Can the tea tree oil (Australian native plant: Melaleuca alternifolia Cheel) be an alternative treatment for human demodicosis on skin?

Abstract:

:Australian tea tree oil (TTO) and its extract terpinen-4-ol (T4O) are found to be effective in moderating demodex-related diseases. Their possible effects are lowering the mite counts, relieving the demodex-related symptoms and modulating the immune system especially the inflammatory response. This review summarizes the topical treatments of TTO and T4O in human demodicosis, their possible mechanism of actions, side-effects and potential resistance in treating this condition. Although current treatments other than TTO and T4O are relatively effective in controlling the demodex mite population and the related symptoms, more research on the efficacy and drug delivery technology is needed in order to assess its potential as an alternative treatment with minimal side-effect profile, low toxicity and low risk of demodex resistance.

journal_name

Parasitology

journal_title

Parasitology

authors

Lam NSK,Long XX,Griffin RC,Chen MK,Doery JC

doi

10.1017/S0031182018000495

subject

Has Abstract

pub_date

2018-10-01 00:00:00

pages

1510-1520

issue

12

eissn

0031-1820

issn

1469-8161

pii

S0031182018000495

journal_volume

145

pub_type

杂志文章,评审
  • Parasitism and phenotypic change in colonial hosts.

    abstract::Changes in host phenotype are often attributed to manipulation that enables parasites to complete trophic transmission cycles. We characterized changes in host phenotype in a colonial host–endoparasite system that lacks trophic transmission (the freshwater bryozoan Fredericella sultana and myxozoan parasite Tetracapsu...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/S0031182013000899

    authors: Hartikainen H,Fontes I,Okamura B

    更新日期:2013-09-01 00:00:00

  • Changes in adenosine transport associated with melaminophenyl arsenical (Mel CY) resistance in Trypanosoma evansi: down-regulation and affinity changes of the P2 transporter.

    abstract::Studies of the kinetics of adenosine transport were carried out on the P1 and P2 transporters of drug-sensitive Trypanosoma evansi and its cloned derivative, resistant to the melaminophenyl arsenical Mel CY. Characterization of adenosine uptake was made by estimation of the maximum concentration taken up at time infin...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/s003118200300413x

    authors: Suswam EA,Ross CA,Martin RJ

    更新日期:2003-12-01 00:00:00

  • Species delimitation in trematodes using DNA sequences: Middle-American Clinostomum as a case study.

    abstract::The recent development of genetic methods allows the delineation of species boundaries, especially in organisms where morphological characters are not reliable to differentiate species. However, few empirical studies have used these tools to delineate species among parasitic metazoans. Here we investigate the species ...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/S0031182016001517

    authors: Pérez-Ponce DE León G,García-Varela M,Pinacho-Pinacho CD,Sereno-Uribe AL,Poulin R

    更新日期:2016-11-01 00:00:00

  • Plasmodium vivax Duffy binding protein: a modular evolutionary proposal.

    abstract::The population of malaria-causing parasites is characterized by great genetic diversity. Knowledge of the polymorphism generation mechanism is a central issue for developing effective vaccines against malaria and understanding the parasite population structure. Plasmodium vivax genetic diversity has been explained in ...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/s0031182003004773

    authors: Martinez P,Suarez CF,Cardenas PP,Patarroyo MA

    更新日期:2004-04-01 00:00:00

  • Relative host body condition and food availability influence epidemic dynamics: a Poecilia reticulata-Gyrodactylus turnbulli host-parasite model.

    abstract::Understanding disease transmission is important to species management and human health. Host body condition, nutrition and disease susceptibility interact in a complex manner, and while the individual effects of these variables are well known, our understanding of how they interact and translate to population dynamics...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/S0031182012001667

    authors: Tadiri CP,Dargent F,Scott ME

    更新日期:2013-03-01 00:00:00

  • Time of treatment influences the appearance of drug-resistant parasites in Plasmodium falciparum infections.

    abstract::A deterministic mathematical model which predicts the probability of developing a new drug-resistant parasite population within the human host is reported. The model incorporates the host's specific antibody response to PfEMP1, and also investigates the influence of chemotherapy on the probability of developing a viab...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/s0031182001008824

    authors: Gatton ML,Hogarth W,Saul A

    更新日期:2001-12-01 00:00:00

  • Availability of caecal habitat as a density-dependent limit on survivorship of Leptorhynchoides thecatus in green sunfish, Lepomis cyanellus.

    abstract::Distribution of Leptorhynchoides thecatus (Acanthocephala: Rhadinorhynchidae) among the pyloric caeca and the relationship between site and rate of maturation were studied in laboratory infections of 10, 25 and 40 cystacanths fed to green sunfish, Lepomis cyanellus. After 1 week fish fed at each intensity had signific...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/s0031182000061539

    authors: Ewald JA,Nickol BB

    更新日期:1989-06-01 00:00:00

  • Triggering and modulation of the host-parasite interplay by Echinococcus multilocularis: a review.

    abstract::As more facts emerge regarding the ways in which E. multilocularis-derived molecules trigger the host immune response and modulate the host-parasite interplay, it becomes possible to envisage how the parasite can survive and proliferate in its intermediate host, while in other hosts it dies out. Through effects on cel...

    journal_title:Parasitology

    pub_type: 杂志文章,评审

    doi:10.1017/S0031182009991533

    authors: Mejri N,Hemphill A,Gottstein B

    更新日期:2010-03-01 00:00:00

  • Immunogenicity of a hybrid Plasmodium falciparum malaria antigen.

    abstract::A recombinant baculovirus-expressed hybrid protein containing epitopes for the C-terminal fragment of the Plasmodium falciparum precursor to the major merozoite surface antigens (PMMSA) and the tetrapeptide repeats of the circumsporozoite protein (CSP) was assessed for its immunogenicity. Murine MHC-II restriction of ...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/s0031182000076733

    authors: Lockyer MJ,Cooper H,Tite J,Rowan W,Crowe JS

    更新日期:1993-06-01 00:00:00

  • Effects of meteorological factors on epidemic malaria in Ethiopia: a statistical modelling approach based on theoretical reasoning.

    abstract::This study was conducted to quantify the association between meteorological variables and incidence of Plasmodium falciparum in areas with unstable malaria transmission in Ethiopia. We used morbidity data pertaining to microscopically confirmed cases reported from 35 sites throughout Ethiopia over a period of approxim...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/s0031182004005013

    authors: Abeku TA,De Vlas SJ,Borsboom GJ,Tadege A,Gebreyesus Y,Gebreyohannes H,Alamirew D,Seifu A,Nagelkerke NJ,Habbema JD

    更新日期:2004-06-01 00:00:00

  • Morphological and molecular characterization of renal ciliates infecting farmed snails in Spain.

    abstract::Renal infections by parasitic ciliates were studied in adult snails of Helix aspersa aspersa and Helix aspersa maxima collected from 2 mixed rearing system-based heliciculture farms located in Galicia (NW Spain). The occurrence of ciliates was also examined in slugs (Deroceras reticulatum) invading the greenhouses whe...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/S0031182009006040

    authors: Segade P,Kher CP,Lynn DH,Iglesias R

    更新日期:2009-06-01 00:00:00

  • Synergistic antimalarial activity of ketones with rufigallol and vitamin C.

    abstract::Malaria remains a major cause of human morbidity and mortality worldwide. Plasmodium falciparum, the most virulent of the 4 human Plasmodium species causing malaria, is potentially life threatening, is increasing in prevalence and is becoming even more resistant to in-use drugs. In light of the growing problem of mult...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/S0031182005008267

    authors: Mahajan SS,Kamath VR,Ghatpande SS

    更新日期:2005-10-01 00:00:00

  • Characterization of two cDNAs encoding cysteine proteinases from the soybean cyst nematode Heterodera glycines.

    abstract::Two cDNAs encoding cysteine proteinases were isolated from a cDNA library constructed from feeding females of Heterodera glycines. The library was screened with a cysteine proteinase gene fragment originally amplified from cDNA of H. glycines. Database searches predict that 1 cDNA (hgcp-I) encodes a cathepsin L-like p...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:

    authors: Urwin PE,Lilley CJ,McPherson MJ,Atkinson HJ

    更新日期:1997-06-01 00:00:00

  • Mathematical models of parasite responses to host immune defences.

    abstract::We examine the evolution of microparasites in response to the immune system of vertebrate hosts. We first describe a simple model for an acute infection. This model suggests that the within-host dynamics of the microparasite will be a 'race' between parasite multiplication and a clonally expanding response by the host...

    journal_title:Parasitology

    pub_type: 杂志文章,评审

    doi:10.1017/s003118209700200x

    authors: Antia R,Lipsitch M

    更新日期:1997-01-01 00:00:00

  • Widespread infection of the Eastern red-spotted newt (Notophthalmus viridescens) by a new species of Amphibiocystidium, a genus of fungus-like mesomycetozoan parasites not previously reported in North America.

    abstract::Given the worldwide decline of amphibian populations due to emerging infectious diseases, it is imperative that we identify and address the causative agents. Many of the pathogens recently implicated in amphibian mortality and morbidity have been fungal or members of a poorly understood group of fungus-like protists, ...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/S0031182007003708

    authors: Raffel TR,Bommarito T,Barry DS,Witiak SM,Shackelton LA

    更新日期:2008-02-01 00:00:00

  • Studies on cell-cycle synchronization in the asexual erythrocytic stages of Plasmodium falciparum.

    abstract::Multiplication of Plasmodium parasites within human erythrocytes is essential to malarial disease. The cell-division cycle of this organism, however, is still poorly understood. In other eukaryotes, various techniques for (apparent) cell-cycle synchronization have been used to shed light on the mechanisms involved in ...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/S0031182006001466

    authors: Naughton JA,Bell A

    更新日期:2007-03-01 00:00:00

  • Altered lysophospholipase B responsiveness in lactating mice infected with intestinal nematode parasites.

    abstract::Lactating and nulliparous outbred Swiss (CF-1 strain) mice were infected at 12-16 weeks of age with Nippostrongylus brasiliensis or Trichinella spiralis. Lysophospholipase B levels in the intestinal tissue and faecal pellets were greatly in infected lactating mice in contrast to infected nulliparous mice. Correlated w...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/s0031182000054998

    authors: Ngwenya BZ

    更新日期:1980-08-01 00:00:00

  • Ribonucleic acid synthesis in Plasmodium knowlesi maintained both in vivo and in vitro.

    abstract::RNA extracted from purified parasites of Plasmodium knowlesi was fractionated using agarose gel electrophoresis. Preparations from para sites grown both in vivo and in vitro contained species of RNA with sedimentation coefficients of 4-0S, 5-0S, 16-6S, 24-2S, 31-4S, 38-0S and 48-3S. There was less RNA present in paras...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/s0031182000046655

    authors: Trigg PI,Shakespeare PG,Burt SJ,Kyd SI

    更新日期:1975-10-01 00:00:00

  • Diversity, distribution and biogeographical origins of Plasmodium parasites from the New Zealand bellbird (Anthornis melanura).

    abstract::Understanding the origin of invasive parasites and ecological transmission barriers on the distribution of mosquito-borne pathogens is enriched by molecular phylogenetic approaches now that large databases are becoming available. Here we assess the biogeographical relationships among haemosporidian blood parasites and...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/S0031182011001491

    authors: Baillie SM,Brunton DH

    更新日期:2011-12-01 00:00:00

  • Matrix metalloproteinases mediate the metastatic phenotype of Theileria annulata-transformed cells.

    abstract::Theileria annulata infects and reversibly transforms bovine leucocytes. The parasite-transformed cells are immortalized, metastatic and express a number of metalloproteinases including matrix metalloproteinase 9 which they secrete. All the metalloproteinases observed on substrate gels are inhibited by tissue inhibitor...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/s0031182000081518

    authors: Adamson RE,Hall FR

    更新日期:1996-11-01 00:00:00

  • Parasite development and adaptive specialization.

    abstract::The complex life-cycles of parasitic animals are a product of exploiting the process of development to generate organisms with different biological potentials within a species. Successive stages of the parasite adapt to functions such as host invasion and transmission, and to the colonization of a variety of niches, o...

    journal_title:Parasitology

    pub_type: 杂志文章,评审

    doi:10.1017/s0031182000083451

    authors: Bianco AE,Maizels RM

    更新日期:1989-01-01 00:00:00

  • The effect of non-immune stresses on the development of Strongyloides ratti.

    abstract::Strongyloides ratti is a parasitic nematode of rats. The host immune response against S. ratti affects the development of its free-living generation, favouring the development of free-living adult males and females at the expense of directly developing, infective 3rd-stage larvae. However, how the host immune response...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/s0031182005007675

    authors: Crook M,Viney ME

    更新日期:2005-09-01 00:00:00

  • A global sensitivity analysis for African sleeping sickness.

    abstract::African sleeping sickness is a parasitic disease transmitted through the bites of tsetse flies of the genus Glossina. We constructed mechanistic models for the basic reproduction number, R0, of Trypanosoma brucei gambiense and Trypanosoma brucei rhodesiense, respectively the causative agents of West and East African h...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/S0031182010001496

    authors: Davis S,Aksoy S,Galvani A

    更新日期:2011-04-01 00:00:00

  • Molecular evolution of freshwater snail intermediate hosts within the Bulinus forskalii group.

    abstract::Freshwater snails of the Bulinus forskalii group are one of four Bulinus species complexes responsible for the transmission of schistosomes in Africa and adjacent regions. The species status of these conchologically variable and widely distributed planorbids remains unclear, and parasite compatibility varies considera...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/s0031182001008381

    authors: Jones CS,Rollinson D,Mimpfoundi R,Ouma J,Kariuki HC,Noble LR

    更新日期:2001-01-01 00:00:00

  • Boophilus microplus: the effect of histamine on the attachment of cattle-tick larvae--studies in vivo and in vitro.

    abstract::Circumstantial evidence suggests that the earlier detachment of Boophilus microplus larvae from highly resistant cattle follows the release of histamine at the attachment site. In vivo and in vitro experiments show that a proportion of the larvae will detach following injection or infusion of histamine. Other mediator...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/s0031182000000950

    authors: Kemp DH,Bourne A

    更新日期:1980-06-01 00:00:00

  • Efficacy of narasin against hepatic and intestinal coccidiosis in rabbits.

    abstract::The anticoccidial effect of narasin against Eimeria flavescens, E. intestinalis, E. magna, E. perforans and E. stiedai was tested in experimentally infected rabbits. The drug was highly effective in reducing oocyst output and in preventing clinical signs. Maximum activity as measured by oocyst discharge was achieved w...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/s0031182000085309

    authors: Peeters JE,Geeroms R,Antoine O,Mammerickx M,Halen P

    更新日期:1981-10-01 00:00:00

  • The effect of temperature on times to hatching of eggs of the nematode Ostertagia circumcincta.

    abstract::A delayed gamma distribution satisfactorily described the distribution of times to hatching of Ostertagia circumcincta eggs incubated in 0.1% saline at temperatures between 6 and 20 degrees C. Below 6 degree C hatching of eggs was extremely variable. The relationship between rates of development and temperature within...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/s0031182000061874

    authors: Young RR,Anderson N,Overend D,Tweedie RL,Malafant KW,Preston GA

    更新日期:1980-12-01 00:00:00

  • Modulation of host cell receptors: a mechanism for the survival of malaria parasites.

    abstract::Intra-erythrocytic stages of malaria parasites can alter the surface of their host cells and release toxins which induce the production of cytokines, which in turn can up- or down-regulate the expression of adhesion receptors on the surface of microvascular endothelial cells. New adhesion receptors on endothelial cell...

    journal_title:Parasitology

    pub_type: 杂志文章,评审

    doi:10.1017/s0031182097002345

    authors: Hommel M

    更新日期:1997-01-01 00:00:00

  • DNA base composition of filarial nematodes.

    abstract::We have determined the molar content of guanine + cytosine (GC content) of DNA of the filarial nematode (Brugia malayi, Brugia pahangi and Dirofilaria imitis) and of the free-living soil nematodes Caenorhabditis elegans and have analysed the DNA for the presence of methylcytosine. Two independent methods, thermal dena...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/s0031182000066750

    authors: Rothstein N,Stoller TJ,Rajan TV

    更新日期:1988-08-01 00:00:00

  • Dissection of the hierarchy and synergism of the bile derived signal on Cryptosporidium parvum excystation and infectivity.

    abstract::Bile salts have been identified as an important trigger for excystation of Cryptosporidium oocysts but the hierarchy or synergism of this signal in relation to other triggers involved in excystation is poorly understood. In addition to excystation, bile salts have also been reported to increase the invasiveness of spo...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/S0031182012000984

    authors: King BJ,Keegan AR,Phillips R,Fanok S,Monis PT

    更新日期:2012-10-01 00:00:00