Abstract:
:The occurrence of multiple-clone Plasmodium falciparum haploid blood-stage infections is a pre-requisite for cross-fertilization and genetic exchange at the diploid stage in the mosquito. Using monoclonal antibodies against 3 polymorphic blood-stage antigens, a method of two-colour differential immunofluorescence allowed the resolution of between 1 and 4 clones/isolate. A mean of 2 P. falciparum clones was detected in the blood of malaria patients in The Gambia. The mean number of clones/patient showed no correlation with age, parasitaemia, or disease severity. There was a slight difference in mean number between sample periods, probably reflecting temporal differences in transmission intensity. A statistical analysis of 2-locus genetic diversity of clones within isolates concludes that not all multiple-clone infections result from superinfection, but that some are due to single multiple-clone inoculations.
journal_name
Parasitologyjournal_title
Parasitologyauthors
Conway DJ,Greenwood BM,McBride JSdoi
10.1017/s0031182000059217subject
Has Abstractpub_date
1991-08-01 00:00:00pages
1-6eissn
0031-1820issn
1469-8161journal_volume
103 Pt 1pub_type
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