

    abstract:BACKGROUND AND PURPOSE:The aim of our study was to compare outcome and its determinants in familial subarachnoid hemorrhage and in sporadic subarachnoid hemorrhage in a large and well-documented patient population. METHODS:Patients with aneurysmal subarachnoid hemorrhage (SAH) treated at the Department of Neurosurgery...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.30.5.1099

    authors: Ronkainen A,Niskanen M,Piironen R,Hernesniemi J

    更新日期:1999-05-01 00:00:00

  • Fibroblast Growth Factor 23 Is Associated With Subclinical Cerebrovascular Damage: The Northern Manhattan Study.

    abstract:BACKGROUND AND PURPOSE:Elevated fibroblast growth factor 23 (FGF23) regulates phosphate homeostasis and is linked with mortality, cardiovascular events, and stroke. However, the role of FGF23 as a risk factor for subclinical cerebrovascular damage is unclear. METHODS:We used multivariable linear and logistic regressio...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/STROKEAHA.115.012379

    authors: Wright CB,Shah NH,Mendez AJ,DeRosa JT,Yoshita M,Elkind MS,Sacco RL,DeCarli C,Rundek T,Silverberg S,Dong C,Wolf M

    更新日期:2016-04-01 00:00:00

  • Targeted Infarction of the Internal Capsule in the Rat Using Microstimulation Guidance.

    abstract::Background and Purpose- Lacunar strokes are subcortical infarcts with small size and high disability rates, largely due to injury of the corticospinal tract in the internal capsule (IC). Current rodent models of lacunar infarcts are created based on stereotactic coordinates. We tested the hypothesis that better unders...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/STROKEAHA.119.025646

    authors: Wen TC,Sindhurakar A,Ramirez VC,Park H,Gupta D,Carmel JB

    更新日期:2019-09-01 00:00:00

  • Stroke in the People's Republic of China. I. Geographic variations in incidence and risk factors.

    abstract:BACKGROUND AND PURPOSE:Stroke is a major cause of death in the People's Republic of China (PRC), and the geographic distribution of stroke death varies substantially. We conducted an ecological analysis to investigate the relationship of prevalence of hypertension and other risk factors with stroke incidence and mortal...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:

    authors: He J,Klag MJ,Wu Z,Whelton PK

    更新日期:1995-12-01 00:00:00

  • Three-dimensional MRI analysis of individual volume of Lacunes in CADASIL.

    abstract:BACKGROUND AND PURPOSE:Three-dimensional MRI segmentation may be useful to better understand the physiopathology of lacunar infarctions. Using this technique, the distribution of lacunar infarctions volumes has been recently reported in patients with cerebral autosomal-dominant arteriopathy with subcortical infarcts an...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/STROKEAHA.108.520825

    authors: Hervé D,Godin O,Dufouil C,Viswanathan A,Jouvent E,Pachaï C,Guichard JP,Bousser MG,Dichgans M,Chabriat H

    更新日期:2009-01-01 00:00:00

  • Effect of COVID-19 on Emergent Stroke Care: A Regional Experience.

    abstract:BACKGROUND AND PURPOSE:Anecdotal evidence suggests that the coronavirus disease 2019 (COVID-19) pandemic mitigation efforts may inadvertently discourage patients from seeking treatment for stroke with resultant increased morbidity and mortality. Analysis of regional data, while hospital capacities for acute stroke care...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/STROKEAHA.120.030499

    authors: Hsiao J,Sayles E,Antzoulatos E,Stanton RJ,Sucharew H,Broderick JP,Demel SL,Flaherty ML,Grossman AW,Kircher C,Kreitzer N,Peariso K,Prestigiacomo CJ,Shirani P,Walsh KB,Lampton H,Adeoye O,Khatri P

    更新日期:2020-09-01 00:00:00

  • Effects of a new thyrotropin-releasing hormone derivative on behavioral changes after focal cerebral ischemia in rats.

    abstract::We observed the effects of a new thyrotropin-releasing hormone derivative, YM-14673 (N alpha-[[(S)-4-oxo-2-azetidinyl]carbonyl]-L-histidyl-L-prolinamide dihydrate), on behavioral changes in rats for 3 weeks after focal cerebral ischemia. Under halothane anesthesia, the left middle cerebral artery was occluded via a tr...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.20.3.362

    authors: Yamamoto M,Tamura A,Kirino T,Shimizu M,Sano K

    更新日期:1989-03-01 00:00:00

  • Mevastatin, an HMG-CoA reductase inhibitor, reduces stroke damage and upregulates endothelial nitric oxide synthase in mice.

    abstract:BACKGROUND AND PURPOSE:The 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors (statins) lower serum cholesterol and decrease the incidence of stroke and cardiovascular disease. There is growing evidence that statins exert some of their beneficial effects independent of cholesterol lowering. Indeed, we...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.32.4.980

    authors: Amin-Hanjani S,Stagliano NE,Yamada M,Huang PL,Liao JK,Moskowitz MA

    更新日期:2001-04-01 00:00:00

  • Glucose affects the severity of hypoxic-ischemic brain injury in newborn pigs.

    abstract:BACKGROUND AND PURPOSE:The administration of glucose has been shown to worsen brain injury in adult animals but has no effect on the severity of injury in newborn rats. We wished to see whether the results in newborn rats could be extended to another newborn animal. METHODS:In 44 0- to 3-day-old piglets, hypoxic-ische...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.24.7.1055

    authors: LeBlanc MH,Huang M,Vig V,Patel D,Smith EE

    更新日期:1993-07-01 00:00:00

  • Are there inequalities in the provision of stroke care? Analysis of an inner-city stroke register.

    abstract:BACKGROUND AND PURPOSE:There is evidence of unequal access to health care interventions even where universal health systems operate. We investigated associations between patients' sociodemographic characteristics and the provision of acute and longer-term stroke care in a multiethnic urban population. METHODS:We used ...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.STR.0000152332.32267.19

    authors: McKevitt C,Coshall C,Tilling K,Wolfe C

    更新日期:2005-02-01 00:00:00

  • Blood flow and vascular reactivity in collaterally perfused brain tissue. Evidence of an ischemic penumbra in patients with acute stroke.

    abstract::In a group of 48 patients with completed stroke, 8 patients had viable collaterally perfused brain tissue which was accessible for rCBF recordings with a two dimensional technique. All 8 had deep subcortical infarcts on CT-scan, and angiographic occlusion of the arteries normally supplying the infarcted territory. The...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.14.3.332

    authors: Olsen TS,Larsen B,Herning M,Skriver EB,Lassen NA

    更新日期:1983-05-01 00:00:00

  • Association Between Thrombus Perviousness Assessed on Computed Tomography and Stroke Cause.

    abstract:BACKGROUND AND PURPOSE:A recent study proposed that thrombus perviousness (TP)-the degree to which contrast agents penetrate the thrombus in an occluded vessel measured on noncontrast computed tomography (NCCT) and CT angiography-may be associated with cardioembolic stroke cause with high specificity. Our aim was to in...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/STROKEAHA.120.031148

    authors: Kufner A,Erdur H,Endres M,Nolte CH,Scheel M,Schlemm L

    更新日期:2020-12-01 00:00:00

  • Changes in cerebral blood flow and metabolism following intraarterial or local administration of nimodipine, before and after experimental subarachnoid hemorrhage in baboons.

    abstract::Experimental subarachnoid hemorrhage (SAH) was induced in baboons by repeated injections of autologous blood into cisterna chiasmatis and cisterna magna, a total of 14-33 ml being injected over 3-4 days. Cerebral blood flow (CBF; 133xenon clearance) and cerebral metabolic rate of oxygen (CMRO2) were measured before, a...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.17.2.220

    authors: Sahlin C,Delgado T,Owman C,Svendgaard NA

    更新日期:1986-03-01 00:00:00

  • Better Collaterals Are Independently Associated With Post-Thrombolysis Recanalization Before Thrombectomy.

    abstract::Background and Purpose- In acute stroke patients with large vessel occlusion, the goal of intravenous thrombolysis (IVT) is to achieve early recanalization (ER). Apart from occlusion site and thrombus length, predictors of early post-IVT recanalization are poorly known. Better collaterals might also facilitate ER, for...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/STROKEAHA.118.022815

    authors: Seners P,Roca P,Legrand L,Turc G,Cottier JP,Cho TH,Arquizan C,Bracard S,Ozsancak C,Ben Hassen W,Naggara O,Lion S,Debiais S,Berthezene Y,Costalat V,Richard S,Magni C,Mas JL,Baron JC,Oppenheim C

    更新日期:2019-04-01 00:00:00

  • A quantitative study of the emotional outcome of people caring for stroke survivors.

    abstract:BACKGROUND AND PURPOSE:Although the physical and, to a lesser extent, emotional outcome of stroke survivors has been well documented, there are far fewer data relating to the outcomes of those who care for them. We aimed to describe the outcome of those caring for stroke patients and to identify both patient and caregi...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.29.9.1867

    authors: Dennis M,O'Rourke S,Lewis S,Sharpe M,Warlow C

    更新日期:1998-09-01 00:00:00

  • Genetics of cerebrovascular disease.

    abstract::Stroke is a complex disease, with both genetic and environmental factors having a role in its pathogenesis. A review of past studies shows some evidence of genetic influences in the development of stroke. This is supported by studies of cardiovascular disease, which indicate major genetic influences at several levels ...

    journal_title:Stroke

    pub_type: 杂志文章,评审

    doi:

    authors: Alberts MJ

    更新日期:1990-11-01 00:00:00

  • The pilot Stroke Data Bank: definition, design, and data.

    abstract::Four university centers collaborated to contribute 1158 patients with acute episodes of cerebrovascular disease to the pilot Stroke Data Bank, initiated by NINCDS in 1978. During the pilot project a standard set of data collection forms were developed and used at each of the collaborating centers. Data on clinical cou...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.15.4.740

    authors: Kunitz SC,Gross CR,Heyman A,Kase CS,Mohr JP,Price TR,Wolf PA

    更新日期:1984-07-01 00:00:00

  • Distribution of the blood flow supplied by the vertebral artery in humans as assessed by emission CT.

    abstract::Though unilateral blood distribution of the vertebral artery has not been studied in humans, it is significant when considering the ischemic events especially embolic occlusion in vertebrobasilar system. To clarify the blood distribution, Krypton-81m was continuously infused into the vertebral arteries of 10 patients....

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.15.3.469

    authors: Taki W,Handa H,Higa T,Tanada S,Fukuyama H,Fujita T,Yonekawa Y,Kameyama M,Torizuka K

    更新日期:1984-05-01 00:00:00

  • Autopsy prevalence of intracranial atherosclerosis in patients with fatal stroke.

    abstract:BACKGROUND AND PURPOSE:The objective of this study was to determine the prevalence of intracranial plaques and stenoses and their causal role in patients with fatal stroke. Intracranial atherosclerosis is considered to be a rare condition with a severe prognosis. However, disease prevalence may be underestimated due to...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/STROKEAHA.107.496513

    authors: Mazighi M,Labreuche J,Gongora-Rivera F,Duyckaerts C,Hauw JJ,Amarenco P

    更新日期:2008-04-01 00:00:00

  • Bridging therapy in acute ischemic stroke: a systematic review and meta-analysis.

    abstract:BACKGROUND AND PURPOSE:Pending the results of randomized controlled trials, the benefit and safety of bridging therapy (combined intravenous and intra-arterial thrombolysis) remain to be determined. The aim of this analysis was to give reliable estimates of efficacy and safety outcomes of bridging therapy. METHODS:We ...

    journal_title:Stroke

    pub_type: 杂志文章,meta分析,评审

    doi:10.1161/STROKEAHA.111.635029

    authors: Mazighi M,Meseguer E,Labreuche J,Amarenco P

    更新日期:2012-05-01 00:00:00

  • Risk of stroke and myocardial infarction after reduction or cessation of cigarette smoking: a cohort study in korean men.

    abstract:BACKGROUND AND PURPOSE:The effect of smoking reduction on cardiovascular disease outcomes has not been studied in Asian populations. METHODS:A total of 475 734 Korean men aged 30 to 58 years, stratified into 9 groups based on smoking status at 2 different time points (1990 and 1992), were followed from 1992 to 2001 fo...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/STROKEAHA.107.512632

    authors: Song YM,Cho HJ

    更新日期:2008-09-01 00:00:00

  • Gender influences the magnitude of the inflammatory response within embolic cerebral infarcts in young rats.

    abstract:BACKGROUND AND PURPOSE:The inflammatory response within cerebral infarcts may have an influence on tissue damage. Since old animals with an impaired immune response have decreased inflammation after experimental cerebral infarction, we postulated that female animals with an increased immune response will have an increa...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.27.3.498

    authors: Li K,Futrell N,Tovar S,Wang LC,Wang DZ,Schultz LR

    更新日期:1996-03-01 00:00:00