Abstract:
:We examine the evolution of microparasites in response to the immune system of vertebrate hosts. We first describe a simple model for an acute infection. This model suggests that the within-host dynamics of the microparasite will be a 'race' between parasite multiplication and a clonally expanding response by the host immune system, resulting either in immune-mediated clearance or host death. In this very simple model, in which there is only a single parasite and host genotype, maximum transmission is obtained by parasites with intermediate rates of growth (and virulence). We examine how these predictions depend on key assumptions about the parasite and the host, and consider how this model may be expanded to incorporate the effect of additional complexities such as host-parasite co-evolution, host polymorphism, and multiple infections.
journal_name
Parasitologyjournal_title
Parasitologyauthors
Antia R,Lipsitch Mdoi
10.1017/s003118209700200xsubject
Has Abstractpub_date
1997-01-01 00:00:00pages
S155-67eissn
0031-1820issn
1469-8161journal_volume
115 Supplpub_type
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