Prevention with low-dose aspirin plus dipyridamole in patients with disabling stroke.

Abstract:

BACKGROUND AND PURPOSE:The combination of low-dose aspirin and dipyridamole is more effective than aspirin alone in reducing the risk of recurrent stroke and other major cardiovascular events in patients with a recent transient ischemic attack or minor stroke. It is unknown whether this also applies to patients with a disabling stroke. METHODS:We reanalyzed the data of 5700 patients from ESPRIT and ESPS-2 to study the effect of aspirin and dipyridamole according to modified Rankin scale (mRS) score at baseline. Primary outcome was vascular events (stroke, myocardial infarction, or vascular death). We used proportional hazards regression to estimate the treatment effect across mRS strata at baseline, and we tested for interactions with treatment. RESULTS:In total, 426 patients (7.5%) had mRS score of 4 or 5 at baseline. The risk of an outcome event increased with mRS score. The relative risk associated with the combination of aspirin and dipyridamole compared to aspirin alone in patients with mRS score 0 to 5 was 0.79 (95% confidence interval, 0.69-0.91). The relative risk according to mRS subcategory score 0 to 4 at baseline varied between 0.73 and 0.96 for vascular events and between 0.62 and 0.96 for stroke. The number of patients with mRS score 5 was too small for reliable estimates, but the data suggest a beneficial effect. There was no evidence of interaction between treatment effect and mRS score at baseline. CONCLUSIONS:The beneficial effect of the combination of low-dose aspirin and dipyridamole was present in all subcategories of the mRS score.

journal_name

Stroke

journal_title

Stroke

authors

Dippel DW,Maasland L,Halkes P,Kappelle LJ,Koudstaal PJ,Algra A,ESPRIT Study Group and the ESPS-2 Investigators.

doi

10.1161/STROKEAHA.110.586453

subject

Has Abstract

pub_date

2010-11-01 00:00:00

pages

2684-6

issue

11

eissn

0039-2499

issn

1524-4628

pii

STROKEAHA.110.586453

journal_volume

41

pub_type

杂志文章,多中心研究,随机对照试验

相关文献

STROKE文献大全
  • Role of transcranial Doppler and stump pressure during carotid endarterectomy.

    abstract:BACKGROUND AND PURPOSE:The aim of our study was to clarify the pathophysiology of perioperative cerebral complications during carotid endarterectomy in our series. METHODS:By means of transcranial Doppler ultrasonography and stump pressure measurement, we monitored 112 patients who underwent carotid endarterectomy und...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.28.12.2448

    authors: Finocchi C,Gandolfo C,Carissimi T,Del Sette M,Bertoglio C

    更新日期:1997-12-01 00:00:00

  • Intracerebral hematomas disappear on T2*-weighted images during normobaric oxygen therapy.

    abstract:BACKGROUND AND PURPOSE:The aim of the present study was to investigate the effects of normobaric oxygen (NBO) therapy on T2*-weighted images of intracranial hemorrhages (ICHs). METHODS:Two common models of ICH were performed in mice, and longitudinal T2*-weighted images of the hematomas were acquired under normoxia or...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/STROKEAHA.113.002045

    authors: Gaberel T,Gakuba C,Hebert M,Montagne A,Agin V,Rubio M,Emery E,Vivien D,Gauberti M

    更新日期:2013-12-01 00:00:00

  • Relation between serum albumin and carotid atherosclerosis: the NHLBI Family Heart Study.

    abstract:BACKGROUND AND PURPOSE:Lower concentrations of albumin have been positively related to coronary disease. The aim of this project was to assess the association between serum albumin and carotid atherosclerosis. METHODS:B-mode ultrasound was used to assess carotid plaques and intima-media thickness (IMT) among white sub...

    journal_title:Stroke

    pub_type: 杂志文章,多中心研究

    doi:10.1161/01.str.0000048675.97975.84

    authors: Djoussé L,Rothman KJ,Cupples LA,Arnett DK,Ellison RC,NHLBI Family Heart Study.

    更新日期:2003-01-01 00:00:00

  • Admission Glucose and Effect of Intra-Arterial Treatment in Patients With Acute Ischemic Stroke.

    abstract:BACKGROUND AND PURPOSE:Hyperglycemia on admission is common after ischemic stroke. It is associated with unfavorable outcome after treatment with intravenous thrombolysis and after intra-arterial treatment. Whether hyperglycemia influences the effect of reperfusion treatment is unknown. We assessed whether increased ad...

    journal_title:Stroke

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1161/STROKEAHA.116.016071

    authors: Osei E,den Hertog HM,Berkhemer OA,Fransen PSS,Roos YBWEM,Beumer D,van Oostenbrugge RJ,Schonewille WJ,Boiten J,Zandbergen AAM,Koudstaal PJ,Dippel DWJ,MR CLEAN Investigators.

    更新日期:2017-05-01 00:00:00

  • Impact of early blood pressure variability on stroke outcomes after thrombolysis: the SAMURAI rt-PA Registry.

    abstract:BACKGROUND AND PURPOSE:The present study determines associations between early blood pressure (BP) variability and stroke outcomes after intravenous thrombolysis. METHODS:In 527 stroke patients receiving intravenous alteplase (0.6 mg/kg), BP was measured 8 times within the first 25 hours. BP variability was determined...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/STROKEAHA.112.681007

    authors: Endo K,Kario K,Koga M,Nakagawara J,Shiokawa Y,Yamagami H,Furui E,Kimura K,Hasegawa Y,Okada Y,Okuda S,Namekawa M,Miyagi T,Osaki M,Minematsu K,Toyoda K

    更新日期:2013-03-01 00:00:00

  • Endocrine Regulator rFGF21 (Recombinant Human Fibroblast Growth Factor 21) Improves Neurological Outcomes Following Focal Ischemic Stroke of Type 2 Diabetes Mellitus Male Mice.

    abstract::Background and Purpose- The complexity and heterogeneity of stroke, as well as the associated comorbidities, may render neuroprotective drugs less efficacious in clinical practice. Therefore, the development of targeted therapies to specific patient subsets has become a high priority in translational stroke research. ...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/STROKEAHA.118.022119

    authors: Jiang Y,Liu N,Wang Q,Yu Z,Lin L,Yuan J,Guo S,Ahn BJ,Wang XJ,Li X,Lo EH,Sun X,Wang X

    更新日期:2018-12-01 00:00:00

  • Alteration in abundance and compartmentalization of inflammation-related miRNAs in plasma after intracerebral hemorrhage.

    abstract:BACKGROUND AND PURPOSE:We tested the hypothesis that circulating microRNAs (miRNAs) present in plasma might display a specific signature in patients with intracerebral hemorrhage. METHODS:Global miRNA profiles were determined with the Agilent Human miRNA Microarray platform, and validated by quantitative polymerase ch...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/STROKEAHA.111.000835

    authors: Guo D,Liu J,Wang W,Hao F,Sun X,Wu X,Bu P,Zhang Y,Liu Y,Liu F,Zhang Q,Jiang F

    更新日期:2013-06-01 00:00:00

  • Fluoxetine treatment in poststroke depression, emotional incontinence, and anger proneness: a double-blind, placebo-controlled study.

    abstract:BACKGROUND AND PURPOSE:The efficacy and safety of the selective serotonin reuptake inhibitor fluoxetine have rarely been studied in the treatment of poststroke emotional disturbances. METHODS:Stroke patients (152) who had poststroke depression (PSD), emotional incontinence (PSEI), or anger proneness (PSAP) were studie...

    journal_title:Stroke

    pub_type: 杂志文章,随机对照试验

    doi:10.1161/01.STR.0000190892.93663.e2

    authors: Choi-Kwon S,Han SW,Kwon SU,Kang DW,Choi JM,Kim JS

    更新日期:2006-01-01 00:00:00

  • Stroke awareness and knowledge retention in children: The Brain Child Project.

    abstract:BACKGROUND AND PURPOSE:Efforts at public education to improve adults' response to stroke symptoms continue to be disappointing, and very little has been developed to improve the knowledge base of children regarding brain attacks. Children may be able to exert a positive influence on adult behavior and to learn positive...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/hs0202.102728

    authors: Dressman LA,Hunter J

    更新日期:2002-02-01 00:00:00

  • Longitudinal study of regional cerebral blood flow changes in depression after stroke.

    abstract:BACKGROUND:We studied 60 patients longitudinally to examine relations between regional cerebral blood flow and depressive states after stroke. METHODS:Poststroke depressive states were assessed by the Zung Self-Rating Depression Scale (SDS). Regional cerebral blood flow was measured using the 133xenon inhalation metho...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.23.12.1716

    authors: Yamaguchi S,Kobayashi S,Koide H,Tsunematsu T

    更新日期:1992-12-01 00:00:00

  • Left ventricular mass indexed to height and prevalent MRI cerebrovascular disease in an African American cohort: the Atherosclerotic Risk in Communities study.

    abstract:BACKGROUND AND PURPOSE:Previous studies have demonstrated that echocardiographic left ventricular mass (LVM) is an independent risk factor for stroke in whites. Despite the greater burden of stroke, the echocardiographic predictors of stroke in African Americans remain poorly understood. METHODS:This investigation is ...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.STR.0000154893.68957.55

    authors: Fox ER,Taylor HA Jr,Benjamin EJ,Ding J,Liebson PR,Arnett D,Quin EM,Skelton TN

    更新日期:2005-03-01 00:00:00

  • Asymptomatic embolization in subjects with atrial fibrillation not taking anticoagulants: a prospective study.

    abstract:BACKGROUND AND PURPOSE:Embolism is believed to be the major cause of stroke in patients with nonvalvular atrial fibrillation (NVAF). The detection of asymptomatic embolic signals (ES) in individuals with NVAF might allow identification of patients at high risk of stroke and monitoring of therapy in individual subjects....

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.29.9.1810

    authors: Cullinane M,Wainwright R,Brown A,Monaghan M,Markus HS

    更新日期:1998-09-01 00:00:00

  • Potential consequences for recruitment, power, and external validity of requirements for additional risk factors for eligibility in randomized controlled trials in secondary prevention of stroke.

    abstract:BACKGROUND AND PURPOSE:Eligibility criteria determine the external validity (generalizability) of the results of randomized controlled trials. To increase the number of outcome events, and hence statistical power, some recent stroke prevention trials have required additional vascular risk factors for eligibility. METH...

    journal_title:Stroke

    pub_type: 杂志文章,随机对照试验

    doi:10.1161/01.STR.0000195125.59349.23

    authors: Howard SC,Algra A,Warlow CP,Rothwell PM

    更新日期:2006-01-01 00:00:00

  • Economic consequences of early inpatient discharge to community-based rehabilitation for stroke in an inner-London teaching hospital.

    abstract:BACKGROUND AND PURPOSE:In an inner-London teaching hospital, a randomized trial of "conventional" care versus early discharge to community-based therapy found no significant differences in clinical outcomes between patient groups. This report examines the economic consequences of the alternative strategies. METHODS:On...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.30.4.729

    authors: Beech R,Rudd AG,Tilling K,Wolfe CD

    更新日期:1999-04-01 00:00:00

  • Ultrasonographic evaluation of vertebral artery to detect vertebrobasilar axis occlusion.

    abstract:BACKGROUND AND PURPOSE:We performed the present study to determine whether the site of occlusion in the vertebrobasilar circulation could be identified by the measurement of blood flow velocity in the bilateral vertebral arteries. METHODS:Using color-coded duplex carotid ultrasonography, we measured the time-averaged ...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.25.5.1006

    authors: Kimura K,Yasaka M,Moriyasu H,Tsuchiya T,Yamaguchi T

    更新日期:1994-05-01 00:00:00

  • Intra- and interrater reliability of ischemic lesion volume measurements on diffusion-weighted, mean transit time and fluid-attenuated inversion recovery MRI.

    abstract:BACKGROUND AND PURPOSE:We investigated the intra- and interrater reliability of ischemic lesion volumes measurements assessed by different MRI sequences at various times from onset. METHODS:Ischemic lesion volumes were measured for intrarater reliability using diffusion-weighted (DWI), mean transit time (MTT) perfusio...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.STR.0000249416.77132.1a

    authors: Luby M,Bykowski JL,Schellinger PD,Merino JG,Warach S

    更新日期:2006-12-01 00:00:00

  • A prediction model for functional recovery in stroke.

    abstract:BACKGROUND AND PURPOSE:Stroke-related physical disability can diminish quality of daily living, place care burden on families, and increase need for long-term institutionalization. We developed a prognostic index for use in research and with potential for adaptation to clinical practice that establishes the likelihood ...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.28.3.550

    authors: Stineman MG,Maislin G,Fiedler RC,Granger CV

    更新日期:1997-03-01 00:00:00

  • SERPINA3 polymorphism is not associated with primary intracerebral hemorrhage in a Polish population.

    abstract:BACKGROUND AND PURPOSE:Genetic factors involved in the pathogenesis of primary intracerebral hemorrhage (PICH) remain unknown. One of the candidate genes is SERPINA3. Results of a Spanish study suggested that TT genotype of the A/T SERPINA3 polymorphism in the signal peptide sequence was a risk factor for PICH in normo...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.STR.0000202655.64413.0c

    authors: Pera J,Slowik A,Dziedzic T,Szczudlik A

    更新日期:2006-03-01 00:00:00

  • Effect of baseline CT scan appearance and time to recanalization on clinical outcomes in endovascular thrombectomy of acute ischemic strokes.

    abstract:BACKGROUND AND PURPOSE:the Penumbra Pivotal Stroke Trial reported a 25% good outcome (modified Rankin scale score ≤ 2) despite an 81% recanalization rate. We evaluated the association of a favorable initial noncontrast CT and a short time to recanalization in predicting good outcome. METHODS:data were from the Penumbr...

    journal_title:Stroke

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1161/STROKEAHA.110.594481

    authors: Goyal M,Menon BK,Coutts SB,Hill MD,Demchuk AM,Penumbra Pivotal Stroke Trial Investigators, Calgary Stroke Program, and the Seaman MR Research Center.

    更新日期:2011-01-01 00:00:00

  • Effects of aging and hypertension on endothelium-dependent vascular relaxation in rat carotid artery.

    abstract::We evaluated the effects of aging and hypertension on endothelium-dependent relaxation of rat common carotid arteries using 14-week-old (young) and 11-month-old (old) Wistar-Kyoto rats (WKY) and age-matched spontaneously hypertensive rats (SHR). Isometric tension of common carotid artery ring segments was measured. Wi...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.19.7.892

    authors: Hongo K,Nakagomi T,Kassell NF,Sasaki T,Lehman M,Vollmer DG,Tsukahara T,Ogawa H,Torner J

    更新日期:1988-07-01 00:00:00

  • Hemolysate-induced contraction in smooth muscle cells of the guinea pig basilar artery.

    abstract::The hemolysate (10(-5)-10(-2) times dilution; original hemoglobin concentration was 0.83 +/- 0.10 X 10(-3)M) evoked the contraction in a dose dependent manner, and this contraction was composed of low and high sensitive responses as estimated from the Eadie-Hofstee's plot. Indomethacin (10(-7)-10(-5)M) inhibited the l...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.15.3.503

    authors: Fujiwara S,Kuriyama H

    更新日期:1984-05-01 00:00:00

  • Cerebral pathophysiology in hemorrhagic shock. Nuclide scan data, fluorescence microscopy, and anatomic correlations.

    abstract::Nineteen unanesthetized sheep were given Evans blue dye or radionuclide and then were incrementally bled into hemorrhagic shock (BP less than 50/25) by withdrawal of blood over a period of approximately one hour. Four sheep served as controls for histologic data. Static nuclide brain scans performed in 6 bled sheep d...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.11.1.50

    authors: Bronshvag MM

    更新日期:1980-01-01 00:00:00

  • Cellular responses of bioabsorbable polymeric material and Guglielmi detachable coil in experimental aneurysms.

    abstract:BACKGROUND AND PURPOSE:Acceleration of healing mechanisms is a promising approach to improve current limitations of endovascular aneurysm therapy with the use of platinum coils. We evaluated a new endovascular therapeutic, bioabsorbable polymeric material (BPM), which may promote cellular reaction in the aneurysms. ME...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.0000014423.20476.ee

    authors: Murayama Y,Viñuela F,Tateshima S,Gonzalez NR,Song JK,Mahdavieh H,Iruela-Arispe L

    更新日期:2002-04-01 00:00:00

  • Cardioembolic stroke from atrial septal aneurysm.

    abstract::Atrial septal aneurysm is an uncommon occult cardiac source of cerebral embolism. It is usually asymptomatic, and clinical cardiologic examination and electrocardiography fail to reveal its presence. We report a case of a 34-year-old woman with sudden right hemiplegia and aphasia from occlusion of the left carotid sip...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.19.5.640

    authors: Di Pasquale G,Andreoli A,Grazi P,Dominici P,Pinelli G

    更新日期:1988-05-01 00:00:00

  • Reduced risk of intracerebral hemorrhage with dynamic recreational exercise but not with heavy work activity.

    abstract:BACKGROUND AND PURPOSE:It is unclear whether intracerebral hemorrhage (ICH) is associated with dynamic or static exercise. Our aim was to assess whether such an association exists. METHODS:A case-control study was undertaken involving 331 consecutive cases of primary ICH and 331 age- and sex-matched community-based ne...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/hs0202.102878

    authors: Thrift AG,Donnan GA,McNeil JJ

    更新日期:2002-02-01 00:00:00

  • Prognosis for survival after an initial stroke.

    abstract:BACKGROUND AND PURPOSE:We studied prognosis for survival after an initial stroke in 662 patients who survived at least 30 days after onset while taking into account age, sex, the number of neurological deficits from the initial stroke, stroke type, and five selected medical conditions: hypertension, myocardial infarcti...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.26.11.2011

    authors: Lai SM,Alter M,Friday G,Sobel E

    更新日期:1995-11-01 00:00:00

  • Cerebral blood flow in normal pressure hydrocephalus.

    abstract::A xenon-133 method was used to measure cerebral blood flow (CBF) before and after cerebrospinal fluid (CSF) removal in patients with normal pressure hydrocephalus (NPH). Preliminary results suggested that shunting should be performed on patients whose CBF increased after CSF removal. There was a significant increase i...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.18.6.1074

    authors: Mamo HL,Meric PC,Ponsin JC,Rey AC,Luft AG,Seylaz JA

    更新日期:1987-11-01 00:00:00

  • Emboli formation rather than inflammatory mediators are responsible for increased cerebral water content after conventional and assisted beating-heart myocardial revascularization in a porcine model.

    abstract:BACKGROUND AND PURPOSE:Emboli and proinflammatory mediators are suspected of generating cerebral edema after coronary surgery. In contrast to cardiopulmonary bypass (CPB), off-pump coronary artery bypass surgery (OPCAB) reduces microemboli count and proinflammatory mediator release but carries the risk of hemodynamic i...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/STROKEAHA.107.496620

    authors: Bierbach B,Meier M,Kasper-König W,Heimann A,Alessandri B,Horstick G,Oelert H,Kempski O

    更新日期:2008-01-01 00:00:00

  • One-year outcome after cerebral infarction in whites, blacks, and Hispanics.

    abstract::Little is known about outcome after cerebral infarction for different ethnic groups. Of 590 stroke patients hospitalized from 1983 to 1986 at the Neurological Institute, cerebral infarction over age 39 years occurred in 135 whites, 177 blacks, and 82 Hispanics. Outcome after cerebral infarction differed by ethnicity. ...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.22.3.305

    authors: Sacco RL,Hauser WA,Mohr JP,Foulkes MA

    更新日期:1991-03-01 00:00:00

  • Predictors of rehemorrhage after treatment of ruptured intracranial aneurysms: the Cerebral Aneurysm Rerupture After Treatment (CARAT) study.

    abstract:BACKGROUND AND PURPOSE:The primary purpose of intracranial aneurysm treatment is to prevent rupture. Risk factors for rupture after aneurysm treatment have not been clearly established, and the need to completely occlude aneurysms is debated. METHODS:The Cerebral Aneurysm Rerupture After Treatment (CARAT) study is an ...

    journal_title:Stroke

    pub_type: 杂志文章,多中心研究

    doi:10.1161/STROKEAHA.107.495747

    authors: Johnston SC,Dowd CF,Higashida RT,Lawton MT,Duckwiler GR,Gress DR,CARAT Investigators.

    更新日期:2008-01-01 00:00:00