Abstract:
:The superoxide dismutases (SODs) protect oxygen-using cells against reactive oxygen species, the potentially toxic by-products of respiration, oxidative metabolism, and radiation. We have previously shown that genetic disruption of CuZn SOD (SOD1) in Drosophila imparts a recessive phenotype of reduced lifespan, infertility, and hypersensitivity to oxidative stress. We now show that the absence of SOD1 increases spontaneous genomic damage. The increase in spontaneous mutation rate occurs in SOD1-null mutants in somatic cells as well as in the germ line. Further, we show that specific DNA repair-defective mutations, which are easily tolerated in SOD1(+) flies, lead to high mortality when introduced into the SOD1-null homozygous mutant background.
journal_name
Genomejournal_title
Genomeauthors
Woodruff RC,Phillips JP,Hilliker AJdoi
10.1139/g04-083subject
Has Abstractpub_date
2004-12-01 00:00:00pages
1029-35issue
6eissn
0831-2796issn
1480-3321pii
g04-083journal_volume
47pub_type
杂志文章相关文献
GENOME文献大全abstract::Genetic diversity of 33 Elymus caninus accessions was investigated using isozyme, RAPD, and microsatellite markers. The three assays differed in the amount of polymorphism detected. Microsatellites detected the highest polymorphism. Six microsatellite primer pairs generated a total of 74 polymorphic bands (alleles), w...
journal_title:Genome
pub_type: 杂志文章
doi:
更新日期:1999-06-01 00:00:00
abstract::In this paper we analyze genetically and cytologically a Y-chromosome 2 translocation with several markers, some of which are potentially useful for large scale sex separation. The breakpoint of this Y-2 translocation is located at region 6B on the trichogene polytene chromosome map. It is found that, in strains carry...
journal_title:Genome
pub_type: 杂志文章
doi:10.1139/g95-145
更新日期:1995-12-01 00:00:00
abstract::Resistance to common root rot and black point, caused by Cochliobolus sativus, was evaluated in alien chromosome substitution and addition lines of the cultivars 'Cadet' and 'Rescue'. Substitution of chromosome 5B in 'Rescue' with 5Ag from Agropyron elongatum decreased root rot susceptibility to a level intermediate b...
journal_title:Genome
pub_type: 杂志文章
doi:10.1139/g93-023
更新日期:1993-02-01 00:00:00
abstract::Polymerase chain reaction was used, with single 10-mer primers of arbitrary sequence, to amplify random regions of genomic DNA from a diploid cultivated alfalfa backcross population. Segregation of the random amplified polymorphic DNA (RAPD) fragments was analysed to determine if RAPD markers are suitable for use as g...
journal_title:Genome
pub_type: 杂志文章
doi:10.1139/g92-014
更新日期:1992-02-01 00:00:00
abstract::The genome sizes of 8 species of amphipods collected from the Canadian Arctic were estimated by flow cytometry. Haploid genome sizes ranged from 2.94 +/- 0.04 pg DNA in Acanthostepheia malmgreni (Oedicerotidae) to 64.62 +/- 2.85 pg in Ampelisca macrocephala (Ampeliscidae). The value for Ampelisca macrocephala represen...
journal_title:Genome
pub_type: 杂志文章
doi:10.1139/g06-155
更新日期:2007-02-01 00:00:00
abstract::Eucalyptus globulus subsp. globulus Labill. (Tasmanian Blue Gum), native to southeast Australia, is a benchmark species for the pulp and paper industry. We genotyped 397 trees from 16 populations of E. globulus representing the native diversity in Australia using 24 microsatellite loci. Eight genetically distinct grou...
journal_title:Genome
pub_type: 杂志文章
doi:10.1139/gen-2016-0218
更新日期:2017-09-01 00:00:00
abstract::European hazelnut (Corylus avellana L.) is a strictly cross-pollinated diploid tree species, which has its northernmost populations in Fennoscandia, and it was one of the first species to recolonize northern Europe after the last ice age. Hazelnut produces edible nuts in Finland but nowadays they are underutilized as ...
journal_title:Genome
pub_type: 杂志文章
doi:10.1139/gen-2018-0193
更新日期:2019-08-01 00:00:00
abstract::The results of the development of oil palm (Elaeis guineensis Jacq.) microsatellite markers are given step by step, from the screening of libraries enriched in (GA)n, (GT)n, and (CCG)n simple-sequence repeats (SSRs) to the final characterisation of 21 SSR loci. Also published are primer sequences, estimates of allele ...
journal_title:Genome
pub_type: 杂志文章
doi:
更新日期:2001-06-01 00:00:00
abstract::European hazelnut (Corylus avellana L.) is the only economically important nut crop in the family Betulaceae. Because of its small genome size (~385 Mb / 1C), relatively short life cycle, availability of a dense linkage map, and amenability to transformation by Agrobacterium, the European hazelnut could serve as a mod...
journal_title:Genome
pub_type: 杂志文章
doi:10.1139/g11-048
更新日期:2011-10-01 00:00:00
abstract::To gain insights into the structure and function of the wheat (Triticum aestivum L.) genomes, we identified 278 ESTs related to abiotic stress (cold, heat, drought, salinity, and aluminum) from 7671 ESTs previously mapped to wheat chromosomes. Of the 278 abiotic stress related ESTs, 259 (811 loci) were assigned to chr...
journal_title:Genome
pub_type: 杂志文章
doi:10.1139/g06-094
更新日期:2006-10-01 00:00:00
abstract::Quantitative trait locus (QTL) analysis was used to study the evolution of genes controlling the timing of flowering in four Brassica genomes that are all extensively replicated. Comparative mapping showed that a chromosomal region from the top of Arabidopsis thaliana chromosome 5 corresponded to three homoeologous co...
journal_title:Genome
pub_type: 杂志文章
doi:
更新日期:2001-10-01 00:00:00
abstract::Amplified fragment length polymorphism (AFLP) was used to obtain information on the within-species genetic variability of the tobacco cyst-nematode (TCN) complex. AFLP was found to be well suited to this type of study. The current classification of TCN was confirmed. Results indicate that the Globodera tabacum solanac...
journal_title:Genome
pub_type: 杂志文章
doi:10.1139/g01-091
更新日期:2001-12-01 00:00:00
abstract::Polycelis nigra is a free-living simultaneous hermaphroditic flatworm that has amphimictic and pseudogamous parthenogenetic biotypes. Sexual individuals are always diploid (2n = 16) and pseudogamous parthenogens are polyploid (usually triploid). Two types of supernumerary chromosomes are found in parthenogens, those r...
journal_title:Genome
pub_type: 杂志文章
doi:10.1139/g97-810
更新日期:1997-12-01 00:00:00
abstract::Vernalization response (Vrn) genes play a major role in determining the flowering/maturity times of spring-sown wheat. We characterized a representative set of 40 western Canadian adapted spring wheat cultivars/lines for 3 Vrn loci. The 40 genotypes were screened, along with 4 genotypes of known Vrn genes, using previ...
journal_title:Genome
pub_type: 杂志文章
doi:10.1139/g07-028
更新日期:2007-05-01 00:00:00
abstract::Trigeneric hybrids offer opportunities to transfer alien traits into cultivated wheat. In this study, a new trigeneric hybrid involving species of Triticum, Psathyrostachys, and Thinopyrum was synthesized by crossing Triticum aestivum L. (wheat)--Thinopyrum intermedium (Host) Barkworth & D.R. Dewey amphiploid Zhong 3 ...
journal_title:Genome
pub_type: 杂志文章
doi:10.1139/g2012-025
更新日期:2012-05-01 00:00:00
abstract::The nearly complete mitochondrial (mt) genome of an egg parasitoid, Trissolcus basalis (Wollaston), was sequenced using both 454 and Illumina next-generation sequencing technologies. A portion of the noncoding region remained unsequenced, possibly owing to the presence of repeats. The sequenced portion of the genome i...
journal_title:Genome
pub_type: 杂志文章
doi:10.1139/g2012-005
更新日期:2012-03-01 00:00:00
abstract::The molecular characterization of C-banded regions of Secale montanum Guss. by means of in situ hybridization was performed in order to provide new information about their chromosome structure relative to cultivated rye, Secale cereale L. Accurate identification of individual chromosomes was achieved using simultaneou...
journal_title:Genome
pub_type: 杂志文章
doi:10.1139/g95-101
更新日期:1995-08-01 00:00:00
abstract::Conceptual aspects of estimation of genetic components of variance and covariance under selection are discussed, with special attention to likelihood methods. Certain selection processes are described and alternative likelihoods that can be used for analysis are specified. There is a mathematical relationship between ...
journal_title:Genome
pub_type: 杂志文章
doi:10.1139/g89-136
更新日期:1989-01-01 00:00:00
abstract::The Mpv17l protein has two isoforms, M-LPL and M-LPS, which both regulate the production of reactive oxygen species (ROS) and protect against mitochondrial oxidative stress and apoptosis. M-LPL is ubiquitously expressed, while M-LPS is expressed mostly in the kidney of aged animals. We identified a variety of transcri...
journal_title:Genome
pub_type: 杂志文章
doi:10.1139/g09-061
更新日期:2009-11-01 00:00:00
abstract::Southern hybridization analysis of Indian muntjac genomic DNA with the Eco-Taq bovine genomic protamine probe revealed a simple banding pattern. The pattern of hybridization was identical with that previously observed in the genus Bos. This suggested that the bovine probe specifically hybridized to the Indian muntjac ...
journal_title:Genome
pub_type: 杂志文章
doi:10.1139/g90-068
更新日期:1990-06-01 00:00:00
abstract::Genetic variation in Gir cattle (Bos indicus) has so far not been well characterized. In this study, we used whole genome sequencing of three Gir bulls and a pooled sample from another 11 bulls to identify polymorphisms and loci under selection. A total of 9 990 733 single nucleotide polymorphisms (SNPs) and 604 308 i...
journal_title:Genome
pub_type: 杂志文章
doi:10.1139/gen-2013-0082
更新日期:2013-10-01 00:00:00
abstract::Thermosensitive genic male-sterile (TGMS) rice is widely used in hybrid rice production. Because of its specific temperature requirement, it can be used only in a narrow rice-growing zone in Asia. A newly discovered TGMS line, G20S, has an opposite phenotype compared with normal TGMS lines. G20S is completely sterile ...
journal_title:Genome
pub_type: 杂志文章
doi:10.1139/g09-092
更新日期:2010-02-01 00:00:00
abstract::Fire blight is a devastating bacterial disease of rosaceous plants. Its damage to apple production is a major concern, since no existing control option has proven to be completely effective. Some commercial apple varieties, such as 'Florina' and 'Nova Easygro', exhibit a consistent level of resistance to fire blight. ...
journal_title:Genome
pub_type: 杂志文章
doi:10.1139/g10-047
更新日期:2010-09-01 00:00:00
abstract::Being an essential mineral nutrient, potassium (K+) plays numerous important roles in plant growth and development and determines the yield and quality of crop products. The cellular level of K+ is controlled to a large extent by the K+ transporter, which belongs to the KT/HAK/KUP (HAK) family. However, little is know...
journal_title:Genome
pub_type: 杂志文章
doi:10.1139/gen-2018-0187
更新日期:2019-04-01 00:00:00
abstract::In the root meristem cells of the rice line AMR, which causes loss of heterozygosity in its hybrids, both normal and assortment mitoses were observed. During normal mitosis, chromosomes did not form homologous pairs at metaphase; all chromosomes lined up at the equatorial plate and 2 chromatids of each chromosome disj...
journal_title:Genome
pub_type: 杂志文章
doi:10.1139/g06-015
更新日期:2006-05-01 00:00:00
abstract::Using a complementary (c)DNA-amplified fragment length polymorphism (AFLP) approach, we investigated differential gene expression linked to resistance mechanisms during the incompatible potato - Globodera pallida interaction. Expression was compared between a resistant and a susceptible potato clone, inoculated or not...
journal_title:Genome
pub_type: 杂志文章
doi:10.1139/g07-015
更新日期:2007-04-01 00:00:00
abstract::Five nonallelic copies of the dispersed (GATA)n repeated sequence of Drosophila melanogaster (referred to as GATA elements) have been sequenced and analysed. The GATA elements range in size from 111 to 444 bp, consisting predominantly of tandemly repeated GATAs, interspersed with variants of the subunit. The types and...
journal_title:Genome
pub_type: 杂志文章
doi:10.1139/g90-113
更新日期:1990-10-01 00:00:00
abstract::The cryptic wheat-alien translocation T5DL.5DS-5MgS(0.95), with leaf rust and stripe rust resistance genes Lr57 and Yr40 transferred from Aegilops geniculata (UgMg) into common wheat, was further analyzed. Molecular genetic analysis using physically mapped ESTs showed that the alien segment in T5DL.5DS-5MgS(0.95) repr...
journal_title:Genome
pub_type: 杂志文章
doi:10.1139/G09-076
更新日期:2009-12-01 00:00:00
abstract::Oilseed rape (Brassica napus) is an allotetraploid species consisting of two genomes, derived from B. rapa (A genome) and B. oleracea (C genome). The presence of these two genomes makes single nucleotide polymorphism (SNP) marker identification and SNP analysis more challenging than in diploid species, as for a given ...
journal_title:Genome
pub_type: 杂志文章
doi:10.1139/G10-079
更新日期:2010-11-01 00:00:00
abstract::Three long terminal repeat (LTR) sequences of Ty1-copia retrotransposons were identified in cucumber (Cucumis sativus L.) and named Tcs 1, Tcs 2, and Tcs 3. A sequence-specific amplification polymorphism (SSAP) marker system based on these LTR sequences displayed a higher level of polymorphism than AFLPs in cucumber. ...
journal_title:Genome
pub_type: 杂志文章
doi:10.1139/g07-067
更新日期:2007-09-01 00:00:00