Vector survival and parasite infection: the effect of Wuchereria bancrofti on its vector Culex quinquefasciatus.


:This paper investigates a cohort of 2187 laboratory reared Culex quinquefasciatus fed on 69 human volunteers, including 59 persons with different levels of Wuchereria bancrofti microfilariae and 10 without microfilaria. Mosquitoes were followed until death. Mosquito survival was analysed in relation to the level of microfilaria in the human and larval count in the dead mosquito. Vector mortality during the extrinsic incubation period (12 days post-engorgement) was significantly higher in mosquitoes fed on microfilaraemic volunteers (50%) than in those fed on amicrofilaraemics (29%). Both the percentage infected and the geometric mean parasite density was significantly higher among mosquitoes which died before 13 days (45% infected and 10 larvae per infected mosquito) than those surviving beyond 13 days (39% and 2.2), suggesting a parasite loss of more than 80% during the extrinsic incubation period. A large proportion (62%) of the mosquitoes that died during the early of phase of parasite development were infected (36% in low, 26% in medium and 90% in high human Mf-density). Survival analysis showed that the parasite load in mosquitoes and the human Mf-density for a given parasite load are independent risk factors of vector survival. Overall, the hazard of dying was found to be 11-15 times higher among mosquitoes fed on microfilaraemic volunteers than those fed on amicrofilaraemics. The hazard doubles for every increase of about 60-70 parasites in the vector. As a consequence of the parasite-induced reduction in vector survival, the transmission success of the parasite is reduced. The implication of the results on control/elimination of lymphatic filariasis using mass-drug administration is discussed.






Krishnamoorthy K,Subramanian S,Van Oortmarssen GJ,Habbema JD,Das PK




Has Abstract


2004-07-01 00:00:00




Pt 1








  • Host-parasite relationship between congenital Toxoplasma infection and mouse brain: role of small vessels.

    abstract::Small vessels showing inflammatory cell infiltrates were invariably observed in the vicinity of intact Toxoplasma tissue cysts within the brains of mice congenitally infected with the protozoan. Lymphocytes were observed in intimate contact with the luminal aspect of the endothelium, penetrating into the thickened bas...


    pub_type: 杂志文章


    authors: Sims TA,Hay J

    更新日期:1995-02-01 00:00:00

  • Female mice mate preferentially with non-parasitized males.

    abstract::If parasitic infection is a driving force in female mate choice, then females should preferentially select parasite-free males. The role of infection on female mate choice in mammals was assessed using a 3-chambered apparatus. A female CD-1 mouse was allowed to choose between 2 tethered male mice, 1 uninfected and 1 i...


    pub_type: 杂志文章


    authors: Ehman KD,Scott ME

    更新日期:2002-11-01 00:00:00

  • Tick immunobiology.

    abstract::Ticks are of vast medical and veterinary public health importance due to direct damage caused by feeding and their roles in transmitting well known and emerging infectious agents. Ticks and tick-borne pathogens stimulate the immune system of the host. Those immune interactions are of importance in tick biology, pathog...


    pub_type: 杂志文章,评审


    authors: Brossard M,Wikel SK

    更新日期:2004-01-01 00:00:00

  • The formation of the first-stage cuticle within the egg of Trichostrongylus colubriformis.

    abstract::The ultrastructure of the formation of the first-stage cuticle within the egg of Trichostrongylus colubriformis is described. The first indication of cuticle formation was the formation of the epicuticle external to the epidermal plasma membrane. This becomes thickened to form the epicuticle of the fully formed cuticl...


    pub_type: 杂志文章


    authors: Wharton DA,Bone LW

    更新日期:1988-12-01 00:00:00

  • Immunocytochemical demonstration of neuropeptides in the nervous system of the liver fluke, Fasciola hepatica (Trematoda, Digenea).

    abstract::The localization and distribution of neuropeptides in the nervous system of the liver fluke, Fasciola hepatica at different stages in the development of the adult fluke have been determined by an indirect immunofluorescence technique, using antisera to 19 vertebrate peptides and the invertebrate neuropeptide, FMRFamid...


    pub_type: 杂志文章


    authors: Magee RM,Fairweather I,Johnston CF,Halton DW,Shaw C

    更新日期:1989-04-01 00:00:00

  • Glucose-restriction increases Trichomonas vaginalis cellular damage towards HeLa cells and proteolytic activity of cysteine proteinases (CPs), such as TvCP2.

    abstract::Trichomonas vaginalis induces cellular damage to the host cells (cytotoxicity) through the proteolytic activity of multiple proteinases of the cysteine type (CPs). Some CPs are modulated by environmental factors such as iron, zinc, polyamines, etc. Thus, the goal of this study was to assess the effect of glucose on T....


    pub_type: 杂志文章


    authors: Miranda-Ozuna JFT,Rivera-Rivas LA,Cárdenas-Guerra RE,Hernández-García MS,Rodríguez-Cruz S,González-Robles A,Chavez-Munguía B,Arroyo R

    更新日期:2019-08-01 00:00:00

  • Experimental combination therapy using low doses of benznidazole and allopurinol in mouse models of Trypanosoma cruzi chronic infection.

    abstract::This study evaluated the effectiveness of low doses of benznidazole (BNZ) on continuous administration (BNZc), combined with allopurinol (ALO), in C57BL/6J and C3H/HeN mice infected with Trypanosoma cruzi Nicaragua strain and T. cruzi Sylvio-X10/4 clone. TcN-C57BL/6J was also treated with intermittent doses of BNZ (BN...


    pub_type: 杂志文章


    authors: Rial MS,Scalise ML,López Alarcón M,Esteva MI,Búa J,Benatar AF,Prado NG,Riarte AR,Fichera LE

    更新日期:2019-03-01 00:00:00

  • The relationship of Hammondia hammondi and Sarcocystis mucosa to other heteroxenous cyst-forming coccidia as inferred by phylogenetic analysis of the 18S SSU ribosomal DNA sequence.

    abstract::The complete sequence of the 18S small subunit (SSU) ribosomal DNA of Hammondia hammondi and Sarcocystis mucosa was obtained and compared to SSU rDNA sequences of Neospora caninum, Toxoplasma gondii, Besnoitia besnoiti, 2 species of Frenkelia, 3 species of Isospora, and 13 species of Sarcocystis. Analyses showed that ...


    pub_type: 杂志文章


    authors: Jenkins MC,Ellis JT,Liddell S,Ryce C,Munday BL,Morrison DA,Dubey JP

    更新日期:1999-08-01 00:00:00

  • Diverse single-amino-acid repeat profiles in the genus Cryptosporidium.

    abstract::Genome sequencing has greatly contributed to our understanding of parasitic protozoa. This is particularly the case for Cryptosporidium species (phylum Apicomplexa) which are difficult to propagate. Because of their polymorphic nature, simple sequence repeats have been used extensively as genotypic markers to differen...


    pub_type: 杂志文章


    authors: Widmer G

    更新日期:2018-08-01 00:00:00

  • Effects of parasites upon non-host predator avoidance behaviour in native and invasive gammarids.

    abstract::The acanthocephalan parasite, Polymorphus minutus, manipulates its intermediate hosts' (gammarids) behaviour, presumably to facilitate its transmission to the definitive hosts. A fundamental question is whether this capability has evolved to target gammarids in general, or specifically sympatric gammarids. We assessed...


    pub_type: 杂志文章


    authors: Farahani S,Palsbøll PJ,Pen I,Komdeur J

    更新日期:2020-11-13 00:00:00

  • Experimental mixed infection of Leishmania (Leishmania) amazonensis and Leishmania (L.) infantum in hamsters (Mesocricetus auratus).

    abstract::In South America, visceral leishmaniasis is frequently caused by Leishmania infantum and, at an unknown frequency, by Leishmania amazonensis. Therefore, mixed infections with these organisms are possible. Mixed infections might affect the clinical course, immune response, diagnosis, treatment and epidemiology of the d...


    pub_type: 杂志文章


    authors: DE Lima Celeste JL,Venuto Moura AP,França-Silva JC,Matos DE Sousa G,Oliveira Silva S,Norma Melo M,Luiz Tafuri W,Carvalho Souza C,Monteiro DE Andrade H

    更新日期:2017-08-01 00:00:00

  • An in silico structure-based approach to anti-infective drug discovery.

    abstract::In light of the low success rate of target-based genomics and HTS (High Throughput Screening) approaches in anti-infective drug discovery, in silico structure-based drug design (SBDD) is becoming increasingly prominent at the forefront of drug discovery. In silico SBDD can be used to identify novel enzyme inhibitors r...


    pub_type: 杂志文章,评审


    authors: Cunningham F,McPhillie MJ,Johnson AP,Fishwick CW

    更新日期:2014-01-01 00:00:00

  • The interaction between the gelatin-binding domain of fibronectin and the attachment of Pasteuria penetrans endospores to nematode cuticle.

    abstract::Pasteuria penetrans is a Gram-positive endospore-producing bacterium that is a parasite of root-knot nematodes. Attachment of endospores to the cuticle of the nematode is the first stage in the infection process. Western blot analysis with monoclonal and polyclonal antibodies that recognize the 30 kDa heparin-binding ...


    pub_type: 杂志文章


    authors: Mohan S,Fould S,Davies KG

    更新日期:2001-09-01 00:00:00

  • Can Wolbachia modulate the fecundity costs of Plasmodium in mosquitoes?

    abstract::Vertically transmitted parasites (VTPs) such as Wolbachia are expected not only to minimize the damage they inflict on their hosts, but also to protect their hosts against the damaging effects of coinfecting parasites. By modifying the fitness costs of the infection, VTPs can therefore play an important role in the ev...


    pub_type: 杂志文章


    authors: Zélé F,Denoyelle J,Duron O,Rivero A

    更新日期:2018-05-01 00:00:00

  • Immunomodulatory agents in the laboratory and clinic.

    abstract::This paper reviews naturally occurring and synthetic compounds that either enhance immune defences or lower both natural and acquired immunity. Immunomodulatory agents used both for laboratory study and clinically for the management of immunologically based diseases are considered. ...


    pub_type: 杂志文章,评审


    authors: Nüssler AK,Thomson AW

    更新日期:1992-01-01 00:00:00

  • Babesia parasites develop and are transmitted by the non-vector soft tick Ornithodoros moubata (Acari: Argasidae).

    abstract::Ornithodoros moubata ticks were fed on blood infected with Babesia equi. However, the parasites were quickly cleared as evidenced by the disappearance of B. equi-specific ribosomal RNA from the ticks. We hypothesized that if the Babesia parasite can escape midgut-associated barriers a non-vector tick can become infect...


    pub_type: 杂志文章


    authors: Battsetseg B,Matsuo T,Xuan X,Boldbaatar D,Chee SH,Umemiya R,Sakaguchi T,Hatta T,Zhou J,Verdida AR,Taylor D,Fujisaki K

    更新日期:2007-01-01 00:00:00

  • An investigation of fructose utilization in Acanthocheilonema viteae.

    abstract::The capacity of Acanthocheilonema viteae to metabolize fructose was investigated in vitro. In common with other filarial species A. viteae oxidized fructose to lactate but its rate of consumption was only 40% of the glucose-containing control value. Fructose was not incorporated into glycogen. Release of 14CO2 from [U...


    pub_type: 杂志文章


    authors: Hayes DJ,Carter NS

    更新日期:1990-12-01 00:00:00

  • A Cooperia punctata gene family encoding 14 kDa excretory-secretory antigens conserved for trichostrongyloid nematodes.

    abstract::A polymorphic set of 14 kDa excretory-secretory (E-S) antigen-encoding cDNAs, with similarity to a previously characterized 15 kDa E-S antigen of Haemonchus contortus, was cloned from Cooperia punctata. Five cDNAs encoding predicted proteins of 70-80% identity were sequenced. Genomic analyses of individuals proved the...


    pub_type: 杂志文章


    authors: Yatsuda AP,De Vries E,Vieira Bressan MC,Eysker M

    更新日期:2001-12-01 00:00:00

  • A new thrombospondin-related anonymous protein homologue in Neospora caninum (NcMIC2-like1).

    abstract::Neospora caninum is an Apicomplexan protozoan that has the dog as a definitive host and cattle (among other animals) as intermediate hosts. It causes encephalopathy in dogs and abortion in cows, with significant loss in worldwide livestock. As any Apicomplexan, the parasite invades the cells using proteins contained i...


    pub_type: 杂志文章


    authors: Pereira LM,Candido-Silva JA,De Vries E,Yatsuda AP

    更新日期:2011-03-01 00:00:00

  • Strongyloides ratti: studies of 75Se-labelled larvae of the homogonic strain in female hosts.

    abstract::A prediction of the hypothesis of Wilson (1977, 1980 a, b) to account for larval migration of homogonic Strongyloides ratti in the host is that the pattern of invasion of the mammary gland of a lactating rat will be quantitatively similar on both sides and independent of the point of entry into the body. Twenty-one su...


    pub_type: 杂志文章


    authors: Wilson PA,Simpson NE

    更新日期:1982-06-01 00:00:00

  • Detection of eight Cryptosporidium genotypes in surface and waste waters in Europe.

    abstract::Cryptosporidia are important protozoan parasites of vertebrates, and a number of species and genotypes, with different host ranges, have been described. In this study a protocol was established for the detection and the genetic characterization of Cryptosporidium spp. isolated from various types of surface waters (riv...


    pub_type: 杂志文章


    authors: Ward PI,Deplazes P,Regli W,Rinder H,Mathis A

    更新日期:2002-04-01 00:00:00

  • Alternative oxidase inhibitors as antiparasitic agents against scuticociliatosis.

    abstract::Philasterides dicentrarchi causes a severe disease in turbot, and at present there are no drugs available to treat infected fish. We have previously demonstrated that, in addition to the classical respiratory pathway, P. dicentrarchi possesses an alternative mitochondrial respiratory pathway that is cyanide-insensitiv...


    pub_type: 杂志文章


    authors: Mallo N,Lamas J,Leiro JM

    更新日期:2014-09-01 00:00:00

  • Economic costs of protistan and metazoan parasites to global mariculture.

    abstract::Parasites have a major impact on global finfish and shellfish aquaculture, having significant effects on farm production, sustainability and economic viability. Parasite infections and impacts can, according to pathogen and context, be considered to be either unpredictable/sporadic or predictable/regular. Although bot...


    pub_type: 杂志文章,评审


    authors: Shinn AP,Pratoomyot J,Bron JE,Paladini G,Brooker EE,Brooker AJ

    更新日期:2015-01-01 00:00:00

  • Sub-cellular fractionation of Trypanosoma brucei. Isolation and characterization of plasma membranes.

    abstract::A procedure is described for the isolation of sub-cellular fractions from bloodstream forms of Trypanosoma brucei. The method leaves intact most of the nuclei, mitochondria and microbodies. All the fractions have been chemically characterized and tested for 10 enzymatic markers. About 5% of total cell protein was isol...


    pub_type: 杂志文章


    authors: Rovis L,Baekkeskov S

    更新日期:1980-06-01 00:00:00

  • Development of a strategy for the identification of surface proteins in the pathogenic microsporidian Nosema bombycis.

    abstract::Parasite-host interactions mediated by cell surface proteins have been implicated as a critical step in infections caused by the microsporidian Nosema bombycis. Such cell surface proteins are considered as promising diagnostic markers and targets for drug development. However, little research has specifically addresse...


    pub_type: 杂志文章


    authors: Zhao W,Hao Y,Wang L,Zhou Z,Li Z

    更新日期:2015-06-01 00:00:00

  • Induction of immunity in sheep to Fasciola hepatica with mimotopes of cathepsin L selected from a phage display library.

    abstract::An M13 phage random 12-mers peptide library was used to screen cathepsin L mimotopes of Fasciola hepatica and to evaluate their immunogenicity in sheep. Seven clones showed positive reactivity to a rabbit anti-cathepsin L1/L2 antiserum in ELISA, and their amino acid sequences deduced by DNA sequencing were tentatively...


    pub_type: 杂志文章


    authors: Villa-Mancera A,Quiroz-Romero H,Correa D,Ibarra F,Reyes-Pérez M,Reyes-Vivas H,López-Velázquez G,Gazarian K,Gazarian T,Alonso RA

    更新日期:2008-10-01 00:00:00

  • Cellular and biochemical characterization of two closely related triosephosphate isomerases from Trichomonas vaginalis.

    abstract::The glycolytic enzyme triosephosphate isomerase catalyses the isomerization between glyceraldehyde 3-phosphate and dihydroxyacetone phosphate. Here we report that Trichomonas vaginalis contains 2 fully functional tpi genes. Both genes are located in separated chromosomal context with different promoter regulatory elem...


    pub_type: 杂志文章


    authors: Figueroa-Angulo EE,Estrella-Hernández P,Salgado-Lugo H,Ochoa-Leyva A,Gómez Puyou A,Campos SS,Montero-Moran G,Ortega-López J,Saab-Rincón G,Arroyo R,Benítez-Cardoza CG,Brieba LG

    更新日期:2012-11-01 00:00:00

  • Allosteric control of pyrimidine transport in Hymenolepis diminuta: an unusual kinetic isotope effect.

    abstract::A thymine-uracil transport system is present in the plasma membrane brush-border of the tapeworm, Hymenolepis diminuta. The relation between initial uptake and substrate concentration of either thymine or uracil was sigmoidal when 2-14C-labelled substrates were used. In contrast, absorption kinetics of methyl-14C- and...


    pub_type: 杂志文章


    authors: Uglem GL,Dupre RK,Harley JP

    更新日期:1983-10-01 00:00:00

  • The mannitol cycle in Eimeria.

    abstract::A metabolic pathway known as the mannitol cycle has been identified in Eimerian parasites. The pathway is a shunt off of the glycolytic pathway at fructose-6-phosphate (F6P). Two enzymes convert F6P to mannitol and two other enzymes are responsible for converting mannitol back to F6P when it is utilized. Although the ...


    pub_type: 杂志文章,评审


    authors: Schmatz DM

    更新日期:1997-01-01 00:00:00

  • Identification and diagnosis of Leishmania mexicana complex isolates by polymerase chain reaction.

    abstract::Following cloning of Leishmania (L.) amazonensis kinetoplast DNA two recombinant clones were identified: one specific for L. (L.) amazonensis and the other specific for L. (L.) amazonensis and closely related isolates. DNA sequences from these clones were compared with those of other kinetoplastids and oligonucleotide...


    pub_type: 杂志文章


    authors: Eresh S,McCallum SM,Barker DC

    更新日期:1994-11-01 00:00:00